The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:
"Cysteine Rich Protein
".
FunFam 5: Testin isoform 1
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 11 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Zinc ion binding GO:0008270
Interacting selectively and non-covalently with zinc (Zn) ions.
|
63 |
A0M8R4 (/ISS)
A0M8R4 (/ISS)
A0M8R4 (/ISS)
A0M8R4 (/ISS)
A0M8R4 (/ISS)
A0M8R4 (/ISS)
A0M8S5 (/ISS)
A0M8S5 (/ISS)
A0M8U6 (/ISS)
P47226 (/ISS)
(53 more) |
|
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
29 |
A0A0K3AQM0 (/IPI)
A1Z6W3 (/IPI)
B3DGT8 (/IPI)
F1Q6J9 (/IPI)
G5ECN3 (/IPI)
G5EDJ5 (/IPI)
G5EEA4 (/IPI)
G5EF39 (/IPI)
O17833 (/IPI)
O43900 (/IPI)
(19 more) |
|
RNA binding GO:0003723
Interacting selectively and non-covalently with an RNA molecule or a portion thereof.
|
6 | Q9UGI8 (/HDA) Q9UGI8 (/HDA) Q9UGI8 (/HDA) Q9UGI8 (/HDA) Q9UGI8 (/HDA) Q9UGI8 (/HDA) |
|
Zinc ion binding GO:0008270
Interacting selectively and non-covalently with zinc (Zn) ions.
|
6 | Q9UGI8 (/IDA) Q9UGI8 (/IDA) Q9UGI8 (/IDA) Q9UGI8 (/IDA) Q9UGI8 (/IDA) Q9UGI8 (/IDA) |
|
Cadherin binding GO:0045296
Interacting selectively and non-covalently with cadherin, a type I membrane protein involved in cell adhesion.
|
6 | Q9UGI8 (/HDA) Q9UGI8 (/HDA) Q9UGI8 (/HDA) Q9UGI8 (/HDA) Q9UGI8 (/HDA) Q9UGI8 (/HDA) |
|
Protein domain specific binding GO:0019904
Interacting selectively and non-covalently with a specific domain of a protein.
|
5 | G5ECN3 (/IPI) G5EDJ5 (/IPI) G5EEA4 (/IPI) G5EF39 (/IPI) O17833 (/IPI) |
|
Transcription corepressor activity GO:0003714
A protein or a member of a complex that interacts specifically and non-covalently with a DNA-bound DNA-binding transcription factor to repress the transcription of specific genes. Corepressors often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second ATP-dependent class modifies the conformation of chromatin. A third class occludes DNA-binding transcription factor protein-protein interaction domains. A fourth class of corepressors prevents interactions of DNA bound DNA-binding transcription factor with coactivators.
|
4 | Q17QE2 (/ISS) Q5PXT2 (/ISS) Q5PXT2 (/ISS) Q9NZU5 (/ISS) |
|
Transcription corepressor activity GO:0003714
A protein or a member of a complex that interacts specifically and non-covalently with a DNA-bound DNA-binding transcription factor to repress the transcription of specific genes. Corepressors often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second ATP-dependent class modifies the conformation of chromatin. A third class occludes DNA-binding transcription factor protein-protein interaction domains. A fourth class of corepressors prevents interactions of DNA bound DNA-binding transcription factor with coactivators.
|
2 | Q8VEE1 (/IDA) Q8VEE1 (/IDA) |
|
Transcription factor binding GO:0008134
Interacting selectively and non-covalently with a transcription factor, a protein required to initiate or regulate transcription.
|
1 | Q71QF9 (/IPI) |
|
Transcription factor binding GO:0008134
Interacting selectively and non-covalently with a transcription factor, a protein required to initiate or regulate transcription.
|
1 | Q3U5C7 (/ISO) |
|
Zinc ion binding GO:0008270
Interacting selectively and non-covalently with zinc (Zn) ions.
|
1 | P47226 (/ISO) |
There are 79 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Negative regulation of cell population proliferation GO:0008285
Any process that stops, prevents or reduces the rate or extent of cell proliferation.
