The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:

"
Nucleic acid-binding proteins
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 5: Cold shock protein CspE

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 6 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
DNA binding GO:0003677
Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
432 A0A0J1HSJ7 (/ISS) A0A0J1HSJ7 (/ISS) A0A0J1HSJ7 (/ISS) A0A0J1HSJ7 (/ISS) A0A0J1HSJ7 (/ISS) A0A0J1HSJ7 (/ISS) A0A0J1HSJ7 (/ISS) A0A0J1HSJ7 (/ISS) A0A0J1HSJ7 (/ISS) A0A0J1HSJ7 (/ISS)
(422 more)
Transcription antitermination factor activity, RNA binding GO:0001072
Binds to RNA, typically within the nascent RNA transcript, to promote readthrough of a transcription termination site and thus extending the length of the RNA transcript produced. Examples of antitermination factors which bind the nascent RNA include the lambda N protein and the HIV-1 tat protein.
196 P0A972 (/IDA) P0A972 (/IDA) P0A972 (/IDA) P0A972 (/IDA) P0A972 (/IDA) P0A972 (/IDA) P0A972 (/IDA) P0A972 (/IDA) P0A972 (/IDA) P0A972 (/IDA)
(186 more)
Single-stranded DNA binding GO:0003697
Interacting selectively and non-covalently with single-stranded DNA.
196 P0A972 (/IDA) P0A972 (/IDA) P0A972 (/IDA) P0A972 (/IDA) P0A972 (/IDA) P0A972 (/IDA) P0A972 (/IDA) P0A972 (/IDA) P0A972 (/IDA) P0A972 (/IDA)
(186 more)
RNA binding GO:0003723
Interacting selectively and non-covalently with an RNA molecule or a portion thereof.
196 P0A972 (/IDA) P0A972 (/IDA) P0A972 (/IDA) P0A972 (/IDA) P0A972 (/IDA) P0A972 (/IDA) P0A972 (/IDA) P0A972 (/IDA) P0A972 (/IDA) P0A972 (/IDA)
(186 more)
Poly(A) binding GO:0008143
Interacting selectively and non-covalently with a sequence of adenylyl residues in an RNA molecule, such as the poly(A) tail, a sequence of adenylyl residues at the 3' end of eukaryotic mRNA.
196 P0A972 (/IDA) P0A972 (/IDA) P0A972 (/IDA) P0A972 (/IDA) P0A972 (/IDA) P0A972 (/IDA) P0A972 (/IDA) P0A972 (/IDA) P0A972 (/IDA) P0A972 (/IDA)
(186 more)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
164 P0A978 (/IPI) P0A978 (/IPI) P0A978 (/IPI) P0A978 (/IPI) P0A978 (/IPI) P0A978 (/IPI) P0A978 (/IPI) P0A978 (/IPI) P0A978 (/IPI) P0A978 (/IPI)
(154 more)

There are 6 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Regulation of transcription, DNA-templated GO:0006355
Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
460 A0A0J1HSJ7 (/ISS) A0A0J1HSJ7 (/ISS) A0A0J1HSJ7 (/ISS) A0A0J1HSJ7 (/ISS) A0A0J1HSJ7 (/ISS) A0A0J1HSJ7 (/ISS) A0A0J1HSJ7 (/ISS) A0A0J1HSJ7 (/ISS) A0A0J1HSJ7 (/ISS) A0A0J1HSJ7 (/ISS)
(450 more)
Response to cold GO:0009409
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cold stimulus, a temperature stimulus below the optimal temperature for that organism.
460 A0A0J1HSJ7 (/ISS) A0A0J1HSJ7 (/ISS) A0A0J1HSJ7 (/ISS) A0A0J1HSJ7 (/ISS) A0A0J1HSJ7 (/ISS) A0A0J1HSJ7 (/ISS) A0A0J1HSJ7 (/ISS) A0A0J1HSJ7 (/ISS) A0A0J1HSJ7 (/ISS) A0A0J1HSJ7 (/ISS)
(450 more)
Negative regulation of DNA-templated transcription, termination GO:0060567
Any process that decreases the rate, frequency or extent of DNA-dependent transcription termination, the process in which transcription is completed; the formation of phosphodiester bonds ceases, the RNA-DNA hybrid dissociates, and RNA polymerase releases the DNA.
196 P0A972 (/IDA) P0A972 (/IDA) P0A972 (/IDA) P0A972 (/IDA) P0A972 (/IDA) P0A972 (/IDA) P0A972 (/IDA) P0A972 (/IDA) P0A972 (/IDA) P0A972 (/IDA)
(186 more)
Response to cold GO:0009409
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cold stimulus, a temperature stimulus below the optimal temperature for that organism.
164 P0A978 (/IDA) P0A978 (/IDA) P0A978 (/IDA) P0A978 (/IDA) P0A978 (/IDA) P0A978 (/IDA) P0A978 (/IDA) P0A978 (/IDA) P0A978 (/IDA) P0A978 (/IDA)
(154 more)
Pathogenesis GO:0009405
The set of specific processes that generate the ability of an organism to induce an abnormal, generally detrimental state in another organism.
44 Q82ZX2 (/IMP) Q82ZX2 (/IMP) Q82ZX2 (/IMP) Q82ZX2 (/IMP) Q82ZX2 (/IMP) Q82ZX2 (/IMP) Q82ZX2 (/IMP) Q82ZX2 (/IMP) Q82ZX2 (/IMP) Q82ZX2 (/IMP)
(34 more)
Cellular response to cold GO:0070417
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cold stimulus, a temperature stimulus below the optimal temperature for that organism.
10 A5I1L8 (/IMP) A5I1L8 (/IMP) A5I1L8 (/IMP) A5I1L8 (/IMP) A5I1L8 (/IMP) A5I1L8 (/IMP) A5I1L8 (/IMP) A5I1L8 (/IMP) A5I1L8 (/IMP) A5I1L8 (/IMP)

There are 1 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
360 P0A972 (/IDA) P0A972 (/IDA) P0A972 (/IDA) P0A972 (/IDA) P0A972 (/IDA) P0A972 (/IDA) P0A972 (/IDA) P0A972 (/IDA) P0A972 (/IDA) P0A972 (/IDA)
(350 more)
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