The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:

"
Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 48: Ras association (RalGDS/AF-6) and pleckstrin homol...

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 1 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
7 F2Z3U3 (/IPI) F2Z4B7 (/IPI) G5E867 (/IPI) Q70E73 (/IPI) Q7Z5R6 (/IPI) Q8R5A3 (/IPI) Q8R5A3 (/IPI)

There are 3 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Axon extension GO:0048675
Long distance growth of a single axon process involved in cellular development.
3 F2Z3U3 (/IMP) F2Z4B7 (/IMP) G5E867 (/IMP)
T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell GO:0002291
The change in morphology and behavior of a mature or immature T cell resulting from exposure to an antigen for which its T cell receptor is specific bound to an MHC molecule on an antigen presenting cell, leading to the initiation or perpetuation of an immune response.
2 Q8R5A3 (/IDA) Q8R5A3 (/IDA)
Positive regulation of cell adhesion GO:0045785
Any process that activates or increases the frequency, rate or extent of cell adhesion.
2 Q8R5A3 (/IDA) Q8R5A3 (/IDA)

There are 9 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
5 C9K0J5 (/IDA) Q70E73 (/IDA) Q7Z5R6 (/IDA) Q8R5A3 (/IDA) Q8R5A3 (/IDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
5 F2Z3U3 (/ISO) F2Z4B7 (/ISO) G5E867 (/ISO) Q8R5A3 (/ISO) Q8R5A3 (/ISO)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
5 C9K0J5 (/IDA) Q70E73 (/IDA) Q7Z5R6 (/IDA) Q8R5A3 (/IDA) Q8R5A3 (/IDA)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
5 F2Z3U3 (/ISO) F2Z4B7 (/ISO) G5E867 (/ISO) Q8R5A3 (/ISO) Q8R5A3 (/ISO)
Nuclear body GO:0016604
Extra-nucleolar nuclear domains usually visualized by confocal microscopy and fluorescent antibodies to specific proteins.
3 F2Z3U3 (/ISO) F2Z4B7 (/ISO) G5E867 (/ISO)
Cell leading edge GO:0031252
The area of a motile cell closest to the direction of movement.
3 F2Z3U3 (/IDA) F2Z4B7 (/IDA) G5E867 (/IDA)
Nuclear body GO:0016604
Extra-nucleolar nuclear domains usually visualized by confocal microscopy and fluorescent antibodies to specific proteins.
2 C9K0J5 (/IDA) Q70E73 (/IDA)
T cell receptor complex GO:0042101
A protein complex that contains a disulfide-linked heterodimer of T cell receptor (TCR) chains, which are members of the immunoglobulin superfamily, and mediates antigen recognition, ultimately resulting in T cell activation. The TCR heterodimer is associated with the CD3 complex, which consists of the nonpolymorphic polypeptides gamma, delta, epsilon, zeta, and, in some cases, eta (an RNA splice variant of zeta) or Fc epsilon chains.
2 Q8R5A3 (/IDA) Q8R5A3 (/IDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 Q7Z5R6 (/TAS)
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