The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:

"
SH3 Domains
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 28: endophilin-B2 isoform X1

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 8 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
19 Q6AYE2 (/IPI) Q9JK48 (/IPI) Q9NR46 (/IPI) Q9NR46 (/IPI) Q9NR46 (/IPI) Q9NR46 (/IPI) Q9NR46 (/IPI) Q9NR46 (/IPI) Q9NR46 (/IPI) Q9NR46 (/IPI)
(9 more)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
17 Q9NR46 (/IPI) Q9NR46 (/IPI) Q9NR46 (/IPI) Q9NR46 (/IPI) Q9NR46 (/IPI) Q9NR46 (/IPI) Q9NR46 (/IPI) Q9NR46 (/IPI) Q9NR46 (/IPI) Q9NR46 (/IPI)
(7 more)
Cadherin binding GO:0045296
Interacting selectively and non-covalently with cadherin, a type I membrane protein involved in cell adhesion.
17 Q9NR46 (/HDA) Q9NR46 (/HDA) Q9NR46 (/HDA) Q9NR46 (/HDA) Q9NR46 (/HDA) Q9NR46 (/HDA) Q9NR46 (/HDA) Q9NR46 (/HDA) Q9NR46 (/HDA) Q9NR46 (/HDA)
(7 more)
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
6 Q9Y371 (/IPI) Q9Y371 (/IPI) Q9Y371 (/IPI) Q9Y371 (/IPI) Q9Y371 (/IPI) Q9Y371 (/IPI)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
2 Q8R3V5 (/ISO) Q9JK48 (/ISO)
Fatty acid binding GO:0005504
Interacting selectively and non-covalently with fatty acids, aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis.
1 Q9JK48 (/IDA)
Lysophosphatidic acid acyltransferase activity GO:0042171
Catalysis of the transfer of acyl groups from an acyl-CoA to lysophosphatidic acid to form phosphatidic acid.
1 Q9JK48 (/IDA)
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
1 Q9JK48 (/ISO)

There are 41 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Positive regulation of autophagy GO:0010508
Any process that activates, maintains or increases the rate of autophagy. Autophagy is the process in which cells digest parts of their own cytoplasm.
7 Q9JK48 (/IMP) Q9Y371 (/IMP) Q9Y371 (/IMP) Q9Y371 (/IMP) Q9Y371 (/IMP) Q9Y371 (/IMP) Q9Y371 (/IMP)
Autophagic cell death GO:0048102
A form of programmed cell death that is accompanied by the formation of autophagosomes. Autophagic cell death is characterized by lack of chromatin condensation and massive vacuolization of the cytoplasm, with little or no uptake by phagocytic cells.
7 Q9JK48 (/IMP) Q9Y371 (/IMP) Q9Y371 (/IMP) Q9Y371 (/IMP) Q9Y371 (/IMP) Q9Y371 (/IMP) Q9Y371 (/IMP)
Protein localization to vacuolar membrane GO:1903778
A process in which a protein is transported to, or maintained in, a location within a vacuolar membrane.
7 Q9JK48 (/IMP) Q9Y371 (/IMP) Q9Y371 (/IMP) Q9Y371 (/IMP) Q9Y371 (/IMP) Q9Y371 (/IMP) Q9Y371 (/IMP)
Positive regulation of autophagosome assembly GO:2000786
Any process that activates or increases the frequency, rate or extent of autophagic vacuole assembly.
7 Q9JK48 (/IMP) Q9Y371 (/IMP) Q9Y371 (/IMP) Q9Y371 (/IMP) Q9Y371 (/IMP) Q9Y371 (/IMP) Q9Y371 (/IMP)
Regulation of macroautophagy GO:0016241
Any process that modulates the frequency, rate or extent of macroautophagy.
6 Q9Y371 (/TAS) Q9Y371 (/TAS) Q9Y371 (/TAS) Q9Y371 (/TAS) Q9Y371 (/TAS) Q9Y371 (/TAS)
Regulation of protein stability GO:0031647
Any process that affects the structure and integrity of a protein, altering the likelihood of its degradation or aggregation.