|
58 |
A0M8R4 (/ISS)
A0M8R4 (/ISS)
A0M8R4 (/ISS)
A0M8R4 (/ISS)
A0M8R4 (/ISS)
A0M8R4 (/ISS)
A0M8S5 (/ISS)
A0M8S5 (/ISS)
A0M8U6 (/ISS)
P47226 (/ISS)
(48 more) |
|
Defense response to fungus GO:0050832
Reactions triggered in response to the presence of a fungus that act to protect the cell or organism.
|
11 |
M9MRX0 (/IMP)
M9PFX9 (/IMP)
Q8IQQ3 (/IMP)
Q8IQQ3 (/IMP)
Q8MYZ5 (/IMP)
Q9VVB5 (/IMP)
Q9VVB5 (/IMP)
Q9VVB7 (/IMP)
Q9VVB7 (/IMP)
Q9VVB7 (/IMP)
(1 more) |
|
Neural retina development GO:0003407
The progression of the neural retina over time from its initial formation to the mature structure. The neural retina is the part of the retina that contains neurons and photoreceptor cells.
|
8 | A0A2R8Q2U1 (/IMP) B3DGT8 (/IMP) B3DIS8 (/IMP) F1Q6J9 (/IMP) F1REQ6 (/IMP) Q6WGK5 (/IMP) Q7ZZC4 (/IMP) Q7ZZC5 (/IMP) |
|
Kupffer's vesicle development GO:0070121
The progression of the Kupffer's vesicle over time from its initial formation until its mature state. The Kupffer's vesicle is a small but distinctive epithelial sac containing fluid, located midventrally posterior to the yolk cell or its extension, and transiently present during most of the segmentation period.
|
8 | A0A2R8Q2U1 (/IMP) B3DGT8 (/IMP) B3DIS8 (/IMP) F1Q6J9 (/IMP) F1REQ6 (/IMP) Q6WGK5 (/IMP) Q7ZZC4 (/IMP) Q7ZZC5 (/IMP) |
|
Neuron migration GO:0001764
The characteristic movement of an immature neuron from germinal zones to specific positions where they will reside as they mature.
|
7 | B3DGT8 (/IGI) B7ZD69 (/IGI) F1Q6J9 (/IGI) F2Z4V3 (/IGI) Q5SP54 (/IGI) Q6WGK5 (/IGI) Q7ZZC5 (/IGI) |
|
Negative regulation of cell population proliferation GO:0008285
Any process that stops, prevents or reduces the rate or extent of cell proliferation.
|
6 | Q9UGI8 (/IMP) Q9UGI8 (/IMP) Q9UGI8 (/IMP) Q9UGI8 (/IMP) Q9UGI8 (/IMP) Q9UGI8 (/IMP) |
|
Anterior/posterior axis specification GO:0009948
The establishment, maintenance and elaboration of the anterior/posterior axis. The anterior-posterior axis is defined by a line that runs from the head or mouth of an organism to the tail or opposite end of the organism.
|
5 | Q174I2 (/ISS) Q28FG2 (/ISS) Q292U2 (/ISS) Q7QJT4 (/ISS) Q90WV2 (/ISS) |
|
Neuron projection development GO:0031175
The process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites).
|
5 | B3DGT8 (/IMP) F1Q6J9 (/IMP) Q6WGK5 (/IMP) Q7ZZC5 (/IMP) Q80Y24 (/IMP) |
|
Establishment of mitotic spindle orientation GO:0000132
A cell cycle process that sets the alignment of mitotic spindle relative to other cellular structures.
|
4 | B3DGT8 (/IGI) F1Q6J9 (/IGI) Q6WGK5 (/IGI) Q7ZZC5 (/IGI) |
|
Establishment of planar polarity GO:0001736
Coordinated organization of groups of cells in the plane of an epithelium, such that they all orient to similar coordinates.
|
4 | Q174I2 (/ISS) Q28FG2 (/ISS) Q292U2 (/ISS) Q7QJT4 (/ISS) |
|
Heart looping GO:0001947
The tube morphogenesis process in which the primitive heart tube loops asymmetrically. This looping brings the primitive heart chambers into alignment preceding their future integration. Heart looping begins with dextral-looping and ends when the main regional divisions of the mature heart and primordium of the great arterial trunks become established preceeding septation.
