CATH Superfamily 1.25.40.690
The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was: waiting to be named.
FunFam 7: Nucleoporin NUP145
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 5 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
RNA binding GO:0003723
Interacting selectively and non-covalently with an RNA molecule or a portion thereof.
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2 | P49687 (/IDA) P49687 (/IDA) |
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Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
2 | P49687 (/IPI) P49687 (/IPI) |
|
Structural constituent of nuclear pore GO:0017056
The action of a molecule that contributes to the structural integrity of the nuclear pore complex, a protein-lined channel in the nuclear envelope that allows the transfer of macromolecules.
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2 | P49687 (/IGI) P49687 (/IGI) |
|
Structural constituent of nuclear pore GO:0017056
The action of a molecule that contributes to the structural integrity of the nuclear pore complex, a protein-lined channel in the nuclear envelope that allows the transfer of macromolecules.
|
2 | P49687 (/IMP) P49687 (/IMP) |
|
Structural constituent of nuclear pore GO:0017056
The action of a molecule that contributes to the structural integrity of the nuclear pore complex, a protein-lined channel in the nuclear envelope that allows the transfer of macromolecules.
|
2 | P49687 (/IPI) P49687 (/IPI) |
There are 12 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery GO:0000973
The chromosome organization process in which the DNA sequence containing a gene transcribed by RNA polymerase II is maintained in a specific location at the nuclear periphery even after transcription has been repressed.
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2 | P49687 (/IMP) P49687 (/IMP) |
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Double-strand break repair GO:0006302
The repair of double-strand breaks in DNA via homologous and nonhomologous mechanisms to reform a continuous DNA helix.
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2 | P49687 (/IMP) P49687 (/IMP) |
|
TRNA export from nucleus GO:0006409
The directed movement of tRNA from the nucleus to the cytoplasm.
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2 | P49687 (/IMP) P49687 (/IMP) |
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Protein import into nucleus GO:0006606
The directed movement of a protein from the cytoplasm to the nucleus.
|
2 | P49687 (/IGI) P49687 (/IGI) |
|
NLS-bearing protein import into nucleus GO:0006607
The directed movement of a protein bearing a nuclear localization signal (NLS) from the cytoplasm into the nucleus, across the nuclear envelope.
|
2 | P49687 (/IGI) P49687 (/IGI) |
|
Poly(A)+ mRNA export from nucleus GO:0016973
The directed movement of poly(A)+ mRNA out of the nucleus into the cytoplasm.
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2 | P49687 (/IMP) P49687 (/IMP) |
|
Nuclear pore distribution GO:0031081
Any process that establishes the spatial arrangement of nuclear pores within the nuclear envelope.
|
2 | P49687 (/IMP) P49687 (/IMP) |
|
Telomere tethering at nuclear periphery GO:0034398
The process in which a telomere is maintained in a specific location at the nuclear periphery.
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2 | P49687 (/IMP) P49687 (/IMP) |
|
Maintenance of chromatin silencing at telomere GO:0035392
The maintenance of chromatin in a transcriptionally silent state such as heterochromatin at the telomere.
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2 | P49687 (/IMP) P49687 (/IMP) |
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Protein localization to nuclear inner membrane GO:0036228
A process in which a protein is transported to, or maintained in, a location within the nuclear inner membrane.
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2 | P49687 (/IGI) P49687 (/IGI) |
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Positive regulation of transcription, DNA-templated GO:0045893
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
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2 | P49687 (/IDA) P49687 (/IDA) |
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Regulation of nucleocytoplasmic transport GO:0046822
Any process that modulates the frequency, rate or extent of the directed movement of substances between the nucleus and the cytoplasm.
|
2 | P49687 (/IMP) P49687 (/IMP) |
There are 3 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Nuclear pore GO:0005643
Any of the numerous similar discrete openings in the nuclear envelope of a eukaryotic cell, where the inner and outer nuclear membranes are joined.
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2 | P49687 (/IDA) P49687 (/IDA) |
|
Nuclear pore outer ring GO:0031080
A subcomplex of the nuclear pore complex (NPC) that forms the outer rings of the core scaffold, a lattice-like structure that gives the NPC its shape and strength. In S. cerevisiae, the two outer rings each contain multiple copies of the following proteins: Nup133p, Nup120p, Nup145Cp, Nup85p, Nup84p, Seh1p, and Sec13p. In vertebrates, the two outer rings each contain multiple copies of the following proteins: Nup133, Nup160, Nup96, Nup75, Nup107, Seh1, Sec13, Nup43, Nup37, and ALADIN. Components are arranged in 8-fold symmetrical 'spokes' around the central transport channel. A single 'spoke', can be isolated and is sometimes referred to as the Nup84 complex (S. cerevisiae) or the Nup107-160 complex (vertebrates).
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2 | P49687 (/IDA) P49687 (/IDA) |
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Nuclear pore central transport channel GO:0044613
The central substructure of the nuclear pore complex (NPC), through which nucleocytoplasmic transport of RNAs, proteins and small molecules occurs. The central transport channel is filled with FG-nucleoporins, which form a selective barrier and provide a series of binding sites for transporter proteins. Characterized S. cerevisiae FG-nucleoporins include Nup159p, Nup145Np, Nup116p, Nup100p, Nsp1p, Nup57p, Nup49p, Nup42p, Nup53p, Nup59p/Asm4p, Nup60p and Nup1. Characterized vertebrate FG-nucleoporins include Nup214, Nup98, Nup62, Nup54, Nup58/45, NLP1, and Nup153.
|
2 | P49687 (/IDA) P49687 (/IDA) |
