CATH Superfamily 2.30.29.30
Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)
The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:
"Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)
".
FunFam 438: uncharacterized protein LOC108093793 isoform X2
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 3 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Rho guanyl-nucleotide exchange factor activity GO:0005089
Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Rho family. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase.
|
7 | A0A0B4K7T7 (/IMP) A0A0B4LFF8 (/IMP) A1ZAN6 (/IMP) A1ZAN7 (/IMP) O44113 (/IMP) O44381 (/IMP) Q8T9E3 (/IMP) |
Rho guanyl-nucleotide exchange factor activity GO:0005089
Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Rho family. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase.
|
7 | A0A0B4K7T7 (/ISS) A0A0B4LFF8 (/ISS) A1ZAN6 (/ISS) A1ZAN7 (/ISS) O44113 (/ISS) O44381 (/ISS) Q8T9E3 (/ISS) |
Rho guanyl-nucleotide exchange factor activity GO:0005089
Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Rho family. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase.
|
1 | O44113 (/TAS) |
There are 21 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Actin filament organization GO:0007015
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments. Includes processes that control the spatial distribution of actin filaments, such as organizing filaments into meshworks, bundles, or other structures, as by cross-linking.
|
7 | A0A0B4K7T7 (/IMP) A0A0B4LFF8 (/IMP) A1ZAN6 (/IMP) A1ZAN7 (/IMP) O44113 (/IMP) O44381 (/IMP) Q8T9E3 (/IMP) |
Pole cell development GO:0007277
The process whose specific outcome is the progression of the pole cell over time, from its formation to the mature structure.
|
7 | A0A0B4K7T7 (/IMP) A0A0B4LFF8 (/IMP) A1ZAN6 (/IMP) A1ZAN7 (/IMP) O44113 (/IMP) O44381 (/IMP) Q8T9E3 (/IMP) |
Cellularization GO:0007349
The separation of a multi-nucleate cell or syncytium into individual cells. An example of this is found in Drosophila melanogaster embryo development.
|
7 | A0A0B4K7T7 (/IMP) A0A0B4LFF8 (/IMP) A1ZAN6 (/IMP) A1ZAN7 (/IMP) O44113 (/IMP) O44381 (/IMP) Q8T9E3 (/IMP) |
Ventral furrow formation GO:0007370
Formation of a ventral indentation (furrow) from the blastoderm epithelium, which is internalized to form a tube in the interior of the embryo, marking the start of gastrulation.
|
7 | A0A0B4K7T7 (/IMP) A0A0B4LFF8 (/IMP) A1ZAN6 (/IMP) A1ZAN7 (/IMP) O44113 (/IMP) O44381 (/IMP) Q8T9E3 (/IMP) |
Posterior midgut invagination GO:0007374
Formation of a cup-shaped invagination at the posterior end of the embryo, bringing the posterior midgut and hindgut primordia into the interior.
|
7 | A0A0B4K7T7 (/IMP) A0A0B4LFF8 (/IMP) A1ZAN6 (/IMP) A1ZAN7 (/IMP) O44113 (/IMP) O44381 (/IMP) Q8T9E3 (/IMP) |
Anterior midgut invagination GO:0007375
Internalization of the anterior midgut into the interior of the embryo.
|
7 | A0A0B4K7T7 (/IMP) A0A0B4LFF8 (/IMP) A1ZAN6 (/IMP) A1ZAN7 (/IMP) O44113 (/IMP) O44381 (/IMP) Q8T9E3 (/IMP) |
Germ-band extension GO:0007377
Elongation of the germ band on the ventral side of the embryo, accompanied by a halving in width. The elongation process pushes the posterior midgut invagination closed and compresses the amnioserosa further.
|
7 | A0A0B4K7T7 (/IMP) A0A0B4LFF8 (/IMP) A1ZAN6 (/IMP) A1ZAN7 (/IMP) O44113 (/IMP) O44381 (/IMP) Q8T9E3 (/IMP) |
Regulation of cell shape GO:0008360
Any process that modulates the surface configuration of a cell.
|
7 | A0A0B4K7T7 (/IMP) A0A0B4LFF8 (/IMP) A1ZAN6 (/IMP) A1ZAN7 (/IMP) O44113 (/IMP) O44381 (/IMP) Q8T9E3 (/IMP) |
Morphogenesis of embryonic epithelium GO:0016331
The process in which the anatomical structures of embryonic epithelia are generated and organized.
