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CATH Superfamily 2.30.30.40

SH3 Domains

The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:

"
SH3 Domains
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
SC:1SLIT-ROBO Rho GTPase-activating protein 1 isoform 2RIMS-binding protein 2 isoform X1Rho guanine nucleotide exchange factor 9kalirin isoform X1Intersectin 1Ubiquitin-associated and SH3 domain-containing protein BFCH and double SH3 domains protein 2caskin-2 isoform X1SH3 and cysteine-rich domain-containing protein 2Tyrosine-protein kinasePeroxisomal biogenesis factor 131-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gammaNeutrophil cytosol factor 1obscurin isoform X2Cytoplasmic proteinjouberin isoform X2FYN-binding protein-like isoform X2Tyrosine-protein kinaseCas scaffold protein family member 4Tyrosine-protein kinaseFYN-binding protein-like isoform X1Osteoclast-stimulating factor 1crk-like protein isoform X1Nephrocystin 1E3 ubiquitin-protein ligase SH3RF2 isoform X1epidermal growth factor receptor kinase substrate 8-like protein 2GRB2-related adapter protein 2epidermal growth factor receptor kinase substrate 8-like protein 3growth arrest-specific protein 7 isoform X1Actin cytoskeleton-regulatory complex protein SLA1NAP1-binding protein 2Myosin tail region-interacting protein MTI1Myosin ICell death abnormality protein 2Tyrosine-protein kinaseSC:2abl interactor 1 isoform X1nebulin isoform X1Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2RIMS-binding protein 2 isoform X2Formin-binding protein 1-like isoform 1RIMS-binding protein 2 isoform FIntersectin 1SH3 and multiple ankyrin repeat domains protein 2endophilin-B2 isoform X1FCH and double SH3 domains protein 2kalirin isoform X1RAS p21 protein activator 1dynamin-binding protein isoform X1Alpha-(1,6)-fucosyltransferaseMitogen-activated protein kinase kinase kinaseSH3 domain-containing kinase-binding protein 1Cytoplasmic proteinSmall G protein signaling modulator 3 homologneutrophil cytosol factor 1Peroxisomal membrane protein (Pex13)Tyrosine-protein kinaseProline-serine-threonine phosphatase interacting protein 1rho guanine nucleotide exchange factor 26dynamin-binding protein isoform X1Neutrophil cytosolic factor 2SH3 and PX domains 2ASorting nexinTyrosine-protein kinaseProtein BZZ1[PSI+] inducibility protein 3Actin-binding proteinRho GTPase-activating protein 4SC:3Tyrosine-protein kinaseSH3 and PX domain-containing protein 2ASH3 domain-containing kinase-binding protein 1Vav guanine nucleotide exchange factor 3src-like-adapter isoform X1Nitric oxide synthase traffickingRIMS-binding protein 3A-likeSC:4Alkylphosphonate utilization protein PhnAPlectin aE3 ubiquitin-protein ligase HECTD1 isoform X1Desmoplakin aSrc like adaptor 2Intersectin 2SC:51-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gammadynamin-binding protein isoform X1SC:6Voltage-dependent L-type calcium channel subunit beta-2Putative tight junction protein ZO-1Voltage-dependent L-type calcium channel subunit beta-3Voltage-dependent L-type calcium channel subunit beta-1 isoform 1Disks large 1 isoform X3Tight junction protein 3SC:7Sorbin and SH3 domain-containing protein 1 isoform 2Breast cancer anti-estrogen resistance 1Brain-specific angiogenesis inhibitor 1-associated protein 2myc box-dependent-interacting protein 1 isoform X2Putative C-Jun-amino-terminal kinase-interacting protein 2Vav guanine nucleotide exchange factor 3SH3 and PX domain-containing protein 2Aspermatogenesis-associated protein 13 isoform X2Protein kinase activator Bem1Neutrophil cytosol factor 2unconventional myosin-VIIaintersectin-1 isoform