The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:
"RuvB-like helicase, domain II
".
FunFam 1: RuvB-like helicase
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 21 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
68 |
G0RYI5 (/IPI)
O17607 (/IPI)
P60122 (/IPI)
P60122 (/IPI)
P60122 (/IPI)
P60122 (/IPI)
P60122 (/IPI)
Q03940 (/IPI)
Q03940 (/IPI)
Q03940 (/IPI)
(58 more) |
|
DNA helicase activity GO:0003678
Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction drives the unwinding of the DNA helix.
|
60 |
Q8IAT2 (/IDA)
Q8IAT2 (/IDA)
Q8IAT2 (/IDA)
Q8IAT2 (/IDA)
Q8IAT2 (/IDA)
Q8IAT2 (/IDA)
Q8IAT2 (/IDA)
Q8IAT2 (/IDA)
Q8IAT2 (/IDA)
Q8IAT2 (/IDA)
(50 more) |
|
ATPase activity GO:0016887
Catalysis of the reaction: ATP + H2O = ADP + phosphate + 2 H+. May or may not be coupled to another reaction.
|
60 |
Q8IAT2 (/IDA)
Q8IAT2 (/IDA)
Q8IAT2 (/IDA)
Q8IAT2 (/IDA)
Q8IAT2 (/IDA)
Q8IAT2 (/IDA)
Q8IAT2 (/IDA)
Q8IAT2 (/IDA)
Q8IAT2 (/IDA)
Q8IAT2 (/IDA)
(50 more) |
|
Transcription coactivator activity GO:0003713
A protein or a member of a complex that interacts specifically and non-covalently with a DNA-bound DNA-binding transcription factor to activate the transcription of specific genes. Coactivators often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second ATP-dependent class modifies the conformation of chromatin. Another type of coregulator activity is the bridging of a DNA-binding transcription factor to the basal transcription machinery. The Mediator complex, which bridges transcription factors and RNA polymerase, is also a transcription coactivator.
|
37 |
Q9Y265 (/IDA)
Q9Y265 (/IDA)
Q9Y265 (/IDA)
Q9Y265 (/IDA)
Q9Y265 (/IDA)
Q9Y265 (/IDA)
Q9Y265 (/IDA)
Q9Y265 (/IDA)
Q9Y265 (/IDA)
Q9Y265 (/IDA)
(27 more) |
|
TBP-class protein binding GO:0017025
Interacting selectively and non-covalently with a member of the class of TATA-binding proteins (TBP), including any of the TBP-related factors (TRFs).
|
37 |
Q9Y265 (/IDA)
Q9Y265 (/IDA)
Q9Y265 (/IDA)
Q9Y265 (/IDA)
Q9Y265 (/IDA)
Q9Y265 (/IDA)
Q9Y265 (/IDA)
Q9Y265 (/IDA)
Q9Y265 (/IDA)
Q9Y265 (/IDA)
(27 more) |
|
Cadherin binding GO:0045296
Interacting selectively and non-covalently with cadherin, a type I membrane protein involved in cell adhesion.
|
37 |
Q9Y265 (/HDA)
Q9Y265 (/HDA)
Q9Y265 (/HDA)
Q9Y265 (/HDA)
Q9Y265 (/HDA)
Q9Y265 (/HDA)
Q9Y265 (/HDA)
Q9Y265 (/HDA)
Q9Y265 (/HDA)
Q9Y265 (/HDA)
(27 more) |
|
5'-3' DNA helicase activity GO:0043139
Catalysis of the reaction: ATP + H2O = ADP + phosphate; drives the unwinding of the DNA helix in the direction 5' to 3'.
|
32 |
J7HDV0 (/IDA)
Q03940 (/IDA)
Q03940 (/IDA)
Q03940 (/IDA)
Q03940 (/IDA)
Q03940 (/IDA)
Q03940 (/IDA)
Q03940 (/IDA)
Q03940 (/IDA)
Q8IAT2 (/IDA)
(22 more) |
|
TFIID-class transcription factor complex binding GO:0001094
Interacting selectively and non-covalently with a general RNA polymerase II transcription factor belonging to the TFIID complex, one of the factors involved in formation of the preinitiation complex (PIC) by RNA polymerase II.
