The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:
"Cysteine Rich Protein
".
FunFam 59: LIM domain only 2
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 16 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
25 |
P25791 (/IPI)
P25791 (/IPI)
P25791 (/IPI)
P25791 (/IPI)
P25791 (/IPI)
P25791 (/IPI)
P25791 (/IPI)
P25791 (/IPI)
P25791 (/IPI)
P25791 (/IPI)
(15 more) |
|
RNA polymerase II regulatory region sequence-specific DNA binding GO:0000977
Interacting selectively and non-covalently with a specific sequence of DNA that is part of a regulatory region that controls the transcription of a gene or cistron by RNA polymerase II.
|
22 |
P25791 (/IDA)
P25791 (/IDA)
P25791 (/IDA)
P25791 (/IDA)
P25791 (/IDA)
P25791 (/IDA)
P25791 (/IDA)
P25791 (/IDA)
P25791 (/IDA)
P25791 (/IDA)
(12 more) |
|
DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
|
22 |
P25791 (/IDA)
P25791 (/IDA)
P25791 (/IDA)
P25791 (/IDA)
P25791 (/IDA)
P25791 (/IDA)
P25791 (/IDA)
P25791 (/IDA)
P25791 (/IDA)
P25791 (/IDA)
(12 more) |
|
RNA polymerase II activating transcription factor binding GO:0001102
Interacting selectively and non-covalently with an RNA polymerase II transcription activating factor, a protein involved in positive regulation of transcription.
|
22 |
P25791 (/IPI)
P25791 (/IPI)
P25791 (/IPI)
P25791 (/IPI)
P25791 (/IPI)
P25791 (/IPI)
P25791 (/IPI)
P25791 (/IPI)
P25791 (/IPI)
P25791 (/IPI)
(12 more) |
|
DNA-binding transcription activator activity, RNA polymerase II-specific GO:0001228
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to activate or increase transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
|
22 |
P25791 (/IDA)
P25791 (/IDA)
P25791 (/IDA)
P25791 (/IDA)
P25791 (/IDA)
P25791 (/IDA)
P25791 (/IDA)
P25791 (/IDA)
P25791 (/IDA)
P25791 (/IDA)
(12 more) |
|
BHLH transcription factor binding GO:0043425
Interacting selectively and non-covalently with any of the basic Helix-Loop-Helix (bHLH) superfamily of transcription factors, important regulatory components in transcriptional networks of many developmental pathways.
|
22 |
P25791 (/IPI)
P25791 (/IPI)
P25791 (/IPI)
P25791 (/IPI)
P25791 (/IPI)
P25791 (/IPI)
P25791 (/IPI)
P25791 (/IPI)
P25791 (/IPI)
P25791 (/IPI)
(12 more) |
|
Cofactor binding GO:0048037
Interacting selectively and non-covalently with a cofactor, a substance that is required for the activity of an enzyme or other protein. Cofactors may be inorganic, such as the metal atoms zinc, iron, and copper in certain forms, or organic, in which case they are referred to as coenzymes. Cofactors may either be bound tightly to active sites or bind loosely with the substrate.
|
22 |
P25791 (/IPI)
P25791 (/IPI)
P25791 (/IPI)
P25791 (/IPI)
P25791 (/IPI)
P25791 (/IPI)
P25791 (/IPI)
P25791 (/IPI)
P25791 (/IPI)
P25791 (/IPI)
(12 more) |
|
E-box binding GO:0070888
Interacting selectively and non-covalently with an E-box, a DNA motif with the consensus sequence CANNTG that is found in the promoters of a wide array of genes expressed in neurons, muscle and other tissues.
|
22 |
P25791 (/IDA)
P25791 (/IDA)
P25791 (/IDA)
P25791 (/IDA)
P25791 (/IDA)
P25791 (/IDA)
P25791 (/IDA)
P25791 (/IDA)
P25791 (/IDA)
P25791 (/IDA)
(12 more) |
|
RNA polymerase II regulatory region sequence-specific DNA binding GO:0000977
Interacting selectively and non-covalently with a specific sequence of DNA that is part of a regulatory region that controls the transcription of a gene or cistron by RNA polymerase II.
|
3 | P25801 (/ISO) P25801 (/ISO) P25801 (/ISO) |
|
DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
|
3 | P25801 (/ISO) P25801 (/ISO) P25801 (/ISO) |
|
RNA polymerase II activating transcription factor binding GO:0001102
Interacting selectively and non-covalently with an RNA polymerase II transcription activating factor, a protein involved in positive regulation of transcription.