X2Tyrosine-protein kinaseMyosin VIIbSC:8Sorbin and SH3 domain-containing protein 1 isoform 2neutrophil cytosol factor 4Melanoma-derived growth regulatory proteinHigh osmolarity signaling protein SHO1SLIT-ROBO Rho GTPase-activating protein 2SC:9N-acetylmuramoyl-L-alanine amidaseSorbin and SH3 domain-containing protein 1 isoform 2Disks large homolog 1 isoform 2Tyrosine-protein kinaseMicrotubule-actin cross-linking factor 1Kinase C and casein kinase substrate in neurons proteinChemotaxis protein CheWSH3 and PX domain-containing protein 2APutative sam and sh3 domain-containing protein 1Disks large homolog 3 isoform 1rho GTPase-activating protein 32 isoform X2Rho guanine nucleotide exchange factor (GEF) 7SH3 domain containing proteinSpectrin alpha chain, non-erythrocytic 1Chemotaxis protein CheWE3 ubiquitin-protein ligase MIB2, putativeShort stop, isoform KDrebrin-like protein isoform BDisks large homolog 2 isoform 3Chemotaxis protein CheA, putativeendophilin-A1 isoform X2Putative e3 ubiquitin-protein ligase mind-bombrho GTPase-activating protein 26 isoform X1rho GTPase-activating protein 12 isoform X1Dedicator of cytokinesis protein 4Disks large homolog 1 isoform X1SH3 and PX domain-containing protein 2ACytoplasmic proteinPutative E3 ubiquitin-protein ligase SH3RF1adapter molecule crk isoform X1Growth factor receptor-bound protein 2MAGUK p55 subfamily member 6Epidermal growth factor receptor kinase substrate 8Unconventional Myosin IBE3 ubiquitin-protein ligase HERC2 isoform X1phosphatidylinositol 3-kinase regulatory subunit alphaGrowth factor receptor-bound protein 2Putative e3 ubiquitin-protein ligase mib2Peripheral plasma membrane protein CASK isoform X2Tight junction protein ZO-2 isoform 2SH3 and PX domain-containing protein 2BTyrosine-protein kinasesignal transducing adapter molecule 2Src substrate cortactinPeriplakinE3 ubiquitin-protein ligase MIB1 isoform X1Putative E3 ubiquitin-protein ligase SH3RF1Uncharacterized protein, isoform BPutative src kinase-associated phosphoprotein 2Protein arginine N-methyltransferase 2 isoform 1Uncharacterized protein, isoform CSH3 domain-containing YSC84-like protein 1Rho GTPase activating protein 9AmphiphysinBacterial SH3 domain proteinMAGUK p55 subfamily member 5disks large homolog 4 isoform X2FCH and double SH3 domains 1Rho guanine nucleotide exchange factor (GEF) 5SH3 domain-containing kinase-binding protein 1Rho GTPase activating protein 42Sorting nexinSH3 domain-binding protein 4Putative E3 ubiquitin-protein ligase SH3RF1dynamin-binding protein isoform X1Ephexin-1 isoform X1Tyrosine-protein kinaseMAGUK p55 subfamily member 4Discs large 5, isoform AGuanine nucleotide exchange factor VAV2 isoform 255 kDa erythrocyte membrane proteinRho GTPase activating protein 4Uncharacterized protein, isoform Gdynamin-binding protein isoform X1Hematopoietic cell-specific Lyn substrate 1vinexin isoform X2SH3 and PX domain-containing protein 2Amelanoma inhibitory activity protein 2 isoform X2Caspase recruitment domain family member 10Caspase recruitment domain family member 11Tyrosine-protein kinaseAlpha spectrin, isoform CFCH and double SH3 domains proteinadapter molecule crk isoform X1MAGUK p55 subfamily member 7Actin polymerization protein Bzz1MIA SH3 domain ER export factor 3Cell division control proteindynamin-binding protein isoform X1RIM-binding protein, isoform FSH3 and cysteine-rich domain-containing protein 3 isoform X1SH3 domain protein (Cyk3)Mitogen-activated protein kinase kinase kinaseABI gene family member 3Amphiphysin, isoform Brho guanine nucleotide exchange factor 37Tyrosine-protein kinaseRho guanine nucleotide exchange factor (GEF) 