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CATH Superfamily 2.20.100.10

Thrombospondin type-1 (TSP1) repeat

The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:

"
Thrombospondin type-1 (TSP1) repeat
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
SC:1Thrombospondin 1Spondin-1Spondin-1Complement component C6semaphorin-5A isoform X1Unc-5 netrin receptor CAdhesion G protein-coupled receptor B2Adhesion G protein-coupled receptor B2ADAM metallopeptidase with thrombospondin type 1 motif 9A disintegrin and metalloproteinase with thrombospondin motifs 1Unc-5 netrin receptor CADAMTS-like protein 3 isoform AADAM metallopeptidase with thrombospondin type 1 motif 9A disintegrin and metalloproteinase with thrombospondin motifs 3Adhesion G protein-coupled receptor B2Spondin 1aThrombospondin type 1 domain containing 7AThrombospondin, type I, domain containing 7AADAMTS-like 3 isoform 1Thrombospondin type 1 domain containing 7AThrombospondin type 1 domain containing 7AThrombospondin type 1 domain containing 7AThrombospondin type 1 domain containing 7Asemaphorin-5B isoform X1A disintegrin and metalloproteinase with thrombospondin motifs 3Thrombospondin type-1 domain-containing protein 4ADAMTS like 1Spondin 1Thrombospondin type 1 domain containing 7AR-spondin 2ADAM metallopeptidase with thrombospondin type 1 motif, 6A disintegrin and metalloproteinase with thrombospondin motifs 3Thrombospondin type 1 domain containing 7AADAMTS-like protein 1Isthmin 1Spondin-1A disintegrin and metalloproteinase with thrombospondin motifs 12Connective tissue growth factor (Predicted)Spondin 2CYR61 isoform 1thrombospondin type-1 domain-containing protein 4ADAM metallopeptidase with thrombospondin type 1 motif 9ADAMTS like 1ADAMTS like 2R-spondin 3Thrombospondin type 1 domain containing 4ADAMTS-like protein 2Cellular communication network factor 4Thrombospondin type 1 domain containing 4ADAM metallopeptidase with thrombospondin type 1 motif 8Thrombospondin type 1 domain containing 4Thrombospondin type 1 domain containing 7BCartilage intermediate layer protein 2ADAM metallopeptidase with thrombospondin type 1 motif 6ADAMTS-like protein 2ADAMTS-like protein 2ADAMTS-like protein 4 isoform X1R-spondin 1A disintegrin and metalloproteinase with thrombospondin motifs 5Thrombospondin type 1 domain containing 4ADAM metallopeptidase with thrombospondin type 1 motif 12ADAM metallopeptidase with thrombospondin type 1 motif 17adhesion G protein-coupled receptor B1Thrombospondin type 1 domain containing 7BThrombospondin type 1 domain containing 7BA disintegrin and metalloproteinase with thrombospondin motifs 10 preproproteinCellular communication network factor 6A disintegrin and metalloproteinase with thrombospondin motifs 18Hemicentin 1ADAM metallopeptidase with thrombospondin type 1 motif 9Cellular communication network factor 4SCO-spondinADAMTS like 4SCO-spondinA disintegrin and metalloproteinase with thrombospondin motifs 9 isoform X2ADAM metallopeptidase with thrombospondin type 1 motif 12ADAM metallopeptidase with thrombospondin type 1 motif 17ADAMTS-like protein 3ADAM metallopeptidase with thrombospondin type 1 motif 12ADAMTS like 2ADAM metallopeptidase with thrombospondin type 1 motif 17SCO-spondinComplement component C8 beta chainADAMTS like 3WNT1-inducible-signaling pathway protein 2 isoform X1ADAMTS like 4ADAMTS like 3A disintegrin and metalloproteinase with thrombospondin motifs 18Complement component C9A disintegrin and metalloproteinase with thrombospondin motifs 12Somatomedin B and thrombospondin type 1 domain containingADAM metallopeptidase with thrombospondin type 1 motif 13SCO-spondin-like isoform 1ADAM metallopeptidase with thrombospondin type 1 motif, 18Circumsporozoite proteinCartilage intermediate layer protein 1ADAMTS like 5A disintegrin and metalloproteinase with thrombospondin motifs 7SCO-spondinSporozoite surface protein 2No long nerve cord, isoform FComplement component C6SCO-spondinPapilinCircumsporozoite-and TRAP-related proteinSpondin-1Uncharacterized protein, isoform CADAM metallopeptidase with thrombospondin type 1 motif, 13Spondin-1Circumsporozoite-and TRAP-related proteinADAMTS-like protein 4 isoform X1Thrombospondin-related apical membrane proteinTRAP-like proteinUnc-5, isoform BThrombospondin type-1 domain-containing protein 1Thrombospondin protein-1Spondin-1No long nerve cord, isoform DCircumsporozoite-and TRAP-related proteinThrombospondin, type I, domain-containing 7AbLonely heart, isoform ASCO-spondinSCO-spondinSpondin-1-like ProteinCircumsporozoite-and TRAP-related proteinLonely heart, isoform AA disintegrin and metalloproteinase with thrombospondin motifs adt-2A disintegrin and metalloproteinase with thrombospondin motifs adt-2Zinc metalloproteinase dpy-31No long nerve cord, isoform Apapilin isoform X3A disintegrin and metalloproteinase with thrombospondin motifs adt-2Complement factor properdinUncharacterized proteinF-spondinSPONdin (Extracellular matrix glycoprotein) familySPONdin (Extracellular matrix glycoprotein) familyNo long nerve cord, isoform AA disintegrin and metalloproteinase with thrombospondin motifs gon-1Zinc metalloproteinaseLonely heart, isoform AADAM metallopeptidase with thrombospondin type 1 motif 13Complement factor properdinAGAP011765-PASPONdin (Extracellular matrix glycoprotein) familyCBN-PPN-1 proteinA disintegrin and metalloproteinase with thrombospondin motifs gon-1A disintegrin and metalloproteinase with thrombospondin motifs gon-1Protein CBR-MADD-4GM21753SPONdin (Extracellular matrix glycoprotein) familySCO-spondin isoform X3A disintegrin and metalloproteinase with thrombospondin motifs adt-2GD10853Protein CBR-SPON-1GD10853papilin isoform X5Uncharacterized protein, isoform Dspondin-1 isoform X1spondin-1F-spondinSemaphorin 5CUncharacterized proteinZinc metalloproteinaseCCN family member 3Zinc metalloproteinaseADAM metallopeptidase with thrombospondin type 1 motif A, isoform BA disintegrin and metalloproteinase with thrombospondin motifs gon-1Complement factor properdinSemaphorin-5cThrombospondin type 1 domain containing 4Putative reelerComplement C7GD10852GD10852LOC100158609 proteinSCO-spondinPancreatic trypsin inhibitorA disintegrin and metalloproteinase with thrombospondin motifs gon-1Uncharacterized protein, isoform DProtein CBR-MIG-6Thrombospondin type-1 domain-containing protein 7AThrombospondin type-1 domain-containing protein 7AAGAP002424-PAAGAP012813-PAspondin-1-likeLonely heart, isoform AUncharacterized protein, isoform BUncharacterized proteinA disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 17Netrin receptor unc-5Thrombospondin type-1 domain-containing protein 7BUncharacterized proteinPredicted proteinUncharacterized proteinUncharacterized proteinThrombospondin type 1 domain containing 7ASema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5BaThrombospondin type 1 domain containing 7ASemaphorin 5c, isoform AThrombospondin type-1 domain-containing protein 7BThrombospondin type-1 domain-containing protein 7BComplement factor properdinComplement factor properdinComplement factor properdinGolgi apparatus membrane protein TVP23 homologThrombospondin type I repeat-containing single pass transmembrane proteinADAM metallopeptidase with thrombospondin type 1 motif, 6Thrombospondin type-1 domain-containing protein 7BThrombospondin type-1 domain-containing protein 7BThrombospondin type-1 domain-containing protein 7BThrombospondin type-1 domain-containing protein 7BThrombospondin type-1 domain-containing protein 7BThrombospondin type-1 domain-containing protein 7BSemaphorin-5A, putativeSpondin-1-like ProteinUncharacterized proteinkielin/chordin-like proteinUncharacterized proteinMetalloendopeptidaseMetalloendopeptidaseSCO-spondinA disintegrin and metalloproteinase with thrombospondin motifs adt-1 isoform X1A disintegrin and metalloproteinase with thrombospondin motifs gon-1spondin-1-likeA disintegrin and metalloproteinase with thrombospondin motifs gon-1spondin-1-likePutative salivary kunitz domain proteinPutative semaphorinA disintegrin and metalloproteinase with thrombospondin motifs gon-1plasminogen-like isoform X2F-spondinA disintegrin and metalloproteinase with thrombospondin motifs adt-1 isoform X1Semaphorin-5AA disintegrin and metalloproteinase with thrombospondin motifs gon-1A disintegrin and metalloproteinase with thrombospondin motifs adt-1 isoform X1Thrombospondin, type I, domain-containing 7BaUncharacterized proteinAGAP002424-PAUncharacterized proteinThrombospondin type 1 domaincontaining proteinUncharacterized proteinUncharacterized proteinUncharacterized proteinUncharacterized proteinplasminogen-likeUncharacterized proteinUncharacterized proteinPredicted proteinUncharacterized proteinUncharacterized proteinPredicted proteinUncharacterized proteinUncharacterized proteinUncharacterized proteinUncharacterized proteinSemaphorin-5c
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FunFam 187: Lonely heart, isoform A

