The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:

"
Adenylate cyclase-associated CAP, N-terminal domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 1: Adenylyl cyclase-associated protein

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 7 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
6 P17555 (/IPI) P17555 (/IPI) P36621 (/IPI) P40123 (/IPI) P40124 (/IPI) P54654 (/IPI)
Actin binding GO:0003779
Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments.
3 Q7KN55 (/ISS) Q9VPX6 (/ISS) Q9VPX7 (/ISS)
Adenylate cyclase binding GO:0008179
Interacting selectively and non-covalently with the enzyme adenylate cyclase.
3 Q7KN55 (/ISS) Q9VPX6 (/ISS) Q9VPX7 (/ISS)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
3 P17555 (/IPI) P17555 (/IPI) P40123 (/IPI)
Actin binding GO:0003779
Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments.
2 P17555 (/IDA) P17555 (/IDA)
Adenylate cyclase binding GO:0008179
Interacting selectively and non-covalently with the enzyme adenylate cyclase.
2 P17555 (/IDA) P17555 (/IDA)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
1 Q9CYT6 (/ISO)

There are 55 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Actin filament organization GO:0007015
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments. Includes processes that control the spatial distribution of actin filaments, such as organizing filaments into meshworks, bundles, or other structures, as by cross-linking.
5 P17555 (/IMP) P17555 (/IMP) Q7KN55 (/IMP) Q9VPX6 (/IMP) Q9VPX7 (/IMP)
Cell morphogenesis GO:0000902
The developmental process in which the size or shape of a cell is generated and organized.
3 Q7KN55 (/IMP) Q9VPX6 (/IMP) Q9VPX7 (/IMP)
Somitogenesis GO:0001756
The formation of mesodermal clusters that are arranged segmentally along the anterior posterior axis of an embryo.
3 A7E2H8 (/IMP) B8JMD0 (/IMP) Q6YBS2 (/IMP)
Activation of adenylate cyclase activity GO:0007190
Any process that initiates the activity of the inactive enzyme adenylate cyclase.
3 A7E2H8 (/ISS) B8JMD0 (/ISS) Q6YBS2 (/ISS)
Mesodermal cell migration GO:0008078
The orderly movement of mesodermal cells from one site to another.
3 A7E2H8 (/IMP) B8JMD0 (/IMP) Q6YBS2 (/IMP)
Oocyte microtubule cytoskeleton polarization GO:0008103
Establishment and maintenance of a specific axis of polarity of the oocyte microtubule network. The axis is set so that the minus and plus ends of the microtubules of the mid stage oocyte are positioned along the anterior cortex and at the posterior pole, respectively. An example of this is found in Drosophila melanogaster.
3 Q7KN55 (/IMP) Q9VPX6 (/IMP) Q9VPX7 (/IMP)
Actin polymerization or depolymerization GO:0008154
Assembly or disassembly of actin filaments by the addition or removal of actin monomers from a filament.
3 Q7KN55 (/IMP) Q9VPX6 (/IMP) Q9VPX7 (/IMP)
Regulation of cell shape GO:0008360
Any process that modulates the surface configuration of a cell.
3 Q7KN55 (/IMP) Q9VPX6 (/IMP) Q9VPX7 (/IMP)
Chaeta morphogenesis GO:0008407
The process in which the anatomical structures of the chaeta are generated and organized. A chaeta is a sensory multicellular cuticular outgrowth of a specifically differentiated cell.
3 Q7KN55 (/IMP) Q9VPX6 (/IMP) Q9VPX7 (/IMP)
Actin cytoskeleton organization GO:0030036
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins.
3 O65902 (/TAS) O65902 (/TAS) P52481 (/TAS)
Rhabdomere development GO:0042052
The assembly and arrangement of a rhabdomere within a cell. The rhabdomere is the organelle on the apical surface of a photoreceptor cell that contains the visual pigments.
3 Q7KN55 (/IMP) Q9VPX6 (/IMP) Q9VPX7 (/IMP)
Muscle cell cellular homeostasis GO:0046716
The cellular homeostatic process that preserves a muscle cell in a stable functional or structural state.
3 Q7KN55 (/IGI) Q9VPX6 (/IGI) Q9VPX7 (/IGI)
Wing disc dorsal/ventral pattern formation GO:0048190
The establishment, maintenance and elaboration of the dorsal/ventral axis of the wing disc, a precursor to the adult wing.