37SH3 and multiple ankyrin repeat domains proteinPML-RARA regulated adaptor molecule 1Tyrosine-protein kinase FynEpidermal growth factor receptor kinase substrate 8Protein kinase activator Bem1brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 2Insulin receptor tyrosine kinase substrateBAR adaptor protein RVS167Tyrosine-protein kinaseE3 ubiquitin-protein ligase SH3RF2 isoform X2Uncharacterized protein, isoform CRho guanine nucleotide exchange factor 38Chemotaxis protein CheVTyrosine-protein kinaseGuanine nucleotide exchange factor DBSSH3 domain containing 19Myosin XVACdc42-interacting protein 4, isoform FAmidaseSH3 domain containing 19GRB2-related adapter protein 2 isoform X1CLUMA_CG020965, isoform ATyrosine-protein kinaseAbl interactor 2Karst, isoform BTyrosine-protein kinaseNADPH oxidase activator 1SH3 domain-containing protein 19 isoform X2MAGUK p55 subfamily member 3Myosin light chain kinase, smooth muscleNADPH oxidase organizer 1FYN binding protein 2SH3 and cysteine-rich domain-containing protein 2SH3 domain-containing protein DlishCaspase recruitment domain family, member 14Phosphonoacetate hydrolaseChemotaxis protein CheVUncharacterized protein, isoform BRUN and SH3 domain containing 2Uncharacterized protein, isoform CRho GTPase activating protein 27NADPH oxidase organizer 1Tyrosine-protein kinaseSH3 and cysteine rich domain 3NADPH oxidase organizer 1NCK interacting protein with SH3 domainSH3 domain containing 19Menage a trois, isoform CActin binding proteinNon-receptor tyrosine-protein kinase TNK1 isoform X1Peptidase, M23/M37 familyN-acetylmuramoyl-l-alanine amidaseRIMS-binding protein 3A-likeRho-type guanine nucleotide exchange factor, isoform AEphexin, isoform DActivated Cdc42 kinase-likeDynamin associated protein isoform Dap160-2Chemotaxis protein CheWHECT domain and RCC1 family domain containing proteinTyrosine-protein kinaseMyosin I MyoA/Myo5Tyrosine-protein kinaseAbl interactor 2Chemotaxis protein CheWProtein BOI2neutrophil cytosol factor 2 isoform X1Chemotaxis protein CheVRUN and SH3 domain containing 1SH3 domain-containing protein 21HECT E3 ubiquitin ligaseMyoblast city, isoform BE3 ubiquitin-protein ligase HECTD1 isoform X3Uncharacterized proteinSH3 adapter protein SPIN90Blast:Tyrosine-protein kinase Src-1Chemotaxis protein CheWActin binding proteinChemotaxis protein CheWCheW-like proteinSAM domain, SH3 domain and nuclear localization signals 1Spectrin beta chain, non-erythrocyticDreadlocks, isoform Auncharacterized protein LOC108099255 isoform X3Peptidase M24Peptidase M24Uncharacterized protein, isoform DBAI1-associated protein 2-like 2bCalcium channel, voltage-dependent, beta 3bRho guanine nucleotide exchange factor (GEF) 4Microtubule-actin cross-linking factor 1Uncharacterized protein, isoform ACalcium Channel, Beta subunitPhnA domain proteinChemotaxis protein CheWBlast:Tyrosine-protein kinase Src-1Actin polymerization protein Bzz1CheA signal transduction histidine kinaseRho GTPase-activating proteinEndophilin B, isoform AActin cytoskeleton-regulatory complex protein SLA1SH3 domain-containing proteinAbp1pZO-1 (Zonula Occludens tight junctional protein) OrthologSporulation proteinNostrin, isoform HProtein CBG22463Predicted proteinBud site selection proteinPurine-binding chemotaxis protein CheWActin polymerization protein Bzz1Polarized growth protein (Boi2)Related to Cell division control protein 15SH3 domain proteinUnplaced genomic scaffold supercont1.257, whole genome shotgun sequenceCalcium channel, voltage-dependent, beta 2bBud emergence proteinBud emergence protein 1CIN85 and CD2AP related, isoform CE3 ubiquitin-protein ligase hecd-1JNK