The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:
"SH3 Domains
".
FunFam 253: Tyrosine-protein kinase
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 5 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Non-membrane spanning protein tyrosine kinase activity GO:0004715
Catalysis of the reaction: ATP + protein L-tyrosine = ADP + protein L-tyrosine phosphate by a non-membrane spanning protein.
|
6 | G5EE56 (/IDA) P00528 (/IDA) P00528 (/IDA) P00528 (/IDA) P00528 (/IDA) P00528 (/IDA) |
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
6 | G5EE56 (/IPI) P00528 (/IPI) P00528 (/IPI) P00528 (/IPI) P00528 (/IPI) P00528 (/IPI) |
Signaling receptor binding GO:0005102
Interacting selectively and non-covalently with one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function.
|
5 | P00528 (/IPI) P00528 (/IPI) P00528 (/IPI) P00528 (/IPI) P00528 (/IPI) |
Protein tyrosine kinase activity GO:0004713
Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate.
|
1 | G5EE56 (/IDA) |
Netrin receptor binding GO:1990890
Interacting selectively and non-covalently with a netrin receptor.
|
1 | G5EE56 (/IPI) |
There are 45 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Activation of MAPKKK activity GO:0000185
Any process that initiates the activity of the inactive enzyme MAP kinase kinase kinase (MAPKKK).
|
5 | P00528 (/IDA) P00528 (/IDA) P00528 (/IDA) P00528 (/IDA) P00528 (/IDA) |
Germarium-derived egg chamber formation GO:0007293
Construction of a stage-1 egg chamber in the anterior part of the germarium, from the progeny of germ-line and somatic stem cells. An example of this is found in Drosophila melanogaster.
|
5 | P00528 (/IMP) P00528 (/IMP) P00528 (/IMP) P00528 (/IMP) P00528 (/IMP) |
Ovarian nurse cell to oocyte transport GO:0007300
Transfer of constituents synthesized in the ovarian nurse cells to the oocyte, through the ring canals, as the egg chamber is growing. An example of this is found in Drosophila melanogaster.
|
5 | P00528 (/IMP) P00528 (/IMP) P00528 (/IMP) P00528 (/IMP) P00528 (/IMP) |
Female germline ring canal formation GO:0007301
Assembly of the intercellular bridges that connect the germ-line cells of a female cyst.
|
5 | P00528 (/IMP) P00528 (/IMP) P00528 (/IMP) P00528 (/IMP) P00528 (/IMP) |
Cellularization GO:0007349
The separation of a multi-nucleate cell or syncytium into individual cells. An example of this is found in Drosophila melanogaster embryo development.
|
5 | P00528 (/IMP) P00528 (/IMP) P00528 (/IMP) P00528 (/IMP) P00528 (/IMP) |
Axon guidance GO:0007411
The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues.
|
5 | P00528 (/IMP) P00528 (/IMP) P00528 (/IMP) P00528 (/IMP) P00528 (/IMP) |
Open tracheal system development GO:0007424
The process whose specific outcome is the progression of an open tracheal system over time, from its formation to the mature structure. An open tracheal system is a respiratory system, a branched network of epithelial tubes that supplies oxygen to target tissues via spiracles. An example of this is found in Drosophila melanogaster.
|
5 | P00528 (/IMP) P00528 (/IMP) P00528 (/IMP) P00528 (/IMP) P00528 (/IMP) |
Salivary gland morphogenesis GO:0007435
The process in which the anatomical structures of the salivary gland are generated and organized.
|
5 | P00528 (/IMP) P00528 (/IMP) P00528 (/IMP) P00528 (/IMP) P00528 (/IMP) |
Long-term memory GO:0007616
The memory process that deals with the storage, retrieval and modification of information a long time (typically weeks, months or years) after receiving that information. This type of memory is typically dependent on gene transcription regulated by second messenger activation.
|
5 | P00528 (/IMP) P00528 (/IMP) P00528 (/IMP) P00528 (/IMP) P00528 (/IMP) |
Regulation of actin polymerization or depolymerization GO:0008064
Any process that modulates the frequency, rate or extent of the assembly or disassembly of actin filaments by the addition or removal of actin monomers from a filament.
|
5 | P00528 (/IMP) P00528 (/IMP) P00528 (/IMP) P00528 (/IMP) P00528 (/IMP) |
Female germline ring canal formation, actin assembly GO:0008302
Recruitment and organization of actin filaments in female germline ring canals.
|
5 | P00528 (/IMP) P00528 (/IMP) P00528 (/IMP) P00528 (/IMP) P00528 (/IMP) |
Female germline ring canal stabilization GO:0008335
Maintenance of the structural integrity of the ring canals connecting the female germline cyst.
|
5 | P00528 (/IMP) P00528 (/IMP) P00528 (/IMP) P00528 (/IMP) P00528 (/IMP) |
Mushroom body development GO:0016319
The process whose specific outcome is the progression of the mushroom body over time, from its formation to the mature structure. The mushroom body is composed of the prominent neuropil structures of the insect central brain, thought to be crucial for olfactory associated learning. These consist mainly of a bulbous calyx and tightly packaged arrays of thin parallel fibers of the Kenyon cells.