3 Q7KN55 (/IMP) Q9VPX6 (/IMP) Q9VPX7 (/IMP)
Oogenesis GO:0048477
The complete process of formation and maturation of an ovum or female gamete from a primordial female germ cell. Examples of this process are found in Mus musculus and Drosophila melanogaster.
3 Q7KN55 (/IMP) Q9VPX6 (/IMP) Q9VPX7 (/IMP)
Compound eye development GO:0048749
The process whose specific outcome is the progression of the compound eye over time, from its formation to the mature structure. The compound eye is an organ of sight that contains multiple repeating units, often arranged hexagonally. Each unit has its own lens and photoreceptor cell(s) and can generate either a single pixelated image or multiple images, per eye.
3 Q7KN55 (/IMP) Q9VPX6 (/IMP) Q9VPX7 (/IMP)
Photoreceptor cell axon guidance GO:0072499
The chemotaxis process that directs the migration of a photoreceptor cell axon growth cone to its target in the optic lobe in response to a combination of attractive and repulsive cues.
3 Q7KN55 (/IMP) Q9VPX6 (/IMP) Q9VPX7 (/IMP)
Actin filament organization GO:0007015
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments. Includes processes that control the spatial distribution of actin filaments, such as organizing filaments into meshworks, bundles, or other structures, as by cross-linking.
2 P17555 (/IDA) P17555 (/IDA)
Establishment or maintenance of cell polarity GO:0007163
Any cellular process that results in the specification, formation or maintenance of anisotropic intracellular organization or cell growth patterns.
2 P40123 (/TAS) Q01518 (/TAS)
Signal transduction GO:0007165
The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.
2 P40123 (/TAS) Q01518 (/TAS)
Activation of adenylate cyclase activity GO:0007190
Any process that initiates the activity of the inactive enzyme adenylate cyclase.
2 P40123 (/TAS) Q01518 (/TAS)
Ras protein signal transduction GO:0007265
A series of molecular signals within the cell that are mediated by a member of the Ras superfamily of proteins switching to a GTP-bound active state.
2 P17555 (/IMP) P17555 (/IMP)
Pathogenesis GO:0009405
The set of specific processes that generate the ability of an organism to induce an abnormal, generally detrimental state in another organism.
2 Q5A6P9 (/IMP) Q5A6P9 (/IMP)
Unidimensional cell growth GO:0009826
The process in which a cell irreversibly increases in size in one
2 O65902 (/IMP) O65902 (/IMP)
CAMP-mediated signaling GO:0019933
Any intracellular signal transduction in which the signal is passed on within the cell via cyclic AMP (cAMP). Includes production of cAMP, and downstream effectors that further transmit the signal within the cell.
2 Q5A6P9 (/IMP) Q5A6P9 (/IMP)
Actin filament depolymerization GO:0030042
Disassembly of actin filaments by the removal of actin monomers from a filament.
2 P17555 (/IDA) P17555 (/IDA)
Filamentous growth GO:0030447
The process in which a multicellular organism, a unicellular organism or a group of unicellular organisms grow in a threadlike, filamentous shape.
2 Q5A6P9 (/IMP) Q5A6P9 (/IMP)
Positive regulation of actin filament depolymerization GO:0030836
Any process that activates or increases the frequency, rate or extent of actin depolymerization.
2 P17555 (/IDA) P17555 (/IDA)
Cellular response to heat GO:0034605
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism.
2 Q5A6P9 (/IMP) Q5A6P9 (/IMP)
Cellular response to drug GO:0035690
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a drug stimulus. A drug is a substance used in the diagnosis, treatment or prevention of a disease.
2 Q5A6P9 (/IMP) Q5A6P9 (/IMP)
Filamentous growth of a population of unicellular organisms in response to heat GO:0036168
The process in which a group of unicellular organisms grow in a threadlike, filamentous shape in response to an increase in temperature.
2 Q5A6P9 (/IMP) Q5A6P9 (/IMP)
Response to neutral pH GO:0036176
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a neutral pH (pH close to 7) stimulus. pH is a measure of the acidity or basicity of an aqueous solution.
2 Q5A6P9 (/IMP) Q5A6P9 (/IMP)
Filamentous growth of a population of unicellular organisms in response to neutral pH GO:0036178
The process in which a group of unicellular organisms grow in a threadlike, filamentous shape in response to a neutral pH (pH close to 7) stimulus.
