The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:
"RuvB-like helicase, domain II
".
FunFam 2: RuvB-like helicase
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 31 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
49 |
G0RYC2 (/IPI)
Q12464 (/IPI)
Q12464 (/IPI)
Q12464 (/IPI)
Q12464 (/IPI)
Q12464 (/IPI)
Q12464 (/IPI)
Q12464 (/IPI)
Q12464 (/IPI)
Q8ID85 (/IPI)
(39 more) |
|
DNA helicase activity GO:0003678
Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction drives the unwinding of the DNA helix.
|
29 |
Q8ID85 (/IDA)
Q8ID85 (/IDA)
Q8ID85 (/IDA)
Q8ID85 (/IDA)
Q8ID85 (/IDA)
Q8ID85 (/IDA)
Q8ID85 (/IDA)
Q8ID85 (/IDA)
Q8ID85 (/IDA)
Q8ID85 (/IDA)
(19 more) |
|
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
|
16 |
Q4QQS4 (/IPI)
Q9Y230 (/IPI)
Q9Y230 (/IPI)
Q9Y230 (/IPI)
Q9Y230 (/IPI)
Q9Y230 (/IPI)
Q9Y230 (/IPI)
Q9Y230 (/IPI)
Q9Y230 (/IPI)
Q9Y230 (/IPI)
(6 more) |
|
RNA polymerase II core promoter sequence-specific DNA binding GO:0000979
Interacting selectively and non-covalently with a DNA sequence that is part of the core promoter of a RNA polymerase II-transcribed gene.
|
15 |
Q9Y230 (/IDA)
Q9Y230 (/IDA)
Q9Y230 (/IDA)
Q9Y230 (/IDA)
Q9Y230 (/IDA)
Q9Y230 (/IDA)
Q9Y230 (/IDA)
Q9Y230 (/IDA)
Q9Y230 (/IDA)
Q9Y230 (/IDA)
(5 more) |
|
RNA polymerase II distal enhancer sequence-specific DNA binding GO:0000980
Interacting selectively and non-covalently with a RNA polymerase II (Pol II) distal enhancer. In mammalian cells, enhancers are distal sequences that increase the utilization of some promoters, and can function in either orientation and in any location (upstream or downstream) relative to the core promoter.
|
15 |
Q9Y230 (/IDA)
Q9Y230 (/IDA)
Q9Y230 (/IDA)
Q9Y230 (/IDA)
Q9Y230 (/IDA)
Q9Y230 (/IDA)
Q9Y230 (/IDA)
Q9Y230 (/IDA)
Q9Y230 (/IDA)
Q9Y230 (/IDA)
(5 more) |
|
DNA helicase activity GO:0003678
Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction drives the unwinding of the DNA helix.
|
15 |
Q9Y230 (/TAS)
Q9Y230 (/TAS)
Q9Y230 (/TAS)
Q9Y230 (/TAS)
Q9Y230 (/TAS)
Q9Y230 (/TAS)
Q9Y230 (/TAS)
Q9Y230 (/TAS)
Q9Y230 (/TAS)
Q9Y230 (/TAS)
(5 more) |
|
Transcription corepressor activity GO:0003714
A protein or a member of a complex that interacts specifically and non-covalently with a DNA-bound DNA-binding transcription factor to repress the transcription of specific genes. Corepressors often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second ATP-dependent class modifies the conformation of chromatin. A third class occludes DNA-binding transcription factor protein-protein interaction domains. A fourth class of corepressors prevents interactions of DNA bound DNA-binding transcription factor with coactivators.
|
15 |
Q9Y230 (/IDA)
Q9Y230 (/IDA)
Q9Y230 (/IDA)
Q9Y230 (/IDA)
Q9Y230 (/IDA)
Q9Y230 (/IDA)
Q9Y230 (/IDA)
Q9Y230 (/IDA)
Q9Y230 (/IDA)
Q9Y230 (/IDA)
(5 more) |
|
Beta-catenin binding GO:0008013
Interacting selectively and non-covalently with the beta subunit of the catenin complex.
|
15 |
Q9Y230 (/IDA)
Q9Y230 (/IDA)
Q9Y230 (/IDA)
Q9Y230 (/IDA)
Q9Y230 (/IDA)
Q9Y230 (/IDA)
Q9Y230 (/IDA)
Q9Y230 (/IDA)
Q9Y230 (/IDA)
Q9Y230 (/IDA)
(5 more) |
|
ATPase activity GO:0016887
Catalysis of the reaction: ATP + H2O = ADP + phosphate + 2 H+. May or may not be coupled to another reaction.
|
15 |
P83571 (/IDA)
Q8ID85 (/IDA)
Q8ID85 (/IDA)
Q8ID85 (/IDA)
Q8ID85 (/IDA)
Q8ID85 (/IDA)
Q8ID85 (/IDA)
Q8ID85 (/IDA)
Q8ID85 (/IDA)
Q8ID85 (/IDA)
(5 more) |
|
TBP-class protein binding GO:0017025
Interacting selectively and non-covalently with a member of the class of TATA-binding proteins (TBP), including any of the TBP-related factors (TRFs).
|
15 |
Q9Y230 (/IDA)
Q9Y230 (/IDA)
Q9Y230 (/IDA)
Q9Y230 (/IDA)
Q9Y230 (/IDA)
Q9Y230 (/IDA)
Q9Y230 (/IDA)
Q9Y230 (/IDA)
Q9Y230 (/IDA)
Q9Y230 (/IDA)
(5 more) |
|
Chromatin DNA binding GO:0031490
Interacting selectively and non-covalently with DNA that is assembled into chromatin.
|
15 |
Q9Y230 (/IDA)
Q9Y230 (/IDA)
Q9Y230 (/IDA)
Q9Y230 (/IDA)
Q9Y230 (/IDA)
Q9Y230 (/IDA)
Q9Y230 (/IDA)
Q9Y230 (/IDA)
Q9Y230 (/IDA)
Q9Y230 (/IDA)
(5 more) |
|
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
|
15 |
Q9Y230 (/IDA)
Q9Y230 (/IDA)
Q9Y230 (/IDA)
Q9Y230 (/IDA)
Q9Y230 (/IDA)
Q9Y230 (/IDA)
Q9Y230 (/IDA)
Q9Y230 (/IDA)
Q9Y230 (/IDA)
Q9Y230 (/IDA)
(5 more) |
|
Unfolded protein binding GO:0051082
Interacting selectively and non-covalently with an unfolded protein.
|
15 |
Q9Y230 (/TAS)
Q9Y230 (/TAS)
Q9Y230 (/TAS)
Q9Y230 (/TAS)
Q9Y230 (/TAS)
Q9Y230 (/TAS)
Q9Y230 (/TAS)
Q9Y230 (/TAS)
Q9Y230 (/TAS)
Q9Y230 (/TAS)
(5 more) |
|
3'-5' DNA helicase activity GO:0043138
Catalysis of the reaction: ATP + H2O = ADP + phosphate; drives the unwinding of the DNA helix in the direction 3' to 5'.