|
4 | B3DGT8 (/IGI) F1Q6J9 (/IGI) Q6WGK5 (/IGI) Q7ZZC5 (/IGI) |
|
Heart looping GO:0001947
The tube morphogenesis process in which the primitive heart tube loops asymmetrically. This looping brings the primitive heart chambers into alignment preceding their future integration. Heart looping begins with dextral-looping and ends when the main regional divisions of the mature heart and primordium of the great arterial trunks become established preceeding septation.
|
4 | B3DGT8 (/IMP) F1Q6J9 (/IMP) Q6WGK5 (/IMP) Q7ZZC5 (/IMP) |
|
Wnt signaling pathway GO:0016055
The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell and ending with a change in cell state.
|
4 | B3DGT8 (/IGI) F1Q6J9 (/IGI) Q6WGK5 (/IGI) Q7ZZC5 (/IGI) |
|
Cell migration in hindbrain GO:0021535
The orderly movement of a cell that will reside in the hindbrain.
|
4 | B3DGT8 (/IMP) F1Q6J9 (/IMP) Q6WGK5 (/IMP) Q7ZZC5 (/IMP) |
|
Melanosome transport GO:0032402
The directed movement of melanosomes into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
|
4 | A0A2R8Q2U1 (/IGI) B3DIS8 (/IGI) F1REQ6 (/IGI) Q7ZZC4 (/IGI) |
|
Intrahepatic bile duct development GO:0035622
The progression of the intrahepatic bile ducts over time, from their formation to the mature structure. Intrahepatic bile ducts (bile ducts within the liver) collect bile from bile canaliculi in the liver, and connect to the extrahepatic bile ducts (bile ducts outside the liver).
|
4 | B3DGT8 (/IGI) F1Q6J9 (/IGI) Q6WGK5 (/IGI) Q7ZZC5 (/IGI) |
|
Intrahepatic bile duct development GO:0035622
The progression of the intrahepatic bile ducts over time, from their formation to the mature structure. Intrahepatic bile ducts (bile ducts within the liver) collect bile from bile canaliculi in the liver, and connect to the extrahepatic bile ducts (bile ducts outside the liver).
|
4 | B3DGT8 (/IMP) F1Q6J9 (/IMP) Q6WGK5 (/IMP) Q7ZZC5 (/IMP) |
|
Cell migration involved in gastrulation GO:0042074
The migration of individual cells within the blastocyst to help establish the multi-layered body plan of the organism (gastrulation). For example, the migration of cells from the surface to the interior of the embryo (ingression).
|
4 | B3DGT8 (/IGI) F1Q6J9 (/IGI) Q6WGK5 (/IGI) Q7ZZC5 (/IGI) |
|
Cell migration involved in gastrulation GO:0042074
The migration of individual cells within the blastocyst to help establish the multi-layered body plan of the organism (gastrulation). For example, the migration of cells from the surface to the interior of the embryo (ingression).
|
4 | B3DGT8 (/IMP) F1Q6J9 (/IMP) Q6WGK5 (/IMP) Q7ZZC5 (/IMP) |
|
Convergent extension involved in gastrulation GO:0060027
The morphogenetic process in which an epithelium narrows along one axis and lengthens in a perpendicular axis usually resulting in the formation of the three primary germ layers, ectoderm, mesoderm and endoderm.
|
4 | B3DGT8 (/IGI) F1Q6J9 (/IGI) Q6WGK5 (/IGI) Q7ZZC5 (/IGI) |
|
Wnt signaling pathway, planar cell polarity pathway GO:0060071
The series of molecular signals initiated by binding of a Wnt protein to a receptor on the surface of the target cell where activated receptors signal via downstream effectors including C-Jun N-terminal kinase (JNK) to modulate cytoskeletal elements and control cell polarity.
|
4 | Q7Z3G6 (/NAS) Q7Z3G6 (/NAS) Q96MT3 (/NAS) Q96MT3 (/NAS) |
|
Cilium assembly GO:0060271
The assembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole.
