CATH Superfamily 2.30.29.30
Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)
The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:
"Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)
".
FunFam 226: Pleckstrin
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 7 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Protein kinase C binding GO:0005080
Interacting selectively and non-covalently with protein kinase C.
|
2 | Q9JHK5 (/ISO) Q9JHK5 (/ISO) |
|
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
|
2 | Q9JHK5 (/ISO) Q9JHK5 (/ISO) |
|
Phosphatidylinositol-3,4-bisphosphate binding GO:0043325
Interacting selectively and non-covalently with phosphatidylinositol-3,4-bisphosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 3' and 4' positions.
|
2 | Q9JHK5 (/ISO) Q9JHK5 (/ISO) |
|
Protein kinase C binding GO:0005080
Interacting selectively and non-covalently with protein kinase C.
|
1 | P08567 (/IDA) |
|
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
1 | P08567 (/IPI) |
|
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
|
1 | P08567 (/IDA) |
|
Phosphatidylinositol-3,4-bisphosphate binding GO:0043325
Interacting selectively and non-covalently with phosphatidylinositol-3,4-bisphosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 3' and 4' positions.
|
1 | P08567 (/IDA) |
There are 47 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Vesicle docking involved in exocytosis GO:0006904
The initial attachment of a vesicle membrane to a target membrane, mediated by proteins protruding from the membrane of the vesicle and the target membrane, that contributes to exocytosis.
|
2 | Q9JHK5 (/IMP) Q9JHK5 (/IMP) |
|
Integrin-mediated signaling pathway GO:0007229
A series of molecular signals initiated by the binding of extracellular ligand to an integrin on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription.
|
2 | Q9JHK5 (/ISO) Q9JHK5 (/ISO) |
|
Positive regulation of platelet activation GO:0010572
Any process that increases the rate or frequency of platelet activation. Platelet activation is a series of progressive, overlapping events triggered by exposure of the platelets to subendothelial tissue.
|
2 | Q9JHK5 (/IMP) Q9JHK5 (/IMP) |
|
Negative regulation of inositol phosphate biosynthetic process GO:0010920
Any process that decreases the rate, frequency or extent of inositol phosphate biosynthesis. Inositol phosphate biosynthetic processes are the chemical reactions and pathways resulting in the formation of an inositol phosphate, 1,2,3,4,5,6-cyclohexanehexol, with one or more phosphate groups attached.
|
2 | Q9JHK5 (/ISO) Q9JHK5 (/ISO) |
|
Positive regulation of inositol-polyphosphate 5-phosphatase activity GO:0010925
Any process that increases the rate or frequency of inositol-polyphosphate 5-phosphatase activity, the catalysis of the reactions: D-myo-inositol 1,4,5-trisphosphate + H2O = myo-inositol 1,4-bisphosphate + phosphate, and 1D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O = 1D-myo-inositol 1,3,4-trisphosphate + phosphate.
|
2 | Q9JHK5 (/ISO) Q9JHK5 (/ISO) |
|
Cell projection organization GO:0030030
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a prolongation or process extending from a cell, e.g. a flagellum or axon.
|
2 | Q9JHK5 (/ISO) Q9JHK5 (/ISO) |
|
Positive regulation of actin filament depolymerization GO:0030836
Any process that activates or increases the frequency, rate or extent of actin depolymerization.
|
2 | Q9JHK5 (/IMP) Q9JHK5 (/IMP) |
|
Positive regulation of actin filament depolymerization GO:0030836
Any process that activates or increases the frequency, rate or extent of actin depolymerization.
|
2 | Q9JHK5 (/ISO) Q9JHK5 (/ISO) |
|
Phospholipase C-inhibiting G protein-coupled receptor signaling pathway GO:0030845
A G protein-coupled receptor signaling pathway which proceeds with inhibition of phospholipase C (PLC) activity and a subsequent decrease in the levels of cellular inositol trisphosphate (IP3) and diacylglycerol (DAG).
|
2 | Q9JHK5 (/ISO) Q9JHK5 (/ISO) |
|
Cortical actin cytoskeleton organization GO:0030866
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of actin-based cytoskeletal structures in the cell cortex, i.e. just beneath the plasma membrane.
|
2 | Q9JHK5 (/ISO) Q9JHK5 (/ISO) |
|
Ruffle organization GO:0031529
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a ruffle, a projection at the leading edge of a crawling cell.
|
2 | Q9JHK5 (/ISO) Q9JHK5 (/ISO) |
|
Actin cytoskeleton reorganization GO:0031532
A process that is carried out at the cellular level which results in dynamic structural changes to the arrangement of constituent parts of cytoskeletal structures comprising actin filaments and their associated proteins.