|
8 | Q12464 (/IDA) Q12464 (/IDA) Q12464 (/IDA) Q12464 (/IDA) Q12464 (/IDA) Q12464 (/IDA) Q12464 (/IDA) Q12464 (/IDA) |
|
5'-3' DNA helicase activity GO:0043139
Catalysis of the reaction: ATP + H2O = ADP + phosphate; drives the unwinding of the DNA helix in the direction 5' to 3'.
|
8 | Q12464 (/IDA) Q12464 (/IDA) Q12464 (/IDA) Q12464 (/IDA) Q12464 (/IDA) Q12464 (/IDA) Q12464 (/IDA) Q12464 (/IDA) |
|
RNA polymerase II core promoter sequence-specific DNA binding GO:0000979
Interacting selectively and non-covalently with a DNA sequence that is part of the core promoter of a RNA polymerase II-transcribed gene.
|
7 | Q9WTM5 (/ISO) Q9WTM5 (/ISO) Q9WTM5 (/ISO) Q9WTM5 (/ISO) Q9WTM5 (/ISO) Q9WTM5 (/ISO) Q9WTM5 (/ISO) |
|
RNA polymerase II distal enhancer sequence-specific DNA binding GO:0000980
Interacting selectively and non-covalently with a RNA polymerase II (Pol II) distal enhancer. In mammalian cells, enhancers are distal sequences that increase the utilization of some promoters, and can function in either orientation and in any location (upstream or downstream) relative to the core promoter.
|
7 | Q9WTM5 (/ISO) Q9WTM5 (/ISO) Q9WTM5 (/ISO) Q9WTM5 (/ISO) Q9WTM5 (/ISO) Q9WTM5 (/ISO) Q9WTM5 (/ISO) |
|
TFIID-class transcription factor complex binding GO:0001094
Interacting selectively and non-covalently with a general RNA polymerase II transcription factor belonging to the TFIID complex, one of the factors involved in formation of the preinitiation complex (PIC) by RNA polymerase II.
|
7 | Q9WTM5 (/IPI) Q9WTM5 (/IPI) Q9WTM5 (/IPI) Q9WTM5 (/IPI) Q9WTM5 (/IPI) Q9WTM5 (/IPI) Q9WTM5 (/IPI) |
|
DNA helicase activity GO:0003678
Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction drives the unwinding of the DNA helix.
|
7 | Q9WTM5 (/ISO) Q9WTM5 (/ISO) Q9WTM5 (/ISO) Q9WTM5 (/ISO) Q9WTM5 (/ISO) Q9WTM5 (/ISO) Q9WTM5 (/ISO) |
|
Transcription corepressor activity GO:0003714
A protein or a member of a complex that interacts specifically and non-covalently with a DNA-bound DNA-binding transcription factor to repress the transcription of specific genes. Corepressors often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second ATP-dependent class modifies the conformation of chromatin. A third class occludes DNA-binding transcription factor protein-protein interaction domains. A fourth class of corepressors prevents interactions of DNA bound DNA-binding transcription factor with coactivators.
|
7 | Q9WTM5 (/ISO) Q9WTM5 (/ISO) Q9WTM5 (/ISO) Q9WTM5 (/ISO) Q9WTM5 (/ISO) Q9WTM5 (/ISO) Q9WTM5 (/ISO) |
|
ATP binding GO:0005524
Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
|
7 | Q9WTM5 (/IDA) Q9WTM5 (/IDA) Q9WTM5 (/IDA) Q9WTM5 (/IDA) Q9WTM5 (/IDA) Q9WTM5 (/IDA) Q9WTM5 (/IDA) |
|
Beta-catenin binding GO:0008013
Interacting selectively and non-covalently with the beta subunit of the catenin complex.
|
7 | Q9WTM5 (/ISO) Q9WTM5 (/ISO) Q9WTM5 (/ISO) Q9WTM5 (/ISO) Q9WTM5 (/ISO) Q9WTM5 (/ISO) Q9WTM5 (/ISO) |
|
TBP-class protein binding GO:0017025
Interacting selectively and non-covalently with a member of the class of TATA-binding proteins (TBP), including any of the TBP-related factors (TRFs).
|
7 | Q9WTM5 (/ISO) Q9WTM5 (/ISO) Q9WTM5 (/ISO) Q9WTM5 (/ISO) Q9WTM5 (/ISO) Q9WTM5 (/ISO) Q9WTM5 (/ISO) |
|
Chromatin DNA binding GO:0031490
Interacting selectively and non-covalently with DNA that is assembled into chromatin.
|
7 | Q9WTM5 (/ISO) Q9WTM5 (/ISO) Q9WTM5 (/ISO) Q9WTM5 (/ISO) Q9WTM5 (/ISO) Q9WTM5 (/ISO) Q9WTM5 (/ISO) |
|
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
|
7 | Q9WTM5 (/ISO) Q9WTM5 (/ISO) Q9WTM5 (/ISO) Q9WTM5 (/ISO) Q9WTM5 (/ISO) Q9WTM5 (/ISO) Q9WTM5 (/ISO) |
|
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
|
7 | Q9WTM5 (/IPI) Q9WTM5 (/IPI) Q9WTM5 (/IPI) Q9WTM5 (/IPI) Q9WTM5 (/IPI) Q9WTM5 (/IPI) Q9WTM5 (/IPI) |
|
ADP binding GO:0043531
Interacting selectively and non-covalently with ADP, adenosine 5'-diphosphate.
|
7 | Q9WTM5 (/IDA) Q9WTM5 (/IDA) Q9WTM5 (/IDA) Q9WTM5 (/IDA) Q9WTM5 (/IDA) Q9WTM5 (/IDA) Q9WTM5 (/IDA) |
|
ATPase binding GO:0051117
Interacting selectively and non-covalently with an ATPase, any enzyme that catalyzes the hydrolysis of ATP.
|
7 | Q9WTM5 (/IPI) Q9WTM5 (/IPI) Q9WTM5 (/IPI) Q9WTM5 (/IPI) Q9WTM5 (/IPI) Q9WTM5 (/IPI) Q9WTM5 (/IPI) |
|
Transcription corepressor activity GO:0003714
A protein or a member of a complex that interacts specifically and non-covalently with a DNA-bound DNA-binding transcription factor to repress the transcription of specific genes. Corepressors often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second ATP-dependent class modifies the conformation of chromatin. A third class occludes DNA-binding transcription factor protein-protein interaction domains. A fourth class of corepressors prevents interactions of DNA bound DNA-binding transcription factor with coactivators.
