The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:

"
Nucleic acid-binding proteins
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 30: 26S protease regulatory subunit 4

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 6 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
10 P40327 (/IPI) P40327 (/IPI) P40327 (/IPI) P40327 (/IPI) P40327 (/IPI) P40327 (/IPI) P40327 (/IPI) P40327 (/IPI) P40327 (/IPI) P40327 (/IPI)
ATPase activity GO:0016887
Catalysis of the reaction: ATP + H2O = ADP + phosphate + 2 H+. May or may not be coupled to another reaction.
10 P40327 (/IDA) P40327 (/IDA) P40327 (/IDA) P40327 (/IDA) P40327 (/IDA) P40327 (/IDA) P40327 (/IDA) P40327 (/IDA) P40327 (/IDA) P40327 (/IDA)
Proteasome-activating ATPase activity GO:0036402
Catalysis of the reaction: ATP + H2O = ADP + phosphate, which promotes unfolding of protein substrates, and channel opening of the core proteasome.
10 P40327 (/IGI) P40327 (/IGI) P40327 (/IGI) P40327 (/IGI) P40327 (/IGI) P40327 (/IGI) P40327 (/IGI) P40327 (/IGI) P40327 (/IGI) P40327 (/IGI)
Proteasome-activating ATPase activity GO:0036402
Catalysis of the reaction: ATP + H2O = ADP + phosphate, which promotes unfolding of protein substrates, and channel opening of the core proteasome.
10 P40327 (/IMP) P40327 (/IMP) P40327 (/IMP) P40327 (/IMP) P40327 (/IMP) P40327 (/IMP) P40327 (/IMP) P40327 (/IMP) P40327 (/IMP) P40327 (/IMP)
Endopeptidase activity GO:0004175
Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain.
2 Q8IJW0 (/ISS) Q8IJW0 (/ISS)
Ubiquitin protein ligase binding GO:0031625
Interacting selectively and non-covalently with a ubiquitin protein ligase enzyme, any of the E3 proteins.
1 O16368 (/IPI)

There are 30 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Ubiquitin-dependent protein catabolic process GO:0006511
The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein.
15 P40327 (/IMP) P40327 (/IMP) P40327 (/IMP) P40327 (/IMP) P40327 (/IMP) P40327 (/IMP) P40327 (/IMP) P40327 (/IMP) P40327 (/IMP) P40327 (/IMP)
(5 more)
Cellular protein-containing complex localization GO:0034629
A protein complex localization process that takes place at the cellular level; as a result, a protein complex is transported to, or maintained in, a specific location within a cell.
10 P40327 (/IMP) P40327 (/IMP) P40327 (/IMP) P40327 (/IMP) P40327 (/IMP) P40327 (/IMP) P40327 (/IMP) P40327 (/IMP) P40327 (/IMP) P40327 (/IMP)
Peptide catabolic process GO:0043171
The chemical reactions and pathways resulting in the breakdown of peptides, compounds of 2 or more (but usually less than 100) amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another.
10 P40327 (/IMP) P40327 (/IMP) P40327 (/IMP) P40327 (/IMP) P40327 (/IMP) P40327 (/IMP) P40327 (/IMP) P40327 (/IMP) P40327 (/IMP) P40327 (/IMP)
Positive regulation of protein catabolic process GO:0045732
Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds.
10 P40327 (/IDA) P40327 (/IDA) P40327 (/IDA) P40327 (/IDA) P40327 (/IDA) P40327 (/IDA) P40327 (/IDA) P40327 (/IDA) P40327 (/IDA) P40327 (/IDA)
Nonfunctional rRNA decay GO:0070651
An rRNA catabolic process that results in the targeted detection and degradation of aberrant rRNAs contained within translationally defective ribosomes, thereby acting as a quality-control system.
10 P40327 (/IMP) P40327 (/IMP) P40327 (/IMP) P40327 (/IMP) P40327 (/IMP) P40327 (/IMP) P40327 (/IMP) P40327 (/IMP) P40327 (/IMP) P40327 (/IMP)
Proteasome regulatory particle assembly GO:0070682
The aggregation, arrangement and bonding together of a mature, active proteasome regulatory particle complex.
