The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:
"Nucleic acid-binding proteins
".
FunFam 47: tyrosine--tRNA ligase, cytoplasmic isoform X2
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 19 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Tyrosine-tRNA ligase activity GO:0004831
Catalysis of the reaction: L-tyrosine + ATP + tRNA(Tyr) = L-tyrosyl-tRNA(Tyr) + AMP + diphosphate + 2 H(+).
|
3 | P54577 (/TAS) P54577 (/TAS) Q9VV60 (/TAS) |
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
3 | P54577 (/IPI) P54577 (/IPI) Q12904 (/IPI) |
RNA binding GO:0003723
Interacting selectively and non-covalently with an RNA molecule or a portion thereof.
|
2 | P54577 (/HDA) P54577 (/HDA) |
Cytokine activity GO:0005125
Functions to control the survival, growth, differentiation and effector function of tissues and cells.
|
2 | Q12904 (/TAS) Q4G079 (/TAS) |
Interleukin-8 receptor binding GO:0005153
Interacting selectively and non-covalently with the interleukin-8 receptor.
|
2 | P54577 (/TAS) P54577 (/TAS) |
TRNA binding GO:0000049
Interacting selectively and non-covalently with transfer RNA.
|
1 | Q12904 (/IDA) |
TRNA binding GO:0000049
Interacting selectively and non-covalently with transfer RNA.
|
1 | P31230 (/ISO) |
TRNA binding GO:0000049
Interacting selectively and non-covalently with transfer RNA.
|
1 | P31230 (/ISS) |
TRNA binding GO:0000049
Interacting selectively and non-covalently with transfer RNA.
|
1 | Q12904 (/TAS) |
Tyrosine-tRNA ligase activity GO:0004831
Catalysis of the reaction: L-tyrosine + ATP + tRNA(Tyr) = L-tyrosyl-tRNA(Tyr) + AMP + diphosphate + 2 H(+).
|
1 | Q9VV60 (/IDA) |
Showing 1 to 10 of 19 entries
There are 25 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
TRNA aminoacylation for protein translation GO:0006418
The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA and the alpha carboxylic acid group of an amino acid, to be used in ribosome-mediated polypeptide synthesis.
|
3 | P54577 (/TAS) P54577 (/TAS) Q12904 (/TAS) |
Tyrosyl-tRNA aminoacylation GO:0006437
The process of coupling tyrosine to tyrosyl-tRNA, catalyzed by tyrosyl-tRNA synthetase.The tyrosyl-tRNA synthetase is a class-I synthetase. The activated amino acid is transferred to the 2'-OH group of a tyrosine-accetping tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterification.T
|
3 | P54577 (/TAS) P54577 (/TAS) Q9VV60 (/TAS) |
Apoptotic process GO:0006915
A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died.
|
2 | P54577 (/TAS) P54577 (/TAS) |
Inflammatory response GO:0006954
The immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The process is characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages.
|
2 | Q12904 (/TAS) Q4G079 (/TAS) |
Cellular response to DNA damage stimulus GO:0006974
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism.
|
2 | Q6TGS6 (/IMP) Q6TGS6 (/IMP) |
Leukocyte migration GO:0050900
The movement of a leukocyte within or between different tissues and organs of the body.
|
2 | P31230 (/IDA) Q12904 (/IDA) |
Positive regulation of glucagon secretion GO:0070094
Any process that activates or increases the frequency, rate or extent of the regulated release of glucagon.
|
2 | O54873 (/ISS) Q12904 (/ISS) |
Negative regulation of endothelial cell proliferation GO:0001937
Any process that stops, prevents, or reduces the rate or extent of endothelial cell proliferation.
|
1 | Q12904 (/IDA) |
Negative regulation of endothelial cell proliferation GO:0001937
Any process that stops, prevents, or reduces the rate or extent of endothelial cell proliferation.
|
1 | P31230 (/ISO) |
Negative regulation of endothelial cell proliferation GO:0001937
Any process that stops, prevents, or reduces the rate or extent of endothelial cell proliferation.
|
1 | P31230 (/ISS) |
Showing 1 to 10 of 25 entries
There are 17 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
7 | A0A0S2Z4R1 (/IDA) A0A0S2Z4R1 (/IDA) P54577 (/IDA) P54577 (/IDA) Q12904 (/IDA) Q93VB0 (/IDA) Q9SVN5 (/IDA) |
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
4 | P54577 (/TAS) P54577 (/TAS) Q12904 (/TAS) Q9SVN5 (/TAS) |
Nuclear body GO:0016604
Extra-nucleolar nuclear domains usually visualized by confocal microscopy and fluorescent antibodies to specific proteins.
|
4 | A0A0S2Z4R1 (/IDA) A0A0S2Z4R1 (/IDA) P54577 (/IDA) P54577 (/IDA) |
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
|
3 | P54577 (/TAS) P54577 (/TAS) Q12904 (/TAS) |
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
3 | P54577 (/TAS) P54577 (/TAS) Q9VV60 (/TAS) |
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
|
2 | P31230 (/IDA) Q9VV60 (/IDA) |
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
|
2 | O54873 (/ISS) Q12904 (/ISS) |
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
2 | P31230 (/ISO) Q91WQ3 (/ISO) |
Aminoacyl-tRNA synthetase multienzyme complex GO:0017101
A multienzyme complex found in all multicellular eukaryotes composed of eight proteins with aminoacyl-tRNA synthetase activities (abbreviated as: ArgRS, AspRS, GluProRS, GlnRS, IleRS, LeuRS, LysRS, MetRS where RS is the enzyme, preceded by the amino acid it uses as a substrate) as well as three non-synthetase proteins (p43, p38, and p18) with diverse functions. Several of these subunits are known dimers, so the total polypeptide count in the multisynthetase complex is at least fifteen. All of the enzymes in this assembly catalyze the same reaction, the covalent attachment of an amino acid to either the 2'- or 3'-hydroxyl of the 3'-terminal adenosine of tRNA, but using different substrates.
|
2 | P31230 (/IDA) Q12904 (/IDA) |
Aminoacyl-tRNA synthetase multienzyme complex GO:0017101
A multienzyme complex found in all multicellular eukaryotes composed of eight proteins with aminoacyl-tRNA synthetase activities (abbreviated as: ArgRS, AspRS, GluProRS, GlnRS, IleRS, LeuRS, LysRS, MetRS where RS is the enzyme, preceded by the amino acid it uses as a substrate) as well as three non-synthetase proteins (p43, p38, and p18) with diverse functions. Several of these subunits are known dimers, so the total polypeptide count in the multisynthetase complex is at least fifteen. All of the enzymes in this assembly catalyze the same reaction, the covalent attachment of an amino acid to either the 2'- or 3'-hydroxyl of the 3'-terminal adenosine of tRNA, but using different substrates.
|
2 | O54873 (/ISS) P31230 (/ISS) |
Showing 1 to 10 of 17 entries