2 Q5A6P9 (/IMP) Q5A6P9 (/IMP)
Filamentous growth of a population of unicellular organisms in response to biotic stimulus GO:0036180
The process in which a group of unicellular organisms grow in a threadlike, filamentous shape in response to a biotic (living) stimulus.
2 Q5A6P9 (/IMP) Q5A6P9 (/IMP)
Cell growth mode switching, budding to filamentous GO:0036187
The process in which a cell switches from growing as a round budding cell to growing as a filament (elongated cells attached end-to-end). An example of this is the yeast-hyphal transition of Candida albicans.
2 Q5A6P9 (/IMP) Q5A6P9 (/IMP)
Cellular response to neutral pH GO:0036244
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a neutral pH (pH close to 7) stimulus. pH is a measure of the acidity or basicity of an aqueous solution.
2 Q5A6P9 (/IMP) Q5A6P9 (/IMP)
Regulation of adenylate cyclase activity GO:0045761
Any process that modulates the frequency, rate or extent of adenylate cyclase activity.
2 Q5A6P9 (/IMP) Q5A6P9 (/IMP)
Actin filament severing GO:0051014
The process in which an actin filament is broken down into smaller filaments.
2 P17555 (/IDA) P17555 (/IDA)
Seed trichome elongation GO:0090378
The process in which a seed trichome irreversibly increases in size in one
2 Q9ZWM6 (/IEP) Q9ZWM6 (/IEP)
Positive regulation of filamentous growth of a population of unicellular organisms in response to heat GO:1900433
Any process that activates or increases the frequency, rate or extent of filamentous growth of a population of unicellular organisms in response to heat.
2 Q5A6P9 (/IMP) Q5A6P9 (/IMP)
Positive regulation of filamentous growth of a population of unicellular organisms in response to neutral pH GO:1900442
Any process that activates or increases the frequency, rate or extent of filamentous growth of a population of unicellular organisms in response to neutral pH.
2 Q5A6P9 (/IMP) Q5A6P9 (/IMP)
Mitotic cytokinesis GO:0000281
A cell cycle process that results in the division of the cytoplasm of a cell after mitosis, resulting in the separation of the original cell into two daughter cells.
1 P54654 (/IMP)
Cell morphogenesis GO:0000902
The developmental process in which the size or shape of a cell is generated and organized.
1 P40124 (/IGI)
Ameboidal-type cell migration GO:0001667
Cell migration that is accomplished by extension and retraction of a pseudopodium.
1 P40124 (/IMP)
Receptor-mediated endocytosis GO:0006898
An endocytosis process in which cell surface receptors ensure specificity of transport. A specific receptor on the cell surface binds tightly to the extracellular macromolecule (the ligand) that it recognizes; the plasma-membrane region containing the receptor-ligand complex then undergoes endocytosis, forming a transport vesicle containing the receptor-ligand complex and excluding most other plasma-membrane proteins. Receptor-mediated endocytosis generally occurs via clathrin-coated pits and vesicles.
1 P40124 (/IMP)
Pinocytosis GO:0006907
An endocytosis process that results in the uptake of liquid material by cells from their external environment; literally 'cell drinking'. Liquid is enclosed in vesicles, called pinosomes, formed by invagination of the plasma membrane.
1 P54654 (/IMP)
Response to osmotic stress GO:0006970
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating an increase or decrease in the concentration of solutes outside the organism or cell.
1 P54654 (/IMP)
Cytoskeleton organization GO:0007010
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures.
1 P52481 (/TAS)
Establishment or maintenance of cell polarity GO:0007163
Any cellular process that results in the specification, formation or maintenance of anisotropic intracellular organization or cell growth patterns.
1 P54654 (/IGI)
Regulation of gene expression GO:0010468
Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
1 P54654 (/IGI)
Actin cytoskeleton organization GO:0030036
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins.
1 P40124 (/IMP)
Negative regulation of conjugation with cellular fusion GO:0031138
Any process that decreases the rate or frequency of conjugation with cellular fusion.
1 P36621 (/IMP)
Aggregation involved in sorocarp development GO:0031152
The process whose specific outcome is the progression of the aggregate over time, from its formation to the point when a slug is formed. Aggregate development begins in response to starvation and continues by the chemoattractant-mediated movement of cells toward each other. The aggregate is a multicellular structure that gives rise to the slug.