|
4 | A0A2R8Q2U1 (/IMP) B3DIS8 (/IMP) F1REQ6 (/IMP) Q7ZZC4 (/IMP) |
|
Kupffer's vesicle development GO:0070121
The progression of the Kupffer's vesicle over time from its initial formation until its mature state. The Kupffer's vesicle is a small but distinctive epithelial sac containing fluid, located midventrally posterior to the yolk cell or its extension, and transiently present during most of the segmentation period.
|
4 | B3DGT8 (/IGI) F1Q6J9 (/IGI) Q6WGK5 (/IGI) Q7ZZC5 (/IGI) |
|
Determination of digestive tract left/right asymmetry GO:0071907
Determination of the asymmetric location of various parts of the digestive tract with respect to the left and right halves of the organism. The digestive tract is the anatomical structure through which food passes and is processed.
|
4 | B3DGT8 (/IMP) F1Q6J9 (/IMP) Q6WGK5 (/IMP) Q7ZZC5 (/IMP) |
|
Determination of liver left/right asymmetry GO:0071910
Determination of the asymmetric location of the liver with respect to the left and right halves of the organism.
|
4 | B3DGT8 (/IMP) F1Q6J9 (/IMP) Q6WGK5 (/IMP) Q7ZZC5 (/IMP) |
|
Establishment of planar polarity GO:0001736
Coordinated organization of groups of cells in the plane of an epithelium, such that they all orient to similar coordinates.
|
3 | A1Z6W3 (/IMP) Q90Z06 (/IMP) Q90Z06 (/IMP) |
|
Neuron migration GO:0001764
The characteristic movement of an immature neuron from germinal zones to specific positions where they will reside as they mature.
|
3 | B7ZD69 (/IMP) F2Z4V3 (/IMP) Q5SP54 (/IMP) |
|
Protein import into nucleus GO:0006606
The directed movement of a protein from the cytoplasm to the nucleus.
|
3 | Q71QF9 (/IDA) Q96MT3 (/IDA) Q96MT3 (/IDA) |
|
Establishment of tissue polarity GO:0007164
Coordinated organization of groups of cells in a tissue, such that they all orient to similar coordinates.
|
3 | Q174I2 (/ISS) Q292U2 (/ISS) Q7QJT4 (/ISS) |
|
Anterior/posterior axis specification GO:0009948
The establishment, maintenance and elaboration of the anterior/posterior axis. The anterior-posterior axis is defined by a line that runs from the head or mouth of an organism to the tail or opposite end of the organism.
|
3 | A1Z6W3 (/IMP) Q90Z06 (/IMP) Q90Z06 (/IMP) |
|
Regulation of cardiac muscle hypertrophy GO:0010611
Any process that modulates the rate, frequency or extent of the enlargement or overgrowth of all or part of the heart due to an increase in size (not length) of individual cardiac muscle fibers, without cell division.
|
3 | Q8VEE1 (/IMP) Q8VEE1 (/IMP) Q9NZU5 (/IMP) |
|
Regulation of cardiac muscle hypertrophy GO:0010611
Any process that modulates the rate, frequency or extent of the enlargement or overgrowth of all or part of the heart due to an increase in size (not length) of individual cardiac muscle fibers, without cell division.
|
3 | Q17QE2 (/ISS) Q5PXT2 (/ISS) Q5PXT2 (/ISS) |
|
Facial nucleus development GO:0021754
The process whose specific outcome is the progression of the facial nucleus over time, from its formation to the mature structure.
|
3 | B7ZD69 (/IMP) F2Z4V3 (/IMP) Q5SP54 (/IMP) |
|
Hindbrain tangential cell migration GO:0021934
The migration of a cell in the hindbrain in which cells move orthogonal to the direction of radial migration.
|
3 | B7ZD69 (/IMP) F2Z4V3 (/IMP) Q5SP54 (/IMP) |
|
Positive regulation of calcineurin-NFAT signaling cascade GO:0070886
Any process that activates or increases the frequency, rate or extent of signaling via the calcineurin-NFAT signaling cascade.
|
3 | Q8VEE1 (/IMP) Q8VEE1 (/IMP) Q9NZU5 (/IMP) |
|
Positive regulation of calcineurin-NFAT signaling cascade GO:0070886
Any process that activates or increases the frequency, rate or extent of signaling via the calcineurin-NFAT signaling cascade.
