The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:
"Leucine-rich Repeat Variant
".
FunFam 55: AP-3 complex subunit delta
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 2 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
1 | B5DFK6 (/IPI) |
Cargo adaptor activity GO:0140312
Binding directly to the structural scaffolding elements of a vesicle coat (such as clathrin or COPII), and bridging the membrane, cargo, and membrane deformation machinery.
|
1 | P54362 (/ISS) |
There are 43 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Intracellular protein transport GO:0006886
The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell.
|
2 | O14617 (/TAS) O54774 (/TAS) |
Anterograde axonal transport GO:0008089
The directed movement of organelles or molecules along microtubules from the cell body toward the cell periphery in nerve cell axons.
|
2 | O14617 (/ISS) Q865S1 (/ISS) |
Synaptic vesicle budding from endosome GO:0016182
Budding of synaptic vesicles during the formation of constitutive recycling vesicles from early endosomes.
|
2 | B5DFK6 (/IDA) O54774 (/IDA) |
Synaptic vesicle budding from endosome GO:0016182
Budding of synaptic vesicles during the formation of constitutive recycling vesicles from early endosomes.
|
2 | B5DFK6 (/IMP) O54774 (/IMP) |
Anterograde synaptic vesicle transport GO:0048490
The directed movement of synaptic vesicle along axonal microtubules from the cell body to the presynapse.
|
2 | O14617 (/ISS) Q865S1 (/ISS) |
Eye pigment biosynthetic process GO:0006726
The chemical reactions and pathways resulting in the formation of eye pigments, any general or particular coloring matter in living organisms, found or utilized in the eye.
|
1 | P54362 (/IDA) |
Eye pigment biosynthetic process GO:0006726
The chemical reactions and pathways resulting in the formation of eye pigments, any general or particular coloring matter in living organisms, found or utilized in the eye.
|
1 | P54362 (/IEP) |
Eye pigment biosynthetic process GO:0006726
The chemical reactions and pathways resulting in the formation of eye pigments, any general or particular coloring matter in living organisms, found or utilized in the eye.
|
1 | P54362 (/IMP) |
Ommochrome biosynthetic process GO:0006727
The chemical reactions and pathways resulting in the formation of ommochromes, any of a large group of natural polycyclic pigments commonly found in the Arthropoda, particularly in the ommatidia of the compound eye.
|
1 | P54362 (/IMP) |
Zinc ion transport GO:0006829
The directed movement of zinc (Zn II) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
|
1 | O54774 (/TAS) |
Intracellular protein transport GO:0006886
The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell.
|
1 | O54774 (/IMP) |
Exocytosis GO:0006887
A process of secretion by a cell that results in the release of intracellular molecules (e.g. hormones, matrix proteins) contained within a membrane-bounded vesicle. Exocytosis can occur either by full fusion, when the vesicle collapses into the plasma membrane, or by a kiss-and-run mechanism that involves the formation of a transient contact, a pore, between a granule (for exemple of chromaffin cells) and the plasma membrane. The latter process most of the time leads to only partial secretion of the granule content. Exocytosis begins with steps that prepare vesicles for fusion with the membrane (tethering and docking) and ends when molecules are secreted from the cell.
|
1 | P54362 (/IMP) |
Golgi to endosome transport GO:0006895
The directed movement of substances from the Golgi to early sorting endosomes. Clathrin vesicles transport substances from the trans-Golgi to endosomes.
|
1 | P54362 (/NAS) |
Endocytosis GO:0006897
A vesicle-mediated transport process in which cells take up external materials or membrane constituents by the invagination of a small region of the plasma membrane to form a new membrane-bounded vesicle.
|
1 | P54362 (/IMP) |
Lysosomal transport GO:0007041
The directed movement of substances into, out of or within a lysosome.
|
1 | P54362 (/TAS) |
Notch receptor processing GO:0007220
The series of successive proteolytic cleavages of the Notch protein, which result in an active form of the receptor.
|
1 | P54362 (/IMP) |
Ocellus pigment biosynthetic process GO:0008055
The chemical reactions and pathways resulting in the formation of ocellus pigments, any general or particular coloring matter in living organisms, found or utilized in the ocellus, a minute simple eye found in many invertebrates.
|
1 | P54362 (/IDA) |
Eye pigment granule organization GO:0008057
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of intracellular pigment storage granules in the eye.
