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CATH Superfamily 1.50.10.130

Terpene synthase, N-terminal domain

The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:

"
Terpene synthase, N-terminal domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 3: Ent-cassa-12,15-diene synthase

There are 9 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Stemod-13(17)-ene synthase. [EC: 4.2.3.34]
9-alpha-copalyl diphosphate = stemod-13(17)-ene + diphosphate.
  • Catalyzes the committed step in the biosynthesis of the stemodane family of diterpenoid secondary metabolites, some of which possess mild antiviral activity.
  • Also produces stemod-12-ene and stemar-13-ene as minor products.
 9 A0A0E0IQZ4 A0A0E0IQZ4 A0A0E0IQZ4 A0A2Z6BAT9 A0A2Z6BAT9 A0A2Z6BAT9 Q1AHB2 Q1AHB2 Q1AHB2
Ent-isokaurene synthase. [EC: 4.2.3.103]
Ent-copalyl diphosphate = ent-isokaurene + diphosphate.
  • Two enzymes of the rice sub-species Oryza sativa subsp. indica, OsKSL5 and OsKSL6, produce ent-isokaurene.
  • A variant of OsKSL5 from the sub-species Oryza sativa subsp. japonica produces ent-pimara-8(14),15-diene instead (cf. EC 4.2.3.30).
  • Formerly EC 4.2.3.n8.
 2 A4KAG7 A4KAG8
Ent-cassa-12,15-diene synthase. [EC: 4.2.3.28]
Ent-copalyl diphosphate = ent-cassa-12,15-diene + diphosphate.
  • This class I diterpene cyclase produces ent-cassa-12,15-diene, a precursor of the rice phytoalexins (-)-phytocassanes A-E. Phytoalexins are diterpenoid secondary metabolites that are involved in the defense mechanism of the plant, and are produced in response to pathogen attack through the perception of elicitor signal molecules such as chitin oligosaccharide, or after exposure to UV irradiation.
 2 Q00G37 Q0E088
Ent-pimara-8(14),15-diene synthase. [EC: 4.2.3.30]
Ent-copalyl diphosphate = ent-pimara-8(14),15-diene + diphosphate.
  • Unlike EC 4.2.3.29 which can produce both ent-sandaracopimaradiene and ent-pimara-8(14),15-diene, this diterpene cyclase produces only ent-pimara-8(14),15-diene.
  • Ent-pimara-8(14),15-diene is not a precursor in the biosynthesis of either gibberellins or phytoalexins.
 1 Q6Z5J6
Syn-pimara-7,15-diene synthase. [EC: 4.2.3.35]
9-alpha-copalyl diphosphate = 9-beta-pimara-7,15-diene + diphosphate.
  • A class I terpene synthase.
  • 9-beta-pimara-7,15-diene is a precursor of momilactones A and B, rice diterpenoid phytoalexins that are produced in response to attack (by a pathogen, elicitor or UV irradiation) and are involved in the defense mechanism of the plant.
  • Momilactone B can also act as an allochemical, being constitutively produced in the root of the plant and secreted to the rhizosphere where it suppresses the growth of neighboring plants and soil microorganisms.
 1 Q0JEZ8
Ent-sandaracopimaradiene synthase. [EC: 4.2.3.29]
Ent-copalyl diphosphate = ent-sandaracopimara-8(14),15-diene + diphosphate.
  • Ent-sandaracopimaradiene is a precursor of the rice oryzalexins A-F.
  • Phytoalexins are diterpenoid secondary metabolites that are involved in the defense mechanism of the plant, and are produced in response to pathogen attack through the perception of elicitor signal molecules such as chitin oligosaccharide, or after exposure to UV irradiation.
  • As a minor product, this enzyme also forms ent-pimara-8(14),15-diene, which is the sole product of EC 4.2.3.30.
  • Ent-pimara-8(14),15-diene is not a precursor in the biosynthesis of either gibberellins or phytoalexins.
 1 Q2QQJ5
Ent-kaurene synthase. [EC: 4.2.3.19]
Ent-copalyl diphosphate = ent-kaurene + diphosphate.
  • Part of a bifunctional enzyme involved in the biosynthesis of ent- kaurene.
  • See also EC 5.5.1.13.
 1 Q0JA82
Stemar-13-ene synthase. [EC: 4.2.3.33]
9-alpha-copalyl diphosphate = stemar-13-ene + diphosphate.
  • This diterpene cyclase produces stemar-13-ene, a putative precursor of the rice phytoalexin oryzalexin S.
  • Phytoalexins are diterpenoid secondary metabolites that are involved in the defense mechanism of the plant, and are produced in response to pathogen attack through the perception of elicitor signal molecules such as chitin oligosaccharide, or after exposure to UV irradiation.
 1 Q6BDZ9
Gamma-curcumene synthase. [EC: 4.2.3.94]
(2E,6E)-farnesyl diphosphate = gamma-curcumene + diphosphate.
  • One of five sesquiterpenoid synthases in Pogostemon cablin (patchouli).
 1 Q2QQJ5
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