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CATH Superfamily 2.10.110.40

CREB-binding protein/p300 RING domain

The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Superfamily: CREB-binding protein/p300 RING domain

CBP and p300 (also known as CREBBP or KAT3A and EP300 or KAT3B, respectively) are two closely related HATs that are crucial coactivators for gene regulation. CBP and p300 cooperatively bind and coordinate the assembly of multicomponent transcription-factor complexes. CBP and p300 are modular proteins that contain several well-defined domains including the CH1, KIX, CH3 (ZZ-TAZ2) and NCBD domains PMID:23934153. This entry represents the RING domain which has also been referred to as DUF902.

PMID:23934153

GO Diversity

Unique GO annotations
223 Unique GO terms

EC Diversity

Unique EC annotations
1 Unique EC terms

Species Diversity

Unique species annotations
412 Unique species

Sequence/Structure Diversity

Overview of the sequence / structure diversity of this superfamily compared to other superfamilies in CATH. Click on the chart to view the data in more detail.

Superfamily Summary

A general summary of information for this superfamily.
Structures
Domains: 9
Domain clusters (>95% seq id): 2
Domain clusters (>35% seq id): 1
Unique PDBs: 8
Alignments
Structural Clusters (5A): 1
Structural Clusters (9A): 1
FunFam Clusters: 2
Function
Unique EC: 1
Unique GO: 223
Taxonomy
Unique Species: 412
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