The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:

"
Leucine-rich Repeat Variant
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 57: Exportin-2 isoform 1

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 6 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
20 P33307 (/IPI) P33307 (/IPI) P33307 (/IPI) P33307 (/IPI) P33307 (/IPI) P55060 (/IPI) P55060 (/IPI) P55060 (/IPI) P55060 (/IPI) P55060 (/IPI)
(10 more)
Nuclear export signal receptor activity GO:0005049
Combining with a nuclear export signal (NES) on a cargo to be transported, to mediate transport of a the cargo through the nuclear pore, from the nuclear lumen to the cytoplasm. The cargo can be either a RNA or a protein.
13 P55060 (/TAS) P55060 (/TAS) P55060 (/TAS) P55060 (/TAS) P55060 (/TAS) P55060 (/TAS) P55060 (/TAS) P55060 (/TAS) P55060 (/TAS) P55060 (/TAS)
(3 more)
Nuclear export signal receptor activity GO:0005049
Combining with a nuclear export signal (NES) on a cargo to be transported, to mediate transport of a the cargo through the nuclear pore, from the nuclear lumen to the cytoplasm. The cargo can be either a RNA or a protein.
5 P33307 (/IGI) P33307 (/IGI) P33307 (/IGI) P33307 (/IGI) P33307 (/IGI)
Nuclear export signal receptor activity GO:0005049
Combining with a nuclear export signal (NES) on a cargo to be transported, to mediate transport of a the cargo through the nuclear pore, from the nuclear lumen to the cytoplasm. The cargo can be either a RNA or a protein.
5 P33307 (/IPI) P33307 (/IPI) P33307 (/IPI) P33307 (/IPI) P33307 (/IPI)
Nuclear export signal receptor activity GO:0005049
Combining with a nuclear export signal (NES) on a cargo to be transported, to mediate transport of a the cargo through the nuclear pore, from the nuclear lumen to the cytoplasm. The cargo can be either a RNA or a protein.
1 O13671 (/ISO)
GTP binding GO:0005525
Interacting selectively and non-covalently with GTP, guanosine triphosphate.
1 O13671 (/NAS)

There are 6 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein export from nucleus GO:0006611
The directed movement of a protein from the nucleus into the cytoplasm.
5 P33307 (/IGI) P33307 (/IGI) P33307 (/IGI) P33307 (/IGI) P33307 (/IGI)
Protein export from nucleus GO:0006611
The directed movement of a protein from the nucleus into the cytoplasm.
5 P33307 (/IPI) P33307 (/IPI) P33307 (/IPI) P33307 (/IPI) P33307 (/IPI)
Positive regulation of protein export from nucleus GO:0046827
Any process that activates or increases the frequency, rate or extent of directed movement of proteins from the nucleus into the cytoplasm.
5 P33307 (/IMP) P33307 (/IMP) P33307 (/IMP) P33307 (/IMP) P33307 (/IMP)
Protein export from nucleus GO:0006611
The directed movement of a protein from the nucleus into the cytoplasm.
1 Q9XZU1 (/IMP)
Protein export from nucleus GO:0006611
The directed movement of a protein from the nucleus into the cytoplasm.
1 O13671 (/ISO)
Body fluid secretion GO:0007589
The controlled release of a fluid by a cell or tissue in an animal.
1 Q7SZC2 (/IMP)

There are 18 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
14 P55060 (/IDA) P55060 (/IDA) P55060 (/IDA) P55060 (/IDA) P55060 (/IDA) P55060 (/IDA) P55060 (/IDA) P55060 (/IDA) P55060 (/IDA) P55060 (/IDA)
(4 more)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
13 P55060 (/TAS) P55060 (/TAS) P55060 (/TAS) P55060 (/TAS) P55060 (/TAS) P55060 (/TAS) P55060 (/TAS) P55060 (/TAS) P55060 (/TAS) P55060 (/TAS)
(3 more)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
13 P55060 (/IDA) P55060 (/IDA) P55060 (/IDA) P55060 (/IDA) P55060 (/IDA) P55060 (/IDA) P55060 (/IDA) P55060 (/IDA) P55060 (/IDA) P55060 (/IDA)
(3 more)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
13 P55060 (/TAS) P55060 (/TAS) P55060 (/TAS) P55060 (/TAS) P55060 (/TAS) P55060 (/TAS) P55060 (/TAS) P55060 (/TAS) P55060 (/TAS) P55060 (/TAS)
(3 more)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
13 P55060 (/HDA) P55060 (/HDA) P55060 (/HDA) P55060 (/HDA) P55060 (/HDA) P55060 (/HDA) P55060 (/HDA) P55060 (/HDA) P55060 (/HDA) P55060 (/HDA)
(3 more)
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
13 P55060 (/HDA) P55060 (/HDA) P55060 (/HDA) P55060 (/HDA) P55060 (/HDA) P55060 (/HDA) P55060 (/HDA) P55060 (/HDA) P55060 (/HDA) P55060 (/HDA)
(3 more)
Nuclear envelope GO:0005635
The double lipid bilayer enclosing the nucleus and separating its contents from the rest of the cytoplasm; includes the intermembrane space, a gap of width 20-40 nm (also called the perinuclear space).
5 P33307 (/IDA) P33307 (/IDA) P33307 (/IDA) P33307 (/IDA) P33307 (/IDA)
Protein-containing complex GO:0032991
A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.
5 P33307 (/IDA) P33307 (/IDA) P33307 (/IDA) P33307 (/IDA) P33307 (/IDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
3 Q5AYN9 (/IDA) Q5AYN9 (/IDA) Q5AYN9 (/IDA)
Nuclear envelope GO:0005635
The double lipid bilayer enclosing the nucleus and separating its contents from the rest of the cytoplasm; includes the intermembrane space, a gap of width 20-40 nm (also called the perinuclear space).
2 O13671 (/HDA) Q9XZU1 (/HDA)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
1 Q9XZU1 (/HDA)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
1 Q9ERK4 (/ISO)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 Q9XZU1 (/HDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 Q9ERK4 (/ISO)
Plasmodesma GO:0009506
A fine cytoplasmic channel, found in all higher plants, that connects the cytoplasm of one cell to that of an adjacent cell.
1 Q9ZPY7 (/IDA)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
1 Q9ZPY7 (/IDA)
Nuclear membrane GO:0031965
Either of the lipid bilayers that surround the nucleus and form the nuclear envelope; excludes the intermembrane space.
1 O13671 (/HDA)
Nuclear periphery GO:0034399
The portion of the nuclear lumen proximal to the inner nuclear membrane.
1 O13671 (/IDA)
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