10 P40327 (/IMP) P40327 (/IMP) P40327 (/IMP) P40327 (/IMP) P40327 (/IMP) P40327 (/IMP) P40327 (/IMP) P40327 (/IMP) P40327 (/IMP) P40327 (/IMP)
Female gamete generation GO:0007292
Generation of the female gamete; specialised haploid cells produced by meiosis and along with a male gamete takes part in sexual reproduction.
4 Q9SL67 (/IGI) Q9SL67 (/IGI) Q9SZD4 (/IGI) Q9SZD4 (/IGI)
Maintenance of root meristem identity GO:0010078
The process in which an organism retains a population of root meristem cells, preventing the commitment of all stem cell progeny to a differentiated cell fate.
4 Q9SL67 (/IMP) Q9SL67 (/IMP) Q9SZD4 (/IMP) Q9SZD4 (/IMP)
Male gamete generation GO:0048232
Generation of the male gamete; specialised haploid cells produced by meiosis and along with a female gamete takes part in sexual reproduction.
4 Q9SL67 (/IGI) Q9SL67 (/IGI) Q9SZD4 (/IGI) Q9SZD4 (/IGI)
Proteolysis GO:0006508
The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds.
2 Q8IJW0 (/ISS) Q8IJW0 (/ISS)
Response to heat GO:0009408
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism.
2 Q9SZD4 (/IMP) Q9SZD4 (/IMP)
Meristem structural organization GO:0009933
Organization of a region of tissue in a plant that is composed of one or more undifferentiated cells capable of undergoing mitosis and differentiation, thereby effecting growth and development of a plant by giving rise to more meristem or specialized tissue.
2 Q9SZD4 (/IMP) Q9SZD4 (/IMP)
Leaf morphogenesis GO:0009965
The process in which the anatomical structures of the leaf are generated and organized.
2 Q9SZD4 (/IMP) Q9SZD4 (/IMP)
Root morphogenesis GO:0010015
The process in which the anatomical structures of roots are generated and organized. The root is the usually underground part of a seed plant body that originates from the hypocotyl, functions as an organ of absorption, aeration, and food storage or as a means of anchorage and support.
2 Q9SZD4 (/IMP) Q9SZD4 (/IMP)
Lateral root formation GO:0010311
The process that gives rise to a lateral root. This process pertains to the initial formation of a structure from unspecified parts. A lateral root primordium represents an organized group of cells derived from the root pericycle that will differentiate into a new root, as opposed to the initiation of the main root from the embryo proper.
2 Q9SZD4 (/IMP) Q9SZD4 (/IMP)
Meristem growth GO:0035266
The increase in size or mass of a meristem, a region of tissue in a plant that is composed of one or more undifferentiated cells capable of undergoing mitosis and differentiation.
2 Q9SZD4 (/IMP) Q9SZD4 (/IMP)
Proteasome-mediated ubiquitin-dependent protein catabolic process GO:0043161
The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome.
2 Q9SZD4 (/IMP) Q9SZD4 (/IMP)
Proteasome assembly GO:0043248
The aggregation, arrangement and bonding together of a mature, active proteasome complex.
2 Q9SZD4 (/IMP) Q9SZD4 (/IMP)
Innate immune response GO:0045087
Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens.
2 Q9SZD4 (/IMP) Q9SZD4 (/IMP)
Response to cadmium ion GO:0046686
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cadmium (Cd) ion stimulus.
2 Q9SZD4 (/IEP) Q9SZD4 (/IEP)
Root development GO:0048364
The process whose specific outcome is the progression of the root over time, from its formation to the mature structure. The root is the water- and mineral-absorbing part of a plant which is usually underground, does not bear leaves, tends to grow downwards and is typically derived from the radicle of the embryo.
2 Q9SZD4 (/IMP) Q9SZD4 (/IMP)
Shoot system development GO:0048367
The process whose specific outcome is the progression of the shoot system over time, from its formation to the mature structure.
2 Q9SZD4 (/IMP) Q9SZD4 (/IMP)
Phyllome development GO:0048827
The process whose specific outcome is the progression of a phyllome over time, from its formation to the mature structure. A phyllome is a collective term for all the different types of leaves appearing on plants.
2 Q9SZD4 (/IMP) Q9SZD4 (/IMP)
Root cap development GO:0048829
The process whose specific outcome is the progression of the root cap over time, from its formation to the mature structure. The root cap protects the root meristem from friction as the root grows through the soil. The cap is made up of a group of parenchyma cells which secrete a glycoprotein mucilage as a lubricant.