Interacting Protein (Scaffold protein)Muscle M-line assembly protein unc-89SH3 domain-containing proteinHof1pAlkylphosphonate utilization operon protein PhnACIN85 and CD2AP related, isoform DActin cytoskeleton-regulatory complex protein sla1Trio, isoform DPurine-binding chemotaxis protein CheWSignal transducing adapter molecule 1Caspase recruitment domain family, member 11Predicted proteinUncharacterized proteinEndolysinSH3 domain-containing protein 1Disks large homolog 1Transport and Golgi organization protein 1Unplaced genomic scaffold supercont1.11, whole genome shotgun sequenceCytokinesis protein 3Nuclear fusion protein FUS1Bzz1pCell division cycle-related proteinChemotaxis protein CheWserine-rich adhesin for platelets isoform X2GTPase-activating protein rrc-1SH3 and cysteine rich domainUnconventional myosin heavy chain 6N-acetylmuramoyl-L-alanine amidaseSorting nexin1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gammaPutative chemotaxis protein CheVNeutrophil cytosol factor 2Guanine nucleotide exchange factor UNC-73AUnplaced genomic scaffold supercont2.1, whole genome shotgun sequenceCrk oncogene, isoform BPutative N-acetylmuramoyl-L-alanine amidaseTyrosine-protein kinasePeripheral plasma membrane protein CASKHeavy chain, Unconventional MyosinTyrosine-protein kinaseBridging integrator 1AMPHiphysin homologEndophilin-A homologLIM and SH3 proteinVariant sh3 domain containing proteinChemotaxis protein CheWScaffold protein CheW associated with MCPs of classes 40H and 40+24HPlenty of SH3sProtein arginine methyltransferase 2Elongation factor 2 kinasePutative purine-binding chemotaxis protein ChewPutative purine-binding chemotaxis protein ChewPutative purine-binding chemotaxis protein ChewN-acetylmuramoyl-L-alanine amidaseN-acetylmuramoyl-L-alanine amidaseElongation factor 2 kinaseITSN (Intersectin) familyVariant sh3 domain containing proteinNCK (Non-Catalytic region of tyrosine Kinase) adaptor protein familyABl Interactor homologChemotaxis protein CheWAlpha-(1,6)-fucosyltransferaseProtein arginine N-methyltransferase 2N-acetylmuramoyl-L-alanine amidaseITSN (Intersectin) familyUncharacterized proteinRAS p21 protein activator (GTPase activating protein) 1aITSN (Intersectin) familyITSN (Intersectin) familySMAllUncharacterized protein, isoform CProline-serine-threonine phosphatase-interacting protein 1bChemotaxis protein CheAAlkylphosphonate uptake proteinTyrosine-protein kinaseHematopoietic cell-specific Lyn substrate 1Bridging integrator 2bPeripheral-type benzodiazepine receptor-associated protein 1Calcium Channel, Beta subunitProtein CBG22463Rho GTPase-activating protein 27,-likesmall G protein signaling modulator 3 isoform X10Tyrosine-protein kinaseRelated to YSC84-protein involved in the organization of actin cytoskeletonPeroxin 13Uncharacterized proteinChemotaxis protein CheWCell death abnormality protein 2Dynamin-binding proteinTyrosine-protein kinasePredicted proteinLIM and SH3 domain protein 2Neutrophil cytosolic factor 2Neutrophil cytosolic factor 4Meiotically up-regulated gene 137 proteinChemotaxis protein CheVPredicted proteinPredicted proteinvoltage-dependent L-type calcium channel subunit beta-1 isoform X2Protein kinase C and casein kinase substrate in neurons 2Nephronophthisis 1Fus1pPeroxisomal membrane protein, putativePeroxin 13, putativeRas family guanine nucleotide exchange factorPurine-binding chemotaxis protein (CheW)Chemotaxis protein CheWBud emergence protein, putativeBAR domaincontaining proteinPredicted proteinTyrosine-protein kinaseUncharacterized proteinUncharacterized proteinChromosome 16, whole genome shotgun sequenceTyrosine-protein