|
4 | Q9V3K3 (/IMP) Q9V3K3 (/IMP) Q9V3K3 (/IMP) Q9V3K3 (/IMP) |
|
Transcription corepressor activity GO:0003714
A protein or a member of a complex that interacts specifically and non-covalently with a DNA-bound DNA-binding transcription factor to repress the transcription of specific genes. Corepressors often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second ATP-dependent class modifies the conformation of chromatin. A third class occludes DNA-binding transcription factor protein-protein interaction domains. A fourth class of corepressors prevents interactions of DNA bound DNA-binding transcription factor with coactivators.
|
2 | Q16TA2 (/ISS) Q29DI0 (/ISS) |
|
DNA helicase activity GO:0003678
Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction drives the unwinding of the DNA helix.
|
1 | P83571 (/ISS) |
There are 57 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
DNA repair GO:0006281
The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway.
|
15 |
Q9Y230 (/TAS)
Q9Y230 (/TAS)
Q9Y230 (/TAS)
Q9Y230 (/TAS)
Q9Y230 (/TAS)
Q9Y230 (/TAS)
Q9Y230 (/TAS)
Q9Y230 (/TAS)
Q9Y230 (/TAS)
Q9Y230 (/TAS)
(5 more) |
|
DNA recombination GO:0006310
Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Interchromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction.
|
15 |
Q9Y230 (/TAS)
Q9Y230 (/TAS)
Q9Y230 (/TAS)
Q9Y230 (/TAS)
Q9Y230 (/TAS)
Q9Y230 (/TAS)
Q9Y230 (/TAS)
Q9Y230 (/TAS)
Q9Y230 (/TAS)
Q9Y230 (/TAS)
(5 more) |
|
Chromatin remodeling GO:0006338
Dynamic structural changes to eukaryotic chromatin occurring throughout the cell division cycle. These changes range from the local changes necessary for transcriptional regulation to global changes necessary for chromosome segregation.
|
15 |
Q9Y230 (/IMP)
Q9Y230 (/IMP)
Q9Y230 (/IMP)
Q9Y230 (/IMP)
Q9Y230 (/IMP)
Q9Y230 (/IMP)
Q9Y230 (/IMP)
Q9Y230 (/IMP)
Q9Y230 (/IMP)
Q9Y230 (/IMP)
(5 more) |
|
Protein folding GO:0006457
The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure.
|
15 |
Q9Y230 (/TAS)
Q9Y230 (/TAS)
Q9Y230 (/TAS)
Q9Y230 (/TAS)
Q9Y230 (/TAS)
Q9Y230 (/TAS)
Q9Y230 (/TAS)
Q9Y230 (/TAS)
Q9Y230 (/TAS)
Q9Y230 (/TAS)
(5 more) |
|
Cellular response to UV GO:0034644
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ultraviolet radiation (UV light) stimulus. Ultraviolet radiation is electromagnetic radiation with a wavelength in the range of 10 to 380 nanometers.
|
15 |
Q9Y230 (/IMP)
Q9Y230 (/IMP)
Q9Y230 (/IMP)
Q9Y230 (/IMP)
Q9Y230 (/IMP)
Q9Y230 (/IMP)
Q9Y230 (/IMP)
Q9Y230 (/IMP)
Q9Y230 (/IMP)
Q9Y230 (/IMP)
(5 more) |
|
Positive regulation of histone acetylation GO:0035066
Any process that activates or increases the frequency, rate or extent of the addition of an acetyl group to a histone protein.
|
15 |
Q9Y230 (/IMP)
Q9Y230 (/IMP)
Q9Y230 (/IMP)
Q9Y230 (/IMP)
Q9Y230 (/IMP)
Q9Y230 (/IMP)
Q9Y230 (/IMP)
Q9Y230 (/IMP)
Q9Y230 (/IMP)
Q9Y230 (/IMP)
(5 more) |
|
Histone H4 acetylation GO:0043967
The modification of histone H4 by the addition of an acetyl group.
|
15 |
Q9Y230 (/IDA)
Q9Y230 (/IDA)
Q9Y230 (/IDA)
Q9Y230 (/IDA)
Q9Y230 (/IDA)
Q9Y230 (/IDA)
Q9Y230 (/IDA)
Q9Y230 (/IDA)
Q9Y230 (/IDA)
Q9Y230 (/IDA)
(5 more) |
|
Histone H2A acetylation GO:0043968
The modification of histone H2A by the addition of an acetyl group.
|
15 |
Q9Y230 (/IDA)
Q9Y230 (/IDA)
Q9Y230 (/IDA)
Q9Y230 (/IDA)
Q9Y230 (/IDA)
Q9Y230 (/IDA)
Q9Y230 (/IDA)
Q9Y230 (/IDA)
Q9Y230 (/IDA)
Q9Y230 (/IDA)
(5 more) |
|
Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
|
15 |
Q9Y230 (/IMP)
Q9Y230 (/IMP)
Q9Y230 (/IMP)
Q9Y230 (/IMP)
Q9Y230 (/IMP)
Q9Y230 (/IMP)
Q9Y230 (/IMP)
Q9Y230 (/IMP)
Q9Y230 (/IMP)
Q9Y230 (/IMP)
(5 more) |
|
Establishment of protein localization to chromatin GO:0071169
The directed movement of a protein to a part of a chromosome that is organized into chromatin.
|
15 |
Q9Y230 (/IMP)
Q9Y230 (/IMP)
Q9Y230 (/IMP)
Q9Y230 (/IMP)
Q9Y230 (/IMP)
Q9Y230 (/IMP)
Q9Y230 (/IMP)
Q9Y230 (/IMP)
Q9Y230 (/IMP)
Q9Y230 (/IMP)
(5 more) |
|
Cellular response to estradiol stimulus GO:0071392
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of stimulus by estradiol, a C18 steroid hormone hydroxylated at C3 and C17 that acts as a potent estrogen.
|
15 |
Q9Y230 (/IMP)
Q9Y230 (/IMP)
Q9Y230 (/IMP)
Q9Y230 (/IMP)
Q9Y230 (/IMP)
Q9Y230 (/IMP)
Q9Y230 (/IMP)
Q9Y230 (/IMP)
Q9Y230 (/IMP)
Q9Y230 (/IMP)
(5 more) |
|
Transcriptional activation by promoter-enhancer looping GO:0071733
The formation and maintenance of DNA loops that juxtapose the promoter and enhancer regions of RNA polymerase II-transcribed genes and activate transcription from an RNA polymerase II promoter.
|
15 |
Q9Y230 (/IMP)
Q9Y230 (/IMP)
Q9Y230 (/IMP)
Q9Y230 (/IMP)
Q9Y230 (/IMP)
Q9Y230 (/IMP)
Q9Y230 (/IMP)
Q9Y230 (/IMP)
Q9Y230 (/IMP)
Q9Y230 (/IMP)
(5 more) |
|
Negative regulation of estrogen receptor binding GO:0071899
Any process that stops, prevents, or reduces the frequency, rate or extent of estrogen receptor binding, interacting selectively with an estrogen receptor.
