The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:
"Ankyrin repeat-containing domain
".
FunFam 145: NF-kappa-B inhibitor-like protein 1 isoform X1
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 1 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
2 | Q9UBC1 (/IPI) Q9UBC1 (/IPI) |
There are 17 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Negative regulation of lipopolysaccharide-mediated signaling pathway GO:0031665
Any process that stops, prevents, or reduces the frequency, rate or extent of signaling in response to detection of lipopolysaccharide.
|
11 |
O88995 (/ISS)
Q5TM19 (/ISS)
Q5TM19 (/ISS)
Q5TM19 (/ISS)
Q5TM19 (/ISS)
Q5TM19 (/ISS)
Q861W0 (/ISS)
Q861W0 (/ISS)
Q861W0 (/ISS)
Q8R2H1 (/ISS)
(1 more) |
Negative regulation of NF-kappaB transcription factor activity GO:0032088
Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of the transcription factor NF-kappaB.
|
11 |
O88995 (/ISS)
Q5TM19 (/ISS)
Q5TM19 (/ISS)
Q5TM19 (/ISS)
Q5TM19 (/ISS)
Q5TM19 (/ISS)
Q861W0 (/ISS)
Q861W0 (/ISS)
Q861W0 (/ISS)
Q8R2H1 (/ISS)
(1 more) |
Negative regulation of tumor necrosis factor production GO:0032720
Any process that stops, prevents, or reduces the frequency, rate, or extent of tumor necrosis factor production.
|
11 |
O88995 (/ISS)
Q5TM19 (/ISS)
Q5TM19 (/ISS)
Q5TM19 (/ISS)
Q5TM19 (/ISS)
Q5TM19 (/ISS)
Q861W0 (/ISS)
Q861W0 (/ISS)
Q861W0 (/ISS)
Q8R2H1 (/ISS)
(1 more) |
Negative regulation of toll-like receptor signaling pathway GO:0034122
Any process that stops, prevents, or reduces the frequency, rate, or extent of toll-like receptor signaling pathway.
|
11 |
O88995 (/ISS)
Q5TM19 (/ISS)
Q5TM19 (/ISS)
Q5TM19 (/ISS)
Q5TM19 (/ISS)
Q5TM19 (/ISS)
Q861W0 (/ISS)
Q861W0 (/ISS)
Q861W0 (/ISS)
Q8R2H1 (/ISS)
(1 more) |
Cellular response to lipopolysaccharide GO:0071222
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipopolysaccharide stimulus; lipopolysaccharide is a major component of the cell wall of gram-negative bacteria.
|
11 |
O88995 (/ISS)
Q5TM19 (/ISS)
Q5TM19 (/ISS)
Q5TM19 (/ISS)
Q5TM19 (/ISS)
Q5TM19 (/ISS)
Q861W0 (/ISS)
Q861W0 (/ISS)
Q861W0 (/ISS)
Q8R2H1 (/ISS)
(1 more) |
Negative regulation of lipopolysaccharide-mediated signaling pathway GO:0031665
Any process that stops, prevents, or reduces the frequency, rate or extent of signaling in response to detection of lipopolysaccharide.
|
2 | Q9UBC1 (/IDA) Q9UBC1 (/IDA) |
Negative regulation of NF-kappaB transcription factor activity GO:0032088
Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of the transcription factor NF-kappaB.
|
2 | Q9UBC1 (/IDA) Q9UBC1 (/IDA) |
Negative regulation of tumor necrosis factor production GO:0032720
Any process that stops, prevents, or reduces the frequency, rate, or extent of tumor necrosis factor production.
|
2 | Q9UBC1 (/IMP) Q9UBC1 (/IMP) |
Negative regulation of toll-like receptor signaling pathway GO:0034122
Any process that stops, prevents, or reduces the frequency, rate, or extent of toll-like receptor signaling pathway.
|
2 | Q9UBC1 (/IDA) Q9UBC1 (/IDA) |
Cytoplasmic sequestering of transcription factor GO:0042994
The selective interaction of a transcription factor with specific molecules in the cytoplasm, thereby inhibiting its translocation into the nucleus.
|
2 | Q9UBC1 (/TAS) Q9UBC1 (/TAS) |
Cellular response to lipopolysaccharide GO:0071222
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipopolysaccharide stimulus; lipopolysaccharide is a major component of the cell wall of gram-negative bacteria.
|
2 | Q9UBC1 (/IDA) Q9UBC1 (/IDA) |
I-kappaB kinase/NF-kappaB signaling GO:0007249
The process in which a signal is passed on to downstream components within the cell through the I-kappaB-kinase (IKK)-dependent activation of NF-kappaB. The cascade begins with activation of a trimeric IKK complex (consisting of catalytic kinase subunits IKKalpha and/or IKKbeta, and the regulatory scaffold protein NEMO) and ends with the regulation of transcription of target genes by NF-kappaB. In a resting state, NF-kappaB dimers are bound to I-kappaB proteins, sequestering NF-kappaB in the cytoplasm. Phosphorylation of I-kappaB targets I-kappaB for ubiquitination and proteasomal degradation, thus releasing the NF-kappaB dimers, which can translocate to the nucleus to bind DNA and regulate transcription.
|
1 | O88995 (/IDA) |
Negative regulation of lipopolysaccharide-mediated signaling pathway GO:0031665
Any process that stops, prevents, or reduces the frequency, rate or extent of signaling in response to detection of lipopolysaccharide.
|
1 | O88995 (/ISO) |
Negative regulation of NF-kappaB transcription factor activity GO:0032088
Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of the transcription factor NF-kappaB.
|
1 | O88995 (/ISO) |
Negative regulation of tumor necrosis factor production GO:0032720
Any process that stops, prevents, or reduces the frequency, rate, or extent of tumor necrosis factor production.
|
1 | O88995 (/ISO) |
Negative regulation of toll-like receptor signaling pathway GO:0034122
Any process that stops, prevents, or reduces the frequency, rate, or extent of toll-like receptor signaling pathway.
|
1 | O88995 (/ISO) |
Cellular response to lipopolysaccharide GO:0071222
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipopolysaccharide stimulus; lipopolysaccharide is a major component of the cell wall of gram-negative bacteria.
|
1 | O88995 (/ISO) |
There are 4 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
10 | Q5TM19 (/ISS) Q5TM19 (/ISS) Q5TM19 (/ISS) Q5TM19 (/ISS) Q5TM19 (/ISS) Q861W0 (/ISS) Q861W0 (/ISS) Q861W0 (/ISS) Q8R2H1 (/ISS) Q9TSV7 (/ISS) |
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
3 | O88995 (/IDA) Q9UBC1 (/IDA) Q9UBC1 (/IDA) |
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
1 | O88995 (/ISO) |
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
1 | O88995 (/IDA) |