|
2 | Q9JHK5 (/ISO) Q9JHK5 (/ISO) |
|
Positive regulation of actin filament bundle assembly GO:0032233
Any process that activates or increases the frequency, rate or extent of the assembly of actin filament bundles.
|
2 | Q9JHK5 (/ISO) Q9JHK5 (/ISO) |
|
Positive regulation of integrin activation GO:0033625
Any process that activates or increases the frequency, rate, or extent of integrin activation.
|
2 | Q9JHK5 (/IMP) Q9JHK5 (/IMP) |
|
Negative regulation of G protein-coupled receptor signaling pathway GO:0045744
Any process that stops, prevents, or reduces the frequency, rate or extent of G protein-coupled receptor signaling pathway.
|
2 | Q9JHK5 (/ISO) Q9JHK5 (/ISO) |
|
Phosphatidylinositol metabolic process GO:0046488
The chemical reactions and pathways involving phosphatidylinositol, any glycophospholipid in which a sn-glycerol 3-phosphate residue is esterified to the 1-hydroxyl group of 1D-myo-inositol.
|
2 | Q9JHK5 (/ISO) Q9JHK5 (/ISO) |
|
Regulation of cell diameter GO:0060305
Any process that modulates the diameter of a cell, the length of a line segment that crosses through the center of a circular section through a cell.
|
2 | Q9JHK5 (/ISO) Q9JHK5 (/ISO) |
|
Thrombin-activated receptor signaling pathway GO:0070493
The series of molecular signals generated as a consequence of a thrombin-activated receptor binding to one of its physiological ligands.
|
2 | Q9JHK5 (/IMP) Q9JHK5 (/IMP) |
|
Thrombin-activated receptor signaling pathway GO:0070493
The series of molecular signals generated as a consequence of a thrombin-activated receptor binding to one of its physiological ligands.
|
2 | Q9JHK5 (/ISO) Q9JHK5 (/ISO) |
|
Platelet aggregation GO:0070527
The adhesion of one platelet to one or more other platelets via adhesion molecules.
|
2 | Q9JHK5 (/IMP) Q9JHK5 (/IMP) |
|
Protein kinase C signaling GO:0070528
A series of reactions, mediated by the intracellular serine/threonine kinase protein kinase C, which occurs as a result of a single trigger reaction or compound.
|
2 | Q9JHK5 (/IMP) Q9JHK5 (/IMP) |
|
Protein secretion by platelet GO:0070560
The regulated release of proteins by a platelet or group of platelets.
|
2 | Q9JHK5 (/IMP) Q9JHK5 (/IMP) |
|
Hematopoietic progenitor cell differentiation GO:0002244
The process in which precursor cell type acquires the specialized features of a hematopoietic progenitor cell, a class of cell types including myeloid progenitor cells and lymphoid progenitor cells.
|
1 | P08567 (/IEP) |
|
Platelet degranulation GO:0002576
The regulated exocytosis of secretory granules containing preformed mediators such as histamine and serotonin by a platelet.
|
1 | P08567 (/IEP) |
|
Platelet degranulation GO:0002576
The regulated exocytosis of secretory granules containing preformed mediators such as histamine and serotonin by a platelet.
|
1 | P08567 (/TAS) |
|
Vesicle docking involved in exocytosis GO:0006904
The initial attachment of a vesicle membrane to a target membrane, mediated by proteins protruding from the membrane of the vesicle and the target membrane, that contributes to exocytosis.
|
1 | P08567 (/ISS) |
|
Integrin-mediated signaling pathway GO:0007229
A series of molecular signals initiated by the binding of extracellular ligand to an integrin on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription.
|
1 | P08567 (/IDA) |
|
Positive regulation of platelet activation GO:0010572
Any process that increases the rate or frequency of platelet activation. Platelet activation is a series of progressive, overlapping events triggered by exposure of the platelets to subendothelial tissue.
|
1 | P08567 (/ISS) |
|
Negative regulation of inositol phosphate biosynthetic process GO:0010920
Any process that decreases the rate, frequency or extent of inositol phosphate biosynthesis. Inositol phosphate biosynthetic processes are the chemical reactions and pathways resulting in the formation of an inositol phosphate, 1,2,3,4,5,6-cyclohexanehexol, with one or more phosphate groups attached.