|
15 |
Q9Y230 (/IMP)
Q9Y230 (/IMP)
Q9Y230 (/IMP)
Q9Y230 (/IMP)
Q9Y230 (/IMP)
Q9Y230 (/IMP)
Q9Y230 (/IMP)
Q9Y230 (/IMP)
Q9Y230 (/IMP)
Q9Y230 (/IMP)
(5 more) |
|
Negative regulation of canonical Wnt signaling pathway GO:0090090
Any process that decreases the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes.
|
15 |
Q9Y230 (/IDA)
Q9Y230 (/IDA)
Q9Y230 (/IDA)
Q9Y230 (/IDA)
Q9Y230 (/IDA)
Q9Y230 (/IDA)
Q9Y230 (/IDA)
Q9Y230 (/IDA)
Q9Y230 (/IDA)
Q9Y230 (/IDA)
(5 more) |
|
Positive regulation of telomerase RNA localization to Cajal body GO:1904874
Any process that activates or increases the frequency, rate or extent of telomerase RNA localization to Cajal body.
|
15 |
Q9Y230 (/HMP)
Q9Y230 (/HMP)
Q9Y230 (/HMP)
Q9Y230 (/HMP)
Q9Y230 (/HMP)
Q9Y230 (/HMP)
Q9Y230 (/HMP)
Q9Y230 (/HMP)
Q9Y230 (/HMP)
Q9Y230 (/HMP)
(5 more) |
|
Chromatin remodeling GO:0006338
Dynamic structural changes to eukaryotic chromatin occurring throughout the cell division cycle. These changes range from the local changes necessary for transcriptional regulation to global changes necessary for chromosome segregation.
|
9 | O94692 (/IPI) Q12464 (/IPI) Q12464 (/IPI) Q12464 (/IPI) Q12464 (/IPI) Q12464 (/IPI) Q12464 (/IPI) Q12464 (/IPI) Q12464 (/IPI) |
|
Histone exchange GO:0043486
The replacement, within chromatin, of resident histones or histone subunits with alternative, sometimes variant, histones or subunits.
|
9 | O94692 (/IPI) Q12464 (/IPI) Q12464 (/IPI) Q12464 (/IPI) Q12464 (/IPI) Q12464 (/IPI) Q12464 (/IPI) Q12464 (/IPI) Q12464 (/IPI) |
|
Box C/D snoRNP assembly GO:0000492
The aggregation, arrangement and bonding together of proteins and a box C/D snoRNA to form a box C/D small nucleolar ribonucleoprotein (snoRNP) complex.
|
8 | Q12464 (/IMP) Q12464 (/IMP) Q12464 (/IMP) Q12464 (/IMP) Q12464 (/IMP) Q12464 (/IMP) Q12464 (/IMP) Q12464 (/IMP) |
|
Regulation of transcription by RNA polymerase II GO:0006357
Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II.
|
8 | Q12464 (/IMP) Q12464 (/IMP) Q12464 (/IMP) Q12464 (/IMP) Q12464 (/IMP) Q12464 (/IMP) Q12464 (/IMP) Q12464 (/IMP) |
|
RRNA processing GO:0006364
Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules.
|
8 | Q12464 (/IMP) Q12464 (/IMP) Q12464 (/IMP) Q12464 (/IMP) Q12464 (/IMP) Q12464 (/IMP) Q12464 (/IMP) Q12464 (/IMP) |
|
Histone H4 acetylation GO:0043967
The modification of histone H4 by the addition of an acetyl group.
|
8 | Q2TBU9 (/ISS) Q9WTM5 (/ISS) Q9WTM5 (/ISS) Q9WTM5 (/ISS) Q9WTM5 (/ISS) Q9WTM5 (/ISS) Q9WTM5 (/ISS) Q9WTM5 (/ISS) |
|
Histone H2A acetylation GO:0043968
The modification of histone H2A by the addition of an acetyl group.
|
8 | Q2TBU9 (/ISS) Q9WTM5 (/ISS) Q9WTM5 (/ISS) Q9WTM5 (/ISS) Q9WTM5 (/ISS) Q9WTM5 (/ISS) Q9WTM5 (/ISS) Q9WTM5 (/ISS) |
|
Chromatin remodeling GO:0006338
Dynamic structural changes to eukaryotic chromatin occurring throughout the cell division cycle. These changes range from the local changes necessary for transcriptional regulation to global changes necessary for chromosome segregation.
|
7 | Q9WTM5 (/ISO) Q9WTM5 (/ISO) Q9WTM5 (/ISO) Q9WTM5 (/ISO) Q9WTM5 (/ISO) Q9WTM5 (/ISO) Q9WTM5 (/ISO) |
|
Cellular response to UV GO:0034644
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ultraviolet radiation (UV light) stimulus. Ultraviolet radiation is electromagnetic radiation with a wavelength in the range of 10 to 380 nanometers.
|
7 | Q9WTM5 (/ISO) Q9WTM5 (/ISO) Q9WTM5 (/ISO) Q9WTM5 (/ISO) Q9WTM5 (/ISO) Q9WTM5 (/ISO) Q9WTM5 (/ISO) |
|
Positive regulation of histone acetylation GO:0035066
Any process that activates or increases the frequency, rate or extent of the addition of an acetyl group to a histone protein.
|
7 | Q9WTM5 (/ISO) Q9WTM5 (/ISO) Q9WTM5 (/ISO) Q9WTM5 (/ISO) Q9WTM5 (/ISO) Q9WTM5 (/ISO) Q9WTM5 (/ISO) |
|
Histone H4 acetylation GO:0043967
The modification of histone H4 by the addition of an acetyl group.
|
7 | Q9WTM5 (/ISO) Q9WTM5 (/ISO) Q9WTM5 (/ISO) Q9WTM5 (/ISO) Q9WTM5 (/ISO) Q9WTM5 (/ISO) Q9WTM5 (/ISO) |
|
Histone H2A acetylation GO:0043968
The modification of histone H2A by the addition of an acetyl group.
|
7 | Q9WTM5 (/ISO) Q9WTM5 (/ISO) Q9WTM5 (/ISO) Q9WTM5 (/ISO) Q9WTM5 (/ISO) Q9WTM5 (/ISO) Q9WTM5 (/ISO) |
|
Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
|
7 | Q9WTM5 (/ISO) Q9WTM5 (/ISO) Q9WTM5 (/ISO) Q9WTM5 (/ISO) Q9WTM5 (/ISO) Q9WTM5 (/ISO) Q9WTM5 (/ISO) |
|
Establishment of protein localization to chromatin GO:0071169
The directed movement of a protein to a part of a chromosome that is organized into chromatin.