|
5 | P00528 (/IMP) P00528 (/IMP) P00528 (/IMP) P00528 (/IMP) P00528 (/IMP) |
Peptidyl-tyrosine phosphorylation GO:0018108
The phosphorylation of peptidyl-tyrosine to form peptidyl-O4'-phospho-L-tyrosine.
|
5 | P00528 (/IGI) P00528 (/IGI) P00528 (/IGI) P00528 (/IGI) P00528 (/IGI) |
Actin cytoskeleton organization GO:0030036
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins.
|
5 | P00528 (/IMP) P00528 (/IMP) P00528 (/IMP) P00528 (/IMP) P00528 (/IMP) |
Parallel actin filament bundle assembly GO:0030046
Assembly of actin filament bundles in which the filaments are tightly packed (approximately 10-20 nm apart) and oriented with the same polarity.
|
5 | P00528 (/IMP) P00528 (/IMP) P00528 (/IMP) P00528 (/IMP) P00528 (/IMP) |
Germarium-derived female germ-line cyst encapsulation GO:0030708
Formation of a single follicular epithelium around the germ-line derived cells of a cyst formed in the germarium. An example of this process is found in Drosophila melanogaster.
|
5 | P00528 (/IMP) P00528 (/IMP) P00528 (/IMP) P00528 (/IMP) P00528 (/IMP) |
Oocyte karyosome formation GO:0030717
The chromosome organization process in which meiotic chromosomes in the oocyte nucleus cluster together to form a compact spherical structure called the karyosome.
|
5 | P00528 (/IMP) P00528 (/IMP) P00528 (/IMP) P00528 (/IMP) P00528 (/IMP) |
Ovarian fusome organization GO:0030723
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the fusome of ovarian cells, an organelle derived from the spectrosome. It anchors the mitotic spindle pole to provide orientation during cystoblast cell divisions.
|
5 | P00528 (/IMP) P00528 (/IMP) P00528 (/IMP) P00528 (/IMP) P00528 (/IMP) |
Adherens junction organization GO:0034332
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an adherens junction. An adherens junction is a cell junction at which the cytoplasmic face of the plasma membrane is attached to actin filaments.
|
5 | P00528 (/IMP) P00528 (/IMP) P00528 (/IMP) P00528 (/IMP) P00528 (/IMP) |
Filtration diaphragm assembly GO:0036058
The aggregation, arrangement and bonding together of a set of components to form a filtration diaphragm, a specialized cell-cell junction found between the cells of the excretory system, which provides a barrier for filtration of blood or hemolymph.
|
5 | P00528 (/IMP) P00528 (/IMP) P00528 (/IMP) P00528 (/IMP) P00528 (/IMP) |
Positive regulation of epidermal growth factor receptor signaling pathway GO:0045742
Any process that activates or increases the frequency, rate or extent of epidermal growth factor receptor signaling pathway activity.
|
5 | P00528 (/IGI) P00528 (/IGI) P00528 (/IGI) P00528 (/IGI) P00528 (/IGI) |
Positive regulation of fibroblast growth factor receptor signaling pathway GO:0045743
Any process that activates or increases the frequency, rate or extent of fibroblast growth factor receptor signaling pathway activity.
|
5 | P00528 (/IMP) P00528 (/IMP) P00528 (/IMP) P00528 (/IMP) P00528 (/IMP) |
Positive regulation of sevenless signaling pathway GO:0045874
Any process that activates or increases the frequency, rate or extent of the sevenless signaling pathway.
|
5 | P00528 (/IGI) P00528 (/IGI) P00528 (/IGI) P00528 (/IGI) P00528 (/IGI) |
Negative regulation of synaptic growth at neuromuscular junction GO:0045886
Any process that stops, prevents, or reduces the frequency, rate or extent of synaptic growth at neuromuscular junction.
|
5 | P00528 (/IGI) P00528 (/IGI) P00528 (/IGI) P00528 (/IGI) P00528 (/IGI) |
Regulation of synaptic plasticity GO:0048167
A process that modulates synaptic plasticity, the ability of synapses to change as circumstances require. They may alter function, such as increasing or decreasing their sensitivity, or they may increase or decrease in actual numbers.
|
5 | P00528 (/IGI) P00528 (/IGI) P00528 (/IGI) P00528 (/IGI) P00528 (/IGI) |
Oogenesis GO:0048477
The complete process of formation and maturation of an ovum or female gamete from a primordial female germ cell. Examples of this process are found in Mus musculus and Drosophila melanogaster.
|
5 | P00528 (/IMP) P00528 (/IMP) P00528 (/IMP) P00528 (/IMP) P00528 (/IMP) |
Epithelial cell-cell adhesion GO:0090136
The attachment of an epithelial cell to another epithelial cell via adhesion molecules.
