CATH Superfamily 2.30.29.30
Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)
The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:
"Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)
".
FunFam 161: Rho GTPase activating protein 42
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 2 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
GTPase activator activity GO:0005096
Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP.
|
5 | A6NI28 (/IDA) A6NI28 (/IDA) A6NI28 (/IDA) A6NI28 (/IDA) B2RQE8 (/IDA) |
|
GTPase activator activity GO:0005096
Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP.
|
1 | B2RQE8 (/ISO) |
There are 5 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Activation of GTPase activity GO:0090630
Any process that initiates the activity of an inactive GTPase through the replacement of GDP by GTP.
|
4 | A6NI28 (/IDA) A6NI28 (/IDA) A6NI28 (/IDA) A6NI28 (/IDA) |
|
Negative regulation of systemic arterial blood pressure GO:0003085
The process that reduces the force with which blood travels through the systemic arterial circulatory system.
|
1 | B2RQE8 (/IGI) |
|
Negative regulation of Rho protein signal transduction GO:0035024
Any process that stops, prevents, or reduces the frequency, rate or extent of Rho protein signal transduction.
|
1 | B2RQE8 (/IMP) |
|
Activation of GTPase activity GO:0090630
Any process that initiates the activity of an inactive GTPase through the replacement of GDP by GTP.
|
1 | B2RQE8 (/ISO) |
|
Negative regulation of vascular smooth muscle contraction GO:1904694
Any process that stops, prevents or reduces the frequency, rate or extent of vascular smooth muscle contraction.
|
1 | B2RQE8 (/IMP) |
There are 0 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
