The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:
"This entry includes the Ebola VP35 protein, which acts as a component of the viral RNA polymerase complex, a viral assembly factor, and an inhibitor of host interferon (IFN) production. This superfamily represents the C-terminal beta-sheet subdomain of the inhibitory domain located at the C-terminus of VP35.
VP35 contains an N-terminal coiled-coil domain required for its oligomerisation and a C-terminal dsRNA-binding region (inhibitory domain, IID). The C-terminus mediates the dsRNA binding activity, which is critical for viral suppression of innate immunity and for virulence PMID:19122151.
The VP35 IID structure is organised into 2 subdomains: an N-terminal alpha-helical subdomain and a C-terminal beta-sheet subdomain. The beta-sheet subdomain (residues 294-340) is composed of a 4-stranded mixed beta-sheet and a short helical segment PMID:19122151.
| Structures | |
|---|---|
| Domains: | 65 |
| Domain clusters (>95% seq id): | 4 |
| Domain clusters (>35% seq id): | 1 |
| Unique PDBs: | 25 |
| Alignments | |
| Structural Clusters (5A): | 1 |
| Structural Clusters (9A): | 1 |
| FunFam Clusters: | 1 |
| Function | |
| Unique EC: | |
| Unique GO: | 11 |
| Taxonomy | |
| Unique Species: | 18 |
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