CATH Superfamily 2.30.30.1150
The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was: waiting to be named.
FunFam 4: E3 ubiquitin-protein ligase UHRF1
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 18 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Zinc ion binding GO:0008270
Interacting selectively and non-covalently with zinc (Zn) ions.
|
2 | Q7TPK1 (/ISS) Q8VDF2 (/ISS) |
|
Histone binding GO:0042393
Interacting selectively and non-covalently with a histone, any of a group of water-soluble proteins found in association with the DNA of eukaroytic chromosomes. They are involved in the condensation and coiling of chromosomes during cell division and have also been implicated in nonspecific suppression of gene activity.
|
2 | Q7TPK1 (/ISS) Q8VDF2 (/ISS) |
|
Proximal promoter sequence-specific DNA binding GO:0000987
Interacting selectively and non-covalently with a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in the proximal promoter. The proximal promoter is in cis with and relatively close to the core promoter.
|
1 | Q8VDF2 (/ISO) |
|
Ubiquitin-protein transferase activity GO:0004842
Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y --> Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages.
|
1 | Q8VDF2 (/ISO) |
|
Ubiquitin-protein transferase activity GO:0004842
Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y --> Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages.
|
1 | Q7TPK1 (/ISS) |
|
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
1 | Q8VDF2 (/IPI) |
|
Zinc ion binding GO:0008270
Interacting selectively and non-covalently with zinc (Zn) ions.
|
1 | Q8VDF2 (/ISO) |
|
Methyl-CpG binding GO:0008327
Interacting selectively and non-covalently with a methylated cytosine/guanine dinucleotide.
|
1 | Q8VDF2 (/ISO) |
|
Nucleosomal histone binding GO:0031493
Interacting selectively and non-covalently with a histone that is assembled into a nucleosome.
|
1 | Q8VDF2 (/IDA) |
|
Methylated histone binding GO:0035064
Interacting selectively and non-covalently with a histone in which a residue has been modified by methylation. Histones are any of a group of water-soluble proteins found in association with the DNA of eukaroytic chromosomes.
|
1 | Q8VDF2 (/IDA) |
|
Methylated histone binding GO:0035064
Interacting selectively and non-covalently with a histone in which a residue has been modified by methylation. Histones are any of a group of water-soluble proteins found in association with the DNA of eukaroytic chromosomes.
|
1 | Q8VDF2 (/ISO) |
|
Methylated histone binding GO:0035064
Interacting selectively and non-covalently with a histone in which a residue has been modified by methylation. Histones are any of a group of water-soluble proteins found in association with the DNA of eukaroytic chromosomes.
|
1 | Q7TPK1 (/ISS) |
|
Histone binding GO:0042393
Interacting selectively and non-covalently with a histone, any of a group of water-soluble proteins found in association with the DNA of eukaroytic chromosomes. They are involved in the condensation and coiling of chromosomes during cell division and have also been implicated in nonspecific suppression of gene activity.
|
1 | Q8VDF2 (/ISO) |
|
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
|
1 | Q8VDF2 (/IPI) |
|
Hemi-methylated DNA-binding GO:0044729
Interacting selectively and non-covalently with double-stranded hemi-methylated DNA at replication foci (one strand methylated, while the other strand is unmethylated). Methylation of cytosine or adenine in DNA is an important mechanism for establishing stable heritable epigenetic marks.
|
1 | Q8VDF2 (/IDA) |
|
Hemi-methylated DNA-binding GO:0044729
Interacting selectively and non-covalently with double-stranded hemi-methylated DNA at replication foci (one strand methylated, while the other strand is unmethylated). Methylation of cytosine or adenine in DNA is an important mechanism for establishing stable heritable epigenetic marks.
|
1 | Q8VDF2 (/ISO) |
|
Hemi-methylated DNA-binding GO:0044729
Interacting selectively and non-covalently with double-stranded hemi-methylated DNA at replication foci (one strand methylated, while the other strand is unmethylated). Methylation of cytosine or adenine in DNA is an important mechanism for establishing stable heritable epigenetic marks.
|
1 | Q7TPK1 (/ISS) |
|
Ubiquitin protein ligase activity GO:0061630
Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S -> X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues.
|
1 | Q8VDF2 (/IDA) |
There are 17 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Ubiquitin-dependent protein catabolic process GO:0006511
The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein.
|
2 | Q7TPK1 (/ISS) Q8VDF2 (/ISS) |
|
Histone ubiquitination GO:0016574
The modification of histones by addition of ubiquitin groups.
|
2 | Q7TPK1 (/ISS) Q8VDF2 (/ISS) |
|
Protein autoubiquitination GO:0051865
The ubiquitination by a protein of one or more of its own amino acid residues, or residues on an identical protein. Ubiquitination occurs on the lysine residue by formation of an isopeptide crosslink.
|
2 | Q7TPK1 (/ISS) Q8VDF2 (/ISS) |
|
Negative regulation of transcription by RNA polymerase II GO:0000122
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
|
1 | Q8VDF2 (/IDA) |
|
Negative regulation of transcription by RNA polymerase II GO:0000122
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
|
1 | Q8VDF2 (/ISO) |
|
Negative regulation of transcription by RNA polymerase II GO:0000122
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
|
1 | Q7TPK1 (/ISS) |
|
Ubiquitin-dependent protein catabolic process GO:0006511
The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein.
