The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:

"
Ankyrin repeat-containing domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 88: short transient receptor potential channel 1 isofo...

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 9 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
7 P48995 (/IPI) P48995 (/IPI) P48995 (/IPI) P48995 (/IPI) P48995 (/IPI) P48995 (/IPI) Q61056 (/IPI)
Cation channel activity GO:0005261
Enables the energy-independent passage of cations across a lipid bilayer down a concentration gradient.
6 P48995 (/EXP) P48995 (/EXP) P48995 (/EXP) P48995 (/EXP) P48995 (/EXP) P48995 (/EXP)
Calcium channel activity GO:0005262
Enables the facilitated diffusion of a calcium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism.
6 P48995 (/TAS) P48995 (/TAS) P48995 (/TAS) P48995 (/TAS) P48995 (/TAS) P48995 (/TAS)
Store-operated calcium channel activity GO:0015279
A ligand-gated ion channel activity which transports calcium in response to emptying of intracellular calcium stores.
6 P48995 (/TAS) P48995 (/TAS) P48995 (/TAS) P48995 (/TAS) P48995 (/TAS) P48995 (/TAS)
Inositol 1,4,5 trisphosphate binding GO:0070679
Interacting selectively and non-covalently with inositol 1,4,5 trisphosphate.
6 P48995 (/IDA) P48995 (/IDA) P48995 (/IDA) P48995 (/IDA) P48995 (/IDA) P48995 (/IDA)
Cation channel activity GO:0005261
Enables the energy-independent passage of cations across a lipid bilayer down a concentration gradient.
1 Q61056 (/ISO)
Store-operated calcium channel activity GO:0015279
A ligand-gated ion channel activity which transports calcium in response to emptying of intracellular calcium stores.
1 Q61056 (/IMP)
Ion channel binding GO:0044325
Interacting selectively and non-covalently with one or more specific sites on an ion channel, a protein complex that spans a membrane and forms a water-filled channel across the phospholipid bilayer allowing selective ion transport down its electrochemical gradient.
1 Q61056 (/ISO)
Inositol 1,4,5 trisphosphate binding GO:0070679
Interacting selectively and non-covalently with inositol 1,4,5 trisphosphate.
1 Q61056 (/ISO)

