The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:

"
Ankyrin repeat-containing domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 85: Notch-regulated ankyrin repeat-containing protein ...

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 0 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

There are 23 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Negative regulation of Notch signaling pathway GO:0045746
Any process that stops, prevents, or reduces the frequency, rate or extent of the Notch signaling pathway.
40 Q7Z6K4 (/IMP) Q7Z6K4 (/IMP) Q7Z6K4 (/IMP) Q7Z6K4 (/IMP) Q7Z6K4 (/IMP) Q7Z6K4 (/IMP) Q7Z6K4 (/IMP) Q7Z6K4 (/IMP) Q7Z6K4 (/IMP) Q7Z6K4 (/IMP)
(30 more)
Branching involved in blood vessel morphogenesis GO:0001569
The process of coordinated growth and sprouting of blood vessels giving rise to the organized vascular system.
25 Q7T3X9 (/IMP) Q7T3X9 (/IMP) Q7T3Y0 (/IMP) Q7T3Y0 (/IMP) Q7T3Y0 (/IMP) Q91ZA8 (/IMP) Q91ZA8 (/IMP) Q91ZA8 (/IMP) Q91ZA8 (/IMP) Q91ZA8 (/IMP)
(15 more)
Sprouting angiogenesis GO:0002040
The extension of new blood vessels from existing vessels into avascular tissues, this process includes the specialization of endothelial cells into leading tip and stalk cells, proliferation and migration of the endothelial cells and cell adhesion resulting in angiogenic sprout fusion or lumen formation.
25 Q7T3X9 (/IMP) Q7T3X9 (/IMP) Q7T3Y0 (/IMP) Q7T3Y0 (/IMP) Q7T3Y0 (/IMP) Q91ZA8 (/IMP) Q91ZA8 (/IMP) Q91ZA8 (/IMP) Q91ZA8 (/IMP) Q91ZA8 (/IMP)
(15 more)
Blood vessel endothelial cell proliferation involved in sprouting angiogenesis GO:0002043
The multiplication or reproduction of blood vessel endothelial cells, resulting in the expansion of a cell population contributing to sprouting angiogenesis.
25 Q7T3X9 (/IMP) Q7T3X9 (/IMP) Q7T3Y0 (/IMP) Q7T3Y0 (/IMP) Q7T3Y0 (/IMP) Q91ZA8 (/IMP) Q91ZA8 (/IMP) Q91ZA8 (/IMP) Q91ZA8 (/IMP) Q91ZA8 (/IMP)
(15 more)
Regulation of cell-cell adhesion GO:0022407
Any process that modulates the frequency, rate or extent of attachment of a cell to another cell.
25 Q7T3X9 (/IMP) Q7T3X9 (/IMP) Q7T3Y0 (/IMP) Q7T3Y0 (/IMP) Q7T3Y0 (/IMP) Q91ZA8 (/IMP) Q91ZA8 (/IMP) Q91ZA8 (/IMP) Q91ZA8 (/IMP) Q91ZA8 (/IMP)
(15 more)
Notch signaling pathway GO:0007219
A series of molecular signals initiated by the binding of an extracellular ligand to the receptor Notch on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription.
23 A4II29 (/ISS) Q5U5A6 (/ISS) Q5U5A6 (/ISS) Q91ZA8 (/ISS) Q91ZA8 (/ISS) Q91ZA8 (/ISS) Q91ZA8 (/ISS) Q91ZA8 (/ISS) Q91ZA8 (/ISS) Q91ZA8 (/ISS)
(13 more)
Negative regulation of transcription by RNA polymerase II GO:0000122
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
20 Q91ZA8 (/IGI) Q91ZA8 (/IGI) Q91ZA8 (/IGI) Q91ZA8 (/IGI) Q91ZA8 (/IGI) Q91ZA8 (/IGI) Q91ZA8 (/IGI) Q91ZA8 (/IGI) Q91ZA8 (/IGI) Q91ZA8 (/IGI)
(10 more)
Branching involved in blood vessel morphogenesis GO:0001569
The process of coordinated growth and sprouting of blood vessels giving rise to the organized vascular system.