|
1 | Q8VDF2 (/ISO) |
|
Maintenance of DNA methylation GO:0010216
Any process involved in maintaining the methylation state of a nucleotide sequence.
|
1 | Q8VDF2 (/IMP) |
|
Maintenance of DNA methylation GO:0010216
Any process involved in maintaining the methylation state of a nucleotide sequence.
|
1 | Q8VDF2 (/ISO) |
|
Maintenance of DNA methylation GO:0010216
Any process involved in maintaining the methylation state of a nucleotide sequence.
|
1 | Q7TPK1 (/ISS) |
|
Histone monoubiquitination GO:0010390
The modification of histones by addition of a single ubiquitin group.
|
1 | Q8VDF2 (/IDA) |
|
Histone ubiquitination GO:0016574
The modification of histones by addition of ubiquitin groups.
|
1 | Q8VDF2 (/ISO) |
|
Positive regulation of cellular protein metabolic process GO:0032270
Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving a protein, occurring at the level of an individual cell.
|
1 | Q8VDF2 (/ISO) |
|
Response to peptide hormone GO:0043434
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a peptide hormone stimulus. A peptide hormone is any of a class of peptides that are secreted into the blood stream and have endocrine functions in living animals.
|
1 | Q7TPK1 (/IEP) |
|
Regulation of epithelial cell proliferation GO:0050678
Any process that modulates the frequency, rate or extent of epithelial cell proliferation.
|
1 | Q8VDF2 (/ISO) |
|
Protein autoubiquitination GO:0051865
The ubiquitination by a protein of one or more of its own amino acid residues, or residues on an identical protein. Ubiquitination occurs on the lysine residue by formation of an isopeptide crosslink.
|
1 | Q8VDF2 (/IDA) |
|
Protein autoubiquitination GO:0051865
The ubiquitination by a protein of one or more of its own amino acid residues, or residues on an identical protein. Ubiquitination occurs on the lysine residue by formation of an isopeptide crosslink.
|
1 | Q8VDF2 (/ISO) |
There are 21 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Euchromatin GO:0000791
A dispersed and relatively uncompacted form of chromatin.
|
2 | Q7TPK1 (/ISS) Q8VDF2 (/ISS) |
|
Nuclear chromatin GO:0000790
The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome in the nucleus.
|
1 | Q8VDF2 (/IDA) |
|
Nuclear chromatin GO:0000790
The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome in the nucleus.
|
1 | Q8VDF2 (/ISO) |
|
Nuclear chromatin GO:0000790
The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome in the nucleus.
|
1 | Q7TPK1 (/ISS) |
|
Euchromatin GO:0000791
A dispersed and relatively uncompacted form of chromatin.
|
1 | Q8VDF2 (/ISO) |
|
Heterochromatin GO:0000792
A compact and highly condensed form of chromatin.
|
1 | Q8VDF2 (/IDA) |
|
Heterochromatin GO:0000792
A compact and highly condensed form of chromatin.
|
1 | Q8VDF2 (/ISO) |
|
Heterochromatin GO:0000792
A compact and highly condensed form of chromatin.
|
1 | Q7TPK1 (/ISS) |
|
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
1 | Q8VDF2 (/IDA) |
|
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
1 | Q8VDF2 (/ISO) |
|
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
1 | Q8VDF2 (/TAS) |
|
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
|
1 | Q8VDF2 (/TAS) |
|
Replication fork GO:0005657
The Y-shaped region of a replicating DNA molecule, resulting from the separation of the DNA strands and in which the synthesis of new strands takes place. Also includes associated protein complexes.
|
1 | Q8VDF2 (/IDA) |
|
Replication fork GO:0005657
The Y-shaped region of a replicating DNA molecule, resulting from the separation of the DNA strands and in which the synthesis of new strands takes place. Also includes associated protein complexes.
|
1 | Q8VDF2 (/ISO) |
|
Replication fork GO:0005657
The Y-shaped region of a replicating DNA molecule, resulting from the separation of the DNA strands and in which the synthesis of new strands takes place. Also includes associated protein complexes.
|
1 | Q7TPK1 (/ISS) |
|
Nuclear heterochromatin GO:0005720
A condensed form of chromatin, occurring in the nucleus during interphase, that stains strongly with basophilic dyes. The DNA of heterochromatin is typically replicated at a later stage in the cell-division cycle than euchromatin.
|
1 | Q8VDF2 (/IDA) |
|
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
1 | Q7TPK1 (/IDA) |
|
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
1 | Q8VDF2 (/ISO) |
|
Nuclear matrix GO:0016363
The dense fibrillar network lying on the inner side of the nuclear membrane.
|
1 | Q8VDF2 (/IDA) |
|
Cytoplasmic vesicle GO:0031410
A vesicle found in the cytoplasm of a cell.
|
1 | Q7TPK1 (/IDA) |
|
Cytoplasmic vesicle GO:0031410
A vesicle found in the cytoplasm of a cell.
|
1 | Q8VDF2 (/ISO) |
