CATH Superfamily 2.30.29.30
Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)
The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:
"Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)
".
FunFam 25: Phosphoinositide phospholipase C
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 4 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
GABA receptor binding GO:0050811
Interacting selectively and non-covalently with the gamma-aminobutyric acid (GABA, 4-aminobutyrate) receptor.
|
3 | Q62688 (/IDA) Q9UPR0 (/IDA) Q9UPR0 (/IDA) |
|
GABA receptor binding GO:0050811
Interacting selectively and non-covalently with the gamma-aminobutyric acid (GABA, 4-aminobutyrate) receptor.
|
2 | Q3USB7 (/ISO) Q8K394 (/ISO) |
|
Phospholipase C activity GO:0004629
Catalysis of the reaction: a phospholipid + H2O = 1,2-diacylglycerol + a phosphatidate.
|
1 | Q15111 (/TAS) |
|
GABA receptor binding GO:0050811
Interacting selectively and non-covalently with the gamma-aminobutyric acid (GABA, 4-aminobutyrate) receptor.
|
1 | Q3USB7 (/TAS) |
There are 11 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Negative regulation of cold-induced thermogenesis GO:0120163
Any process that stops, prevents, or reduces the rate of cold-induced thermogenesis.
|
7 | A0A0G2K4N6 (/ISS) F1LP62 (/ISS) F1M324 (/ISS) Q15111 (/ISS) Q62688 (/ISS) Q9UPR0 (/ISS) Q9UPR0 (/ISS) |
|
Gamma-aminobutyric acid signaling pathway GO:0007214
The series of molecular signals generated by the binding of gamma-aminobutyric acid (GABA, 4-aminobutyrate), an amino acid which acts as a neurotransmitter in some organisms, to a cell surface receptor.
|
2 | Q3USB7 (/IGI) Q8K394 (/IGI) |
|
Regulation of synaptic transmission, GABAergic GO:0032228
Any process that modulates the frequency, rate or extent of GABAergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter gamma-aminobutyric acid (GABA).
|
2 | Q3USB7 (/IGI) Q8K394 (/IGI) |
|
Regulation of peptidyl-serine phosphorylation GO:0033135
Any process that modulates the frequency, rate or extent of the phosphorylation of peptidyl-serine.
|
2 | Q3USB7 (/IGI) Q8K394 (/IGI) |
|
Negative regulation of cold-induced thermogenesis GO:0120163
Any process that stops, prevents, or reduces the rate of cold-induced thermogenesis.
|
2 | Q3USB7 (/IGI) Q8K394 (/IGI) |
|
Positive regulation of receptor binding GO:1900122
Any process that activates or increases the frequency, rate or extent of a protein or other molecule binding to a receptor.
|
2 | Q3USB7 (/IGI) Q8K394 (/IGI) |
|
B cell proliferation involved in immune response GO:0002322
The expansion of a B cell population by cell division following B cell activation during an immune response.
|
1 | Q8K394 (/IMP) |
|
B-1a B cell differentiation GO:0002337
The process in which B cells acquire the specialized features of B-1a B cells. B-1a B cells are B-1 cells that express CD5 and arise from fetal liver precursors.
|
1 | Q8K394 (/IMP) |
|
Regulation of synaptic transmission, GABAergic GO:0032228
Any process that modulates the frequency, rate or extent of GABAergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter gamma-aminobutyric acid (GABA).
|
1 | Q3USB7 (/IMP) |
|
Intracellular signal transduction GO:0035556
The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell.
|
1 | Q15111 (/TAS) |
|
Negative regulation of B cell receptor signaling pathway GO:0050859
Any process that stops, prevents, or reduces the frequency, rate or extent of signaling pathways initiated by the cross-linking of an antigen receptor on a B cell.
|
1 | Q8K394 (/IMP) |
There are 1 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
1 | Q3USB7 (/IDA) |
