The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:

"
Thrombospondin type-1 (TSP1) repeat
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
SC:1Thrombospondin 1Spondin-1Spondin-1Complement component C6semaphorin-5A isoform X1Unc-5 netrin receptor CAdhesion G protein-coupled receptor B2Adhesion G protein-coupled receptor B2ADAM metallopeptidase with thrombospondin type 1 motif 9A disintegrin and metalloproteinase with thrombospondin motifs 1Unc-5 netrin receptor CADAMTS-like protein 3 isoform AADAM metallopeptidase with thrombospondin type 1 motif 9A disintegrin and metalloproteinase with thrombospondin motifs 3Adhesion G protein-coupled receptor B2Spondin 1aThrombospondin type 1 domain containing 7AThrombospondin, type I, domain containing 7AADAMTS-like 3 isoform 1Thrombospondin type 1 domain containing 7AThrombospondin type 1 domain containing 7AThrombospondin type 1 domain containing 7AThrombospondin type 1 domain containing 7Asemaphorin-5B isoform X1A disintegrin and metalloproteinase with thrombospondin motifs 3Thrombospondin type-1 domain-containing protein 4ADAMTS like 1Spondin 1Thrombospondin type 1 domain containing 7AR-spondin 2ADAM metallopeptidase with thrombospondin type 1 motif, 6A disintegrin and metalloproteinase with thrombospondin motifs 3Thrombospondin type 1 domain containing 7AADAMTS-like protein 1Isthmin 1Spondin-1A disintegrin and metalloproteinase with thrombospondin motifs 12Connective tissue growth factor (Predicted)Spondin 2CYR61 isoform 1thrombospondin type-1 domain-containing protein 4ADAM metallopeptidase with thrombospondin type 1 motif 9ADAMTS like 1ADAMTS like 2R-spondin 3Thrombospondin type 1 domain containing 4ADAMTS-like protein 2Cellular communication network factor 4Thrombospondin type 1 domain containing 4ADAM metallopeptidase with thrombospondin type 1 motif 8Thrombospondin type 1 domain containing 4Thrombospondin type 1 domain containing 7BCartilage intermediate layer protein 2ADAM metallopeptidase with thrombospondin type 1 motif 6ADAMTS-like protein 2ADAMTS-like protein 2ADAMTS-like protein 4 isoform X1R-spondin 1A disintegrin and metalloproteinase with thrombospondin motifs 5Thrombospondin type 1 domain containing 4ADAM metallopeptidase with thrombospondin type 1 motif 12ADAM metallopeptidase with thrombospondin type 1 motif 17adhesion G protein-coupled receptor B1Thrombospondin type 1 domain containing 7BThrombospondin type 1 domain containing 7BA disintegrin and metalloproteinase with thrombospondin motifs 10 preproproteinCellular communication network factor 6A disintegrin and metalloproteinase with thrombospondin motifs 18Hemicentin 1ADAM metallopeptidase with thrombospondin type 1 motif 9Cellular communication network factor 4SCO-spondinADAMTS like 4SCO-spondinA disintegrin and metalloproteinase with thrombospondin motifs 9 isoform X2ADAM metallopeptidase with thrombospondin type 1 motif 12ADAM metallopeptidase with thrombospondin type 1 motif 17ADAMTS-like protein 3ADAM metallopeptidase with thrombospondin type 1 motif 12ADAMTS like 2ADAM metallopeptidase with thrombospondin type 1 motif 17SCO-spondinComplement component C8 beta chainADAMTS like 3WNT1-inducible-signaling pathway protein 2 isoform X1ADAMTS like 4ADAMTS like 3A disintegrin and metalloproteinase with thrombospondin motifs 18Complement component C9A disintegrin and metalloproteinase with thrombospondin motifs 12Somatomedin B and thrombospondin type 1 domain containingADAM metallopeptidase with thrombospondin type 1 motif 13SCO-spondin-like isoform 1ADAM metallopeptidase with thrombospondin type 1 motif, 18Circumsporozoite proteinCartilage intermediate layer protein 1ADAMTS like 5A disintegrin and metalloproteinase with thrombospondin motifs 7SCO-spondinSporozoite surface protein 2No long nerve cord, isoform FComplement component C6SCO-spondinPapilinCircumsporozoite-and TRAP-related proteinSpondin-1Uncharacterized protein, isoform CADAM metallopeptidase with thrombospondin type 1 motif, 13Spondin-1Circumsporozoite-and TRAP-related proteinADAMTS-like protein 4 isoform X1Thrombospondin-related apical membrane proteinTRAP-like proteinUnc-5, isoform BThrombospondin type-1 domain-containing protein 1Thrombospondin protein-1Spondin-1No long nerve cord, isoform DCircumsporozoite-and TRAP-related proteinThrombospondin, type I, domain-containing 7AbLonely heart, isoform ASCO-spondinSCO-spondinSpondin-1-like ProteinCircumsporozoite-and TRAP-related proteinLonely heart, isoform AA disintegrin and metalloproteinase with thrombospondin motifs adt-2A disintegrin and metalloproteinase with thrombospondin motifs adt-2Zinc metalloproteinase