The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:

"
Metal Binding Protein, Guanine Nucleotide Exchange Factor; Chain A
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
« Back to all FunFams

FunFam 1: Tumor protein, translationally-controlled 1

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 6 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Calcium ion binding GO:0005509
Interacting selectively and non-covalently with calcium ions (Ca2+).
37 A5JST3 (/ISS) P43347 (/ISS) P61288 (/ISS) P61288 (/ISS) P61288 (/ISS) P61288 (/ISS) P61288 (/ISS) P61288 (/ISS) P61288 (/ISS) P61288 (/ISS)
(27 more)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
33 P13693 (/IPI) P13693 (/IPI) P13693 (/IPI) P13693 (/IPI) P13693 (/IPI) P13693 (/IPI) P13693 (/IPI) P13693 (/IPI) P13693 (/IPI) P13693 (/IPI)
(23 more)
RNA binding GO:0003723
Interacting selectively and non-covalently with an RNA molecule or a portion thereof.
30 P13693 (/HDA) P13693 (/HDA) P13693 (/HDA) P13693 (/HDA) P13693 (/HDA) P13693 (/HDA) P13693 (/HDA) P13693 (/HDA) P13693 (/HDA) P13693 (/HDA)
(20 more)
Calcium ion binding GO:0005509
Interacting selectively and non-covalently with calcium ions (Ca2+).
30 P13693 (/IDA) P13693 (/IDA) P13693 (/IDA) P13693 (/IDA) P13693 (/IDA) P13693 (/IDA) P13693 (/IDA) P13693 (/IDA) P13693 (/IDA) P13693 (/IDA)
(20 more)
Calcium ion binding GO:0005509
Interacting selectively and non-covalently with calcium ions (Ca2+).
3 P63028 (/ISO) P63028 (/ISO) P63028 (/ISO)
Transcription factor binding GO:0008134
Interacting selectively and non-covalently with a transcription factor, a protein required to initiate or regulate transcription.
3 P63028 (/IPI) P63028 (/IPI) P63028 (/IPI)

There are 11 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Calcium ion transport GO:0006816
The directed movement of calcium (Ca) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
30 P13693 (/IC) P13693 (/IC) P13693 (/IC) P13693 (/IC) P13693 (/IC) P13693 (/IC) P13693 (/IC) P13693 (/IC) P13693 (/IC) P13693 (/IC)
(20 more)
Cellular calcium ion homeostasis GO:0006874
Any process involved in the maintenance of an internal steady state of calcium ions at the level of a cell.
30 P13693 (/IC) P13693 (/IC) P13693 (/IC) P13693 (/IC) P13693 (/IC) P13693 (/IC) P13693 (/IC) P13693 (/IC) P13693 (/IC) P13693 (/IC)
(20 more)
Response to virus GO:0009615
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a virus.
30 P13693 (/IEP) P13693 (/IEP) P13693 (/IEP) P13693 (/IEP) P13693 (/IEP) P13693 (/IEP) P13693 (/IEP) P13693 (/IEP) P13693 (/IEP) P13693 (/IEP)
(20 more)
Regulation of apoptotic process GO:0042981
Any process that modulates the occurrence or rate of cell death by apoptotic process.
30 P13693 (/NAS) P13693 (/NAS) P13693 (/NAS) P13693 (/NAS) P13693 (/NAS) P13693 (/NAS) P13693 (/NAS) P13693 (/NAS) P13693 (/NAS) P13693 (/NAS)
(20 more)
Negative regulation of apoptotic process GO:0043066
Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process.
30 P13693 (/TAS) P13693 (/TAS) P13693 (/TAS) P13693 (/TAS) P13693 (/TAS) P13693 (/TAS) P13693 (/TAS) P13693 (/TAS) P13693 (/TAS) P13693 (/TAS)
(20 more)
Negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage GO:1902230
Any process that stops, prevents or reduces the frequency, rate or extent of intrinsic apoptotic signaling pathway in response to DNA damage.
30 P13693 (/IMP) P13693 (/IMP) P13693 (/IMP) P13693 (/IMP) P13693 (/IMP) P13693 (/IMP) P13693 (/IMP) P13693 (/IMP) P13693 (/IMP) P13693 (/IMP)
(20 more)
Spermatogenesis GO:0007283
The process of formation of spermatozoa, including spermatocytogenesis and spermiogenesis.
3 P63029 (/IEP) P63029 (/IEP) P63029 (/IEP)
Cell population proliferation GO:0008283
The multiplication or reproduction of cells, resulting in the expansion of a cell population.
3 P63029 (/TAS) P63029 (/TAS) P63029 (/TAS)
Stem cell population maintenance GO:0019827
The process by which an organism or tissue maintains a population of stem cells of a single type. This can be achieved by a number of mechanisms: stem cell asymmetric division maintains stem cell numbers; stem cell symmetric division increases them; maintenance of a stem cell niche maintains the conditions for commitment to the stem cell fate for some types of stem cell; stem cells may arise de novo from other cell types.
3 P63028 (/IMP) P63028 (/IMP) P63028 (/IMP)
Negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage GO:1902230
Any process that stops, prevents or reduces the frequency, rate or extent of intrinsic apoptotic signaling pathway in response to DNA damage.
3 P63028 (/ISO) P63028 (/ISO) P63028 (/ISO)
Negative regulation of ectoderm development GO:2000384
Any process that stops, prevents or reduces the frequency, rate or extent of ectoderm development.
3 P63028 (/IMP) P63028 (/IMP) P63028 (/IMP)

There are 24 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
76 A0A0B4J2C3 (/IDA) A0A0B4J2C3 (/IDA) A0A0B4J2C3 (/IDA) A0A0B4J2C3 (/IDA) A0A0B4J2C3 (/IDA) A0A0B4J2C3 (/IDA) A0A0P1J1R0 (/IDA) A0A0P1J1R0 (/IDA) A0A0P1J1R0 (/IDA) A0A0P1J1R0 (/IDA)
(66 more)
Spindle pole GO:0000922
Either of the ends of a spindle, where spindle microtubules are organized; usually contains a microtubule organizing center and accessory molecules, spindle microtubules and astral microtubules.
43 P43347 (/ISS) P43348 (/ISS) P61288 (/ISS) P61288 (/ISS) P61288 (/ISS) P61288 (/ISS) P61288 (/ISS) P61288 (/ISS) P61288 (/ISS) P61288 (/ISS)
(33 more)
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
37 A5JST3 (/ISS) P43347 (/ISS) P61288 (/ISS) P61288 (/ISS) P61288 (/ISS) P61288 (/ISS) P61288 (/ISS) P61288 (/ISS) P61288 (/ISS) P61288 (/ISS)
(27 more)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
37 A5JST3 (/ISS) P43347 (/ISS) P61288 (/ISS) P61288 (/ISS) P61288 (/ISS) P61288 (/ISS) P61288 (/ISS) P61288 (/ISS) P61288 (/ISS) P61288 (/ISS)
(27 more)
Multivesicular body GO:0005771
A type of endosome in which regions of the limiting endosomal membrane invaginate to form internal vesicles; membrane proteins that enter the internal vesicles are sequestered from the cytoplasm.
37 A5JST3 (/ISS) P43347 (/ISS) P61288 (/ISS) P61288 (/ISS) P61288 (/ISS) P61288 (/ISS) P61288 (/ISS) P61288 (/ISS) P61288 (/ISS) P61288 (/ISS)
(27 more)
Cytoplasmic microtubule GO:0005881
Any microtubule in the cytoplasm of a cell.
37 A5JST3 (/ISS) P43347 (/ISS) P61288 (/ISS) P61288 (/ISS) P61288 (/ISS) P61288 (/ISS) P61288 (/ISS) P61288 (/ISS) P61288 (/ISS) P61288 (/ISS)
(27 more)
Spindle pole GO:0000922
Either of the ends of a spindle, where spindle microtubules are organized; usually contains a microtubule organizing center and accessory molecules, spindle microtubules and astral microtubules.
30 P13693 (/IDA) P13693 (/IDA) P13693 (/IDA) P13693 (/IDA) P13693 (/IDA) P13693 (/IDA) P13693 (/IDA) P13693 (/IDA) P13693 (/IDA) P13693 (/IDA)
(20 more)
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
30 P13693 (/IDA) P13693 (/IDA) P13693 (/IDA) P13693 (/IDA) P13693 (/IDA) P13693 (/IDA) P13693 (/IDA) P13693 (/IDA) P13693 (/IDA) P13693 (/IDA)
(20 more)
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
30 P13693 (/TAS) P13693 (/TAS) P13693 (/TAS) P13693 (/TAS) P13693 (/TAS) P13693 (/TAS) P13693 (/TAS) P13693 (/TAS) P13693 (/TAS) P13693 (/TAS)
(20 more)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
30 P13693 (/IDA) P13693 (/IDA) P13693 (/IDA) P13693 (/IDA) P13693 (/IDA) P13693 (/IDA) P13693 (/IDA) P13693 (/IDA) P13693 (/IDA) P13693 (/IDA)