20 Q91ZA8 (/ISS) Q91ZA8 (/ISS) Q91ZA8 (/ISS) Q91ZA8 (/ISS) Q91ZA8 (/ISS) Q91ZA8 (/ISS) Q91ZA8 (/ISS) Q91ZA8 (/ISS) Q91ZA8 (/ISS) Q91ZA8 (/ISS)
(10 more)
Positive regulation of endothelial cell proliferation GO:0001938
Any process that activates or increases the rate or extent of endothelial cell proliferation.
20 Q91ZA8 (/IMP) Q91ZA8 (/IMP) Q91ZA8 (/IMP) Q91ZA8 (/IMP) Q91ZA8 (/IMP) Q91ZA8 (/IMP) Q91ZA8 (/IMP) Q91ZA8 (/IMP) Q91ZA8 (/IMP) Q91ZA8 (/IMP)
(10 more)
Sprouting angiogenesis GO:0002040
The extension of new blood vessels from existing vessels into avascular tissues, this process includes the specialization of endothelial cells into leading tip and stalk cells, proliferation and migration of the endothelial cells and cell adhesion resulting in angiogenic sprout fusion or lumen formation.
20 Q91ZA8 (/ISS) Q91ZA8 (/ISS) Q91ZA8 (/ISS) Q91ZA8 (/ISS) Q91ZA8 (/ISS) Q91ZA8 (/ISS) Q91ZA8 (/ISS) Q91ZA8 (/ISS) Q91ZA8 (/ISS) Q91ZA8 (/ISS)
(10 more)
Notch signaling pathway GO:0007219
A series of molecular signals initiated by the binding of an extracellular ligand to the receptor Notch on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription.
20 Q7Z6K4 (/IDA) Q7Z6K4 (/IDA) Q7Z6K4 (/IDA) Q7Z6K4 (/IDA) Q7Z6K4 (/IDA) Q7Z6K4 (/IDA) Q7Z6K4 (/IDA) Q7Z6K4 (/IDA) Q7Z6K4 (/IDA) Q7Z6K4 (/IDA)
(10 more)
Notch signaling pathway GO:0007219
A series of molecular signals initiated by the binding of an extracellular ligand to the receptor Notch on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription.
20 Q91ZA8 (/ISO) Q91ZA8 (/ISO) Q91ZA8 (/ISO) Q91ZA8 (/ISO) Q91ZA8 (/ISO) Q91ZA8 (/ISO) Q91ZA8 (/ISO) Q91ZA8 (/ISO) Q91ZA8 (/ISO) Q91ZA8 (/ISO)
(10 more)
Regulation of cell-cell adhesion GO:0022407
Any process that modulates the frequency, rate or extent of attachment of a cell to another cell.
20 Q91ZA8 (/ISS) Q91ZA8 (/ISS) Q91ZA8 (/ISS) Q91ZA8 (/ISS) Q91ZA8 (/ISS) Q91ZA8 (/ISS) Q91ZA8 (/ISS) Q91ZA8 (/ISS) Q91ZA8 (/ISS) Q91ZA8 (/ISS)
(10 more)
Somite rostral/caudal axis specification GO:0032525
The establishment, maintenance and elaboration of the rostro-caudal axis of a somite, prior to the morphological formation of a somite boundary.
20 Q91ZA8 (/IMP) Q91ZA8 (/IMP) Q91ZA8 (/IMP) Q91ZA8 (/IMP) Q91ZA8 (/IMP) Q91ZA8 (/IMP) Q91ZA8 (/IMP) Q91ZA8 (/IMP) Q91ZA8 (/IMP) Q91ZA8 (/IMP)
(10 more)
Negative regulation of T cell differentiation GO:0045581
Any process that stops, prevents, or reduces the frequency, rate or extent of T cell differentiation.
