Any process that stops, prevents or reduces the rate or extent of cell proliferation.

A cell aging process stimulated in response to cellular stress, whereby normal cells lose the ability to divide through irreversible cell cycle arrest.

A regulatory process that halts progression through the cell cycle during one of the normal phases (G1, S, G2, M).

Any process that stops, prevents or decreases the rate of addition of phosphate groups to a molecule.

Any signalling pathway that decreases or inhibits the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G1 phase to S phase of the mitotic cell cycle.

Any process that modulates the frequency, rate or extent of cyclin-dependent protein serine/threonine kinase activity.

Any process that modulates the frequency, rate or extent of cyclin-dependent protein serine/threonine kinase activity.

The mitotic cell cycle transition by which a cell in G2 commits to M phase. The process begins when the kinase activity of M cyclin/CDK complex reaches a threshold high enough for the cell cycle to proceed. This is accomplished by activating a positive feedback loop that results in the accumulation of unphosphorylated and active M cyclin/CDK complex.

A regulatory process that halts progression through the cell cycle during one of the normal phases (G1, S, G2, M).

A cell cycle checkpoint that ensures accurate chromosome replication and segregation by preventing progression through a mitotic cell cycle until conditions are suitable for the cell to proceed to the next stage.

Any process that stops, prevents or reduces the rate or extent of cell proliferation.

The process in which a myeloid precursor cell acquires specializes features of a megakaryocyte.

Any process that activates or increases the frequency, rate or extent of TGF-beta receptor signaling pathway activity.

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an extracellular stimulus.

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nutrient stimulus.

Any process that stops, prevents or decreases the rate of addition of phosphate groups to a molecule.

Any process that stops, prevents or reduces the rate or extent of epithelial cell proliferation.

The mitotic cell cycle transition by which a cell in G2 commits to M phase. The process begins when the kinase activity of M cyclin/CDK complex reaches a threshold high enough for the cell cycle to proceed. This is accomplished by activating a positive feedback loop that results in the accumulation of unphosphorylated and active M cyclin/CDK complex.

A cell cycle checkpoint that ensures accurate chromosome replication and segregation by preventing progression through a mitotic cell cycle until conditions are suitable for the cell to proceed to the next stage.

The process in which a myeloid precursor cell acquires specializes features of a megakaryocyte.

Any process that activates or increases the frequency, rate or extent of TGF-beta receptor signaling pathway activity.

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an extracellular stimulus.

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nutrient stimulus.

Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.

Any process that stops, prevents or reduces the rate or extent of epithelial cell proliferation.

A regulatory process that halts progression through the cell cycle during one of the normal phases (G1, S, G2, M).

A regulatory process that halts progression through the cell cycle during one of the normal phases (G1, S, G2, M).

Any process that stops, prevents or reduces the rate or extent of cell proliferation.

Any process that stops, prevents or decreases the rate of addition of phosphate groups to a molecule.

Any process that stops, prevents, or reduces the frequency, rate or extent of cyclin-dependent protein serine/threonine kinase activity.

A cell aging process stimulated in response to cellular stress, whereby normal cells lose the ability to divide through irreversible cell cycle arrest.

Any process that modulates the frequency, rate or extent of cyclin-dependent protein serine/threonine kinase activity.

The mitotic cell cycle transition by which a cell in G1 commits to S phase. The process begins with the build up of G1 cyclin-dependent kinase (G1 CDK), resulting in the activation of transcription of G1 cyclins. The process ends with the positive feedback of the G1 cyclins on the G1 CDK which commits the cell to S phase, in which DNA replication is initiated.

The mitotic cell cycle transition by which a cell in G2 commits to M phase. The process begins when the kinase activity of M cyclin/CDK complex reaches a threshold high enough for the cell cycle to proceed. This is accomplished by activating a positive feedback loop that results in the accumulation of unphosphorylated and active M cyclin/CDK complex.

Any process that stops, prevents, or reduces the rate or extent of cell adhesion to the extracellular matrix.

A cell cycle checkpoint that ensures accurate chromosome replication and segregation by preventing progression through a mitotic cell cycle until conditions are suitable for the cell to proceed to the next stage.

A series of molecular signals within the cell that are mediated by a member of the Ras superfamily of proteins switching to a GTP-bound active state.

A developmental process that is a deterioration and loss of function over time. Aging includes loss of functions such as resistance to disease, homeostasis, and fertility, as well as wear and tear. Aging includes cellular senescence, but is more inclusive. May precede death and may succeed developmental maturation (GO:0021700).

Any process that stops, prevents or reduces the rate or extent of cell proliferation.

Any process that stops, prevents, or reduces the frequency, rate, extent or direction of cell growth.

Any process that activates or increases the frequency, rate or extent of TGF-beta receptor signaling pathway activity.

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an extracellular stimulus.

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nutrient stimulus.

Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of the transcription factor NF-kappaB.

Any process that activates or increases the frequency, rate, or extent of smooth muscle cell apoptotic process.

The assembly of chromatin into senescence-associated heterochromatin foci (SAHF), transcriptionally-silent heterochromatin structures present in senescent cells, containing the condensed chromatin of one chromosome, and enriched for histone modifications. Formation of these chromatin structures is thought to repress expression of proliferation-promoting genes.

Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.

The process whose specific outcome is the progression of the spleen over time, from its formation to the mature structure. The spleen is a large vascular lymphatic organ composed of white and red pulp, involved both in hemopoietic and immune system functions.

Any process that stops, prevents or reduces the rate or extent of epithelial cell proliferation.

Any process that stops or decreases the rate or extent of glial cell proliferation.

A cell aging process associated with the dismantling of a cell as a response to telomere shortening and/or cellular aging.

Any signalling pathway that decreases or inhibits the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G1 phase to S phase of the cell cycle.

Any process that activates or increases the frequency, rate or extent of macrophage apoptotic process.

Any signalling pathway that decreases or inhibits the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G1 phase to S phase of the mitotic cell cycle.

Any process that activates or increases the frequency, rate or extent of cellular senescence.

The mitotic cell cycle transition by which a cell in G1 commits to S phase. The process begins with the build up of G1 cyclin-dependent kinase (G1 CDK), resulting in the activation of transcription of G1 cyclins. The process ends with the positive feedback of the G1 cyclins on the G1 CDK which commits the cell to S phase, in which DNA replication is initiated.

Addition of multiple ubiquitin groups to a protein, forming a ubiquitin chain.

The autophagic process in which mitochondria are delivered to the vacuole and degraded in response to changing cellular conditions.

The process whose specific outcome is the progression of the liver over time, from its formation to the mature structure. The liver is an exocrine gland which secretes bile and functions in metabolism of protein and carbohydrate and fat, synthesizes substances involved in the clotting of the blood, synthesizes vitamin A, detoxifies poisonous substances, stores glycogen, and breaks down worn-out erythrocytes.

Any process that stops, prevents, or reduces the rate or extent of cell adhesion to the extracellular matrix.

Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.

Any process that stops, prevents, or reduces the frequency, rate or extent of protein kinase activity.

Any process that initiates the activity of the inactive enzyme cysteine-type endopeptidase in the context of an apoptotic process.

A developmental process that is a deterioration and loss of function over time. Aging includes loss of functions such as resistance to disease, homeostasis, and fertility, as well as wear and tear. Aging includes cellular senescence, but is more inclusive. May precede death and may succeed developmental maturation (GO:0021700).

An aging process that has as participant a cell after a cell has stopped dividing. Cell aging may occur when a cell has temporarily stopped dividing through cell cycle arrest (GO:0007050) or when a cell has permanently stopped dividing, in which case it is undergoing cellular senescence (GO:0090398). May precede cell death (GO:0008219) and succeed cell maturation (GO:0048469).

The process whose specific outcome is the progression of the epidermis over time, from its formation to the mature structure. The epidermis is the outer epithelial layer of an animal, it may be a single layer that produces an extracellular material (e.g. the cuticle of arthropods) or a complex stratified squamous epithelium, as in the case of many vertebrate species.

The morphological and physiological alterations undergone by mitochondria during apoptosis.

The synthesis of ribosomal RNA (rRNA), any RNA that forms part of the ribosomal structure, from a DNA template.

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating an increase or decrease in the concentration of salt (particularly but not exclusively sodium and chloride ions) in the environment.

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic substance stimulus.

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organonitrogen stimulus. An organonitrogen compound is formally a compound containing at least one carbon-nitrogen bond.

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organonitrogen stimulus. An organonitrogen compound is formally a compound containing at least one carbon-nitrogen bond.

Any signalling pathway that modulates the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G2 phase to M phase of the mitotic cell cycle.

Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.

Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic cyclic compound stimulus.

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic cyclic compound stimulus.

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic cyclic compound stimulus.

The process whose specific outcome is the progression of the cerebellum over time, from its formation to the mature structure. The cerebellum is the portion of the brain in the back of the head between the cerebrum and the pons. In mice, the cerebellum controls balance for walking and standing, modulates the force and range of movement and is involved in the learning of motor skills.

Generation of cells within the nervous system.

Any process that stops, prevents, or reduces the frequency, rate, extent or direction of cell growth.

Any process that activates or increases the frequency, rate or extent of epithelial cell differentiation.

Any process that decreases the stability of a protein, making it more vulnerable to degradative processes or aggregation.

Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of the transcription factor NF-kappaB.

Any process that stops, prevents, or reduces the frequency, rate or extent of protein binding.

Any process that activates or increases the frequency, rate or extent of the addition of SUMO groups to a protein.