|
5 | P60122 (/IPI) P60122 (/IPI) P60122 (/IPI) P60122 (/IPI) P60122 (/IPI) |
|
DNA helicase activity GO:0003678
Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction drives the unwinding of the DNA helix.
|
5 | P60122 (/ISO) P60122 (/ISO) P60122 (/ISO) P60122 (/ISO) P60122 (/ISO) |
|
Transcription coactivator activity GO:0003713
A protein or a member of a complex that interacts specifically and non-covalently with a DNA-bound DNA-binding transcription factor to activate the transcription of specific genes. Coactivators often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second ATP-dependent class modifies the conformation of chromatin. Another type of coregulator activity is the bridging of a DNA-binding transcription factor to the basal transcription machinery. The Mediator complex, which bridges transcription factors and RNA polymerase, is also a transcription coactivator.
|
5 | P60122 (/ISO) P60122 (/ISO) P60122 (/ISO) P60122 (/ISO) P60122 (/ISO) |
Showing 1 to 10 of 21 entries
There are 47 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Regulation of transcription by RNA polymerase II GO:0006357
Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II.
|
37 |
Q9Y265 (/TAS)
Q9Y265 (/TAS)
Q9Y265 (/TAS)
Q9Y265 (/TAS)
Q9Y265 (/TAS)
Q9Y265 (/TAS)
Q9Y265 (/TAS)
Q9Y265 (/TAS)
Q9Y265 (/TAS)
Q9Y265 (/TAS)
(27 more) |
|
Spermatogenesis GO:0007283
The process of formation of spermatozoa, including spermatocytogenesis and spermiogenesis.
|
37 |
Q9Y265 (/TAS)
Q9Y265 (/TAS)
Q9Y265 (/TAS)
Q9Y265 (/TAS)
Q9Y265 (/TAS)
Q9Y265 (/TAS)
Q9Y265 (/TAS)
Q9Y265 (/TAS)
Q9Y265 (/TAS)
Q9Y265 (/TAS)
(27 more) |
|
Protein deubiquitination GO:0016579
The removal of one or more ubiquitin groups from a protein.
|
37 |
Q9Y265 (/TAS)
Q9Y265 (/TAS)
Q9Y265 (/TAS)
Q9Y265 (/TAS)
Q9Y265 (/TAS)
Q9Y265 (/TAS)
Q9Y265 (/TAS)
Q9Y265 (/TAS)
Q9Y265 (/TAS)
Q9Y265 (/TAS)
(27 more) |
|
CENP-A containing nucleosome assembly GO:0034080
The formation of nucleosomes containing the histone H3 variant CENP-A to form centromeric chromatin. This specialised chromatin occurs at centromeric region in point centromeres, and the central core in modular centromeres.
|
37 |
Q9Y265 (/TAS)
Q9Y265 (/TAS)
Q9Y265 (/TAS)
Q9Y265 (/TAS)
Q9Y265 (/TAS)
Q9Y265 (/TAS)
Q9Y265 (/TAS)
Q9Y265 (/TAS)
Q9Y265 (/TAS)
Q9Y265 (/TAS)
(27 more) |
|
Histone H4 acetylation GO:0043967
The modification of histone H4 by the addition of an acetyl group.
|
37 |
Q9Y265 (/IDA)
Q9Y265 (/IDA)
Q9Y265 (/IDA)
Q9Y265 (/IDA)
Q9Y265 (/IDA)
Q9Y265 (/IDA)
Q9Y265 (/IDA)
Q9Y265 (/IDA)
Q9Y265 (/IDA)
Q9Y265 (/IDA)
(27 more) |
|
Histone H2A acetylation GO:0043968
The modification of histone H2A by the addition of an acetyl group.