|
1 | P54362 (/IMP) |
Anterograde axonal transport GO:0008089
The directed movement of organelles or molecules along microtubules from the cell body toward the cell periphery in nerve cell axons.
|
1 | O54774 (/IMP) |
Determination of adult lifespan GO:0008340
The control of viability and duration in the adult phase of the life-cycle.
|
1 | P54362 (/IMP) |
Synaptic vesicle budding from endosome GO:0016182
Budding of synaptic vesicles during the formation of constitutive recycling vesicles from early endosomes.
|
1 | O54774 (/ISO) |
Vesicle-mediated transport GO:0016192
A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane.
|
1 | O54774 (/TAS) |
Antigen processing and presentation GO:0019882
The process in which an antigen-presenting cell expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex.
|
1 | O54774 (/IMP) |
Melanosome organization GO:0032438
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a melanosome. A melanosome is a tissue-specific, membrane-bounded cytoplasmic organelle within which melanin pigments are synthesized and stored.
|
1 | O14617 (/IC) |
Protein localization to organelle GO:0033365
A process in which a protein is transported to, or maintained in, a location within an organelle.
|
1 | O54774 (/IMP) |
Endosome to melanosome transport GO:0035646
The directed movement of substances from endosomes to the melanosome, a specialised lysosome-related organelle.
|
1 | O14617 (/IMP) |
Endosome to melanosome transport GO:0035646
The directed movement of substances from endosomes to the melanosome, a specialised lysosome-related organelle.
|
1 | O54774 (/ISO) |
Intracellular transport GO:0046907
The directed movement of substances within a cell.
|
1 | P54362 (/TAS) |
Antigen processing and presentation, exogenous lipid antigen via MHC class Ib GO:0048007
The process in which an antigen-presenting cell expresses lipid antigen of exogenous origin in association with an MHC class Ib protein complex on its cell surface. Class Ib here refers to non-classical class I molecules, such as those of the CD1 family.
|
1 | O54774 (/IMP) |
Compound eye pigmentation GO:0048072
Establishment of a pattern of pigment in the compound eye.
|
1 | P54362 (/IGI) |
Anterograde synaptic vesicle transport GO:0048490
The directed movement of synaptic vesicle along axonal microtubules from the cell body to the presynapse.
|
1 | O54774 (/IMP) |
Synaptic vesicle membrane organization GO:0048499
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the membrane surrounding a synaptic vesicle.
|
1 | O54774 (/IMP) |
Positive regulation of NK T cell differentiation GO:0051138
Any process that activates or increases the frequency, rate or extent of natural killer T cell differentiation.
|
1 | O54774 (/IMP) |
Negative regulation of gene silencing by RNA GO:0060967
Any process that decreases the rate, frequency, or extent of gene silencing by RNA. Gene silencing by RNA is the process in which RNA molecules inactivate expression of target genes.
|
1 | P54362 (/IMP) |
Regulation of sequestering of zinc ion GO:0061088
Any process that modulates the rate, frequency, or extent of sequestering of zinc ion. Sequestering of zinc ion is the process of binding or confining zinc ions such that they are separated from other components of a biological system.
|
1 | O14617 (/IMP) |
Regulation of sequestering of zinc ion GO:0061088
Any process that modulates the rate, frequency, or extent of sequestering of zinc ion. Sequestering of zinc ion is the process of binding or confining zinc ions such that they are separated from other components of a biological system.
|
1 | O54774 (/ISO) |
Regulation of sequestering of zinc ion GO:0061088
Any process that modulates the rate, frequency, or extent of sequestering of zinc ion. Sequestering of zinc ion is the process of binding or confining zinc ions such that they are separated from other components of a biological system.
|
1 | O54774 (/TAS) |
Protein localization to membrane GO:0072657
A process in which a protein is transported to, or maintained in, a specific location in a membrane.
|
1 | O14617 (/IMP) |
Protein localization to membrane GO:0072657
A process in which a protein is transported to, or maintained in, a specific location in a membrane.
|
1 | O54774 (/ISO) |
Neurotransmitter receptor transport, postsynaptic endosome to lysosome GO:0098943
The directed movement of neurotransmitter receptor from the postsynaptic endosome in tranpsort vesicles to the lysosome for degradation.
|
1 | O54774 (/IDA) |
Neurotransmitter receptor transport, postsynaptic endosome to lysosome GO:0098943
The directed movement of neurotransmitter receptor from the postsynaptic endosome in tranpsort vesicles to the lysosome for degradation.