Any process that stops, prevents or reduces the rate or extent of mammary gland epithelial cell proliferation.

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cytokine stimulus.

Any process that activates or increases the frequency, rate, or extent of smooth muscle cell apoptotic process.

Any process by which an organism retains a population of somatic stem cells, undifferentiated cells in the embryo or adult which can undergo unlimited division and give rise to cell types of the body other than those of the germ-line.

The assembly of chromatin into senescence-associated heterochromatin foci (SAHF), transcriptionally-silent heterochromatin structures present in senescent cells, containing the condensed chromatin of one chromosome, and enriched for histone modifications. Formation of these chromatin structures is thought to repress expression of proliferation-promoting genes.

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a drug stimulus. A drug is a substance used in the diagnosis, treatment or prevention of a disease.

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a drug stimulus. A drug is a substance used in the diagnosis, treatment or prevention of a disease.

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a drug stimulus. A drug is a substance used in the diagnosis, treatment or prevention of a disease.

Any process involved in the maintenance of an internal steady state of glucose within an organism or cell.

Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process.

Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process.

Any process that activates, maintains or increases the rate of the cascade of processes induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, in response to the detection of DNA damage.

Any process that stops, prevents, or reduces the frequency, rate or extent of cyclin-dependent protein serine/threonine kinase activity.

Any process that stops, prevents or reduces the rate or extent of progression through the cell cycle.

Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.

Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.

Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.

Any process that modulates the frequency, rate or extent of the directed movement of substances between the nucleus and the cytoplasm.

Any process that modulates the frequency, rate or extent of the directed movement of proteins from the nucleus to the cytoplasm.

Any process involved in maintaining the structure and integrity of a protein and preventing it from degradation or aggregation.

The process in which the potential difference across the mitochondrial membrane is reduced from its steady state level.

Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process of mammary epithelial cells during mammary gland involution.

Any process that stops or decreases the rate or extent of glial cell proliferation.

A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a caloric restriction, insufficient food energy intake.

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydrogen peroxide (H2O2) stimulus.

A protein ubiquitination process in which a polymer of ubiquitin, formed by linkages between lysine residues at position 63 of the ubiquitin monomers, is added to a protein. K63-linked ubiquitination does not target the substrate protein for degradation, but is involved in several pathways, notably as a signal to promote error-free DNA postreplication repair.

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a fatty acid stimulus.

Any process that increases the rate, frequency, or extent of cell cycle arrest, the process in which the cell cycle is halted during one of the normal phases.

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucose stimulus.

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a transforming growth factor beta stimulus.

A cell aging process stimulated in response to cellular stress, whereby normal cells lose the ability to divide through irreversible cell cycle arrest.

A cell aging process associated with the dismantling of a cell as a response to telomere shortening and/or cellular aging.

Any process that activates or increases the frequency, rate or extent of protein localization to nucleus.

Any process that activates or increases the frequency, rate or extent of signal transduction by p53 class mediator.

Any process that modulates the frequency, rate or extent of apoptotic DNA fragmentation.

Any signalling pathway that decreases or inhibits the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G1 phase to S phase of the cell cycle.

Any process that stops, prevents or reduces the frequency, rate or extent of proteolysis involved in cellular protein catabolic process.

Any process that stops, prevents or reduces the frequency, rate or extent of proteolysis involved in cellular protein catabolic process.

Any process that modulates the frequency, rate or extent of protein targeting to mitochondrion.

Any process that stops, prevents or reduces the frequency, rate or extent of ubiquitin protein ligase activity.

The generation of amyloid fibrils, insoluble fibrous protein aggregates exhibiting beta sheet structure, from proteins.

Any process that stops, prevents, or reduces the frequency, rate or extent of ubiquitin-dependent protein catabolic process

Any process that stops, prevents, or reduces the frequency, rate or extent of ubiquitin-dependent protein catabolic process

Any process that activates or increases the frequency, rate or extent of macrophage apoptotic process.

Any process that stops, prevents or reduces the frequency, rate or extent of hepatocyte proliferation.

Any process that stops, prevents or reduces the frequency, rate or extent of hepatocyte proliferation.

Any process that stops, prevents or reduces the frequency, rate or extent of protein neddylation.

Any process that activates or increases the frequency, rate or extent of cellular senescence.

A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.

A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

A transcriptionally-silent heterochromatin structure present in senescent cells. Contains the condensed chromatin of one chromosome and is enriched for histone modifications. Thought to repress expression of proliferation-promoting genes.

That part of the nuclear content other than the chromosomes or the nucleolus.

That part of the nuclear content other than the chromosomes or the nucleolus.

A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.

A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.

A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.

A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.

A transcriptionally-silent heterochromatin structure present in senescent cells. Contains the condensed chromatin of one chromosome and is enriched for histone modifications. Thought to repress expression of proliferation-promoting genes.