|
37 |
Q9Y265 (/IDA)
Q9Y265 (/IDA)
Q9Y265 (/IDA)
Q9Y265 (/IDA)
Q9Y265 (/IDA)
Q9Y265 (/IDA)
Q9Y265 (/IDA)
Q9Y265 (/IDA)
Q9Y265 (/IDA)
Q9Y265 (/IDA)
(27 more) |
|
Positive regulation of canonical Wnt signaling pathway GO:0090263
Any process that increases the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes.
|
37 |
Q9Y265 (/IDA)
Q9Y265 (/IDA)
Q9Y265 (/IDA)
Q9Y265 (/IDA)
Q9Y265 (/IDA)
Q9Y265 (/IDA)
Q9Y265 (/IDA)
Q9Y265 (/IDA)
Q9Y265 (/IDA)
Q9Y265 (/IDA)
(27 more) |
|
Beta-catenin-TCF complex assembly GO:1904837
The aggregation, arrangement and bonding together of a set of components to form a beta-catenin-TCF complex.
|
37 |
Q9Y265 (/TAS)
Q9Y265 (/TAS)
Q9Y265 (/TAS)
Q9Y265 (/TAS)
Q9Y265 (/TAS)
Q9Y265 (/TAS)
Q9Y265 (/TAS)
Q9Y265 (/TAS)
Q9Y265 (/TAS)
Q9Y265 (/TAS)
(27 more) |
|
Positive regulation of telomerase RNA localization to Cajal body GO:1904874
Any process that activates or increases the frequency, rate or extent of telomerase RNA localization to Cajal body.
|
37 |
Q9Y265 (/HMP)
Q9Y265 (/HMP)
Q9Y265 (/HMP)
Q9Y265 (/HMP)
Q9Y265 (/HMP)
Q9Y265 (/HMP)
Q9Y265 (/HMP)
Q9Y265 (/HMP)
Q9Y265 (/HMP)
Q9Y265 (/HMP)
(27 more) |
|
DNA repair GO:0006281
The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway.
|
13 |
Q8IIU3 (/ISS)
Q8IIU3 (/ISS)
Q8IIU3 (/ISS)
Q8IIU3 (/ISS)
Q8IIU3 (/ISS)
Q8IIU3 (/ISS)
Q8IIU3 (/ISS)
Q8IIU3 (/ISS)
Q8IIU3 (/ISS)
Q8IIU3 (/ISS)
(3 more) |
Showing 1 to 10 of 47 entries
There are 44 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
55 |
J7HDV0 (/IDA)
O17607 (/IDA)
P60123 (/IDA)
P60123 (/IDA)
P60123 (/IDA)
P60123 (/IDA)
P60123 (/IDA)
Q03940 (/IDA)
Q03940 (/IDA)
Q03940 (/IDA)
(45 more) |
|
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
|
53 |
E7ETR0 (/IDA)
E7ETR0 (/IDA)
E7ETR0 (/IDA)
E7ETR0 (/IDA)
E7ETR0 (/IDA)
E7ETR0 (/IDA)
E7ETR0 (/IDA)
E7ETR0 (/IDA)
E7ETR0 (/IDA)
E7ETR0 (/IDA)
(43 more) |
|
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
52 |
E7ETR0 (/IDA)
E7ETR0 (/IDA)
E7ETR0 (/IDA)
E7ETR0 (/IDA)
E7ETR0 (/IDA)
E7ETR0 (/IDA)
E7ETR0 (/IDA)
E7ETR0 (/IDA)
E7ETR0 (/IDA)
E7ETR0 (/IDA)
(42 more) |
|
Swr1 complex GO:0000812
A multisubunit protein complex that is involved in chromatin remodeling. It is required for the incorporation of the histone variant H2AZ into chromatin. In S. cerevisiae, the complex contains Swr1p, a Swi2/Snf2-related ATPase, and 12 additional subunits.