|
7 | Q9WTM5 (/ISO) Q9WTM5 (/ISO) Q9WTM5 (/ISO) Q9WTM5 (/ISO) Q9WTM5 (/ISO) Q9WTM5 (/ISO) Q9WTM5 (/ISO) |
|
Cellular response to estradiol stimulus GO:0071392
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of stimulus by estradiol, a C18 steroid hormone hydroxylated at C3 and C17 that acts as a potent estrogen.
|
7 | Q9WTM5 (/ISO) Q9WTM5 (/ISO) Q9WTM5 (/ISO) Q9WTM5 (/ISO) Q9WTM5 (/ISO) Q9WTM5 (/ISO) Q9WTM5 (/ISO) |
|
Transcriptional activation by promoter-enhancer looping GO:0071733
The formation and maintenance of DNA loops that juxtapose the promoter and enhancer regions of RNA polymerase II-transcribed genes and activate transcription from an RNA polymerase II promoter.
|
7 | Q9WTM5 (/ISO) Q9WTM5 (/ISO) Q9WTM5 (/ISO) Q9WTM5 (/ISO) Q9WTM5 (/ISO) Q9WTM5 (/ISO) Q9WTM5 (/ISO) |
|
Negative regulation of estrogen receptor binding GO:0071899
Any process that stops, prevents, or reduces the frequency, rate or extent of estrogen receptor binding, interacting selectively with an estrogen receptor.
|
7 | Q9WTM5 (/ISO) Q9WTM5 (/ISO) Q9WTM5 (/ISO) Q9WTM5 (/ISO) Q9WTM5 (/ISO) Q9WTM5 (/ISO) Q9WTM5 (/ISO) |
|
Negative regulation of canonical Wnt signaling pathway GO:0090090
Any process that decreases the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes.
|
7 | Q9WTM5 (/ISO) Q9WTM5 (/ISO) Q9WTM5 (/ISO) Q9WTM5 (/ISO) Q9WTM5 (/ISO) Q9WTM5 (/ISO) Q9WTM5 (/ISO) |
|
Chromatin remodeling GO:0006338
Dynamic structural changes to eukaryotic chromatin occurring throughout the cell division cycle. These changes range from the local changes necessary for transcriptional regulation to global changes necessary for chromosome segregation.
|
4 | Q9V3K3 (/IC) Q9V3K3 (/IC) Q9V3K3 (/IC) Q9V3K3 (/IC) |
|
Chromatin silencing GO:0006342
Repression of transcription by altering the structure of chromatin, e.g. by conversion of large regions of DNA into an inaccessible state often called heterochromatin.
|
4 | Q9V3K3 (/IMP) Q9V3K3 (/IMP) Q9V3K3 (/IMP) Q9V3K3 (/IMP) |
|
Imaginal disc-derived leg morphogenesis GO:0007480
The process in which the anatomical structures of a leg derived from an imaginal disc are generated and organized. A leg is a limb on which an animal walks and stands. An example of this is found in Drosophila melanogaster.
|
4 | Q9V3K3 (/IMP) Q9V3K3 (/IMP) Q9V3K3 (/IMP) Q9V3K3 (/IMP) |
|
Negative regulation of gene expression GO:0010629
Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
|
4 | Q9V3K3 (/IMP) Q9V3K3 (/IMP) Q9V3K3 (/IMP) Q9V3K3 (/IMP) |
|
Histone acetylation GO:0016573
The modification of a histone by the addition of an acetyl group.
|
4 | Q9V3K3 (/IDA) Q9V3K3 (/IDA) Q9V3K3 (/IDA) Q9V3K3 (/IDA) |
|
Ecdysone-mediated induction of salivary gland cell autophagic cell death GO:0035072
Any process induced by ecdysone that directly activates salivary gland programmed cell death during salivary gland histolysis.
|
4 | Q9V3K3 (/IMP) Q9V3K3 (/IMP) Q9V3K3 (/IMP) Q9V3K3 (/IMP) |
|
Regulation of cell population proliferation GO:0042127
Any process that modulates the frequency, rate or extent of cell proliferation.
|
4 | Q9V3K3 (/IMP) Q9V3K3 (/IMP) Q9V3K3 (/IMP) Q9V3K3 (/IMP) |
|
Histone exchange GO:0043486
The replacement, within chromatin, of resident histones or histone subunits with alternative, sometimes variant, histones or subunits.
|
4 | Q9V3K3 (/IDA) Q9V3K3 (/IDA) Q9V3K3 (/IDA) Q9V3K3 (/IDA) |
|
Negative regulation of canonical Wnt signaling pathway GO:0090090
Any process that decreases the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes.
|
4 | Q9V3K3 (/IMP) Q9V3K3 (/IMP) Q9V3K3 (/IMP) Q9V3K3 (/IMP) |
|
Positive regulation of transcription of nucleolar large rRNA by RNA polymerase I GO:1901838
Any process that activates or increases the frequency, rate or extent of transcription of nuclear large rRNA mediated by RNA polymerase I.
|
4 | Q9V3K3 (/IMP) Q9V3K3 (/IMP) Q9V3K3 (/IMP) Q9V3K3 (/IMP) |
|
Histone acetylation GO:0016573
The modification of a histone by the addition of an acetyl group.
|
2 | Q16TA2 (/ISS) Q29DI0 (/ISS) |
|
Regulation of cell population proliferation GO:0042127
Any process that modulates the frequency, rate or extent of cell proliferation.
|
2 | Q16TA2 (/ISS) Q29DI0 (/ISS) |
|
Histone exchange GO:0043486
The replacement, within chromatin, of resident histones or histone subunits with alternative, sometimes variant, histones or subunits.
|
2 | Q16TA2 (/ISS) Q29DI0 (/ISS) |
|
Negative regulation of canonical Wnt signaling pathway GO:0090090
Any process that decreases the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes.
|
2 | Q16TA2 (/ISS) Q29DI0 (/ISS) |
|
Epithelial cilium movement involved in extracellular fluid movement GO:0003351
The directed, self-propelled movement of cilia of epithelial cells. Depending on the type of cell, there may be one or many cilia per cell. This movement is usually coordinated between many epithelial cells, and serves to move extracellular fluid.
|
1 | P83571 (/IMP) |
|
Heart development GO:0007507
The process whose specific outcome is the progression of the heart over time, from its formation to the mature structure. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood.
|
1 | P83571 (/IMP) |
|
ATP-dependent chromatin remodeling GO:0043044
Dynamic structural changes to eukaryotic chromatin that require energy from the hydrolysis of ATP, ranging from local changes necessary for transcriptional regulation to global changes necessary for chromosome segregation, mediated by ATP-dependent chromatin-remodelling factors.
|
1 | O94692 (/IDA) |
|
Motile cilium assembly GO:0044458
The aggregation, arrangement and bonding together of a set of components to form a motile cilium.