6 Q9Y371 (/HMP) Q9Y371 (/HMP) Q9Y371 (/HMP) Q9Y371 (/HMP) Q9Y371 (/HMP) Q9Y371 (/HMP)
Positive regulation of protein oligomerization GO:0032461
Any process that activates or increases the frequency, rate or extent of protein oligomerization.
6 Q9Y371 (/IDA) Q9Y371 (/IDA) Q9Y371 (/IDA) Q9Y371 (/IDA) Q9Y371 (/IDA) Q9Y371 (/IDA)
Regulation of cytokinesis GO:0032465
Any process that modulates the frequency, rate or extent of the division of the cytoplasm of a cell and its separation into two daughter cells.
6 Q9Y371 (/IMP) Q9Y371 (/IMP) Q9Y371 (/IMP) Q9Y371 (/IMP) Q9Y371 (/IMP) Q9Y371 (/IMP)
Receptor catabolic process GO:0032801
The chemical reactions and pathways resulting in the breakdown of a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function.
6 Q9Y371 (/IMP) Q9Y371 (/IMP) Q9Y371 (/IMP) Q9Y371 (/IMP) Q9Y371 (/IMP) Q9Y371 (/IMP)
Cellular response to amino acid starvation GO:0034198
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of amino acids.
6 Q9Y371 (/IMP) Q9Y371 (/IMP) Q9Y371 (/IMP) Q9Y371 (/IMP) Q9Y371 (/IMP) Q9Y371 (/IMP)
Cellular response to glucose starvation GO:0042149
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of glucose.
6 Q9Y371 (/IMP) Q9Y371 (/IMP) Q9Y371 (/IMP) Q9Y371 (/IMP) Q9Y371 (/IMP) Q9Y371 (/IMP)
Protein complex oligomerization GO:0051259
The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of component monomers; protein oligomers may be composed of different or identical monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer.
6 Q9Y371 (/IDA) Q9Y371 (/IDA) Q9Y371 (/IDA) Q9Y371 (/IDA) Q9Y371 (/IDA) Q9Y371 (/IDA)
Membrane fission GO:0090148
A process that is carried out at the cellular level which results in the separation of a single continuous membrane into two membranes.
6 Q9Y371 (/IMP) Q9Y371 (/IMP) Q9Y371 (/IMP) Q9Y371 (/IMP) Q9Y371 (/IMP) Q9Y371 (/IMP)
Positive regulation of membrane tubulation GO:1903527
Any process that activates or increases the frequency, rate or extent of membrane tubulation.
6 Q9Y371 (/IMP) Q9Y371 (/IMP) Q9Y371 (/IMP) Q9Y371 (/IMP) Q9Y371 (/IMP) Q9Y371 (/IMP)
Positive regulation of protein targeting to mitochondrion GO:1903955
Any process that activates or increases the frequency, rate or extent of protein targeting to mitochondrion.
6 Q9Y371 (/HMP) Q9Y371 (/HMP) Q9Y371 (/HMP) Q9Y371 (/HMP) Q9Y371 (/HMP) Q9Y371 (/HMP)
Phosphatidic acid biosynthetic process GO:0006654
The chemical reactions and pathways resulting in the formation of phosphatidic acid, any derivative of glycerol phosphate in which both the remaining hydroxyl groups of the glycerol moiety are esterified with fatty acids.
1 Q9JK48 (/IDA)
Apoptotic process GO:0006915
A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died.
1 Q9JK48 (/ISO)
Phospholipid biosynthetic process GO:0008654
The chemical reactions and pathways resulting in the formation of phospholipids, any lipid containing phosphoric acid as a mono- or diester.
1 Q9JK48 (/IDA)
Positive regulation of autophagy GO:0010508
Any process that activates, maintains or increases the rate of autophagy. Autophagy is the process in which cells digest parts of their own cytoplasm.
1 Q9JK48 (/ISO)
Positive regulation of protein oligomerization GO:0032461
Any process that activates or increases the frequency, rate or extent of protein oligomerization.
1 Q9JK48 (/ISO)
Regulation of cytokinesis GO:0032465
Any process that modulates the frequency, rate or extent of the division of the cytoplasm of a cell and its separation into two daughter cells.
1 Q9JK48 (/ISO)
Receptor catabolic process GO:0032801
The chemical reactions and pathways resulting in the breakdown of a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function.