|
3 | P25801 (/ISO) P25801 (/ISO) P25801 (/ISO) |
|
DNA-binding transcription activator activity, RNA polymerase II-specific GO:0001228
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to activate or increase transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
|
3 | P25801 (/ISO) P25801 (/ISO) P25801 (/ISO) |
|
Chromatin binding GO:0003682
Interacting selectively and non-covalently with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase.
|
3 | P25801 (/IDA) P25801 (/IDA) P25801 (/IDA) |
|
BHLH transcription factor binding GO:0043425
Interacting selectively and non-covalently with any of the basic Helix-Loop-Helix (bHLH) superfamily of transcription factors, important regulatory components in transcriptional networks of many developmental pathways.
|
3 | P25801 (/ISO) P25801 (/ISO) P25801 (/ISO) |
|
Cofactor binding GO:0048037
Interacting selectively and non-covalently with a cofactor, a substance that is required for the activity of an enzyme or other protein. Cofactors may be inorganic, such as the metal atoms zinc, iron, and copper in certain forms, or organic, in which case they are referred to as coenzymes. Cofactors may either be bound tightly to active sites or bind loosely with the substrate.
|
3 | P25801 (/ISO) P25801 (/ISO) P25801 (/ISO) |
|
E-box binding GO:0070888
Interacting selectively and non-covalently with an E-box, a DNA motif with the consensus sequence CANNTG that is found in the promoters of a wide array of genes expressed in neurons, muscle and other tissues.
|
3 | P25801 (/ISO) P25801 (/ISO) P25801 (/ISO) |
There are 20 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Multicellular organism development GO:0007275
The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult).
|
22 |
P25791 (/TAS)
P25791 (/TAS)
P25791 (/TAS)
P25791 (/TAS)
P25791 (/TAS)
P25791 (/TAS)
P25791 (/TAS)
P25791 (/TAS)
P25791 (/TAS)
P25791 (/TAS)
(12 more) |
|
MRNA transcription by RNA polymerase II GO:0042789
The cellular synthesis of messenger RNA (mRNA) from a DNA template by RNA polymerase II, originating at an RNA polymerase II promoter.
|
22 |
P25791 (/IDA)
P25791 (/IDA)
P25791 (/IDA)
P25791 (/IDA)
P25791 (/IDA)
P25791 (/IDA)
P25791 (/IDA)
P25791 (/IDA)
P25791 (/IDA)
P25791 (/IDA)
(12 more) |
|
Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
|
22 |
P25791 (/IDA)
P25791 (/IDA)
P25791 (/IDA)
P25791 (/IDA)
P25791 (/IDA)
P25791 (/IDA)
P25791 (/IDA)
P25791 (/IDA)
P25791 (/IDA)
P25791 (/IDA)
(12 more) |
|
Cellular response to thyroid hormone stimulus GO:0097067
A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a thyroid hormone stimulus.
|
22 |
P25791 (/IDA)
P25791 (/IDA)
P25791 (/IDA)
P25791 (/IDA)
P25791 (/IDA)
P25791 (/IDA)
P25791 (/IDA)
P25791 (/IDA)
P25791 (/IDA)
P25791 (/IDA)
(12 more) |
|
Regulation of hematopoietic stem cell differentiation GO:1902036
Any process that modulates the frequency, rate or extent of hematopoietic stem cell differentiation.
|
22 |
P25791 (/TAS)
P25791 (/TAS)
P25791 (/TAS)
P25791 (/TAS)
P25791 (/TAS)
P25791 (/TAS)
P25791 (/TAS)
P25791 (/TAS)
P25791 (/TAS)
P25791 (/TAS)
(12 more) |
|
Erythrocyte differentiation GO:0030218
The process in which a myeloid precursor cell acquires specializes features of an erythrocyte.
|
3 | Q90XH3 (/IGI) Q90XH3 (/IGI) Q9PTJ3 (/IGI) |
|
Embryonic hemopoiesis GO:0035162
The stages of blood cell formation that take place within the embryo.
|
3 | P25801 (/IGI) P25801 (/IGI) P25801 (/IGI) |
|
MRNA transcription by RNA polymerase II GO:0042789
The cellular synthesis of messenger RNA (mRNA) from a DNA template by RNA polymerase II, originating at an RNA polymerase II promoter.