|
3 | Q17QE2 (/ISS) Q5PXT2 (/ISS) Q5PXT2 (/ISS) |
|
Motor neuron migration GO:0097475
The orderly movement of a motor neuron from one site to another. A motor neuron is an efferent neuron that passes from the central nervous system or a ganglion toward or to a muscle and conducts an impulse that causes movement.
|
3 | B7ZD69 (/IMP) F2Z4V3 (/IMP) Q5SP54 (/IMP) |
|
Negative regulation of transcription by RNA polymerase II GO:0000122
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
|
2 | Q8VEE1 (/IGI) Q8VEE1 (/IGI) |
|
Neural crest cell migration GO:0001755
The characteristic movement of cells from the dorsal ridge of the neural tube to a variety of locations in a vertebrate embryo.
|
2 | Q7ZXE9 (/IMP) Q7ZXE9 (/IMP) |
|
Neural tube closure GO:0001843
The last step in the formation of the neural tube, where the paired neural folds are brought together and fuse at the dorsal midline.
|
2 | Q96MT3 (/IMP) Q96MT3 (/IMP) |
|
Protein import into nucleus GO:0006606
The directed movement of a protein from the cytoplasm to the nucleus.
|
2 | Q96MT3 (/IMP) Q96MT3 (/IMP) |
|
Regulation of cardiac muscle hypertrophy GO:0010611
Any process that modulates the rate, frequency or extent of the enlargement or overgrowth of all or part of the heart due to an increase in size (not length) of individual cardiac muscle fibers, without cell division.
|
2 | Q8VEE1 (/ISO) Q8VEE1 (/ISO) |
|
Positive regulation of protein ubiquitination GO:0031398
Any process that activates or increases the frequency, rate or extent of the addition of ubiquitin groups to a protein.
|
2 | Q96MT3 (/IDA) Q96MT3 (/IDA) |
|
Positive regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0032436
Any process that activates or increases the frequency, rate or extent of the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome.
|
2 | Q96MT3 (/IDA) Q96MT3 (/IDA) |
|
Negative regulation of transcription, DNA-templated GO:0045892
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
|
2 | Q96MT3 (/IDA) Q96MT3 (/IDA) |
|
Convergent extension involved in gastrulation GO:0060027
The morphogenetic process in which an epithelium narrows along one axis and lengthens in a perpendicular axis usually resulting in the formation of the three primary germ layers, ectoderm, mesoderm and endoderm.
|
2 | Q90Z06 (/IMP) Q90Z06 (/IMP) |
|
Convergent extension involved in gastrulation GO:0060027
The morphogenetic process in which an epithelium narrows along one axis and lengthens in a perpendicular axis usually resulting in the formation of the three primary germ layers, ectoderm, mesoderm and endoderm.
|
2 | Q28FG2 (/ISS) Q90WV2 (/ISS) |
|
Dendrite self-avoidance GO:0070593
The process in which dendrites recognize and avoid contact with sister dendrites from the same cell.
|
2 | Q9U1I1 (/IMP) Q9U1I1 (/IMP) |
|
Positive regulation of calcineurin-NFAT signaling cascade GO:0070886
Any process that activates or increases the frequency, rate or extent of signaling via the calcineurin-NFAT signaling cascade.
|
2 | Q8VEE1 (/ISO) Q8VEE1 (/ISO) |
|
Negative regulation of canonical Wnt signaling pathway GO:0090090
Any process that decreases the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes.
|
2 | Q96MT3 (/IDA) Q96MT3 (/IDA) |
|
Negative regulation of cardiac muscle cell myoblast differentiation GO:2000691
Any process that stops, prevents or reduces the frequency, rate or extent of cardiac muscle cell myoblast differentiation.
|
2 | Q96MT3 (/IDA) Q96MT3 (/IDA) |
|
Establishment of planar polarity GO:0001736
Coordinated organization of groups of cells in the plane of an epithelium, such that they all orient to similar coordinates.
