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CATH Superfamily 2.30.30.30

The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
SC:1Eukaryotic translation initiation factor 5ADNA/RNA-binding protein KIN17, putativeWoronin body major protein HEX1Translation initiation factor 5AE3 ubiquitin-protein ligase UHRF2SC:260S ribosomal protein L1450S ribosomal protein L14eSC:360S ribosomal protein L2650S ribosomal protein L24SC:440S ribosomal protein S4Transcription elongation factor SPT5Transcription elongation factor SPT5Transcription elongation factor SPT540S ribosomal protein S4Transcription elongation factor SPT5Transcription elongation factor SPT550S ribosomal protein L2Transcription termination/antitermination factor NusGElongation factor P50S ribosomal protein L2460S ribosomal protein L8Eukaryotic translation initiation factor 5A50S ribosomal protein L2, chloroplasticElongation factor PElongation factor P-like protein60S ribosomal protein L6E3 ubiquitin-protein ligase HERC2Transcription elongation factor SPT5Tumor suppressor p53-binding protein 160S ribosomal protein L660S ribosomal protein L1450S ribosomal protein L24Transcription elongation factor SPT539S ribosomal protein L2, mitochondrial60S ribosomal protein L14-1Transcription elongation factor SPT5Transcription elongation factor SPT5Transcription elongation factor SPT540S ribosomal protein S4-339S ribosomal protein L24, mitochondrial50S ribosomal protein L2Transcription termination/antitermination protein NusGElongation factor P-like proteinTranscription termination/antitermination factor NusGElongation factor POrganellar elongation factor P50S ribosomal protein L24Transcription elongation factor SPT5Elongation factor PPutative 60S ribosomal protein L660S ribosomal protein L2, mitochondrialMitochondrial ribosomal protein L2Uncharacterized protein60S ribosomal protein L1450S ribosomal protein L2450S ribosomal protein L24Protein RNA-directed DNA methylation 3Transcription elongation factor SPT550S ribosomal protein L250S ribosomal subunit L24Transcription elongation factor SPT5Transcription elongation factor SPT5Transcription elongation factor SPT5Putative 40S ribosomal protein L14Transcription elongation factor SPT5SPT5 homolog, DSIF elongation factor subunit60S ribosomal protein L14, putative60S ribosomal protein L14, putative60S ribosomal protein L14 putativePutative ribosomal protein L230S ribosomal protein S4e60S ribosomal protein L6Ribosomal protein L24/L26-like proteinKOW motif domain protein30S ribosomal protein S4eTranscription elongation regulator-like proteinTranscription termination/antitermination protein NusGTranscription elongation factor SPT55'-3' exoribonuclease 1Transcription termination/antitermination protein NusGTranscription elongation factor SPT5Eukaryotic translation initiation factor 5A60S ribosomal protein L40, mitochondrial50S ribosomal protein L24Transcription elongation factor SPT5Related to SPT5-transcription elongation protein50S ribosomal protein L2Transcription elongation factor SPT5Ribosomal Protein, Large subunitProbable 39S ribosomal protein L24, mitochondrialTranscription termination/antitermination protein NusG30S ribosomal protein S4e40S ribosomal protein S4, X isoform, putativeTranscription initiation factor SPT5, putativeLSU ribosomal protein L14ETranscription termination/antitermination protein NusGPTAC1340S ribosomal protein S4Transcription initiation factor SPT5, putative50S ribosomal protein L24Ribosomal protein L26Uncharacterized proteinElongation factor PElongation factor PElongation factor P 1Uncharacterized proteinApicoplast ribosomal protein L2Ribosomal protein L14, putativeElongation factor P (EF-P) KOW-like domain containing protein, putative50S ribosomal protein L2450S ribosomal protein L2450S ribosomal protein L2 (AFU_orthologue AFUA_4G12170)60S ribosomal protein RML2, mitochondrial50S small subunit ribosomal protein L2Translation elongation factor EF-PTranscription elongation factor SPT55'-3' exoribonuclease 1Putative ribosomal protein S4 (RPS4A) family protein60S ribosomal protein L26-160S ribosomal protein L14Ribosomal protein L26, putativeUncharacterized protein60S ribosomal protein L14-139S ribosomal protein L24, mitochondrialYALI0A20526p50S ribosomal protein L24, chloroplasticG patch domain and KOW motifsPutative 60S ribosomal protein L14Ribosomal protein L24Uncharacterized proteinUncharacterized protein60S ribosomal protein L2, mitochondrialRibosomal protein L2Translation elongation factor PTranscription elongation factor SPT5Transcription elongation factor SPT5Transcription elongation factor SPT5Uncharacterized protein30S ribosomal protein S4eRibosomal protein L1460S ribosomal protein L1460S ribosomal protein L145'-3' exoribonuclease 160S ribosomal protein L26-1Eukaryotic translation initiation factor 5AUncharacterized protein60S ribosomal protein L26-1Mitochondrial ribosomal protein L2460S ribosomal protein L6Uncharacterized proteinOs01g0140500 protein60S ribosomal protein L26-1Mitochondrial ribosomal protein L2454S ribosomal protein L40, mitochondrial50S ribosomal protein L24Uncharacterized proteinRibosomal protein L29Mitochondrial elongation factor PGlobal transcription factorSPT5 homolog, DSIF elongation factor subunitUncharacterized proteinPredicted proteinUncharacterized proteinUncharacterized proteinUncharacterized proteinp53-binding protein 1Uncharacterized protein
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FunFam 18: Transcription elongation factor SPT5

