The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:

"
Nucleic acid-binding proteins
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 161: Ribonuclease R

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 7 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
3'-5'-exoribonuclease activity GO:0000175
Catalysis of the sequential cleavage of mononucleotides from a free 3' terminus of an RNA molecule.
16 P21499 (/IDA) P21499 (/IDA) P21499 (/IDA) P21499 (/IDA) P21499 (/IDA) P21499 (/IDA) P21499 (/IDA) P21499 (/IDA) P21499 (/IDA) P21499 (/IDA)
(6 more)
Ribonuclease activity GO:0004540
Catalysis of the hydrolysis of phosphodiester bonds in chains of RNA.
16 P21499 (/IMP) P21499 (/IMP) P21499 (/IMP) P21499 (/IMP) P21499 (/IMP) P21499 (/IMP) P21499 (/IMP) P21499 (/IMP) P21499 (/IMP) P21499 (/IMP)
(6 more)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
16 P21499 (/IPI) P21499 (/IPI) P21499 (/IPI) P21499 (/IPI) P21499 (/IPI) P21499 (/IPI) P21499 (/IPI) P21499 (/IPI) P21499 (/IPI) P21499 (/IPI)
(6 more)
Ribonuclease R activity GO:0008997
Catalysis of the reaction: RNA + H2O = 5'-phosphomononucleotides. Cleaves RNA in the 3' to 5' direction, leaving an undigested core of 3-5 nucleotides.
16 P21499 (/IDA) P21499 (/IDA) P21499 (/IDA) P21499 (/IDA) P21499 (/IDA) P21499 (/IDA) P21499 (/IDA) P21499 (/IDA) P21499 (/IDA) P21499 (/IDA)
(6 more)
Exoribonuclease activity, producing 5'-phosphomonoesters GO:0016896
Catalysis of the hydrolysis of ester linkages within ribonucleic acids by removing nucleotide residues from the 3' or 5' end to yield 5' phosphomonoesters.
16 P21499 (/IDA) P21499 (/IDA) P21499 (/IDA) P21499 (/IDA) P21499 (/IDA) P21499 (/IDA) P21499 (/IDA) P21499 (/IDA) P21499 (/IDA) P21499 (/IDA)
(6 more)
3'-5' RNA helicase activity GO:0034458
Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction drives the unwinding of an RNA helix in the direction 3' to 5'.
16 P21499 (/IDA) P21499 (/IDA) P21499 (/IDA) P21499 (/IDA) P21499 (/IDA) P21499 (/IDA) P21499 (/IDA) P21499 (/IDA) P21499 (/IDA) P21499 (/IDA)
(6 more)
Ribonuclease R activity GO:0008997
Catalysis of the reaction: RNA + H2O = 5'-phosphomononucleotides. Cleaves RNA in the 3' to 5' direction, leaving an undigested core of 3-5 nucleotides.
6 Q8EAG7 (/ISS) Q9KNY1 (/ISS) Q9KNY1 (/ISS) Q9KNY1 (/ISS) Q9KNY1 (/ISS) Q9KNY1 (/ISS)

There are 4 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
MRNA catabolic process GO:0006402
The chemical reactions and pathways resulting in the breakdown of mRNA, messenger RNA, which is responsible for carrying the coded genetic 'message', transcribed from DNA, to sites of protein assembly at the ribosomes.
16 P21499 (/IMP) P21499 (/IMP) P21499 (/IMP) P21499 (/IMP) P21499 (/IMP) P21499 (/IMP) P21499 (/IMP) P21499 (/IMP) P21499 (/IMP) P21499 (/IMP)
(6 more)
Response to cold GO:0009409
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cold stimulus, a temperature stimulus below the optimal temperature for that organism.
16 P21499 (/IEP) P21499 (/IEP) P21499 (/IEP) P21499 (/IEP) P21499 (/IEP) P21499 (/IEP) P21499 (/IEP) P21499 (/IEP) P21499 (/IEP) P21499 (/IEP)
(6 more)
NcRNA processing GO:0034470
Any process that results in the conversion of one or more primary non-coding RNA (ncRNA) transcripts into one or more mature ncRNA molecules.
16 P21499 (/IMP) P21499 (/IMP) P21499 (/IMP) P21499 (/IMP) P21499 (/IMP) P21499 (/IMP) P21499 (/IMP) P21499 (/IMP) P21499 (/IMP) P21499 (/IMP)
(6 more)
RNA processing GO:0006396
Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules.
6 Q8EAG7 (/ISS) Q9KNY1 (/ISS) Q9KNY1 (/ISS) Q9KNY1 (/ISS) Q9KNY1 (/ISS) Q9KNY1 (/ISS)

There are 1 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
16 P21499 (/IDA) P21499 (/IDA) P21499 (/IDA) P21499 (/IDA) P21499 (/IDA) P21499 (/IDA) P21499 (/IDA) P21499 (/IDA) P21499 (/IDA) P21499 (/IDA)
(6 more)
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