1 P54654 (/IGI)
Contractile vacuole organization GO:0033298
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a contractile vacuole. A specialized vacuole that fills with water from the cytoplasm and then discharges this externally by the opening of contractile vacuole pores.
1 P54654 (/IMP)
Neutrophil degranulation GO:0043312
The regulated exocytosis of secretory granules containing preformed mediators such as proteases, lipases, and inflammatory mediators by a neutrophil.
1 Q01518 (/TAS)
Cell-cell adhesion GO:0098609
The attachment of one cell to another cell via adhesion molecules.
1 P54654 (/IGI)

There are 23 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
5 P40124 (/IDA) P54654 (/IDA) Q7KN55 (/IDA) Q9VPX6 (/IDA) Q9VPX7 (/IDA)
Extracellular region GO:0005576
The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
2 P40124 (/TAS) Q01518 (/TAS)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
2 O65902 (/IDA) O65902 (/IDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
2 P40124 (/TAS) Q9VPX7 (/TAS)
Actin cortical patch GO:0030479
An endocytic patch that consists of an actin-containing structure found at the plasma membrane in cells; formed of networks of branched actin filaments that lie just beneath the plasma membrane and assemble, move, and disassemble rapidly. An example of this is the actin cortical patch found in Saccharomyces cerevisiae.
2 P17555 (/IDA) P17555 (/IDA)
Mating projection tip GO:0043332
The apex of the mating projection in unicellular fungi exposed to mating pheromone; site of polarized growth.
2 P17555 (/HDA) P17555 (/HDA)
Division septum GO:0000935
A cell septum which forms as part of the division site and functions in the compartmentalization of a cell into two daughter cells at division. A division septum spans a cell and does not allow exchange of organelles or cytoplasm between compartments.
1 P36621 (/IDA)
Phagocytic cup GO:0001891
An invagination of the cell membrane formed by an actin dependent process during phagocytosis. Following internalization it is converted into a phagosome.
1 P54654 (/IDA)
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
1 P40124 (/HDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 P36621 (/HDA)
Vacuolar membrane GO:0005774
The lipid bilayer surrounding the vacuole and separating its contents from the cytoplasm of the cell.
1 P54654 (/IDA)
Focal adhesion GO:0005925
Small region on the surface of a cell that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments.
1 Q01518 (/HDA)
Cell cortex GO:0005938
The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins.
1 P54654 (/IDA)
Postsynaptic density GO:0014069
An electron dense network of proteins within and adjacent to the postsynaptic membrane of an asymmetric, neuron-neuron synapse. Its major components include neurotransmitter receptors and the proteins that spatially and functionally organize them such as anchoring and scaffolding molecules, signaling enzymes and cytoskeletal components.
1 Q9CYT6 (/IDA)
Phagocytic vesicle membrane GO:0030670
The lipid bilayer surrounding a phagocytic vesicle.
1 P54654 (/IDA)
Cortical actin cytoskeleton GO:0030864
The portion of the actin cytoskeleton, comprising filamentous actin and associated proteins, that lies just beneath the plasma membrane.
1 P40124 (/IDA)
Extracellular matrix GO:0031012
A structure lying external to one or more cells, which provides structural support, biochemical or biomechanical cues for cells or tissues.
1 P54654 (/HDA)
Pseudopodium GO:0031143
A temporary protrusion or retractile process of a cell, associated with flowing movements of the protoplasm, and serving for locomotion and feeding.
1 P54654 (/IDA)
Vesicle GO:0031982
Any small, fluid-filled, spherical organelle enclosed by membrane.
1 P54654 (/IDA)
Azurophil granule lumen GO:0035578
The volume enclosed by the membrane of an azurophil granule, a primary lysosomal granule found in neutrophil granulocytes that contains a wide range of hydrolytic enzymes and is released into the extracellular fluid.
1 Q01518 (/TAS)
Growing cell tip GO:0035838
The region at either end of the longest axis of a cylindrical or elongated cell, where polarized growth occurs.
1 P36621 (/IDA)
Macropinosome GO:0044354
A membrane-bounded, uncoated intracellular vesicle formed by the process of macropinocytosis.
1 P54654 (/IDA)
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
1 Q01518 (/HDA)
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