20 Q91ZA8 (/IDA) Q91ZA8 (/IDA) Q91ZA8 (/IDA) Q91ZA8 (/IDA) Q91ZA8 (/IDA) Q91ZA8 (/IDA) Q91ZA8 (/IDA) Q91ZA8 (/IDA) Q91ZA8 (/IDA) Q91ZA8 (/IDA)
(10 more)
Negative regulation of Notch signaling pathway GO:0045746
Any process that stops, prevents, or reduces the frequency, rate or extent of the Notch signaling pathway.
20 Q91ZA8 (/IGI) Q91ZA8 (/IGI) Q91ZA8 (/IGI) Q91ZA8 (/IGI) Q91ZA8 (/IGI) Q91ZA8 (/IGI) Q91ZA8 (/IGI) Q91ZA8 (/IGI) Q91ZA8 (/IGI) Q91ZA8 (/IGI)
(10 more)
Negative regulation of Notch signaling pathway GO:0045746
Any process that stops, prevents, or reduces the frequency, rate or extent of the Notch signaling pathway.
20 Q91ZA8 (/ISO) Q91ZA8 (/ISO) Q91ZA8 (/ISO) Q91ZA8 (/ISO) Q91ZA8 (/ISO) Q91ZA8 (/ISO) Q91ZA8 (/ISO) Q91ZA8 (/ISO) Q91ZA8 (/ISO) Q91ZA8 (/ISO)
(10 more)
Positive regulation of canonical Wnt signaling pathway GO:0090263
Any process that increases the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes.
20 Q7Z6K4 (/IMP) Q7Z6K4 (/IMP) Q7Z6K4 (/IMP) Q7Z6K4 (/IMP) Q7Z6K4 (/IMP) Q7Z6K4 (/IMP) Q7Z6K4 (/IMP) Q7Z6K4 (/IMP) Q7Z6K4 (/IMP) Q7Z6K4 (/IMP)
(10 more)
Positive regulation of canonical Wnt signaling pathway GO:0090263
Any process that increases the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes.
20 Q91ZA8 (/ISO) Q91ZA8 (/ISO) Q91ZA8 (/ISO) Q91ZA8 (/ISO) Q91ZA8 (/ISO) Q91ZA8 (/ISO) Q91ZA8 (/ISO) Q91ZA8 (/ISO) Q91ZA8 (/ISO) Q91ZA8 (/ISO)
(10 more)
Negative regulation of Notch signaling pathway involved in somitogenesis GO:1902367
Any process that stops, prevents or reduces the frequency, rate or extent of Notch signaling pathway involved in somitogenesis.
20 Q91ZA8 (/IMP) Q91ZA8 (/IMP) Q91ZA8 (/IMP) Q91ZA8 (/IMP) Q91ZA8 (/IMP) Q91ZA8 (/IMP) Q91ZA8 (/IMP) Q91ZA8 (/IMP) Q91ZA8 (/IMP) Q91ZA8 (/IMP)
(10 more)
Sprouting angiogenesis GO:0002040
The extension of new blood vessels from existing vessels into avascular tissues, this process includes the specialization of endothelial cells into leading tip and stalk cells, proliferation and migration of the endothelial cells and cell adhesion resulting in angiogenic sprout fusion or lumen formation.
5 Q7T3X9 (/IGI) Q7T3X9 (/IGI) Q7T3Y0 (/IGI) Q7T3Y0 (/IGI) Q7T3Y0 (/IGI)
Neural crest cell migration GO:0001755
The characteristic movement of cells from the dorsal ridge of the neural tube to a variety of locations in a vertebrate embryo.
3 Q7T3Y0 (/IMP) Q7T3Y0 (/IMP) Q7T3Y0 (/IMP)
Pigment cell differentiation GO:0050931
The process in which a relatively unspecialized cell acquires the specialized features of a pigmented cell, such as a melanocyte.
3 Q7T3Y0 (/IMP) Q7T3Y0 (/IMP) Q7T3Y0 (/IMP)

There are 0 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
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