dpy-31No long nerve cord, isoform Apapilin isoform X3A disintegrin and metalloproteinase with thrombospondin motifs adt-2Complement factor properdinUncharacterized proteinF-spondinSPONdin (Extracellular matrix glycoprotein) familySPONdin (Extracellular matrix glycoprotein) familyNo long nerve cord, isoform AA disintegrin and metalloproteinase with thrombospondin motifs gon-1Zinc metalloproteinaseLonely heart, isoform AADAM metallopeptidase with thrombospondin type 1 motif 13Complement factor properdinAGAP011765-PASPONdin (Extracellular matrix glycoprotein) familyCBN-PPN-1 proteinA disintegrin and metalloproteinase with thrombospondin motifs gon-1A disintegrin and metalloproteinase with thrombospondin motifs gon-1Protein CBR-MADD-4GM21753SPONdin (Extracellular matrix glycoprotein) familySCO-spondin isoform X3A disintegrin and metalloproteinase with thrombospondin motifs adt-2GD10853Protein CBR-SPON-1GD10853papilin isoform X5Uncharacterized protein, isoform Dspondin-1 isoform X1spondin-1F-spondinSemaphorin 5CUncharacterized proteinZinc metalloproteinaseCCN family member 3Zinc metalloproteinaseADAM metallopeptidase with thrombospondin type 1 motif A, isoform BA disintegrin and metalloproteinase with thrombospondin motifs gon-1Complement factor properdinSemaphorin-5cThrombospondin type 1 domain containing 4Putative reelerComplement C7GD10852GD10852LOC100158609 proteinSCO-spondinPancreatic trypsin inhibitorA disintegrin and metalloproteinase with thrombospondin motifs gon-1Uncharacterized protein, isoform DProtein CBR-MIG-6Thrombospondin type-1 domain-containing protein 7AThrombospondin type-1 domain-containing protein 7AAGAP002424-PAAGAP012813-PAspondin-1-likeLonely heart, isoform AUncharacterized protein, isoform BUncharacterized proteinA disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 17Netrin receptor unc-5Thrombospondin type-1 domain-containing protein 7BUncharacterized proteinPredicted proteinUncharacterized proteinUncharacterized proteinThrombospondin type 1 domain containing 7ASema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5BaThrombospondin type 1 domain containing 7ASemaphorin 5c, isoform AThrombospondin type-1 domain-containing protein 7BThrombospondin type-1 domain-containing protein 7BComplement factor properdinComplement factor properdinComplement factor properdinGolgi apparatus membrane protein TVP23 homologThrombospondin type I repeat-containing single pass transmembrane proteinADAM metallopeptidase with thrombospondin type 1 motif, 6Thrombospondin type-1 domain-containing protein 7BThrombospondin type-1 domain-containing protein 7BThrombospondin type-1 domain-containing protein 7BThrombospondin type-1 domain-containing protein 7BThrombospondin type-1 domain-containing protein 7BThrombospondin type-1 domain-containing protein 7BSemaphorin-5A, putativeSpondin-1-like ProteinUncharacterized proteinkielin/chordin-like proteinUncharacterized proteinMetalloendopeptidaseMetalloendopeptidaseSCO-spondinA disintegrin and metalloproteinase with thrombospondin motifs adt-1 isoform X1A disintegrin and metalloproteinase with thrombospondin motifs gon-1spondin-1-likeA disintegrin and metalloproteinase with thrombospondin motifs gon-1spondin-1-likePutative salivary kunitz domain proteinPutative semaphorinA disintegrin and metalloproteinase with thrombospondin motifs gon-1plasminogen-like isoform X2F-spondinA disintegrin and metalloproteinase with thrombospondin motifs adt-1 isoform X1Semaphorin-5AA disintegrin and metalloproteinase with thrombospondin motifs gon-1A disintegrin and metalloproteinase with thrombospondin motifs adt-1 isoform X1Thrombospondin, type I, domain-containing 7BaUncharacterized proteinAGAP002424-PAUncharacterized proteinThrombospondin type 1 domaincontaining proteinUncharacterized proteinUncharacterized proteinUncharacterized proteinUncharacterized proteinplasminogen-likeUncharacterized proteinUncharacterized proteinPredicted proteinUncharacterized proteinUncharacterized proteinPredicted proteinUncharacterized proteinUncharacterized proteinUncharacterized proteinUncharacterized proteinSemaphorin-5c
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FunFam 122: SCO-spondin

GO Diversity

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EC Diversity

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Species Diversity

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Statistics

Members
CATH Domains: 0
Sequences: 14
Annotations
Unique GO: 4
Unique EC: 0
Unique Species: 12
Representative
Rep ID: Q8CG65/2335-2389
Inherited Annotations: 0
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