|
3 | P25801 (/ISO) P25801 (/ISO) P25801 (/ISO) |
|
Negative regulation of erythrocyte differentiation GO:0045647
Any process that stops, prevents, or reduces the frequency, rate or extent of erythrocyte differentiation.
|
3 | P25801 (/IMP) P25801 (/IMP) P25801 (/IMP) |
|
Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
|
3 | P25801 (/IGI) P25801 (/IGI) P25801 (/IGI) |
|
Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
|
3 | P25801 (/ISO) P25801 (/ISO) P25801 (/ISO) |
|
Cellular response to thyroid hormone stimulus GO:0097067
A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a thyroid hormone stimulus.
|
3 | P25801 (/ISO) P25801 (/ISO) P25801 (/ISO) |
|
Blood vessel development GO:0001568
The process whose specific outcome is the progression of a blood vessel over time, from its formation to the mature structure. The blood vessel is the vasculature carrying blood.
|
1 | Q9PTJ3 (/IMP) |
|
Endothelial cell proliferation GO:0001935
The multiplication or reproduction of endothelial cells, resulting in the expansion of a cell population. Endothelial cells are thin flattened cells which line the inside surfaces of body cavities, blood vessels, and lymph vessels, making up the endothelium.
|
1 | Q9PTJ3 (/IMP) |
|
Hemopoiesis GO:0030097
The process whose specific outcome is the progression of the myeloid and lymphoid derived organ/tissue systems of the blood and other parts of the body over time, from formation to the mature structure. The site of hemopoiesis is variable during development, but occurs primarily in bone marrow or kidney in many adult vertebrates.
|
1 | Q9PTJ3 (/IMP) |
|
Erythrocyte differentiation GO:0030218
The process in which a myeloid precursor cell acquires specializes features of an erythrocyte.
|
1 | Q5M8V8 (/ISS) |
|
Fin regeneration GO:0031101
The regrowth of fin tissue following its loss or destruction.
|
1 | Q9PTJ3 (/IMP) |
|
Embryonic hemopoiesis GO:0035162
The stages of blood cell formation that take place within the embryo.
|
1 | Q9PTJ3 (/IMP) |
|
Erythrocyte development GO:0048821
The process whose specific outcome is the progression of an erythrocyte over time, from its formation to the mature structure.
|
1 | Q9PTJ3 (/IMP) |
|
Retinal blood vessel morphogenesis GO:0061304
The process whose specific outcome is the progression of a blood vessel of the retina over time, from its formation to the mature structure.
|
1 | Q9PTJ3 (/IMP) |
There are 7 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
|
22 |
P25791 (/TAS)
P25791 (/TAS)
P25791 (/TAS)
P25791 (/TAS)
P25791 (/TAS)
P25791 (/TAS)
P25791 (/TAS)
P25791 (/TAS)
P25791 (/TAS)
P25791 (/TAS)
(12 more) |
|
Transcription factor complex GO:0005667
A protein complex that is capable of associating with DNA by direct binding, or via other DNA-binding proteins or complexes, and regulating transcription.
|
22 |
P25791 (/IDA)
P25791 (/IDA)
P25791 (/IDA)
P25791 (/IDA)
P25791 (/IDA)
P25791 (/IDA)
P25791 (/IDA)
P25791 (/IDA)
P25791 (/IDA)
P25791 (/IDA)
(12 more) |
|
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
4 | Q5M8V8 (/ISS) Q90XH3 (/ISS) Q90XH3 (/ISS) Q9PTJ3 (/ISS) |
|
Protein-containing complex GO:0032991
A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.
|
4 | Q5M8V8 (/ISS) Q90XH3 (/ISS) Q90XH3 (/ISS) Q9PTJ3 (/ISS) |
|
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
3 | P25801 (/IDA) P25801 (/IDA) P25801 (/IDA) |
|
Transcription factor complex GO:0005667
A protein complex that is capable of associating with DNA by direct binding, or via other DNA-binding proteins or complexes, and regulating transcription.
|
3 | P25801 (/ISO) P25801 (/ISO) P25801 (/ISO) |
|
Protein-containing complex GO:0032991
A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.
|
3 | P25801 (/IPI) P25801 (/IPI) P25801 (/IPI) |