2 Q9SZD4 (/IMP) Q9SZD4 (/IMP)
Response to misfolded protein GO:0051788
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a misfolded protein stimulus.
2 Q9SZD4 (/IMP) Q9SZD4 (/IMP)
Regulation of gene silencing GO:0060968
Any process that modulates the rate, frequency, or extent of gene silencing, the transcriptional or post-transcriptional process carried out at the cellular level that results in long-term gene inactivation.
2 Q9SZD4 (/IMP) Q9SZD4 (/IMP)
Seedling development GO:0090351
The process whose specific outcome is the progression of the seedling over time, beginning with seed germination and ending when the first adult leaves emerge.
2 Q9SZD4 (/IMP) Q9SZD4 (/IMP)
Mitotic cytokinesis GO:0000281
A cell cycle process that results in the division of the cytoplasm of a cell after mitosis, resulting in the separation of the original cell into two daughter cells.
1 Q55BV5 (/IMP)
Negative regulation of gene expression GO:0010629
Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
1 O16368 (/IMP)
Sorocarp development GO:0030587
The process whose specific outcome is the progression of the sorocarp over time, from its formation to the mature structure. The process begins with the aggregation of individual cells and ends with the mature sorocarp. The sorocarp is a structure containing a spore-bearing sorus that sits on top of a stalk. An example of this process is found in Dictyostelium discoideum.
1 Q55BV5 (/IMP)

There are 14 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
10 P40327 (/IDA) P40327 (/IDA) P40327 (/IDA) P40327 (/IDA) P40327 (/IDA) P40327 (/IDA) P40327 (/IDA) P40327 (/IDA) P40327 (/IDA) P40327 (/IDA)
Proteasome regulatory particle, base subcomplex GO:0008540
The subcomplex of the proteasome regulatory particle that directly associates with the proteasome core complex.
10 P40327 (/IDA) P40327 (/IDA) P40327 (/IDA) P40327 (/IDA) P40327 (/IDA) P40327 (/IDA) P40327 (/IDA) P40327 (/IDA) P40327 (/IDA) P40327 (/IDA)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
5 Q386D8 (/IDA) Q386D8 (/IDA) Q386D8 (/IDA) Q386D8 (/IDA) Q9NC99 (/IDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
5 Q386D8 (/IDA) Q386D8 (/IDA) Q386D8 (/IDA) Q386D8 (/IDA) Q9NC99 (/IDA)
Proteasome regulatory particle GO:0005838
A multisubunit complex, which caps one or both ends of the proteasome core complex. This complex recognizes and unfolds ubiquitinated proteins, and translocates them to the proteasome core complex.
5 Q386D8 (/IDA) Q386D8 (/IDA) Q386D8 (/IDA) Q386D8 (/IDA) Q9NC99 (/IDA)
Proteasome complex GO:0000502
A large multisubunit complex which catalyzes protein degradation, found in eukaryotes, archaea and some bacteria. In eukaryotes, this complex consists of the barrel shaped proteasome core complex and one or two associated proteins or complexes that act in regulating entry into or exit from the core.
4 Q9SL67 (/IDA) Q9SL67 (/IDA) Q9SZD4 (/IDA) Q9SZD4 (/IDA)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
4 Q4QG45 (/ISO) Q4QG45 (/ISO) Q4QG45 (/ISO) Q4QG45 (/ISO)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
4 Q4QG45 (/ISO) Q4QG45 (/ISO) Q4QG45 (/ISO) Q4QG45 (/ISO)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
2 Q9SZD4 (/TAS) Q9SZD4 (/TAS)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
2 Q9SL67 (/IDA) Q9SL67 (/IDA)
Proteasome regulatory particle GO:0005838
A multisubunit complex, which caps one or both ends of the proteasome core complex. This complex recognizes and unfolds ubiquitinated proteins, and translocates them to the proteasome core complex.
2 Q8IJW0 (/ISS) Q8IJW0 (/ISS)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
2 Q9SL67 (/IDA) Q9SL67 (/IDA)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
2 Q9SZD4 (/IDA) Q9SZD4 (/IDA)
Phagocytic vesicle GO:0045335
A membrane-bounded intracellular vesicle that arises from the ingestion of particulate material by phagocytosis.
1 Q55BV5 (/HDA)
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