|
1 | P83571 (/IGI) |
|
Motile cilium assembly GO:0044458
The aggregation, arrangement and bonding together of a set of components to form a motile cilium.
|
1 | P83571 (/IMP) |
|
Negative regulation of transcription, DNA-templated GO:0045892
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
|
1 | P83571 (/IDA) |
|
Digestive tract development GO:0048565
The process whose specific outcome is the progression of the digestive tract over time, from its formation to the mature structure. The digestive tract is the anatomical structure through which food passes and is processed.
|
1 | P83571 (/IMP) |
|
Regulation of nucleosome density GO:0060303
Any process that modulates the number of nucleosomes in a given region of a chromosome.
|
1 | O94692 (/IDA) |
|
Regulation of heart growth GO:0060420
Any process that modulates the rate or extent of heart growth. Heart growth is the increase in size or mass of the heart.
|
1 | P83571 (/IMP) |
|
Axonemal dynein complex assembly GO:0070286
The aggregation, arrangement and bonding together of a set of components to form an axonemal dynein complex, a dynein complex found in eukaryotic cilia and flagella, in which the motor domain heads interact with adjacent microtubules to generate a sliding force which is converted to a bending motion.
|
1 | P83571 (/IMP) |
There are 41 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
45 |
Q12464 (/IDA)
Q12464 (/IDA)
Q12464 (/IDA)
Q12464 (/IDA)
Q12464 (/IDA)
Q12464 (/IDA)
Q12464 (/IDA)
Q12464 (/IDA)
Q583J3 (/IDA)
Q583J3 (/IDA)
(35 more) |
|
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
|
27 |
M0R0Y3 (/IDA)
M0R0Y3 (/IDA)
M0R0Y3 (/IDA)
M0R0Y3 (/IDA)
M0R0Y3 (/IDA)
M0R0Y3 (/IDA)
M0R0Y3 (/IDA)
M0R0Y3 (/IDA)
M0R0Y3 (/IDA)
M0R0Y3 (/IDA)
(17 more) |
|
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
27 |
M0R0Y3 (/IDA)
M0R0Y3 (/IDA)
M0R0Y3 (/IDA)
M0R0Y3 (/IDA)
M0R0Y3 (/IDA)
M0R0Y3 (/IDA)
M0R0Y3 (/IDA)
M0R0Y3 (/IDA)
M0R0Y3 (/IDA)
M0R0Y3 (/IDA)
(17 more) |
|
Swr1 complex GO:0000812
A multisubunit protein complex that is involved in chromatin remodeling. It is required for the incorporation of the histone variant H2AZ into chromatin. In S. cerevisiae, the complex contains Swr1p, a Swi2/Snf2-related ATPase, and 12 additional subunits.
|
24 |
O94692 (/IDA)
Q12464 (/IDA)
Q12464 (/IDA)
Q12464 (/IDA)
Q12464 (/IDA)
Q12464 (/IDA)
Q12464 (/IDA)
Q12464 (/IDA)
Q12464 (/IDA)
Q9Y230 (/IDA)
(14 more) |
|
R2TP complex GO:0097255
A highly conserved protein complex comprised of two ATP-dependent DNA helicases (Rvb1p and Rvb2p in yeast, Pontin52 and Reptin52 in humans), Pih1p in yeast or PIH1D1 in humans, and Tah1 in yeast or RPAP3 in humans. The complex associates with Hsp90 and is thought to have a role in assembly of large protein or protein/nucleic acid complexes. In this role it is involved in multiple processes such as box C/D snoRNP biogenesis, phosphatidylinositol-3 kinase-related protein kinase (PIKK) signaling, RNA polymerase II assembly, and others.
|
23 |
Q12464 (/IDA)
Q12464 (/IDA)
Q12464 (/IDA)
Q12464 (/IDA)
Q12464 (/IDA)
Q12464 (/IDA)
Q12464 (/IDA)
Q12464 (/IDA)
Q9Y230 (/IDA)
Q9Y230 (/IDA)
(13 more) |
|
Ino80 complex GO:0031011
A multisubunit protein complex that contains the Ino80p ATPase; exhibits chromatin remodeling activity and 3' to 5' DNA helicase activity.
|
20 |
O94692 (/IDA)
Q9V3K3 (/IDA)
Q9V3K3 (/IDA)
Q9V3K3 (/IDA)
Q9V3K3 (/IDA)
Q9Y230 (/IDA)
Q9Y230 (/IDA)
Q9Y230 (/IDA)
Q9Y230 (/IDA)
Q9Y230 (/IDA)
(10 more) |
|
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
19 |
Q583J3 (/IDA)
Q583J3 (/IDA)
Q583J3 (/IDA)
Q583J3 (/IDA)
Q9Y230 (/IDA)
Q9Y230 (/IDA)
Q9Y230 (/IDA)
Q9Y230 (/IDA)
Q9Y230 (/IDA)
Q9Y230 (/IDA)
(9 more) |
|
NuA4 histone acetyltransferase complex GO:0035267
A complex having histone acetylase activity on chromatin, as well as ATPase, DNA helicase and structural DNA binding activities. The complex is thought to be involved in double-strand DNA break repair. Subunits of the human complex include HTATIP/TIP60, TRRAP, RUVBL1, BUVBL2, beta-actin and BAF53/ACTL6A. In yeast, the complex has 13 subunits, including the catalytic subunit Esa1 (homologous to human Tip60).
|
19 |
Q9V3K3 (/IDA)
Q9V3K3 (/IDA)
Q9V3K3 (/IDA)
Q9V3K3 (/IDA)
Q9Y230 (/IDA)
Q9Y230 (/IDA)
Q9Y230 (/IDA)
Q9Y230 (/IDA)
Q9Y230 (/IDA)
Q9Y230 (/IDA)
(9 more) |
|
Intracellular GO:0005622
The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm.
|
15 |
Q9Y230 (/IDA)
Q9Y230 (/IDA)
Q9Y230 (/IDA)
Q9Y230 (/IDA)
Q9Y230 (/IDA)
Q9Y230 (/IDA)
Q9Y230 (/IDA)
Q9Y230 (/IDA)
Q9Y230 (/IDA)
Q9Y230 (/IDA)
(5 more) |
|
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
|
15 |
Q9Y230 (/TAS)
Q9Y230 (/TAS)
Q9Y230 (/TAS)
Q9Y230 (/TAS)
Q9Y230 (/TAS)
Q9Y230 (/TAS)
Q9Y230 (/TAS)
Q9Y230 (/TAS)
Q9Y230 (/TAS)
Q9Y230 (/TAS)
(5 more) |
|
Nuclear euchromatin GO:0005719
The dispersed less dense form of chromatin in the interphase nucleus. It exists in at least two forms, a some being in the form of transcriptionally active chromatin which is the least condensed, while the rest is inactive euchromatin which is more condensed than active chromatin but less condensed than heterochromatin.