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 0 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

There are 2 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO TermAnnotationsEvidence
Larval heart development GO:0007508
The process whose specific outcome is the progression of the larval heart over time, from its formation to the mature structure. In Drosophila the larval heart (dorsal vessel) is a continuous tube of mesodormal cells that runs beneath the dorsal midline of the epidermis, divided into an anterior aorta and a posterior heart proper.
 3 E1JHE3 (/IMP) Q8MSF8 (/IMP) Q9VKV3 (/IMP)
Positive regulation of extracellular matrix assembly GO:1901203
Any process that activates or increases the frequency, rate or extent of extracellular matrix assembly.
 3 E1JHE3 (/IMP) Q8MSF8 (/IMP) Q9VKV3 (/IMP)
Showing 1 to 2 of 2 entries

There are 1 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO TermAnnotationsEvidence
Collagen-containing extracellular matrix GO:0062023
An extracellular matrix consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that provides not only essential physical scaffolding for the cellular constituents but can also initiate crucial biochemical and biomechanical cues required for tissue morphogenesis, differentiation and homeostasis. The components are secreted by cells in the vicinity and form a sheet underlying or overlying cells such as endothelial and epithelial cells.
 3 E1JHE3 (/IDA) Q8MSF8 (/IDA) Q9VKV3 (/IDA)
Showing 1 to 1 of 1 entries
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