1 Q9JK48 (/ISO)
Cellular response to amino acid starvation GO:0034198
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of amino acids.
1 Q9JK48 (/ISO)
Cellular response to glucose starvation GO:0042149
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of glucose.
1 Q9JK48 (/ISO)
Positive regulation of phosphatidylinositol 3-kinase activity GO:0043552
Any process that activates or increases the frequency, rate or extent of phosphatidylinositol 3-kinase activity.
1 Q9JK48 (/IMP)
Autophagic cell death GO:0048102
A form of programmed cell death that is accompanied by the formation of autophagosomes. Autophagic cell death is characterized by lack of chromatin condensation and massive vacuolization of the cytoplasm, with little or no uptake by phagocytic cells.
1 Q9JK48 (/ISO)
Positive regulation of dendrite morphogenesis GO:0050775
Any process that activates or increases the frequency, rate or extent of dendrite morphogenesis.
1 Q6AYE2 (/IMP)
Positive regulation of dendrite morphogenesis GO:0050775
Any process that activates or increases the frequency, rate or extent of dendrite morphogenesis.
1 Q9JK48 (/ISO)
'de novo' posttranslational protein folding GO:0051084
The process of assisting in the correct noncovalent folding of newly formed polypeptides or folding intermediates of polypeptides that have exited the ribosome and/or have been stabilized and transferred by other chaperone proteins. This process could involve several cycles of ATP hydrolysis.
1 Q9JK48 (/IDA)
Protein complex oligomerization GO:0051259
The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of component monomers; protein oligomers may be composed of different or identical monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer.
1 Q9JK48 (/ISO)
Positive regulation of neurotrophin TRK receptor signaling pathway GO:0051388
Any process that activates or increases the frequency, rate or extent of the neurotrophin TRK receptor signaling pathway.
1 Q6AYE2 (/IMP)
Positive regulation of neurotrophin TRK receptor signaling pathway GO:0051388
Any process that activates or increases the frequency, rate or extent of the neurotrophin TRK receptor signaling pathway.
1 Q9JK48 (/ISO)
Membrane fission GO:0090148
A process that is carried out at the cellular level which results in the separation of a single continuous membrane into two membranes.
1 Q9JK48 (/ISO)
Positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway GO:1900740
Any process that activates or increases the frequency, rate or extent of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway.
1 Q9JK48 (/IMP)
Positive regulation of membrane tubulation GO:1903527
Any process that activates or increases the frequency, rate or extent of membrane tubulation.
1 Q9JK48 (/ISO)
Protein localization to vacuolar membrane GO:1903778
A process in which a protein is transported to, or maintained in, a location within a vacuolar membrane.
1 Q9JK48 (/ISO)
Positive regulation of dendrite extension GO:1903861
Any process that activates or increases the frequency, rate or extent of dendrite extension.
1 Q6AYE2 (/IMP)
Positive regulation of dendrite extension GO:1903861
Any process that activates or increases the frequency, rate or extent of dendrite extension.
1 Q9JK48 (/ISO)
Regulation of early endosome to late endosome transport GO:2000641
Any process that modulates the frequency, rate or extent of early endosome to late endosome transport.
1 Q6AYE2 (/IMP)
Regulation of early endosome to late endosome transport GO:2000641
Any process that modulates the frequency, rate or extent of early endosome to late endosome transport.
1 Q9JK48 (/ISO)
Positive regulation of autophagosome assembly GO:2000786
Any process that activates or increases the frequency, rate or extent of autophagic vacuole assembly.