|
7 | A0A0B4K7T7 (/IMP) A0A0B4LFF8 (/IMP) A1ZAN6 (/IMP) A1ZAN7 (/IMP) O44113 (/IMP) O44381 (/IMP) Q8T9E3 (/IMP) |
Regulation of embryonic cell shape GO:0016476
Any process that modulates the surface configuration of an embryonic cell.
|
7 | A0A0B4K7T7 (/IGI) A0A0B4LFF8 (/IGI) A1ZAN6 (/IGI) A1ZAN7 (/IGI) O44113 (/IGI) O44381 (/IGI) Q8T9E3 (/IGI) |
Regulation of embryonic cell shape GO:0016476
Any process that modulates the surface configuration of an embryonic cell.
|
7 | A0A0B4K7T7 (/IMP) A0A0B4LFF8 (/IMP) A1ZAN6 (/IMP) A1ZAN7 (/IMP) O44113 (/IMP) O44381 (/IMP) Q8T9E3 (/IMP) |
Pseudocleavage involved in syncytial blastoderm formation GO:0030589
Formation of furrows in the cytoplasm between nuclei during cell cycles in embryos that contribute to the formation of the syncytial blastoderm. An example of this process is found in Drosophila melanogaster.
|
7 | A0A0B4K7T7 (/IMP) A0A0B4LFF8 (/IMP) A1ZAN6 (/IMP) A1ZAN7 (/IMP) O44113 (/IMP) O44381 (/IMP) Q8T9E3 (/IMP) |
Actin cytoskeleton reorganization GO:0031532
A process that is carried out at the cellular level which results in dynamic structural changes to the arrangement of constituent parts of cytoskeletal structures comprising actin filaments and their associated proteins.
|
7 | A0A0B4K7T7 (/IMP) A0A0B4LFF8 (/IMP) A1ZAN6 (/IMP) A1ZAN7 (/IMP) O44113 (/IMP) O44381 (/IMP) Q8T9E3 (/IMP) |
Positive regulation of Rho protein signal transduction GO:0035025
Any process that activates or increases the frequency, rate or extent of Rho protein signal transduction.
|
7 | A0A0B4K7T7 (/IMP) A0A0B4LFF8 (/IMP) A1ZAN6 (/IMP) A1ZAN7 (/IMP) O44113 (/IMP) O44381 (/IMP) Q8T9E3 (/IMP) |
Spiracle morphogenesis, open tracheal system GO:0035277
The process in which the anatomical structures of a spiracle are generated and organized. Spiracles are the openings in the insect open tracheal system; externally they connect to the epidermis and internally they connect to the tracheal trunk.
|
7 | A0A0B4K7T7 (/IMP) A0A0B4LFF8 (/IMP) A1ZAN6 (/IMP) A1ZAN7 (/IMP) O44113 (/IMP) O44381 (/IMP) Q8T9E3 (/IMP) |
Regulation of myosin II filament organization GO:0043519
Any process that modulates the frequency, rate or extent of the assembly, arrangement of constituent parts, or disassembly of a bipolar filament composed of myosin II molecules.
|
7 | A0A0B4K7T7 (/IMP) A0A0B4LFF8 (/IMP) A1ZAN6 (/IMP) A1ZAN7 (/IMP) O44113 (/IMP) O44381 (/IMP) Q8T9E3 (/IMP) |
Regulation of axonogenesis GO:0050770
Any process that modulates the frequency, rate or extent of axonogenesis, the generation of an axon, the long process of a neuron.
|
7 | A0A0B4K7T7 (/IGI) A0A0B4LFF8 (/IGI) A1ZAN6 (/IGI) A1ZAN7 (/IGI) O44113 (/IGI) O44381 (/IGI) Q8T9E3 (/IGI) |
Actin-mediated cell contraction GO:0070252
The actin filament-based process in which cytoplasmic actin filaments slide past one another resulting in contraction of all or part of the cell body.
