A process that results in the breakdown of the extracellular matrix.

The regulated exocytosis of secretory granules containing preformed mediators such as proteases, lipases, and inflammatory mediators by a neutrophil.

Any process that stops, prevents or reduces the frequency, rate or extent of metallopeptidase activity.

Any process that stops, prevents or reduces the rate or extent of cell proliferation.

The process of formation of spermatozoa, including spermatocytogenesis and spermiogenesis.

The process whose specific outcome is the progression of the central nervous system over time, from its formation to the mature structure. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain and spinal cord. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord.

A developmental process that is a deterioration and loss of function over time. Aging includes loss of functions such as resistance to disease, homeostasis, and fertility, as well as wear and tear. Aging includes cellular senescence, but is more inclusive. May precede death and may succeed developmental maturation (GO:0021700).

Any process that modulates the frequency, rate or extent of Rap protein signal transduction.

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cytokine stimulus.

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a drug stimulus. A drug is a substance used in the diagnosis, treatment or prevention of a disease.

Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the MAPK cascade.

Any process that activates or increases the frequency, rate or extent of neuron differentiation.

Any process that activates or increases the frequency, rate or extent of adenylate cyclase activity.

Any process that stops, prevents, or reduces the frequency, rate or extent of the hydrolysis of a peptide bond or bonds within a protein.

Any process that stops, prevents or reduces the rate or extent of progression through the mitotic cell cycle.

Any process that stops, prevents, or reduces the frequency, rate or extent of Ras protein signal transduction.

Any process that stops, prevents or reduces the rate or extent of cell proliferation.

Any process that modulates the frequency, rate or extent of Rap protein signal transduction.

Any process that modulates the frequency, rate or extent of signal transduction mediated by the MAP kinase (MAPK) cascade.

Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the MAPK cascade.

Any process that modulates the frequency, rate or extent of neuron differentiation.

Any process that modulates the frequency, rate or extent of neuron differentiation.

Any process that activates or increases the frequency, rate or extent of neuron differentiation.

Any process that activates or increases the frequency, rate or extent of adenylate cyclase activity.

Any process that stops, prevents, or reduces the frequency, rate or extent of the hydrolysis of a peptide bond or bonds within a protein.

Any process that stops, prevents or reduces the rate or extent of progression through the mitotic cell cycle.

Any process that stops, prevents, or reduces the frequency, rate or extent of Ras protein signal transduction.

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic substance stimulus.

Any process that stops, prevents or reduces the frequency, rate or extent of metallopeptidase activity.

The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.

The volume enclosed by the membrane of a specific granule, a granule with a membranous, tubular internal structure, found primarily in mature neutrophil cells. Most are released into the extracellular fluid. Specific granules contain lactoferrin, lysozyme, vitamin B12 binding protein and elastase.

An extracellular matrix consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that provides not only essential physical scaffolding for the cellular constituents but can also initiate crucial biochemical and biomechanical cues required for tissue morphogenesis, differentiation and homeostasis. The components are secreted by cells in the vicinity and form a sheet underlying or overlying cells such as endothelial and epithelial cells.

Any membrane-enclosed lumen that is part of a tertiary granule.

Any membrane-enclosed lumen that is part of a ficolin-1-rich granule.

That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.

The external part of the cell wall and/or plasma membrane.

The migrating motile tip of a growing neuron projection, where actin accumulates, and the actin cytoskeleton is the most dynamic.

A prolongation or process extending from a nerve cell, e.g. an axon or dendrite.

The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites.

A collagen-containing extracellular matrix consisting of a thin layer of dense material found in various animal tissues interposed between the cells and the adjacent connective tissue. It consists of the basal lamina plus an associated layer of reticulin fibers.

That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.

That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.

The external part of the cell wall and/or plasma membrane.

The migrating motile tip of a growing neuron projection, where actin accumulates, and the actin cytoskeleton is the most dynamic.

A prolongation or process extending from a nerve cell, e.g. an axon or dendrite.

The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites.