The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:

"
Lipase, subunit A
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 1: Dickkopf WNT-signaling pathway inhibitor 2

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 9 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO TermAnnotationsEvidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
8 A0A0B5JK99 (/IPI) F1QAX3 (/IPI) O54908 (/IPI) O94907 (/IPI) O94907 (/IPI) Q08CR4 (/IPI) Q9PWH3 (/IPI) Q9W6D9 (/IPI)
Co-receptor binding GO:0039706
Interacting selectively and non-covalently with a coreceptor. A coreceptor acts in cooperation with a primary receptor to transmit a signal within the cell.
4 O57464 (/IPI) O94907 (/IPI) O94907 (/IPI) Q9QYZ8 (/IPI)
Growth factor activity GO:0008083
The function that stimulates a cell to grow or proliferate. Most growth factors have other actions besides the induction of cell growth or proliferation.
2 O94907 (/TAS) O94907 (/TAS)
Co-receptor binding GO:0039706
Interacting selectively and non-covalently with a coreceptor. A coreceptor acts in cooperation with a primary receptor to transmit a signal within the cell.
2 O94907 (/TAS) O94907 (/TAS)
Receptor antagonist activity GO:0048019
The activity of a gene product that interacts with a receptor to decrease the ability of the receptor agonist to bind and activate the receptor.
2 O94907 (/IDA) O94907 (/IDA)
Low-density lipoprotein particle receptor binding GO:0050750
Interacting selectively and non-covalently with a low-density lipoprotein receptor.
2 O94907 (/IDA) O94907 (/IDA)
Co-receptor binding GO:0039706
Interacting selectively and non-covalently with a coreceptor. A coreceptor acts in cooperation with a primary receptor to transmit a signal within the cell.
1 O54908 (/ISO)
Receptor antagonist activity GO:0048019
The activity of a gene product that interacts with a receptor to decrease the ability of the receptor agonist to bind and activate the receptor.
1 O54908 (/ISO)
Low-density lipoprotein particle receptor binding GO:0050750
Interacting selectively and non-covalently with a low-density lipoprotein receptor.
1 O54908 (/ISO)
Showing 1 to 9 of 9 entries

There are 101 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO TermAnnotationsEvidence
Negative regulation of canonical Wnt signaling pathway GO:0090090
Any process that decreases the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes.
8 A0A0B5JK99 (/IGI) F1QAX3 (/IGI) O54908 (/IGI) O94907 (/IGI) O94907 (/IGI) Q08CR4 (/IGI) Q9PWH3 (/IGI) Q9W6D9 (/IGI)
Liver development GO:0001889
The process whose specific outcome is the progression of the liver over time, from its formation to the mature structure. The liver is an exocrine gland which secretes bile and functions in metabolism of protein and carbohydrate and fat, synthesizes substances involved in the clotting of the blood, synthesizes vitamin A, detoxifies poisonous substances, stores glycogen, and breaks down worn-out erythrocytes.
7 A0A0B5JK99 (/IGI) A8KB56 (/IGI) B8JIZ2 (/IGI) F1QAX3 (/IGI) Q08CR4 (/IGI) Q9PWH3 (/IGI) Q9W6D9 (/IGI)
Forebrain development GO:0030900
The process whose specific outcome is the progression of the forebrain over time, from its formation to the mature structure. The forebrain is the anterior of the three primary divisions of the developing chordate brain or the corresponding part of the adult brain (in vertebrates, includes especially the cerebral hemispheres, the thalamus, and the hypothalamus and especially in higher vertebrates is the main control center for sensory and associative information processing, visceral functions, and voluntary motor functions).
6 A0A0B5JK99 (/IGI) F1QAX3 (/IGI) O54908 (/IGI) Q08CR4 (/IGI) Q9PWH3 (/IGI) Q9W6D9 (/IGI)
Endocardial cushion development GO:0003197
The progression of a cardiac cushion over time, from its initial formation to the mature structure. The endocardial cushion is a specialized region of mesenchymal cells that will give rise to the heart septa and valves.
5 A0A0B5JK99 (/IMP) F1QAX3 (/IMP) Q08CR4 (/IMP) Q9PWH3 (/IMP) Q9W6D9 (/IMP)
Ectoderm development GO:0007398
The process whose specific outcome is the progression of the ectoderm over time, from its formation to the mature structure. In animal embryos, the ectoderm is the outer germ layer of the embryo, formed during gastrulation.
5 A0A0B5JK99 (/IGI) F1QAX3 (/IGI) Q08CR4 (/IGI) Q9PWH3 (/IGI) Q9W6D9 (/IGI)
Forebrain neuron differentiation GO:0021879
The process in which a relatively unspecialized cell acquires specialized features of a neuron that will reside in the forebrain.
5 A0A0B5JK99 (/IMP) F1QAX3 (/IMP) Q08CR4 (/IMP) Q9PWH3 (/IMP) Q9W6D9 (/IMP)
Negative regulation of Wnt signaling pathway GO:0030178
Any process that stops, prevents, or reduces the frequency, rate or extent of the Wnt signaling pathway.
5 O54908 (/IDA) O57464 (/IDA) O94907 (/IDA) O94907 (/IDA) Q9QYZ8 (/IDA)
Negative regulation of Wnt signaling pathway GO:0030178
Any process that stops, prevents, or reduces the frequency, rate or extent of the Wnt signaling pathway.
5 A0A0B5JK99 (/IGI) F1QAX3 (/IGI) Q08CR4 (/IGI) Q9PWH3 (/IGI) Q9W6D9 (/IGI)
Regulation of cell migration GO:0030334
Any process that modulates the frequency, rate or extent of cell migration.
5 A0A0B5JK99 (/IGI) F1QAX3 (/IGI) Q08CR4 (/IGI) Q9PWH3 (/IGI) Q9W6D9 (/IGI)
Notochord development GO:0030903
The process whose specific outcome is the progression of the notochord over time, from its formation to the mature structure. The notochord is a mesoderm-derived structure located ventral of the developing nerve cord. In vertebrates, the notochord serves as a core around which other mesodermal cells form the vertebrae. In the most primitive chordates, which lack vertebrae, the notochord persists as a substitute for a vertebral column.
5 A0A0B5JK99 (/IGI) F1QAX3 (/IGI) Q08CR4 (/IGI) Q9PWH3 (/IGI) Q9W6D9 (/IGI)
Showing 1 to 10 of 101 entries

There are 10 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO TermAnnotationsEvidence
Extracellular region GO:0005576
The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
5 A0A0B5JK99 (/IDA) F1QAX3 (/IDA) Q08CR4 (/IDA) Q9PWH3 (/IDA) Q9W6D9 (/IDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
5 A0A0B5JK99 (/IDA) F1QAX3 (/IDA) Q08CR4 (/IDA) Q9PWH3 (/IDA) Q9W6D9 (/IDA)
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
4 D3Z9J1 (/IDA) O94907 (/IDA) O94907 (/IDA) Q9UBU2 (/IDA)
Extracellular region GO:0005576
The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
2 O54908 (/ISS) Q9QYZ8 (/ISS)
Extracellular region GO:0005576
The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
2 O94907 (/TAS) O94907 (/TAS)
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
2 O54908 (/ISO) Q9QYZ8 (/ISO)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
2 O94907 (/IDA) O94907 (/IDA)
Early endosome membrane GO:0031901
The lipid bilayer surrounding an early endosome.
2 O94907 (/TAS) O94907 (/TAS)
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
1 Q9UBU2 (/TAS)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
1 O54908 (/ISO)
Showing 1 to 10 of 10 entries
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