|
7 | A0A0B4K7T7 (/IGI) A0A0B4LFF8 (/IGI) A1ZAN6 (/IGI) A1ZAN7 (/IGI) O44113 (/IGI) O44381 (/IGI) Q8T9E3 (/IGI) |
Cell elongation involved in imaginal disc-derived wing morphogenesis GO:0090254
The process in which a cell elongates and contributes to imaginal disc-derived wing morphogenesis.
|
7 | A0A0B4K7T7 (/IMP) A0A0B4LFF8 (/IMP) A1ZAN6 (/IMP) A1ZAN7 (/IMP) O44113 (/IMP) O44381 (/IMP) Q8T9E3 (/IMP) |
Response to wounding GO:0009611
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to the organism.
|
1 | A1ZAN6 (/IMP) |
Apical constriction involved in ventral furrow formation GO:0110072
The actin-mediated process that results in contraction of the apical end of a polarized columnar epithelial cell, contributing to formation of a ventral indentation (furrow) from the blastoderm epithelium, which is internalized to form a tube in the interior of the embryo, marking the start of gastrulation.
|
1 | A1ZAN6 (/IMP) |
There are 8 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Actomyosin contractile ring GO:0005826
A cytoskeletal structure composed of actin filaments and myosin that forms beneath the plasma membrane of many cells, including animal cells and yeast cells, in a plane perpendicular to the axis of the spindle, i.e. the cell division plane. In animal cells, the contractile ring is located at the cleavage furrow. In budding fungal cells, e.g. mitotic S. cerevisiae cells, the contractile ring forms at the mother-bud neck before mitosis.
|
7 | A0A0B4K7T7 (/IDA) A0A0B4LFF8 (/IDA) A1ZAN6 (/IDA) A1ZAN7 (/IDA) O44113 (/IDA) O44381 (/IDA) Q8T9E3 (/IDA) |
Apical plasma membrane GO:0016324
The region of the plasma membrane located at the apical end of the cell.
|
7 | A0A0B4K7T7 (/IDA) A0A0B4LFF8 (/IDA) A1ZAN6 (/IDA) A1ZAN7 (/IDA) O44113 (/IDA) O44381 (/IDA) Q8T9E3 (/IDA) |
Lateral plasma membrane GO:0016328
The portion of the plasma membrane at the lateral side of the cell. In epithelial cells, lateral plasma membranes are on the sides of cells which lie at the interface of adjacent cells.
|
7 | A0A0B4K7T7 (/IDA) A0A0B4LFF8 (/IDA) A1ZAN6 (/IDA) A1ZAN7 (/IDA) O44113 (/IDA) O44381 (/IDA) Q8T9E3 (/IDA) |
Actin cap GO:0030478
Polarized accumulation of cytoskeletal proteins (including F-actin) and regulatory proteins in a cell. An example of this is the actin cap found in Saccharomyces cerevisiae.
|
7 | A0A0B4K7T7 (/IDA) A0A0B4LFF8 (/IDA) A1ZAN6 (/IDA) A1ZAN7 (/IDA) O44113 (/IDA) O44381 (/IDA) Q8T9E3 (/IDA) |
Apical part of cell GO:0045177
The region of a polarized cell that forms a tip or is distal to a base. For example, in a polarized epithelial cell, the apical region has an exposed surface and lies opposite to the basal lamina that separates the epithelium from other tissue.
|
7 | A0A0B4K7T7 (/IDA) A0A0B4LFF8 (/IDA) A1ZAN6 (/IDA) A1ZAN7 (/IDA) O44113 (/IDA) O44381 (/IDA) Q8T9E3 (/IDA) |
Basal part of cell GO:0045178
The region of a cell situated near the base. For example, in a polarized epithelial cell, the basal surface rests on the basal lamina that separates the epithelium from other tissue.
|
7 | A0A0B4K7T7 (/IDA) A0A0B4LFF8 (/IDA) A1ZAN6 (/IDA) A1ZAN7 (/IDA) O44113 (/IDA) O44381 (/IDA) Q8T9E3 (/IDA) |
Apical cortex GO:0045179
The region that lies just beneath the plasma membrane on the apical edge of a cell.
|
7 | A0A0B4K7T7 (/IDA) A0A0B4LFF8 (/IDA) A1ZAN6 (/IDA) A1ZAN7 (/IDA) O44113 (/IDA) O44381 (/IDA) Q8T9E3 (/IDA) |
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
1 | O44113 (/TAS) |