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CATH Superfamily 2.40.10.10

Trypsin-like serine proteases

The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:

"
Trypsin-like serine proteases
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
SC:1Tryptase gamma 1Transmembrane serine protease 7Serine endoprotease DegS, periplasmicCoagulation factor XHepatocyte growth factorSerine protease easterComplement C1r subcomponentmannan-binding lectin serine protease 1 isoform X1Complement C1s subcomponentAcrosinHepatocyte growth factor-like proteinProthrombinTrypsin alphaKallikrein 8 (Neuropsin/ovasin)kallikrein-6 isoform X1Mannan-binding lectin serine protease 2Coagulation factor XIISerine protease HtrAGenome polyproteinChymotrypsin-like elastase family member 1Cationic trypsinProstasinGlandular kallikrein-10Granzyme HProbable serine protease PepD (Serine proteinase) (MTB32B)Vitamin K-dependent protein CAnionic trypsin isoform 1Coagulation factor XIProtease Do-like 5, chloroplasticMyeloblastinSC:3Kallikrein related peptidase 11Tryptase beta-2Hepatocyte growth factorserine proteases 1/2HaptoglobinComplement C1r subcomponentTrypsin betaNeutrophil elastaseHepatocyte growth factor-like 1mannan-binding lectin serine protease 1 isoform X1Urokinase-type plasminogen activatorComplement C1s subcomponentSerine protease easterProthrombinserine protease hepsinMannan-binding lectin serine protease 2Coagulation factor XIIKallikrein related-peptidase 10Protein Z, vitamin K-dependent plasma glycoproteinGenome polyproteinProstate-specific antigenSerine protease grassSerine protease Rv3671cAnionic trypsin-2AzurocidinSC:4Complement C1r subcomponentSC:5Genome polyproteinGenome polyproteinSC:6HaptoglobinProtein Z, vitamin K-dependent plasma glycoproteinSC:7Complement factor ITrypsinGlandular kallikreinSC:8Phage baseplate hub subunitPeriplasmic serine protease DegSTransmembrane protease serineTransmembrane serine protease 3Serine protease 37Serine proteinase stubbleCationic trypsinCoagulation factor Xprotease Do-like 9Complement factor DAtrial natriuretic peptide-converting enzymeChymotrypsin-like elastase family member 1Anionic trypsinGenome polyproteinKallikrein 1Genome polyproteinSerine protease 53Genome polyproteinGenome polyproteinKallikrein 1-related peptidase C9Replicase polyprotein 1aEupolytinSerine proteaseBrain-specific serine protease 4Serine protease 23kallikrein-6 isoform X2Kallikrein 1-related peptidase C9serine proteases 1/2polyserase-2 isoform X1Replicase polyprotein 1aComplement factor b,-likeTrypsin etaserine protease 23probable inactive serine protease 37complement C2 isoform X1NeurotrypsinKallikrein related peptidase 11Zgc:100868Tissue-type plasminogen activatorHepatocyte growth factor activatorHepatocyte growth factortransmembrane protease serine 2Hyaluronan-binding protein 2Urokinase-type plasminogen activatorCLIP-domain serine proteaseglyoxysomal processing protease, glyoxysomal-likeStructural polyproteinStructural polyproteinPredicted proteinSerine protease H137Serine protease 53peroxisomal leader peptide-processing proteaseSerine protease 56Plasma kallikreinserine protease hepsinKallikrein-4Transmembrane protease serine 5Kallikrein related-peptidase 12Glyoxysomal processing protease glyoxysomalKallikrein-4Genome polyproteinDipeptidyl-peptidase 7Protease Do-like 1, chloroplasticInactive serine protease 45Probable threonine protease PRSS50TISP43 isoform 6HepsinHepsinBlast:Serine protease nudelMannan-binding lectin serine protease 1Zgc:112285ORF1a polyproteinSerine protease P16Chymotrypsinogen AORF1a polyproteinPutative serine proteasePeptidase S46 family proteinGenome polyproteininactive serine protease 54TISP43 isoform 4Probable threonine protease PRSS50S46 family peptidaseTequila, isoform DChymotrypsinogen AProtease Do-like 9Inactive serine protease 54Glyoxysomal processing protease glyoxysomalUncharacterized protein, isoform BCoagulation factor II (thrombin)Kallikrein related-peptidase 12GD22965Kallikrein related peptidase 11AcrosinCLIP-domain serine proteaseEnterokinase light chainClip-domain serine proteaseSerine protease