The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:

"
Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 136: Ran-specific GTPase-activating protein-like

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 5 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
10 D4A2G9 (/IPI) P43487 (/IPI) P43487 (/IPI) P43487 (/IPI) P43487 (/IPI) P43487 (/IPI) P43487 (/IPI) P43487 (/IPI) P43487 (/IPI) P43487 (/IPI)
GDP-dissociation inhibitor activity GO:0005092
Prevents the dissociation of GDP from a GTPase, thereby preventing GTP from binding.
9 P43487 (/IMP) P43487 (/IMP) P43487 (/IMP) P43487 (/IMP) P43487 (/IMP) P43487 (/IMP) P43487 (/IMP) P43487 (/IMP) P43487 (/IMP)
Ran GTPase binding GO:0008536
Interacting selectively and non-covalently with Ran, a conserved Ras-like GTP-binding protein, implicated in nucleocytoplasmic transport, cell cycle progression, spindle assembly, nuclear organization and nuclear envelope (NE) assembly.
9 P43487 (/TAS) P43487 (/TAS) P43487 (/TAS) P43487 (/TAS) P43487 (/TAS) P43487 (/TAS) P43487 (/TAS) P43487 (/TAS) P43487 (/TAS)
Cadherin binding GO:0045296
Interacting selectively and non-covalently with cadherin, a type I membrane protein involved in cell adhesion.
9 P43487 (/HDA) P43487 (/HDA) P43487 (/HDA) P43487 (/HDA) P43487 (/HDA) P43487 (/HDA) P43487 (/HDA) P43487 (/HDA) P43487 (/HDA)
GDP-dissociation inhibitor activity GO:0005092
Prevents the dissociation of GDP from a GTPase, thereby preventing GTP from binding.
1 P34022 (/ISO)

There are 13 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Signal transduction GO:0007165
The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.
9 P43487 (/TAS) P43487 (/TAS) P43487 (/TAS) P43487 (/TAS) P43487 (/TAS) P43487 (/TAS) P43487 (/TAS) P43487 (/TAS) P43487 (/TAS)
Viral process GO:0016032
A multi-organism process in which a virus is a participant. The other participant is the host. Includes infection of a host cell, replication of the viral genome, and assembly of progeny virus particles. In some cases the viral genetic material may integrate into the host genome and only subsequently, under particular circumstances, 'complete' its life cycle.
9 P43487 (/TAS) P43487 (/TAS) P43487 (/TAS) P43487 (/TAS) P43487 (/TAS) P43487 (/TAS) P43487 (/TAS) P43487 (/TAS) P43487 (/TAS)
Spindle organization GO:0007051
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the spindle, the array of microtubules and associated molecules that forms between opposite poles of a eukaryotic cell during DNA segregation and serves to move the duplicated chromosomes apart.
4 Q5ZJ38 (/ISS) Q5ZJ38 (/ISS) Q5ZJ38 (/ISS) Q5ZJ38 (/ISS)
Positive regulation of mitotic centrosome separation GO:0046604
Any process that activates or increases the frequency, rate or extent of centrosome separation.
4 Q5ZJ38 (/ISS) Q5ZJ38 (/ISS) Q5ZJ38 (/ISS) Q5ZJ38 (/ISS)
Spindle organization GO:0007051
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the spindle, the array of microtubules and associated molecules that forms between opposite poles of a eukaryotic cell during DNA segregation and serves to move the duplicated chromosomes apart.
1 P34022 (/IDA)
Positive regulation of neuron projection development GO:0010976
Any process that increases the rate, frequency or extent of neuron projection development. Neuron projection development is the process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites).
1 D4A2G9 (/IDA)
Positive regulation of neuron projection development GO:0010976
Any process that increases the rate, frequency or extent of neuron projection development. Neuron projection development is the process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites).
1 D4A2G9 (/IMP)
Positive regulation of neuron projection development GO:0010976
Any process that increases the rate, frequency or extent of neuron projection development. Neuron projection development is the process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites).
1 P34022 (/ISO)
Cellular response to drug GO:0035690
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a drug stimulus. A drug is a substance used in the diagnosis, treatment or prevention of a disease.
1 D4A2G9 (/IEP)
Positive regulation of mitotic centrosome separation GO:0046604
Any process that activates or increases the frequency, rate or extent of centrosome separation.
1 P34022 (/IDA)
Response to calcium ion GO:0051592
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a calcium ion stimulus.
1 D4A2G9 (/IEP)
Cellular response to leptomycin B GO:0072750
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a leptomycin B stimulus.
1 D4A2G9 (/IDA)
Cellular response to leptomycin B GO:0072750
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a leptomycin B stimulus.
1 P34022 (/ISO)

There are 16 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
34 A0A140VK94 (/IDA) A0A140VK94 (/IDA) A0A140VK94 (/IDA) A0A140VK94 (/IDA) A0A140VK94 (/IDA) A0A140VK94 (/IDA) A0A140VK94 (/IDA) A0A140VK94 (/IDA) A0A140VK94 (/IDA) C9JJ34 (/IDA)
(24 more)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
11 D4A2G9 (/IDA) P34022 (/IDA) P43487 (/IDA) P43487 (/IDA) P43487 (/IDA) P43487 (/IDA) P43487 (/IDA) P43487 (/IDA) P43487 (/IDA) P43487 (/IDA)
(1 more)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
9 P43487 (/TAS) P43487 (/TAS) P43487 (/TAS) P43487 (/TAS) P43487 (/TAS) P43487 (/TAS) P43487 (/TAS) P43487 (/TAS) P43487 (/TAS)
Nuclear envelope GO:0005635
The double lipid bilayer enclosing the nucleus and separating its contents from the rest of the cytoplasm; includes the intermembrane space, a gap of width 20-40 nm (also called the perinuclear space).
9 P43487 (/TAS) P43487 (/TAS) P43487 (/TAS) P43487 (/TAS) P43487 (/TAS) P43487 (/TAS) P43487 (/TAS) P43487 (/TAS) P43487 (/TAS)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
9 P43487 (/TAS) P43487 (/TAS) P43487 (/TAS) P43487 (/TAS) P43487 (/TAS) P43487 (/TAS) P43487 (/TAS) P43487 (/TAS) P43487 (/TAS)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
4 Q5ZJ38 (/ISS) Q5ZJ38 (/ISS) Q5ZJ38 (/ISS) Q5ZJ38 (/ISS)
Centrosome GO:0005813
A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle.
4 Q5ZJ38 (/ISS) Q5ZJ38 (/ISS) Q5ZJ38 (/ISS) Q5ZJ38 (/ISS)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
1 D4A2G9 (/IDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
1 P34022 (/ISO)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 P34022 (/ISO)
Centrosome GO:0005813
A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle.
1 P34022 (/IDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 P34022 (/ISO)
Plasma membrane bounded cell projection cytoplasm GO:0032838
All of the contents of a plasma membrane bounded cell projection, excluding the plasma membrane surrounding the projection.
1 D4A2G9 (/IDA)
Plasma membrane bounded cell projection cytoplasm GO:0032838
All of the contents of a plasma membrane bounded cell projection, excluding the plasma membrane surrounding the projection.
1 P34022 (/ISO)
Axon cytoplasm GO:1904115
Any cytoplasm that is part of a axon.
1 D4A2G9 (/IDA)
Axon cytoplasm GO:1904115
Any cytoplasm that is part of a axon.
1 P34022 (/ISO)
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