The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:
"Nucleic acid-binding proteins
".
FunFam 296: Putative DNA helicase MCM8
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 3 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
DNA helicase activity GO:0003678
Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction drives the unwinding of the DNA helix.
|
5 | Q8I5T7 (/ISS) Q8I5T7 (/ISS) Q8I5T7 (/ISS) Q8I5T7 (/ISS) Q8I5T7 (/ISS) |
|
ATP binding GO:0005524
Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
|
5 | Q8I5T7 (/ISS) Q8I5T7 (/ISS) Q8I5T7 (/ISS) Q8I5T7 (/ISS) Q8I5T7 (/ISS) |
|
DNA-dependent ATPase activity GO:0008094
Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction requires the presence of single- or double-stranded DNA, and it drives another reaction.
|
5 | Q8I5T7 (/ISS) Q8I5T7 (/ISS) Q8I5T7 (/ISS) Q8I5T7 (/ISS) Q8I5T7 (/ISS) |
There are 2 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
DNA replication initiation GO:0006270
The process in which DNA-dependent DNA replication is started; this begins with the ATP dependent loading of an initiator complex onto the DNA, this is followed by DNA melting and helicase activity. In bacteria, the gene products that enable the helicase activity are loaded after the initial melting and in archaea and eukaryotes, the gene products that enable the helicase activity are inactive when they are loaded and subsequently activate.
|
5 | Q8I5T7 (/ISS) Q8I5T7 (/ISS) Q8I5T7 (/ISS) Q8I5T7 (/ISS) Q8I5T7 (/ISS) |
|
DNA strand elongation involved in DNA replication GO:0006271
The process in which an existing DNA strand is extended by activities including the addition of nucleotides to the 3' end of the strand, complementary to an existing template, as part of DNA replication.
|
5 | Q8I5T7 (/TAS) Q8I5T7 (/TAS) Q8I5T7 (/TAS) Q8I5T7 (/TAS) Q8I5T7 (/TAS) |
There are 1 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Nuclear pre-replicative complex GO:0005656
A protein-DNA complex assembled at eukaryotic DNA replication origins during late mitosis and G1, allowing the origin to become competent, or 'licensed', for replication. The complex normally includes the origin recognition complex (ORC), Cdc6, Cdt1 and the MiniChromosome Maintenance (Mcm2-7) proteins.
|
5 | Q8I5T7 (/ISS) Q8I5T7 (/ISS) Q8I5T7 (/ISS) Q8I5T7 (/ISS) Q8I5T7 (/ISS) |