|
5 | P00528 (/IMP) P00528 (/IMP) P00528 (/IMP) P00528 (/IMP) P00528 (/IMP) |
Positive regulation of torso signaling pathway GO:0120176
Any process that activates or increases the frequency, rate or extent of the torso signaling pathway.
|
5 | P00528 (/IGI) P00528 (/IGI) P00528 (/IGI) P00528 (/IGI) P00528 (/IGI) |
Establishment of mitotic spindle orientation GO:0000132
A cell cycle process that sets the alignment of mitotic spindle relative to other cellular structures.
|
1 | G5EE56 (/IGI) |
Establishment of mitotic spindle orientation GO:0000132
A cell cycle process that sets the alignment of mitotic spindle relative to other cellular structures.
|
1 | G5EE56 (/IMP) |
Endodermal cell fate specification GO:0001714
The cell fate determination process that results in a cell becoming capable of differentiating autonomously into an endoderm cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed.
|
1 | G5EE56 (/IGI) |
Anterior/posterior axis specification, embryo GO:0008595
The specification of the anterior/posterior axis of the embryo by the products of genes expressed maternally and genes expressed in the zygote.
|
1 | G5EE56 (/IMP) |
Embryo development ending in birth or egg hatching GO:0009792
The process whose specific outcome is the progression of an embryo over time, from zygote formation until the end of the embryonic life stage. The end of the embryonic life stage is organism-specific and may be somewhat arbitrary; for mammals it is usually considered to be birth, for insects the hatching of the first instar larva from the eggshell.
|
1 | G5EE56 (/IMP) |
Gonad morphogenesis GO:0035262
The process in which the anatomical structures of the gonads are generated and organized. A gonad is an animal organ producing gametes, e.g. the testes or the ovary in mammals.
|
1 | G5EE56 (/IGI) |
Gonad morphogenesis GO:0035262
The process in which the anatomical structures of the gonads are generated and organized. A gonad is an animal organ producing gametes, e.g. the testes or the ovary in mammals.
|
1 | G5EE56 (/IMP) |
Peptidyl-tyrosine autophosphorylation GO:0038083
The phosphorylation by a protein of one or more of its own tyrosine amino acid residues, or a tyrosine residue on an identical protein.
|
1 | G5EE56 (/IDA) |
Positive regulation of locomotion GO:0040017
Any process that activates or increases the frequency, rate or extent of locomotion of a cell or organism.
|
1 | G5EE56 (/IGI) |
Positive regulation of embryonic development GO:0040019
Any process that activates or increases the frequency, rate or extent of embryonic development.
|
1 | G5EE56 (/IMP) |
Protein autophosphorylation GO:0046777
The phosphorylation by a protein of one or more of its own amino acid residues (cis-autophosphorylation), or residues on an identical protein (trans-autophosphorylation).
|
1 | G5EE56 (/IDA) |
Embryonic digestive tract morphogenesis GO:0048557
The process in which the anatomical structures of the digestive tract are generated and organized during embryonic development. The digestive tract is the anatomical structure through which food passes and is processed.
|
1 | G5EE56 (/IGI) |
Embryonic digestive tract morphogenesis GO:0048557
The process in which the anatomical structures of the digestive tract are generated and organized during embryonic development. The digestive tract is the anatomical structure through which food passes and is processed.
|
1 | G5EE56 (/IMP) |
Positive regulation of peptidyl-tyrosine phosphorylation GO:0050731
Any process that activates or increases the frequency, rate or extent of the phosphorylation of peptidyl-tyrosine.
|
1 | G5EE56 (/IMP) |
Left/right axis specification GO:0070986
The establishment, maintenance and elaboration of the left/right axis. The left/right axis is defined by a line that runs orthogonal to both the anterior/posterior and dorsal/ventral axes. Each side is defined from the viewpoint of the organism rather of the observer (as per anatomical axes).
|
1 | G5EE56 (/IGI) |
Commissural neuron axon guidance GO:0071679
The process in which the migration of an axon growth cone of a commissural neuron is directed to its target in the brain in response to a combination of attractive and repulsive cues.
|
1 | G5EE56 (/IGI) |
There are 5 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
5 | P00528 (/HDA) P00528 (/HDA) P00528 (/HDA) P00528 (/HDA) P00528 (/HDA) |
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
5 | P00528 (/HDA) P00528 (/HDA) P00528 (/HDA) P00528 (/HDA) P00528 (/HDA) |
Germline ring canal GO:0045172
Germline specific intercellular bridge. During cyst formation in insects, ring canals interconnect the cells of the cyst, facilitating the passage of cytoplasmic components between cells.
|
5 | P00528 (/IDA) P00528 (/IDA) P00528 (/IDA) P00528 (/IDA) P00528 (/IDA) |
Phagocytic cup GO:0001891
An invagination of the cell membrane formed by an actin dependent process during phagocytosis. Following internalization it is converted into a phagosome.
|
1 | G5EE56 (/IDA) |
Contractile fiber GO:0043292
Fibers, composed of actin, myosin, and associated proteins, found in cells of smooth or striated muscle.
|
1 | G5EE56 (/IDA) |