|
46 |
Q03940 (/IDA)
Q03940 (/IDA)
Q03940 (/IDA)
Q03940 (/IDA)
Q03940 (/IDA)
Q03940 (/IDA)
Q03940 (/IDA)
Q03940 (/IDA)
Q9C0X6 (/IDA)
Q9Y265 (/IDA)
(36 more) |
|
R2TP complex GO:0097255
A highly conserved protein complex comprised of two ATP-dependent DNA helicases (Rvb1p and Rvb2p in yeast, Pontin52 and Reptin52 in humans), Pih1p in yeast or PIH1D1 in humans, and Tah1 in yeast or RPAP3 in humans. The complex associates with Hsp90 and is thought to have a role in assembly of large protein or protein/nucleic acid complexes. In this role it is involved in multiple processes such as box C/D snoRNP biogenesis, phosphatidylinositol-3 kinase-related protein kinase (PIKK) signaling, RNA polymerase II assembly, and others.
|
45 |
Q03940 (/IDA)
Q03940 (/IDA)
Q03940 (/IDA)
Q03940 (/IDA)
Q03940 (/IDA)
Q03940 (/IDA)
Q03940 (/IDA)
Q03940 (/IDA)
Q9Y265 (/IDA)
Q9Y265 (/IDA)
(35 more) |
|
Ino80 complex GO:0031011
A multisubunit protein complex that contains the Ino80p ATPase; exhibits chromatin remodeling activity and 3' to 5' DNA helicase activity.
|
39 |
Q9C0X6 (/IDA)
Q9VH07 (/IDA)
Q9Y265 (/IDA)
Q9Y265 (/IDA)
Q9Y265 (/IDA)
Q9Y265 (/IDA)
Q9Y265 (/IDA)
Q9Y265 (/IDA)
Q9Y265 (/IDA)
Q9Y265 (/IDA)
(29 more) |
|
NuA4 histone acetyltransferase complex GO:0035267
A complex having histone acetylase activity on chromatin, as well as ATPase, DNA helicase and structural DNA binding activities. The complex is thought to be involved in double-strand DNA break repair. Subunits of the human complex include HTATIP/TIP60, TRRAP, RUVBL1, BUVBL2, beta-actin and BAF53/ACTL6A. In yeast, the complex has 13 subunits, including the catalytic subunit Esa1 (homologous to human Tip60).
|
38 |
Q9VH07 (/IDA)
Q9Y265 (/IDA)
Q9Y265 (/IDA)
Q9Y265 (/IDA)
Q9Y265 (/IDA)
Q9Y265 (/IDA)
Q9Y265 (/IDA)
Q9Y265 (/IDA)
Q9Y265 (/IDA)
Q9Y265 (/IDA)
(28 more) |
|
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
|
37 |
Q9Y265 (/TAS)
Q9Y265 (/TAS)
Q9Y265 (/TAS)
Q9Y265 (/TAS)
Q9Y265 (/TAS)
Q9Y265 (/TAS)
Q9Y265 (/TAS)
Q9Y265 (/TAS)
Q9Y265 (/TAS)
Q9Y265 (/TAS)
(27 more) |
|
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
|
37 |
Q9Y265 (/HDA)
Q9Y265 (/HDA)
Q9Y265 (/HDA)
Q9Y265 (/HDA)
Q9Y265 (/HDA)
Q9Y265 (/HDA)
Q9Y265 (/HDA)
Q9Y265 (/HDA)
Q9Y265 (/HDA)
Q9Y265 (/HDA)
(27 more) |
|
MLL1 complex GO:0071339
A protein complex that can methylate lysine-4 of histone H3. MLL1/MLL is the catalytic methyltransferase subunit, and the complex also contains the core components ASH2L, HCFC1/HCF1 WDR5 and RBBP5.
|
37 |
Q9Y265 (/IDA)
Q9Y265 (/IDA)
Q9Y265 (/IDA)
Q9Y265 (/IDA)
Q9Y265 (/IDA)
Q9Y265 (/IDA)
Q9Y265 (/IDA)
Q9Y265 (/IDA)
Q9Y265 (/IDA)
Q9Y265 (/IDA)
(27 more) |
Showing 1 to 10 of 44 entries