1 Q9JK48 (/ISO)

There are 23 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
46 A0A024R896 (/IDA) A0A024R896 (/IDA) A0A024R896 (/IDA) A0A024R896 (/IDA) A0A024R896 (/IDA) A0A024R896 (/IDA) A0A024R896 (/IDA) A0A024R896 (/IDA) A0A024R896 (/IDA) A0A024R896 (/IDA)
(36 more)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
30 A0A024R896 (/IDA) A0A024R896 (/IDA) A0A024R896 (/IDA) A0A024R896 (/IDA) A0A024R896 (/IDA) A0A024R896 (/IDA) A0A024R896 (/IDA) A0A024R896 (/IDA) A0A024R896 (/IDA) A0A024R896 (/IDA)
(20 more)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
17 Q9NR46 (/IDA) Q9NR46 (/IDA) Q9NR46 (/IDA) Q9NR46 (/IDA) Q9NR46 (/IDA) Q9NR46 (/IDA) Q9NR46 (/IDA) Q9NR46 (/IDA) Q9NR46 (/IDA) Q9NR46 (/IDA)
(7 more)
Autophagosome membrane GO:0000421
The lipid bilayer surrounding an autophagosome, a double-membrane-bounded vesicle in which endogenous cellular material is sequestered.
6 Q9Y371 (/IDA) Q9Y371 (/IDA) Q9Y371 (/IDA) Q9Y371 (/IDA) Q9Y371 (/IDA) Q9Y371 (/IDA)
Midbody GO:0030496
A thin cytoplasmic bridge formed between daughter cells at the end of cytokinesis. The midbody forms where the contractile ring constricts, and may persist for some time before finally breaking to complete cytokinesis.
6 Q9Y371 (/IDA) Q9Y371 (/IDA) Q9Y371 (/IDA) Q9Y371 (/IDA) Q9Y371 (/IDA) Q9Y371 (/IDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
2 Q8R3V5 (/ISO) Q9JK48 (/ISO)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
2 Q8R3V5 (/ISO) Q9JK48 (/ISO)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
2 Q6AYE2 (/IDA) Q9JK48 (/IDA)
Autophagosome membrane GO:0000421
The lipid bilayer surrounding an autophagosome, a double-membrane-bounded vesicle in which endogenous cellular material is sequestered.
1 Q9JK48 (/ISO)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
1 Q8R3V5 (/ISO)
Mitochondrial envelope GO:0005740
The double lipid bilayer enclosing the mitochondrion and separating its contents from the cell cytoplasm; includes the intermembrane space.
1 Q9JK48 (/ISO)
Early endosome GO:0005769
A membrane-bounded organelle that receives incoming material from primary endocytic vesicles that have been generated by clathrin-dependent and clathrin-independent endocytosis; vesicles fuse with the early endosome to deliver cargo for sorting into recycling or degradation pathways.
1 Q6AYE2 (/IDA)
Early endosome GO:0005769
A membrane-bounded organelle that receives incoming material from primary endocytic vesicles that have been generated by clathrin-dependent and clathrin-independent endocytosis; vesicles fuse with the early endosome to deliver cargo for sorting into recycling or degradation pathways.
1 Q9JK48 (/ISO)
Endoplasmic reticulum GO:0005783
The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
1 Q9JK48 (/IC)
Synaptic vesicle GO:0008021
A secretory organelle, typically 50 nm in diameter, of presynaptic nerve terminals; accumulates in high concentrations of neurotransmitters and secretes these into the synaptic cleft by fusion with the 'active zone' of the presynaptic plasma membrane.
1 Q6AYE2 (/IDA)
Synaptic vesicle GO:0008021
A secretory organelle, typically 50 nm in diameter, of presynaptic nerve terminals; accumulates in high concentrations of neurotransmitters and secretes these into the synaptic cleft by fusion with the 'active zone' of the presynaptic plasma membrane.
1 Q9JK48 (/ISO)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
1 Q9JK48 (/ISO)
Midbody GO:0030496
A thin cytoplasmic bridge formed between daughter cells at the end of cytokinesis. The midbody forms where the contractile ring constricts, and may persist for some time before finally breaking to complete cytokinesis.
1 Q9JK48 (/ISO)
Protein-containing complex GO:0032991
A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.
1 Q9JK48 (/IDA)
Neuron projection GO:0043005
A prolongation or process extending from a nerve cell, e.g. an axon or dendrite.
1 Q6AYE2 (/IDA)
Neuron projection GO:0043005
A prolongation or process extending from a nerve cell, e.g. an axon or dendrite.
1 Q9JK48 (/ISO)
Neuronal cell body GO:0043025
The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites.
1 Q6AYE2 (/IDA)
Neuronal cell body GO:0043025
The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites.
1 Q9JK48 (/ISO)
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