|
1 | A1Z6W3 (/TAS) |
|
Establishment of imaginal disc-derived wing hair orientation GO:0001737
Orientation of hairs in the imaginal disc-derived wing along a proximal-distal axis, such that each cell of the wing produces one wing hair which points in a distal direction.
|
1 | A1Z6W3 (/IMP) |
|
Establishment of imaginal disc-derived wing hair orientation GO:0001737
Orientation of hairs in the imaginal disc-derived wing along a proximal-distal axis, such that each cell of the wing produces one wing hair which points in a distal direction.
|
1 | A1Z6W3 (/TAS) |
|
Morphogenesis of a polarized epithelium GO:0001738
The morphogenetic process in which the anatomical structures of a polarized epithelium are generated and organized. A polarized epithelium is an epithelium where the epithelial sheet is oriented with respect to the planar axis.
|
1 | A1Z6W3 (/IMP) |
|
Neural crest cell migration GO:0001755
The characteristic movement of cells from the dorsal ridge of the neural tube to a variety of locations in a vertebrate embryo.
|
1 | Q6DIR5 (/ISS) |
|
Neural tube closure GO:0001843
The last step in the formation of the neural tube, where the paired neural folds are brought together and fuse at the dorsal midline.
|
1 | Q3U5C7 (/ISO) |
|
Protein import into nucleus GO:0006606
The directed movement of a protein from the cytoplasm to the nucleus.
|
1 | Q3U5C7 (/ISO) |
|
Establishment or maintenance of cell polarity GO:0007163
Any cellular process that results in the specification, formation or maintenance of anisotropic intracellular organization or cell growth patterns.
|
1 | A1Z6W3 (/IMP) |
|
Establishment of tissue polarity GO:0007164
Coordinated organization of groups of cells in a tissue, such that they all orient to similar coordinates.
|
1 | A1Z6W3 (/IMP) |
|
Negative regulation of cell population proliferation GO:0008285
Any process that stops, prevents or reduces the rate or extent of cell proliferation.
|
1 | P47226 (/ISO) |
|
Establishment or maintenance of microtubule cytoskeleton polarity GO:0030951
Any cellular process that results in the specification, formation or maintenance of polarized microtubule-based cytoskeletal structures.
|
1 | A1Z6W3 (/IMP) |
|
Positive regulation of protein ubiquitination GO:0031398
Any process that activates or increases the frequency, rate or extent of the addition of ubiquitin groups to a protein.
|
1 | Q3U5C7 (/ISO) |
|
Positive regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0032436
Any process that activates or increases the frequency, rate or extent of the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome.
|
1 | Q3U5C7 (/ISO) |
|
Aorta development GO:0035904
The progression of the aorta over time, from its initial formation to the mature structure. An aorta is an artery that carries blood from the heart to other parts of the body.
|
1 | Q3U5C7 (/IMP) |
|
Establishment of ommatidial planar polarity GO:0042067
The specification of polarized ommatidia. Ommatidia occur in two chiral forms. The trapezoidal arrangement of photoreceptors in the dorsal part of the eye is the mirror image of that in the ventral part.
|
1 | A1Z6W3 (/IMP) |
|
Positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123
Any process that activates or increases the frequency, rate or extent of I-kappaB kinase/NF-kappaB signaling.
|
1 | Q9Y423 (/IMP) |
|
Cellular protein metabolic process GO:0044267
The chemical reactions and pathways involving a specific protein, rather than of proteins in general, occurring at the level of an individual cell. Includes cellular protein modification.
|
1 | Q9NZU5 (/TAS) |
|
Establishment of protein localization GO:0045184
The directed movement of a protein to a specific location.
|
1 | A1Z6W3 (/TAS) |
|
Maintenance of protein location GO:0045185
Any process in which a protein is maintained in a location and prevented from moving elsewhere. These include sequestration, stabilization to prevent transport elsewhere and the active retrieval of proteins that do move away.
|
1 | A1Z6W3 (/TAS) |
|
Establishment or maintenance of epithelial cell apical/basal polarity GO:0045197
Any cellular process that results in the specification, formation or maintenance of the apicobasal polarity of an epithelial cell.
|
1 | Q80Y24 (/IDA) |
|
Positive regulation of axon extension GO:0045773
Any process that activates or increases the frequency, rate or extent of axon extension.
