The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:

"
Leishmanolysin domain 3
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 3: MSP-A1 surface protease homolog

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 4 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Metalloendopeptidase activity GO:0004222
Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions.
11 Q384F7 (/ISM) Q384P2 (/ISM) Q384P3 (/ISM) Q384S4 (/ISM) Q38C03 (/ISM) Q38C03 (/ISM) Q580F9 (/ISM) Q580G0 (/ISM) Q580G2 (/ISM) Q86ML7 (/ISM)
(1 more)
Protein tyrosine phosphatase activator activity GO:0008160
Increases the activity of a phosphatase, an enzyme which catalyzes of the removal of a phosphate group from a tyrosyl phenolic group of a protein.
4 Q4QHG9 (/IDA) Q4QHH0 (/IDA) Q4QHH1 (/IDA) Q4QHH2 (/IDA)
Metallopeptidase activity GO:0008237
Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions.
1 P08148 (/IMP)
Zinc ion binding GO:0008270
Interacting selectively and non-covalently with zinc (Zn) ions.
1 Q384P2 (/ISM)

There are 7 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Proteolysis GO:0006508
The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds.
11 Q384F7 (/ISM) Q384P2 (/ISM) Q384P3 (/ISM) Q384S4 (/ISM) Q38C03 (/ISM) Q38C03 (/ISM) Q580F9 (/ISM) Q580G0 (/ISM) Q580G2 (/ISM) Q86ML7 (/ISM)
(1 more)
Cell adhesion GO:0007155
The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules.
11 Q384F7 (/ISM) Q384P2 (/ISM) Q384P3 (/ISM) Q384S4 (/ISM) Q38C03 (/ISM) Q38C03 (/ISM) Q580F9 (/ISM) Q580G0 (/ISM) Q580G2 (/ISM) Q86ML7 (/ISM)
(1 more)
Modulation by symbiont of host nitric oxide-mediated signal transduction GO:0044081
Any process in which a symbiont organism modulates the rate, frequency or extent of nitric oxide mediated signal transduction in its host organism. Nitric oxide mediated signal transduction is a series of molecular signals mediated by the detection of nitric oxide (NO).
4 Q4QHG9 (/IMP) Q4QHH0 (/IMP) Q4QHH1 (/IMP) Q4QHH2 (/IMP)
Modulation by symbiont of host protein kinase-mediated signal transduction GO:0075130
Any process in which the symbiont modulates the frequency, rate or extent of protein kinase-mediated signal transduction in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction.
4 Q4QHG9 (/IMP) Q4QHH0 (/IMP) Q4QHH1 (/IMP) Q4QHH2 (/IMP)
Positive regulation by symbiont of host cytokine secretion GO:0036523
Any process in which an organism activates, maintains or increases the frequency, rate or extent of cytokine secretion in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction.
1 P08148 (/IMP)
Catabolism by symbiont of host protein GO:0052014
The chemical reactions and pathways performed by an organism resulting in the breakdown of protein macromolecules within the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction.
1 P08148 (/IMP)
Modulation by symbiont of host inflammatory response GO:0052032
Any process in which an organism modulates the frequency, rate or extent of the inflammatory response of the host organism; the inflammatory response is the immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The host is defined as the larger of the organisms involved in a symbiotic interaction.
1 P08148 (/IMP)

There are 6 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
11 Q384F7 (/ISM) Q384P2 (/ISM) Q384P3 (/ISM) Q384S4 (/ISM) Q38C03 (/ISM) Q38C03 (/ISM) Q580F9 (/ISM) Q580G0 (/ISM) Q580G2 (/ISM) Q86ML7 (/ISM)
(1 more)
Host cell nucleus GO:0042025
A membrane-bounded organelle as it is found in the host cell in which chromosomes are housed and replicated. The host is defined as the larger of the organisms involved in a symbiotic interaction.
4 Q4QHG9 (/IDA) Q4QHH0 (/IDA) Q4QHH1 (/IDA) Q4QHH2 (/IDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 Q384F7 (/IDA)
Endoplasmic reticulum GO:0005783
The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
1 Q384S4 (/IDA)
Nuclear lumen GO:0031981
The volume enclosed by the nuclear inner membrane.
1 Q384F7 (/IDA)
Ciliary plasm GO:0097014
All of the contents of a cilium, excluding the plasma membrane surrounding the cilium.
1 Q384F7 (/IDA)
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