kinaseUncharacterized proteinVariant sh3 domain containing proteinCaspase recruitment domain family member 10rho GTPase-activating protein 27 isoform X1Tyrosine-protein kinaseneutrophil cytosolic factor 1 isoform X1Tyrosine-protein kinaseSH3 domain and tetratricopeptide repeat-containing protein 2neutrophil cytosolic factor 1 isoform X1PACSIN3 isoform 8SH3 domain-containing protein 2Uncharacterized proteinTyrosine-protein kinaseTyrosine-protein kinaseTyrosine-protein kinaseUncharacterized proteinUncharacterized proteinPutative voltage-dependent l-type calcium channel subunit beta-2Probable peroxisomal membrane protein PEX13Uncharacterized proteinSH3 and SYLF domain containing 1SH3 domain protein, conservedHematopoietic cell-specific Lyn substrate 1Uncharacterized proteinUncharacterized proteinCytokinesis and cell polarization-associated protein, putativeUncharacterized proteinUncharacterized proteinSH3 domain-containing YSC84-like protein 1Uncharacterized proteinSH3 and F-BAR domain-containing protein DDB_G0271676F-BAR and double SH3 domains protein 2 isoform X6ACR266WpUncharacterized proteinRIM Binding proteinSLIT-ROBO Rho GTPase-activating protein 3Cell division control protein 25Chemotaxis signal transduction system adaptor protein CheWScaffold protein CheW associated with MCPs of classes 40H and 40+24HPurine-binding chemotaxis protein CheWScaffold protein CheW associated with MCPs of class 44HPositive regulator of CheA protein activity (CheW)YALI0F27643pUncharacterized proteinProtein app1Uncharacterized proteinPeripheral-type benzodiazepine receptor-associated protein 1SH3 and PX domain-containing protein 2BUncharacterized proteinProtein CBR-CED-5Predicted proteinPredicted proteinTyrosine-protein kinaseUncharacterized proteinPredicted proteinPredicted proteinRho GTPase-activating protein gacJJUncharacterized proteinSH3 and multiple ankyrin repeat domains 2JNK-interacting protein 1BAR domaincontaining proteinUncharacterized proteinUncharacterized proteinBAR domaincontaining proteinUncharacterized proteinDynamin-binding proteinBAR domaincontaining proteinAbl protein tyrosine kinasePredicted proteinUncharacterized proteinN-acetylmuramoyl-L-alanine amidaseSmall G protein signaling modulator 3Alpha-(1,6)-fucosyltransferaseUncharacterized proteinProtein CBR-SMA-1Rho GTPase-activating protein 33zinc finger protein (ZZ-type)-2 isoform X1zinc finger protein (ZZ-type)-2 isoform X1Tyrosine-protein kinaseUncharacterized proteinTyrosine-protein kinasephosphatidylinositol 3-kinase regulatory subunit gammaDisks large homolog 1BAR domaincontaining proteinSi:ch211-25d12.7Teichoic acids export ATP-binding protein TagHLysM peptidoglycan-binding domain-containing proteinPlectinTyrosine-protein kinaseEpidermal growth factor receptor kinase substrate 8BAR domaincontaining proteinBAR domaincontaining proteinProtein kinase C and casein kinase substrate in neurons protein 2AaceriABR082WpBrain-specific angiogenesis inhibitor 1-associated protein 2YALI0F19778pF-BAR and double SH3 domains protein 2Formin-binding proteinSH3 domain-containing proteinSH3 domain-containing proteinTyrosine-protein kinaseUncharacterized proteinEPS8 like 1Predicted proteinUncharacterized proteinAGAP000255-PECalcium channel, voltage-dependent, beta 3 subunitUncharacterized proteinPredicted proteinDiscs, large homolog 4Calcium voltage-gated channel auxiliary subunit beta 3Uncharacterized proteinUncharacterized proteinSH3 domain protein, conservedBbc1pPutative truncated guanine nucleotide exchange factor YLL017WCortactin, putativeUncharacterized proteinPredicted proteinSi:dkey-40c11.2Uncharacterized proteinVariant