|
1 | A1Z6W3 (/IGI) |
|
Negative regulation of transcription, DNA-templated GO:0045892
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
|
1 | Q3U5C7 (/ISO) |
|
Wnt signaling pathway, planar cell polarity pathway GO:0060071
The series of molecular signals initiated by binding of a Wnt protein to a receptor on the surface of the target cell where activated receptors signal via downstream effectors including C-Jun N-terminal kinase (JNK) to modulate cytoskeletal elements and control cell polarity.
|
1 | A1Z6W3 (/TAS) |
|
Coronary vasculature development GO:0060976
The process whose specific outcome is the progression of the blood vessels of the heart over time, from its formation to the mature structure.
|
1 | Q3U5C7 (/IMP) |
|
Negative regulation of canonical Wnt signaling pathway GO:0090090
Any process that decreases the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes.
|
1 | Q3U5C7 (/ISO) |
|
Axonal transport GO:0098930
The directed movement of organelles or molecules along microtubules in axons.
|
1 | A1Z6W3 (/IMP) |
|
Positive regulation of axon guidance GO:1902669
Any process that activates or increases the frequency, rate or extent of axon guidance.
|
1 | A1Z6W3 (/IMP) |
|
Negative regulation of cardiac muscle cell myoblast differentiation GO:2000691
Any process that stops, prevents or reduces the frequency, rate or extent of cardiac muscle cell myoblast differentiation.
|
1 | Q3U5C7 (/ISO) |
There are 32 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
62 |
A0M8R4 (/ISS)
A0M8R4 (/ISS)
A0M8R4 (/ISS)
A0M8R4 (/ISS)
A0M8R4 (/ISS)
A0M8R4 (/ISS)
A0M8S5 (/ISS)
A0M8S5 (/ISS)
A0M8U6 (/ISS)
Q00PK1 (/ISS)
(52 more) |
|
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
14 |
A4D0U5 (/IDA)
A4D0U5 (/IDA)
A4D0U5 (/IDA)
A4D0U5 (/IDA)
A4D0U5 (/IDA)
A4D0U5 (/IDA)
Q96MT3 (/IDA)
Q96MT3 (/IDA)
Q9UGI8 (/IDA)
Q9UGI8 (/IDA)
(4 more) |
|
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
13 |
A1Z6W3 (/IDA)
A4D0U5 (/IDA)
A4D0U5 (/IDA)
A4D0U5 (/IDA)
A4D0U5 (/IDA)
A4D0U5 (/IDA)
A4D0U5 (/IDA)
Q9UGI8 (/IDA)
Q9UGI8 (/IDA)
Q9UGI8 (/IDA)
(3 more) |
|
Focal adhesion GO:0005925
Small region on the surface of a cell that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments.
|
12 |
A4D0U5 (/IDA)
A4D0U5 (/IDA)
A4D0U5 (/IDA)
A4D0U5 (/IDA)
A4D0U5 (/IDA)
A4D0U5 (/IDA)
Q9UGI8 (/IDA)
Q9UGI8 (/IDA)
Q9UGI8 (/IDA)
Q9UGI8 (/IDA)
(2 more) |
|
Cell junction GO:0030054
A cellular component that forms a specialized region of connection between two or more cells or between a cell and the extracellular matrix. At a cell junction, anchoring proteins extend through the plasma membrane to link cytoskeletal proteins in one cell to cytoskeletal proteins in neighboring cells or to proteins in the extracellular matrix.
|
12 |
A4D0U5 (/IDA)
A4D0U5 (/IDA)
A4D0U5 (/IDA)
A4D0U5 (/IDA)
A4D0U5 (/IDA)
A4D0U5 (/IDA)
Q9UGI8 (/IDA)
Q9UGI8 (/IDA)
Q9UGI8 (/IDA)
Q9UGI8 (/IDA)
(2 more) |
|
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
10 | A0A024QYW5 (/IDA) A0A024QYW5 (/IDA) H0Y413 (/IDA) O43900 (/IDA) O43900 (/IDA) Q3U5C7 (/IDA) Q8VEE1 (/IDA) Q8VEE1 (/IDA) Q96MT3 (/IDA) Q96MT3 (/IDA) |
|
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
6 | Q9UGI8 (/HDA) Q9UGI8 (/HDA) Q9UGI8 (/HDA) Q9UGI8 (/HDA) Q9UGI8 (/HDA) Q9UGI8 (/HDA) |
|
Focal adhesion GO:0005925
Small region on the surface of a cell that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments.