|
1 | P08567 (/IDA) |
|
Positive regulation of inositol-polyphosphate 5-phosphatase activity GO:0010925
Any process that increases the rate or frequency of inositol-polyphosphate 5-phosphatase activity, the catalysis of the reactions: D-myo-inositol 1,4,5-trisphosphate + H2O = myo-inositol 1,4-bisphosphate + phosphate, and 1D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O = 1D-myo-inositol 1,3,4-trisphosphate + phosphate.
|
1 | P08567 (/IDA) |
|
Cell projection organization GO:0030030
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a prolongation or process extending from a cell, e.g. a flagellum or axon.
|
1 | P08567 (/IDA) |
|
Positive regulation of actin filament depolymerization GO:0030836
Any process that activates or increases the frequency, rate or extent of actin depolymerization.
|
1 | P08567 (/IDA) |
|
Phospholipase C-inhibiting G protein-coupled receptor signaling pathway GO:0030845
A G protein-coupled receptor signaling pathway which proceeds with inhibition of phospholipase C (PLC) activity and a subsequent decrease in the levels of cellular inositol trisphosphate (IP3) and diacylglycerol (DAG).
|
1 | P08567 (/IDA) |
|
Cortical actin cytoskeleton organization GO:0030866
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of actin-based cytoskeletal structures in the cell cortex, i.e. just beneath the plasma membrane.
|
1 | P08567 (/IDA) |
|
Ruffle organization GO:0031529
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a ruffle, a projection at the leading edge of a crawling cell.
|
1 | P08567 (/IDA) |
|
Actin cytoskeleton reorganization GO:0031532
A process that is carried out at the cellular level which results in dynamic structural changes to the arrangement of constituent parts of cytoskeletal structures comprising actin filaments and their associated proteins.
|
1 | P08567 (/IDA) |
|
Positive regulation of actin filament bundle assembly GO:0032233
Any process that activates or increases the frequency, rate or extent of the assembly of actin filament bundles.
|
1 | P08567 (/IDA) |
|
Positive regulation of integrin activation GO:0033625
Any process that activates or increases the frequency, rate, or extent of integrin activation.
|
1 | P08567 (/ISS) |
|
Negative regulation of G protein-coupled receptor signaling pathway GO:0045744
Any process that stops, prevents, or reduces the frequency, rate or extent of G protein-coupled receptor signaling pathway.
|
1 | P08567 (/IDA) |
|
Phosphatidylinositol metabolic process GO:0046488
The chemical reactions and pathways involving phosphatidylinositol, any glycophospholipid in which a sn-glycerol 3-phosphate residue is esterified to the 1-hydroxyl group of 1D-myo-inositol.
|
1 | P08567 (/IDA) |
|
Negative regulation of calcium-mediated signaling GO:0050849
Any process that stops, prevents, or reduces the frequency, rate or extent of calcium-mediated signaling.
|
1 | P08567 (/NAS) |
|
Regulation of cell diameter GO:0060305
Any process that modulates the diameter of a cell, the length of a line segment that crosses through the center of a circular section through a cell.
|
1 | P08567 (/IDA) |
|
Thrombin-activated receptor signaling pathway GO:0070493
The series of molecular signals generated as a consequence of a thrombin-activated receptor binding to one of its physiological ligands.
|
1 | P08567 (/IDA) |
|
Platelet aggregation GO:0070527
The adhesion of one platelet to one or more other platelets via adhesion molecules.
|
1 | P08567 (/HMP) |
|
Platelet aggregation GO:0070527
The adhesion of one platelet to one or more other platelets via adhesion molecules.
|
1 | P08567 (/ISS) |
|
Protein kinase C signaling GO:0070528
A series of reactions, mediated by the intracellular serine/threonine kinase protein kinase C, which occurs as a result of a single trigger reaction or compound.
|
1 | P08567 (/ISS) |
|
Protein secretion by platelet GO:0070560
The regulated release of proteins by a platelet or group of platelets.
|
1 | P08567 (/ISS) |
There are 7 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
2 | Q9JHK5 (/ISO) Q9JHK5 (/ISO) |
|
Ruffle membrane GO:0032587
The portion of the plasma membrane surrounding a ruffle.
|
2 | Q9JHK5 (/ISO) Q9JHK5 (/ISO) |
|
Extracellular region GO:0005576
The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
|
1 | P08567 (/TAS) |
|
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
1 | P08567 (/IDA) |
|
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
1 | P08567 (/TAS) |
|
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
|
1 | P08567 (/HDA) |
|
Ruffle membrane GO:0032587
The portion of the plasma membrane surrounding a ruffle.
|
1 | P08567 (/IDA) |