SH3 domain containing proteinUncharacterized proteinUncharacterized proteinUncharacterized proteinC-terminal Src kinasePredicted proteinRho GTPase-activating protein 10Peroxisomal membrane protein PEX13-like ProteinUncharacterized proteinProtein csh3Uncharacterized proteinVariant SH3 domain containing proteinUncharacterized proteinUncharacterized proteinPredicted proteinCdc42 guanine nucleotide exchange factor (GEF) 9bProtein ste6Chemotaxis signal transduction proteinAEL241WpChemotaxis proteinUncharacterized proteinUncharacterized proteinProtein CBR-DLG-1Uncharacterized proteinCD2-associated protein likeUncharacterized proteinUncharacterized proteinCIN85 and CD2AP related, isoform ECD2-associated protein likePredicted proteinRho GTPase-activating protein gacIIUncharacterized proteinTyrosine-protein kinaseUncharacterized proteinUncharacterized proteinPredicted proteinUncharacterized proteinUncharacterized proteinUncharacterized proteinUncharacterized proteinUncharacterized proteinUncharacterized proteinUncharacterized proteinPredicted proteinUncharacterized proteinUncharacterized proteinUncharacterized proteinTyrosine-protein kinaseRho GTPase-activating protein 4Chemotaxis protein CheZPredicted proteinDynamin binding proteinUncharacterized proteinSH3 and multiple ankyrin repeat domains 3Probable serine/threonine-protein kinase mkcFUncharacterized proteinUncharacterized proteinDiscs, large homolog 4a (Drosophila)Rho GTPase-activating protein 9Predicted proteinUncharacterized proteinSrc kinase associated phosphoprotein 1Predicted proteinUncharacterized proteinSrc like adaptor 2Uncharacterized proteinMAGUK p55 subfamily member 7Wu:fi04e12Uncharacterized proteinEPS8-like 3aUncharacterized proteinUncharacterized proteinPredicted proteinGlutamate 5-kinaseUncharacterized proteinSi:dkey-40c11.2Uncharacterized proteinTyrosine-protein kinaseTyrosine-protein kinaseMindbomb E3 ubiquitin protein ligase 2Uncharacterized proteinUncharacterized proteinProtein vav-1Predicted proteinMyosin-1Tyrosine-protein kinaseUncharacterized proteinTyrosine-protein kinase sid-3Uncharacterized proteinTyrosine-protein kinaseTyrosine-protein kinase PR2-like ProteinUncharacterized proteinUncharacterized proteinSmall G protein signaling modulator 3Rho GTPase-activating protein 27Discs large MAGUK scaffold protein 4Tyrosine-protein kinasePredicted proteinUncharacterized proteinTyrosine-protein kinaseUncharacterized proteinGlycoprotein 6-alpha-L-fucosyltransferase, putativeUncharacterized proteinUncharacterized proteinUncharacterized proteinPredicted proteinUncharacterized proteinUncharacterized proteinPredicted proteinUncharacterized proteinPredicted proteinProtein CBG04143Uncharacterized proteinUncharacterized proteinUncharacterized proteinPredicted proteinUncharacterized proteinUncharacterized proteinVariant SH3 domain containing proteinUncharacterized proteinVariant SH3 domain containing proteinTyrosine-protein kinasePredicted protein
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FunFam 80: Peripheral plasma membrane protein CASK isoform X2

GO Diversity

Unique GO annotations
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48 Unique GO terms

EC Diversity

Unique EC annotations
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1 Unique EC terms

Species Diversity

Unique species annotations
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91 Unique species

Statistics

Members
CATH Domains: 0
Sequences: 236
Annotations
Unique GO: 48
Unique EC: 1
Unique Species: 91
Representative
Rep ID: O70589/575-726
Inherited Annotations: 0
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