|
6 | Q9UGI8 (/HDA) Q9UGI8 (/HDA) Q9UGI8 (/HDA) Q9UGI8 (/HDA) Q9UGI8 (/HDA) Q9UGI8 (/HDA) |
|
Protein-containing complex GO:0032991
A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.
|
6 | Q9UGI8 (/IDA) Q9UGI8 (/IDA) Q9UGI8 (/IDA) Q9UGI8 (/IDA) Q9UGI8 (/IDA) Q9UGI8 (/IDA) |
|
Centrosome GO:0005813
A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle.
|
5 | A0A024QYW5 (/IDA) A0A024QYW5 (/IDA) H0Y413 (/IDA) O43900 (/IDA) O43900 (/IDA) |
|
M band GO:0031430
The midline of aligned thick filaments in a sarcomere; location of specific proteins that link thick filaments. Depending on muscle type the M band consists of different numbers of M lines.
|
5 | G5ECN3 (/IDA) G5EDJ5 (/IDA) G5EEA4 (/IDA) G5EF39 (/IDA) O17833 (/IDA) |
|
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
4 | P47226 (/IDA) Q7Z3G6 (/IDA) Q7Z3G6 (/IDA) Q80Y24 (/IDA) |
|
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
3 | A1Z6W3 (/TAS) Q96MT3 (/TAS) Q96MT3 (/TAS) |
|
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
3 | Q174I2 (/ISS) Q292U2 (/ISS) Q7QJT4 (/ISS) |
|
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
2 | Q3U5C7 (/ISO) Q80VL3 (/ISO) |
|
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
2 | P47226 (/ISO) Q3U5C7 (/ISO) |
|
Cell cortex GO:0005938
The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins.
|
2 | Q7ZXE9 (/IDA) Q7ZXE9 (/IDA) |
|
Nuclear membrane GO:0031965
Either of the lipid bilayers that surround the nucleus and form the nuclear envelope; excludes the intermembrane space.
|
2 | Q96MT3 (/IDA) Q96MT3 (/IDA) |
|
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
1 | Q2TBC4 (/NAS) |
|
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
|
1 | Q9NZU5 (/TAS) |
|
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
1 | Q80Y24 (/ISO) |
|
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
1 | A1Z6W3 (/TAS) |
|
Centrosome GO:0005813
A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle.
|
1 | Q80VL3 (/ISO) |
|
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
1 | P47226 (/ISO) |
|
Focal adhesion GO:0005925
Small region on the surface of a cell that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments.
|
1 | P47226 (/ISO) |
|
Cell cortex GO:0005938
The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins.
|
1 | Q6DIR5 (/ISS) |
|
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
|
1 | A1Z6W3 (/NAS) |
|
Apicolateral plasma membrane GO:0016327
The apical end of the lateral plasma membrane of epithelial cells.
|
1 | Q80Y24 (/IDA) |
|
Lateral plasma membrane GO:0016328
The portion of the plasma membrane at the lateral side of the cell. In epithelial cells, lateral plasma membranes are on the sides of cells which lie at the interface of adjacent cells.
|
1 | Q80Y24 (/IDA) |
|
Cell junction GO:0030054
A cellular component that forms a specialized region of connection between two or more cells or between a cell and the extracellular matrix. At a cell junction, anchoring proteins extend through the plasma membrane to link cytoskeletal proteins in one cell to cytoskeletal proteins in neighboring cells or to proteins in the extracellular matrix.
|
1 | P47226 (/ISO) |
|
Nuclear membrane GO:0031965
Either of the lipid bilayers that surround the nucleus and form the nuclear envelope; excludes the intermembrane space.
|
1 | Q3U5C7 (/ISO) |
|
Protein-containing complex GO:0032991
A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.
|
1 | P47226 (/ISO) |