PepAAGAP011783-PAGenome polyproteinSerine protease 53Kallikrein related peptidase 12CLIP-domain serine proteaseInactive serine protease 35Chymotrypsin-like protease CTRL-1Corin, isoform BPlasminogen activatorVenom plasminogen activator TSV-PAFamily with sequence similarity 111 member AFlocculation FLO11-like proteinMIP06385pGH18608pThrombin-like enzyme saxthrombinComplement C1r subcomponent likeProtease Do-like 7Serine protease DegPProtease Do-like 7AGAP001251-PAJonah 66CiiTrypsin-like serine proteaseCoagulation factor II (thrombin)Genome polyproteinSerine protease 3trypsin-1GG16564Possible proteaseChymotrypsinogen ASerine proteaseTrypsin-like serine proteaseGenome polyproteinIP09419pChymotrypsinogen AZgc:163079Complement component 1, s subcomponentProtease Do-like 5, chloroplasticSerine protease PepAUncharacterized protein, isoform ASi:dkeyp-93a5.2Ovochymase, putativeCoagulation factor II (Thrombin)GM21018CLIP-domain serine proteaseSecreted trypsin-like serine proteaseUncharacterized proteinUncharacterized protein, isoform BPutative low-density lipoprotein receptorchymotrypsin-1Trypsin, putativeSerine protease nudelRT07795pGD11897Membrane-associated serine proteaseLysyl endopeptidaseLysyl endopeptidaseSerine-peptidase 212Serine proteasetrypsin alpha-3serine proteinase stubble isoform X2Serine protease P53Si:dkey-33m11.7Protein Z, vitamin K-dependent plasma glycoprotein aTrypsin domain-containing 1Chymase 1HGF/MSP/plasminogen-like proteinSerine protease nudelUncharacterized proteinSerine protease 1Si:dkey-33m11.8GH15905pGM13756Protease, serine 51GD19101GD10792CG9649 proteinSi:dkey-33m11.7Serine protease 53Trypsin domain-containing 1Serine proteaseBlast:Transmembrane protease serine 6Coagulation factor VIIiAtrial natriuretic peptide-converting enzymePutative trypsinTrypsin, putativeKallikrein related peptidase 13Uncharacterized proteinSerine protease H29Haptoglobinchymotrypsinogen A-likeKLK4 isoform 6GM24079Elastase, neutrophil expressedinactive serine protease 35GG11533Zgc:100868AGAP009216-PAZgc:92511Serine protease H158Trypsin precursorUncharacterized proteinGM14069Transmembrane serine protease 5Transmembrane serine protease 5Uncharacterized proteinTrypsin precursorGM13457MIP04821pUncharacterized proteinUncharacterized proteinIP10114pGM15595AT07689pGG11998Serine proteaseTrypsin domain containing 1Uncharacterized protein, isoform CUncharacterized proteinSerine-type enodpeptidase, putativeCortical granule serine protease 1; Uncharacterized proteinSerine proteaseGranzyme-like ISi:ch211-212d10.1 proteinuncharacterized protein LOC100179458 isoform X1Modular serine proteaseInactive serine protease PAMR1GM18242IP19845pZgc:165423 proteinCoagulation factor precursor, putativeSerine protease easter-like Proteinelastase-1 isoform X1AGAP013254-PAGM13872serine protease gd isoform X1IP20273pAGAP011918-PAKLKBL4 proteinGM13374Putative peptidase Cgl1093Serine protease H65Uncharacterized protein, isoform DComplement component 1, r subcomponentPlasminogen activator, urokinaseUncharacterized proteinComplement component 1, r subcomponentMannose-binding lectin associated serine proteaseUncharacterized proteinCoagulation factor VIILP05421pSerine protease H164GH24985pprostasin-likeUncharacterized proteinGD15727Female reproductive tract proteaseAGAP001252-PAAGAP012315-PAIP19441pAGAP005310-PAMale accessory gland proteinAquariusGM19097Uncharacterized proteinProbable trypsin-like serine proteaseAGAP005196-PATransmembrane protease serine 9-like Protein
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FunFam 252: Serine protease H158

GO Diversity

Unique GO annotations
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4 Unique GO terms

EC Diversity

Unique EC annotations
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0 Unique EC terms

Species Diversity

Unique species annotations
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4 Unique species

Statistics

Members
CATH Domains: 0
Sequences: 5
Annotations
Unique GO: 4
Unique EC: 0
Unique Species: 4
Representative
Rep ID: Q9VGA5/29-253
Inherited Annotations: 0
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