There are 12 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Calcium ion transport GO:0006816
The directed movement of calcium (Ca) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
6 P48995 (/TAS) P48995 (/TAS) P48995 (/TAS) P48995 (/TAS) P48995 (/TAS) P48995 (/TAS)
Melanin biosynthetic process GO:0042438
The chemical reactions and pathways resulting in the formation of melanins, pigments largely of animal origin. High molecular weight polymers of indole quinone, they are irregular polymeric structures and are divided into three groups: allomelanins in the plant kingdom and eumelanins and phaeomelanins in the animal kingdom.
6 P48995 (/IDA) P48995 (/IDA) P48995 (/IDA) P48995 (/IDA) P48995 (/IDA) P48995 (/IDA)
Positive regulation of release of sequestered calcium ion into cytosol GO:0051281
Any process that activates or increases the frequency, rate or extent of the release into the cytosolic compartment of calcium ions sequestered in the endoplasmic reticulum or mitochondria.
6 P48995 (/IDA) P48995 (/IDA) P48995 (/IDA) P48995 (/IDA) P48995 (/IDA) P48995 (/IDA)
Regulation of cytosolic calcium ion concentration GO:0051480
Any process involved in the maintenance of an internal steady state of calcium ions within the cytosol of a cell or between the cytosol and its surroundings.
6 P48995 (/IDA) P48995 (/IDA) P48995 (/IDA) P48995 (/IDA) P48995 (/IDA) P48995 (/IDA)
Response to calcium ion GO:0051592
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a calcium ion stimulus.
6 P48995 (/IDA) P48995 (/IDA) P48995 (/IDA) P48995 (/IDA) P48995 (/IDA) P48995 (/IDA)
Calcium ion transmembrane transport GO:0070588
A process in which a calcium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore.
6 P48995 (/TAS) P48995 (/TAS) P48995 (/TAS) P48995 (/TAS) P48995 (/TAS) P48995 (/TAS)
Regulation of cardiac conduction GO:1903779
Any process that modulates the frequency, rate or extent of cardiac conduction.
6 P48995 (/TAS) P48995 (/TAS) P48995 (/TAS) P48995 (/TAS) P48995 (/TAS) P48995 (/TAS)
Melanin biosynthetic process GO:0042438
The chemical reactions and pathways resulting in the formation of melanins, pigments largely of animal origin. High molecular weight polymers of indole quinone, they are irregular polymeric structures and are divided into three groups: allomelanins in the plant kingdom and eumelanins and phaeomelanins in the animal kingdom.
1 Q61056 (/ISO)
Saliva secretion GO:0046541
The regulated release of saliva from the salivary glands. In man, the saliva is a turbid and slightly viscous fluid, generally of an alkaline reaction, and is secreted by the parotid, submaxillary, and sublingual glands. In the mouth the saliva is mixed with the secretion from the buccal glands. In man and many animals, saliva is an important digestive fluid on account of the presence of the peculiar enzyme, ptyalin.
1 Q61056 (/IMP)
Positive regulation of release of sequestered calcium ion into cytosol GO:0051281
Any process that activates or increases the frequency, rate or extent of the release into the cytosolic compartment of calcium ions sequestered in the endoplasmic reticulum or mitochondria.
1 Q61056 (/ISO)
Regulation of cytosolic calcium ion concentration GO:0051480
Any process involved in the maintenance of an internal steady state of calcium ions within the cytosol of a cell or between the cytosol and its surroundings.
1 Q61056 (/ISO)
Response to calcium ion GO:0051592
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a calcium ion stimulus.
1 Q61056 (/ISO)

There are 13 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
7 P48995 (/TAS) P48995 (/TAS) P48995 (/TAS) P48995 (/TAS) P48995 (/TAS) P48995 (/TAS) Q9PRI8 (/TAS)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
6 P48995 (/IDA) P48995 (/IDA) P48995 (/IDA) P48995 (/IDA) P48995 (/IDA) P48995 (/IDA)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
6 P48995 (/NAS) P48995 (/NAS) P48995 (/NAS) P48995 (/NAS) P48995 (/NAS) P48995 (/NAS)
Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
6 P48995 (/TAS) P48995 (/TAS) P48995 (/TAS) P48995 (/TAS) P48995 (/TAS) P48995 (/TAS)
Receptor complex GO:0043235
Any protein complex that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function.
6 P48995 (/IDA) P48995 (/IDA) P48995 (/IDA) P48995 (/IDA) P48995 (/IDA) P48995 (/IDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 Q61056 (/IDA)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
1 Q61056 (/ISO)
Basolateral plasma membrane GO:0016323
The region of the plasma membrane that includes the basal end and sides of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis.
1 Q61056 (/IMP)
Sarcomere GO:0030017
The repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs.
1 Q61056 (/IDA)
Protein-containing complex GO:0032991
A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.
1 Q61056 (/IPI)
Costamere GO:0043034
Regular periodic sub membranous arrays of vinculin in skeletal and cardiac muscle cells, these arrays link Z-discs to the sarcolemma and are associated with links to extracellular matrix.
1 Q61056 (/IDA)
Receptor complex GO:0043235
Any protein complex that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function.
1 Q61056 (/ISO)
Membrane raft GO:0045121
Any of the small (10-200 nm), heterogeneous, highly dynamic, sterol- and sphingolipid-enriched membrane domains that compartmentalize cellular processes. Small rafts can sometimes be stabilized to form larger platforms through protein-protein and protein-lipid interactions.
1 Q61056 (/IDA)
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