The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:

"
Thrombospondin type-1 (TSP1) repeat
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 43: R-spondin 3

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 4 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Signaling receptor binding GO:0005102
Interacting selectively and non-covalently with one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function.
3 Q2TJ95 (/IPI) Q9BXY4 (/IPI) Q9BXY4 (/IPI)
Signaling receptor binding GO:0005102
Interacting selectively and non-covalently with one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function.
1 Q2TJ95 (/ISO)
Frizzled binding GO:0005109
Interacting selectively and non-covalently with a frizzled (fz) receptor.
1 Q2TJ95 (/IPI)
Heparin binding GO:0008201
Interacting selectively and non-covalently with heparin, any member of a group of glycosaminoglycans found mainly as an intracellular component of mast cells and which consist predominantly of alternating alpha-(1->4)-linked D-galactose and N-acetyl-D-glucosamine-6-sulfate residues.
1 Q2TJ95 (/IDA)

There are 20 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Blood vessel remodeling GO:0001974
The reorganization or renovation of existing blood vessels.
5 Q1RMU1 (/ISS) Q1RMU1 (/ISS) Q5R328 (/ISS) Q9BXY4 (/ISS) Q9BXY4 (/ISS)
Sprouting angiogenesis GO:0002040
The extension of new blood vessels from existing vessels into avascular tissues, this process includes the specialization of endothelial cells into leading tip and stalk cells, proliferation and migration of the endothelial cells and cell adhesion resulting in angiogenic sprout fusion or lumen formation.
5 Q1RMU1 (/ISS) Q1RMU1 (/ISS) Q5R328 (/ISS) Q9BXY4 (/ISS) Q9BXY4 (/ISS)
Positive regulation of non-canonical Wnt signaling pathway GO:2000052
Any process that activates or increases the frequency, rate or extent of non-canonical Wnt-activated signaling pathway.
5 Q1RMU1 (/ISS) Q1RMU1 (/ISS) Q5R328 (/ISS) Q9BXY4 (/ISS) Q9BXY4 (/ISS)
Limb development GO:0060173
The process whose specific outcome is the progression of a limb over time, from its formation to the mature structure. A limb is an appendage of an animal used for locomotion or grasping. Examples include legs, arms or some types of fin.
3 Q1RMU1 (/ISS) Q1RMU1 (/ISS) Q2TJ95 (/ISS)
Regulation of Wnt signaling pathway GO:0030111
Any process that modulates the frequency, rate or extent of the activity of the Wnt signal transduction pathway.
2 Q9BXY4 (/TAS) Q9BXY4 (/TAS)
Positive regulation of Wnt signaling pathway GO:0030177
Any process that activates or increases the frequency, rate or extent of Wnt signal transduction.
2 Q9BXY4 (/IDA) Q9BXY4 (/IDA)
Positive regulation of Wnt signaling pathway GO:0030177
Any process that activates or increases the frequency, rate or extent of Wnt signal transduction.
2 Q1RMU1 (/ISS) Q1RMU1 (/ISS)
Positive regulation of Wnt signaling pathway GO:0030177
Any process that activates or increases the frequency, rate or extent of Wnt signal transduction.
2 Q9BXY4 (/NAS) Q9BXY4 (/NAS)
Positive regulation of Wnt signaling pathway, planar cell polarity pathway GO:2000096
Any process that activates or increases the frequency, rate or extent of Wnt signaling pathway, planar cell polarity pathway.
2 Q9BXY4 (/TAS) Q9BXY4 (/TAS)
Angiogenesis GO:0001525
Blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels.
1 Q2TJ95 (/IMP)
Blood vessel remodeling GO:0001974
The reorganization or renovation of existing blood vessels.
1 Q2TJ95 (/IMP)
Sprouting angiogenesis GO:0002040
The extension of new blood vessels from existing vessels into avascular tissues, this process includes the specialization of endothelial cells into leading tip and stalk cells, proliferation and migration of the endothelial cells and cell adhesion resulting in angiogenic sprout fusion or lumen formation.
1 Q2TJ95 (/IMP)
Positive regulation of Wnt signaling pathway GO:0030177
Any process that activates or increases the frequency, rate or extent of Wnt signal transduction.
1 Q2TJ95 (/ISO)
Posterior lateral line neuromast development GO:0048919
The process whose specific outcome is the progression of the posterior lateral line neuromast over time, from its formation to the mature structure. The neuromast is the sensory receptor of the anterior lateral line system and is composed of a population of sensory hair cells, and nonsensory supporting cells and mantle cells. Neuromast are located superficially on the epithelium or in lateral line canals.
1 Q5R328 (/IMP)
Branching involved in labyrinthine layer morphogenesis GO:0060670
The process in which the branches of the fetal placental villi are generated and organized. The villous part of the placenta is called the labyrinth layer.
1 Q2TJ95 (/IMP)
Negative regulation of canonical Wnt signaling pathway involved in neural plate anterior/posterior pattern formation GO:0060829
Any process that decreases the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin in the anterior end of the neural plate. This regulation sets up a Wnt signaling gradient along the anterior/posterior axis.
1 Q5R328 (/IMP)
Positive regulation of canonical Wnt signaling pathway GO:0090263
Any process that increases the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes.
1 Q2TJ95 (/IDA)
Positive regulation of canonical Wnt signaling pathway GO:0090263
Any process that increases the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes.
1 Q2TJ95 (/IMP)
Positive regulation of non-canonical Wnt signaling pathway GO:2000052
Any process that activates or increases the frequency, rate or extent of non-canonical Wnt-activated signaling pathway.
1 Q2TJ95 (/IMP)
Negative regulation of Wnt signaling pathway involved in dorsal/ventral axis specification GO:2000054
Any process that stops, prevents, or reduces the frequency, rate or extent of Wnt signaling pathway involved in dorsal/ventral axis specification.
1 Q5R328 (/IMP)

There are 3 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Extracellular region GO:0005576
The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
2 Q9BXY4 (/NAS) Q9BXY4 (/NAS)
Extracellular region GO:0005576
The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
2 Q9BXY4 (/TAS) Q9BXY4 (/TAS)
Extracellular region GO:0005576
The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
1 Q2TJ95 (/IDA)
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