(20 more)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
30 P13693 (/IDA) P13693 (/IDA) P13693 (/IDA) P13693 (/IDA) P13693 (/IDA) P13693 (/IDA) P13693 (/IDA) P13693 (/IDA) P13693 (/IDA) P13693 (/IDA)
(20 more)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
30 P13693 (/TAS) P13693 (/TAS) P13693 (/TAS) P13693 (/TAS) P13693 (/TAS) P13693 (/TAS) P13693 (/TAS) P13693 (/TAS) P13693 (/TAS) P13693 (/TAS)
(20 more)
Multivesicular body GO:0005771
A type of endosome in which regions of the limiting endosomal membrane invaginate to form internal vesicles; membrane proteins that enter the internal vesicles are sequestered from the cytoplasm.
30 P13693 (/IDA) P13693 (/IDA) P13693 (/IDA) P13693 (/IDA) P13693 (/IDA) P13693 (/IDA) P13693 (/IDA) P13693 (/IDA) P13693 (/IDA) P13693 (/IDA)
(20 more)
Cytoplasmic microtubule GO:0005881
Any microtubule in the cytoplasm of a cell.
30 P13693 (/IDA) P13693 (/IDA) P13693 (/IDA) P13693 (/IDA) P13693 (/IDA) P13693 (/IDA) P13693 (/IDA) P13693 (/IDA) P13693 (/IDA) P13693 (/IDA)
(20 more)
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
30 P13693 (/HDA) P13693 (/HDA) P13693 (/HDA) P13693 (/HDA) P13693 (/HDA) P13693 (/HDA) P13693 (/HDA) P13693 (/HDA) P13693 (/HDA) P13693 (/HDA)
(20 more)
Spindle pole GO:0000922
Either of the ends of a spindle, where spindle microtubules are organized; usually contains a microtubule organizing center and accessory molecules, spindle microtubules and astral microtubules.
3 P63028 (/ISO) P63028 (/ISO) P63028 (/ISO)
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
3 P63028 (/HDA) P63028 (/HDA) P63028 (/HDA)
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
3 P63028 (/ISO) P63028 (/ISO) P63028 (/ISO)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
3 P63028 (/ISO) P63028 (/ISO) P63028 (/ISO)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
3 P63028 (/IDA) P63028 (/IDA) P63028 (/IDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
3 P63028 (/ISO) P63028 (/ISO) P63028 (/ISO)
Multivesicular body GO:0005771
A type of endosome in which regions of the limiting endosomal membrane invaginate to form internal vesicles; membrane proteins that enter the internal vesicles are sequestered from the cytoplasm.
3 P63028 (/ISO) P63028 (/ISO) P63028 (/ISO)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
3 P63028 (/ISO) P63028 (/ISO) P63028 (/ISO)
Cytoplasmic microtubule GO:0005881
Any microtubule in the cytoplasm of a cell.
3 P63028 (/ISO) P63028 (/ISO) P63028 (/ISO)
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