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 2 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO TermAnnotationsEvidence
Transcription elongation regulator activity GO:0003711
A molecular function that regulates transcriptional elongation by enabling the transition from transcription initiation to elongation or by altering the elongation properties of the enzyme during the elongation phase of transcription.
 1 O13936 (/IC)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
 1 O13936 (/IPI)
Showing 1 to 2 of 2 entries

There are 8 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO TermAnnotationsEvidence
Negative regulation of transcription by RNA polymerase II GO:0000122
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
 1 Q54K42 (/ISS)
Cellular response to starvation GO:0009267
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of nourishment.
 1 Q5ALX3 (/IMP)
Filamentous growth GO:0030447
The process in which a multicellular organism, a unicellular organism or a group of unicellular organisms grow in a threadlike, filamentous shape.
 1 Q5ALX3 (/IMP)
Positive regulation of transcription elongation from RNA polymerase II promoter GO:0032968
Any process that activates or increases the frequency, rate or extent of transcription elongation, the extension of an RNA molecule after transcription initiation and promoter clearance by the addition of ribonucleotides, catalyzed by RNA polymerase II.
 1 O13936 (/IMP)
Filamentous growth of a population of unicellular organisms in response to starvation GO:0036170
The process in which a group of unicellular organisms grow in a threadlike, filamentous shape in response to deprivation of nourishment.
 1 Q5ALX3 (/IMP)
Filamentous growth of a population of unicellular organisms in response to biotic stimulus GO:0036180
The process in which a group of unicellular organisms grow in a threadlike, filamentous shape in response to a biotic (living) stimulus.
 1 Q5ALX3 (/IMP)
Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
 1 Q54K42 (/ISS)
Negative regulation of antisense RNA transcription GO:0060195
Any process that decreases the frequency, rate or extent of the synthesis of antisense RNA, an RNA molecule complementary in sequence to another RNA or DNA molecule, which, by binding the latter, acts to inhibit its function and/or completion of synthesis, on a template of DNA.
 1 O13936 (/IMP)
Showing 1 to 8 of 8 entries

There are 6 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO TermAnnotationsEvidence
Nuclear chromatin GO:0000790
The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome in the nucleus.
 1 O13936 (/IC)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
 1 O13936 (/HDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
 1 Q54K42 (/ISS)
Chromosome GO:0005694
A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information.
 1 Q21338 (/IDA)
DSIF complex GO:0032044
A heterodimeric protein complex formed of Spt4 and Spt5 proteins which is expressed in eukaryotes from yeast to man. DSIF is an inhibitory elongation factor that promotes RNA polymerase II transcriptional pausing, but can also stimulate transcriptional elongation under certain conditions, and may play a role in RNA processing via its physical association with mRNA capping enzymes.
 1 O13936 (/IDA)
DSIF complex GO:0032044
A heterodimeric protein complex formed of Spt4 and Spt5 proteins which is expressed in eukaryotes from yeast to man. DSIF is an inhibitory elongation factor that promotes RNA polymerase II transcriptional pausing, but can also stimulate transcriptional elongation under certain conditions, and may play a role in RNA processing via its physical association with mRNA capping enzymes.
 1 Q21338 (/ISS)
Showing 1 to 6 of 6 entries
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