|
15 |
Q9Y230 (/IDA)
Q9Y230 (/IDA)
Q9Y230 (/IDA)
Q9Y230 (/IDA)
Q9Y230 (/IDA)
Q9Y230 (/IDA)
Q9Y230 (/IDA)
Q9Y230 (/IDA)
Q9Y230 (/IDA)
Q9Y230 (/IDA)
(5 more) |
|
Centrosome GO:0005813
A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle.
|
15 |
Q9Y230 (/IDA)
Q9Y230 (/IDA)
Q9Y230 (/IDA)
Q9Y230 (/IDA)
Q9Y230 (/IDA)
Q9Y230 (/IDA)
Q9Y230 (/IDA)
Q9Y230 (/IDA)
Q9Y230 (/IDA)
Q9Y230 (/IDA)
(5 more) |
|
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
|
15 |
Q9Y230 (/HDA)
Q9Y230 (/HDA)
Q9Y230 (/HDA)
Q9Y230 (/HDA)
Q9Y230 (/HDA)
Q9Y230 (/HDA)
Q9Y230 (/HDA)
Q9Y230 (/HDA)
Q9Y230 (/HDA)
Q9Y230 (/HDA)
(5 more) |
|
MLL1 complex GO:0071339
A protein complex that can methylate lysine-4 of histone H3. MLL1/MLL is the catalytic methyltransferase subunit, and the complex also contains the core components ASH2L, HCFC1/HCF1 WDR5 and RBBP5.
|
15 |
Q9Y230 (/IDA)
Q9Y230 (/IDA)
Q9Y230 (/IDA)
Q9Y230 (/IDA)
Q9Y230 (/IDA)
Q9Y230 (/IDA)
Q9Y230 (/IDA)
Q9Y230 (/IDA)
Q9Y230 (/IDA)
Q9Y230 (/IDA)
(5 more) |
|
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
11 |
P83571 (/ISS)
Q16TA2 (/ISS)
Q29DI0 (/ISS)
Q2TBU9 (/ISS)
Q9WTM5 (/ISS)
Q9WTM5 (/ISS)
Q9WTM5 (/ISS)
Q9WTM5 (/ISS)
Q9WTM5 (/ISS)
Q9WTM5 (/ISS)
(1 more) |
|
Swr1 complex GO:0000812
A multisubunit protein complex that is involved in chromatin remodeling. It is required for the incorporation of the histone variant H2AZ into chromatin. In S. cerevisiae, the complex contains Swr1p, a Swi2/Snf2-related ATPase, and 12 additional subunits.
|
10 | P83571 (/ISS) Q2TBU9 (/ISS) Q9DE27 (/ISS) Q9WTM5 (/ISS) Q9WTM5 (/ISS) Q9WTM5 (/ISS) Q9WTM5 (/ISS) Q9WTM5 (/ISS) Q9WTM5 (/ISS) Q9WTM5 (/ISS) |
|
NuA4 histone acetyltransferase complex GO:0035267
A complex having histone acetylase activity on chromatin, as well as ATPase, DNA helicase and structural DNA binding activities. The complex is thought to be involved in double-strand DNA break repair. Subunits of the human complex include HTATIP/TIP60, TRRAP, RUVBL1, BUVBL2, beta-actin and BAF53/ACTL6A. In yeast, the complex has 13 subunits, including the catalytic subunit Esa1 (homologous to human Tip60).
|
10 | Q16TA2 (/ISS) Q29DI0 (/ISS) Q2TBU9 (/ISS) Q9WTM5 (/ISS) Q9WTM5 (/ISS) Q9WTM5 (/ISS) Q9WTM5 (/ISS) Q9WTM5 (/ISS) Q9WTM5 (/ISS) Q9WTM5 (/ISS) |
|
MLL1 complex GO:0071339
A protein complex that can methylate lysine-4 of histone H3. MLL1/MLL is the catalytic methyltransferase subunit, and the complex also contains the core components ASH2L, HCFC1/HCF1 WDR5 and RBBP5.
|
10 | P83571 (/ISS) Q2TBU9 (/ISS) Q9DE27 (/ISS) Q9WTM5 (/ISS) Q9WTM5 (/ISS) Q9WTM5 (/ISS) Q9WTM5 (/ISS) Q9WTM5 (/ISS) Q9WTM5 (/ISS) Q9WTM5 (/ISS) |
|
Ino80 complex GO:0031011
A multisubunit protein complex that contains the Ino80p ATPase; exhibits chromatin remodeling activity and 3' to 5' DNA helicase activity.
|
9 | O94692 (/IPI) Q12464 (/IPI) Q12464 (/IPI) Q12464 (/IPI) Q12464 (/IPI) Q12464 (/IPI) Q12464 (/IPI) Q12464 (/IPI) Q12464 (/IPI) |
|
Swr1 complex GO:0000812
A multisubunit protein complex that is involved in chromatin remodeling. It is required for the incorporation of the histone variant H2AZ into chromatin. In S. cerevisiae, the complex contains Swr1p, a Swi2/Snf2-related ATPase, and 12 additional subunits.
|
8 | Q12464 (/IPI) Q12464 (/IPI) Q12464 (/IPI) Q12464 (/IPI) Q12464 (/IPI) Q12464 (/IPI) Q12464 (/IPI) Q12464 (/IPI) |
|
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
8 | Q4Q2T4 (/ISO) Q9WTM5 (/ISO) Q9WTM5 (/ISO) Q9WTM5 (/ISO) Q9WTM5 (/ISO) Q9WTM5 (/ISO) Q9WTM5 (/ISO) Q9WTM5 (/ISO) |
|
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
8 | Q4Q2T4 (/ISO) Q9WTM5 (/ISO) Q9WTM5 (/ISO) Q9WTM5 (/ISO) Q9WTM5 (/ISO) Q9WTM5 (/ISO) Q9WTM5 (/ISO) Q9WTM5 (/ISO) |
|
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
8 | Q2TBU9 (/ISS) Q9WTM5 (/ISS) Q9WTM5 (/ISS) Q9WTM5 (/ISS) Q9WTM5 (/ISS) Q9WTM5 (/ISS) Q9WTM5 (/ISS) Q9WTM5 (/ISS) |
|
ASTRA complex GO:0070209
A protein complex that is part of the chromatin remodeling machinery; the acronym stands for ASsembly of Tel, Rvb and Atm-like kinase. In Saccharomyces cerevisiae this complex includes Rvb1p, Rvb2p, Tra1p, Tel2p, Asa1p, Ttilp and Tti2p.
