The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 1: Citrate synthase

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 4 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
142 P0ABH7 (/IPI) P0ABH7 (/IPI) P0ABH7 (/IPI) P0ABH7 (/IPI) P0ABH7 (/IPI) P0ABH7 (/IPI) P0ABH7 (/IPI) P0ABH7 (/IPI) P0ABH7 (/IPI) P0ABH7 (/IPI)
(132 more)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
142 P0ABH7 (/IPI) P0ABH7 (/IPI) P0ABH7 (/IPI) P0ABH7 (/IPI) P0ABH7 (/IPI) P0ABH7 (/IPI) P0ABH7 (/IPI) P0ABH7 (/IPI) P0ABH7 (/IPI) P0ABH7 (/IPI)
(132 more)
Citrate synthase activity GO:0036440
Catalysis of the reaction: acetyl-CoA + H2O + oxaloacetate = citrate + CoA.
12 P14165 (/IDA) P14165 (/IDA) P14165 (/IDA) P14165 (/IDA) P14165 (/IDA) P14165 (/IDA) P14165 (/IDA) P14165 (/IDA) P14165 (/IDA) P14165 (/IDA)
(2 more)
Citrate (Si)-synthase activity GO:0004108
Catalysis of the reaction: acetyl-CoA + H2O + oxaloacetate = citrate + CoA, where the acetyl group is added to the si-face of oxaloacetate; acetyl-CoA thus provides the two carbon atoms of the pro-S carboxymethyl group.
7 Q9KQA8 (/ISS) Q9KQA8 (/ISS) Q9KQA8 (/ISS) Q9KQA8 (/ISS) Q9KQA8 (/ISS) Q9KQA8 (/ISS) Q9KQA8 (/ISS)

There are 2 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Tricarboxylic acid cycle GO:0006099
A nearly universal metabolic pathway in which the acetyl group of acetyl coenzyme A is effectively oxidized to two CO2 and four pairs of electrons are transferred to coenzymes. The acetyl group combines with oxaloacetate to form citrate, which undergoes successive transformations to isocitrate, 2-oxoglutarate, succinyl-CoA, succinate, fumarate, malate, and oxaloacetate again, thus completing the cycle. In eukaryotes the tricarboxylic acid is confined to the mitochondria. See also glyoxylate cycle.
12 P14165 (/IDA) P14165 (/IDA) P14165 (/IDA) P14165 (/IDA) P14165 (/IDA) P14165 (/IDA) P14165 (/IDA) P14165 (/IDA) P14165 (/IDA) P14165 (/IDA)
(2 more)
Tricarboxylic acid cycle GO:0006099
A nearly universal metabolic pathway in which the acetyl group of acetyl coenzyme A is effectively oxidized to two CO2 and four pairs of electrons are transferred to coenzymes. The acetyl group combines with oxaloacetate to form citrate, which undergoes successive transformations to isocitrate, 2-oxoglutarate, succinyl-CoA, succinate, fumarate, malate, and oxaloacetate again, thus completing the cycle. In eukaryotes the tricarboxylic acid is confined to the mitochondria. See also glyoxylate cycle.
7 Q9KQA8 (/ISS) Q9KQA8 (/ISS) Q9KQA8 (/ISS) Q9KQA8 (/ISS) Q9KQA8 (/ISS) Q9KQA8 (/ISS) Q9KQA8 (/ISS)

There are 3 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
142 P0ABH7 (/HDA) P0ABH7 (/HDA) P0ABH7 (/HDA) P0ABH7 (/HDA) P0ABH7 (/HDA) P0ABH7 (/HDA) P0ABH7 (/HDA) P0ABH7 (/HDA) P0ABH7 (/HDA) P0ABH7 (/HDA)
(132 more)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
142 P0ABH7 (/IDA) P0ABH7 (/IDA) P0ABH7 (/IDA) P0ABH7 (/IDA) P0ABH7 (/IDA) P0ABH7 (/IDA) P0ABH7 (/IDA) P0ABH7 (/IDA) P0ABH7 (/IDA) P0ABH7 (/IDA)
(132 more)
Tricarboxylic acid cycle enzyme complex GO:0045239
Any of the heteromeric enzymes that act in the TCA cycle.
12 P14165 (/IDA) P14165 (/IDA) P14165 (/IDA) P14165 (/IDA) P14165 (/IDA) P14165 (/IDA) P14165 (/IDA) P14165 (/IDA) P14165 (/IDA) P14165 (/IDA)
(2 more)
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