|
1 | O54774 (/IMP) |
Vesicle-mediated transport in synapse GO:0099003
Any vesicle-mediated transport that occurs in a synapse
|
1 | O54774 (/IDA) |
Vesicle-mediated transport in synapse GO:0099003
Any vesicle-mediated transport that occurs in a synapse
|
1 | O54774 (/IMP) |
There are 19 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Lysosomal membrane GO:0005765
The lipid bilayer surrounding the lysosome and separating its contents from the cell cytoplasm.
|
2 | O14617 (/HDA) Q6PK82 (/HDA) |
Endosome membrane GO:0010008
The lipid bilayer surrounding an endosome.
|
2 | O14617 (/IDA) O54774 (/IDA) |
Late endosome GO:0005770
A prelysosomal endocytic organelle differentiated from early endosomes by lower lumenal pH and different protein composition. Late endosomes are more spherical than early endosomes and are mostly juxtanuclear, being concentrated near the microtubule organizing center.
|
1 | P54362 (/IDA) |
Endoplasmic reticulum GO:0005783
The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
|
1 | P54362 (/IDA) |
Golgi apparatus GO:0005794
A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions.
|
1 | O14617 (/TAS) |
Golgi stack GO:0005795
The set of thin, flattened membrane-bounded compartments, called cisternae, that form the central portion of the Golgi complex. The stack usually comprises cis, medial, and trans cisternae; the cis- and trans-Golgi networks are not considered part of the stack.
|
1 | P54362 (/IDA) |
Golgi-associated vesicle GO:0005798
Any vesicle associated with the Golgi complex and involved in mediating transport within the Golgi or between the Golgi and other parts of the cell.
|
1 | P54362 (/NAS) |
Trans-Golgi network GO:0005802
The network of interconnected tubular and cisternal structures located within the Golgi apparatus on the side distal to the endoplasmic reticulum, from which secretory vesicles emerge. The trans-Golgi network is important in the later stages of protein secretion where it is thought to play a key role in the sorting and targeting of secreted proteins to the correct destination.
|
1 | O54774 (/TAS) |
Endosome membrane GO:0010008
The lipid bilayer surrounding an endosome.
|
1 | O54774 (/ISO) |
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
|
1 | O14617 (/HDA) |
AP-3 adaptor complex GO:0030123
A heterotetrameric AP-type membrane coat adaptor complex that consists of beta3, delta, mu3 and sigma3 subunits and is found associated with endosomal membranes. AP-3 does not appear to associate with clathrin in all organisms. In at least humans, the AP-3 complex can be heterogeneric due to the existence of multiple subunit isoforms encoded by different genes (beta3A and beta3B, mu3A and mu3B, and sigma3A and sigma3B).
|
1 | Q54WN0 (/IDA) |
AP-3 adaptor complex GO:0030123
A heterotetrameric AP-type membrane coat adaptor complex that consists of beta3, delta, mu3 and sigma3 subunits and is found associated with endosomal membranes. AP-3 does not appear to associate with clathrin in all organisms. In at least humans, the AP-3 complex can be heterogeneric due to the existence of multiple subunit isoforms encoded by different genes (beta3A and beta3B, mu3A and mu3B, and sigma3A and sigma3B).
|
1 | P54362 (/NAS) |
Axon GO:0030424
The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter.
|
1 | O54774 (/IDA) |
Terminal bouton GO:0043195
Terminal inflated portion of the axon, containing the specialized apparatus necessary to release neurotransmitters. The axon terminus is considered to be the whole region of thickening and the terminal bouton is a specialized region of it.
|
1 | O54774 (/IDA) |
Presynapse GO:0098793
The part of a synapse that is part of the presynaptic cell.
|
1 | O54774 (/IDA) |
Postsynapse GO:0098794
The part of a synapse that is part of the post-synaptic cell.
|
1 | O54774 (/IDA) |
Presynaptic endosome GO:0098830
An endosome present in the presynapse that fuses with endocytic vesicles arising in the presynaptic endocytic zone. This organelle is believed to be involved in regeneration of synaptic vesicles.
|
1 | O54774 (/IDA) |
Glutamatergic synapse GO:0098978
A synapse that uses glutamate as a neurotransmitter.
|
1 | O54774 (/IDA) |
Glutamatergic synapse GO:0098978
A synapse that uses glutamate as a neurotransmitter.
|
1 | O54774 (/IMP) |