|
8 | Q12464 (/HDA) Q12464 (/HDA) Q12464 (/HDA) Q12464 (/HDA) Q12464 (/HDA) Q12464 (/HDA) Q12464 (/HDA) Q12464 (/HDA) |
|
R2TP complex GO:0097255
A highly conserved protein complex comprised of two ATP-dependent DNA helicases (Rvb1p and Rvb2p in yeast, Pontin52 and Reptin52 in humans), Pih1p in yeast or PIH1D1 in humans, and Tah1 in yeast or RPAP3 in humans. The complex associates with Hsp90 and is thought to have a role in assembly of large protein or protein/nucleic acid complexes. In this role it is involved in multiple processes such as box C/D snoRNP biogenesis, phosphatidylinositol-3 kinase-related protein kinase (PIKK) signaling, RNA polymerase II assembly, and others.
|
8 | Q12464 (/IPI) Q12464 (/IPI) Q12464 (/IPI) Q12464 (/IPI) Q12464 (/IPI) Q12464 (/IPI) Q12464 (/IPI) Q12464 (/IPI) |
|
Swr1 complex GO:0000812
A multisubunit protein complex that is involved in chromatin remodeling. It is required for the incorporation of the histone variant H2AZ into chromatin. In S. cerevisiae, the complex contains Swr1p, a Swi2/Snf2-related ATPase, and 12 additional subunits.
|
7 | Q9WTM5 (/ISO) Q9WTM5 (/ISO) Q9WTM5 (/ISO) Q9WTM5 (/ISO) Q9WTM5 (/ISO) Q9WTM5 (/ISO) Q9WTM5 (/ISO) |
|
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
|
7 | Q9WTM5 (/ISO) Q9WTM5 (/ISO) Q9WTM5 (/ISO) Q9WTM5 (/ISO) Q9WTM5 (/ISO) Q9WTM5 (/ISO) Q9WTM5 (/ISO) |
|
Nuclear euchromatin GO:0005719
The dispersed less dense form of chromatin in the interphase nucleus. It exists in at least two forms, a some being in the form of transcriptionally active chromatin which is the least condensed, while the rest is inactive euchromatin which is more condensed than active chromatin but less condensed than heterochromatin.
|
7 | Q9WTM5 (/ISO) Q9WTM5 (/ISO) Q9WTM5 (/ISO) Q9WTM5 (/ISO) Q9WTM5 (/ISO) Q9WTM5 (/ISO) Q9WTM5 (/ISO) |
|
Centrosome GO:0005813
A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle.
|
7 | Q9WTM5 (/ISO) Q9WTM5 (/ISO) Q9WTM5 (/ISO) Q9WTM5 (/ISO) Q9WTM5 (/ISO) Q9WTM5 (/ISO) Q9WTM5 (/ISO) |
|
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
7 | Q9WTM5 (/ISO) Q9WTM5 (/ISO) Q9WTM5 (/ISO) Q9WTM5 (/ISO) Q9WTM5 (/ISO) Q9WTM5 (/ISO) Q9WTM5 (/ISO) |
|
Ino80 complex GO:0031011
A multisubunit protein complex that contains the Ino80p ATPase; exhibits chromatin remodeling activity and 3' to 5' DNA helicase activity.
|
7 | Q9WTM5 (/ISO) Q9WTM5 (/ISO) Q9WTM5 (/ISO) Q9WTM5 (/ISO) Q9WTM5 (/ISO) Q9WTM5 (/ISO) Q9WTM5 (/ISO) |
|
NuA4 histone acetyltransferase complex GO:0035267
A complex having histone acetylase activity on chromatin, as well as ATPase, DNA helicase and structural DNA binding activities. The complex is thought to be involved in double-strand DNA break repair. Subunits of the human complex include HTATIP/TIP60, TRRAP, RUVBL1, BUVBL2, beta-actin and BAF53/ACTL6A. In yeast, the complex has 13 subunits, including the catalytic subunit Esa1 (homologous to human Tip60).
|
7 | Q9WTM5 (/ISO) Q9WTM5 (/ISO) Q9WTM5 (/ISO) Q9WTM5 (/ISO) Q9WTM5 (/ISO) Q9WTM5 (/ISO) Q9WTM5 (/ISO) |
|
MLL1 complex GO:0071339
A protein complex that can methylate lysine-4 of histone H3. MLL1/MLL is the catalytic methyltransferase subunit, and the complex also contains the core components ASH2L, HCFC1/HCF1 WDR5 and RBBP5.
|
7 | Q9WTM5 (/ISO) Q9WTM5 (/ISO) Q9WTM5 (/ISO) Q9WTM5 (/ISO) Q9WTM5 (/ISO) Q9WTM5 (/ISO) Q9WTM5 (/ISO) |
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R2TP complex GO:0097255
A highly conserved protein complex comprised of two ATP-dependent DNA helicases (Rvb1p and Rvb2p in yeast, Pontin52 and Reptin52 in humans), Pih1p in yeast or PIH1D1 in humans, and Tah1 in yeast or RPAP3 in humans. The complex associates with Hsp90 and is thought to have a role in assembly of large protein or protein/nucleic acid complexes. In this role it is involved in multiple processes such as box C/D snoRNP biogenesis, phosphatidylinositol-3 kinase-related protein kinase (PIKK) signaling, RNA polymerase II assembly, and others.
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7 | Q9WTM5 (/ISO) Q9WTM5 (/ISO) Q9WTM5 (/ISO) Q9WTM5 (/ISO) Q9WTM5 (/ISO) Q9WTM5 (/ISO) Q9WTM5 (/ISO) |
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Ribonucleoprotein complex GO:1990904
A macromolecular complex containing both protein and RNA molecules.
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7 | Q9WTM5 (/IDA) Q9WTM5 (/IDA) Q9WTM5 (/IDA) Q9WTM5 (/IDA) Q9WTM5 (/IDA) Q9WTM5 (/IDA) Q9WTM5 (/IDA) |
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Histone acetyltransferase complex GO:0000123
A protein complex that possesses histone acetyltransferase activity.
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4 | Q9V3K3 (/IPI) Q9V3K3 (/IPI) Q9V3K3 (/IPI) Q9V3K3 (/IPI) |
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Chloroplast GO:0009507
A chlorophyll-containing plastid with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma.
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3 | Q9FJW0 (/IDA) Q9FJW0 (/IDA) Q9M2X5 (/IDA) |
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Nucleolus GO:0005730
A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
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2 | Q9FJW0 (/IDA) Q9FJW0 (/IDA) |
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Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
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1 | O94692 (/HDA) |
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Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
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1 | O94692 (/HDA) |
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ASTRA complex GO:0070209
A protein complex that is part of the chromatin remodeling machinery; the acronym stands for ASsembly of Tel, Rvb and Atm-like kinase. In Saccharomyces cerevisiae this complex includes Rvb1p, Rvb2p, Tra1p, Tel2p, Asa1p, Ttilp and Tti2p.
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1 | O94692 (/IDA) |
