The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:

"
Leucine-rich Repeat Variant
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 29: Transportin-1 isoform 1

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 4 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
33 O14787 (/IPI) O14787 (/IPI) O14787 (/IPI) O14787 (/IPI) O14787 (/IPI) O14787 (/IPI) O14787 (/IPI) O14787 (/IPI) O14787 (/IPI) O14787 (/IPI)
(23 more)
Nuclear localization sequence binding GO:0008139
Interacting selectively and non-covalently with a nuclear localization sequence, a specific peptide sequence that acts as a signal to localize the protein within the nucleus.
30 O14787 (/TAS) O14787 (/TAS) O14787 (/TAS) O14787 (/TAS) O14787 (/TAS) O14787 (/TAS) O14787 (/TAS) O14787 (/TAS) O14787 (/TAS) O14787 (/TAS)
(20 more)
RNA binding GO:0003723
Interacting selectively and non-covalently with an RNA molecule or a portion thereof.
20 Q92973 (/HDA) Q92973 (/HDA) Q92973 (/HDA) Q92973 (/HDA) Q92973 (/HDA) Q92973 (/HDA) Q92973 (/HDA) Q92973 (/HDA) Q92973 (/HDA) Q92973 (/HDA)
(10 more)
Nuclear localization sequence binding GO:0008139
Interacting selectively and non-covalently with a nuclear localization sequence, a specific peptide sequence that acts as a signal to localize the protein within the nucleus.
4 O76331 (/ISS) Q86PD5 (/ISS) Q8SX88 (/ISS) Q9VRV8 (/ISS)

There are 9 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein import into nucleus GO:0006606
The directed movement of a protein from the cytoplasm to the nucleus.
20 Q92973 (/IDA) Q92973 (/IDA) Q92973 (/IDA) Q92973 (/IDA) Q92973 (/IDA) Q92973 (/IDA) Q92973 (/IDA) Q92973 (/IDA) Q92973 (/IDA) Q92973 (/IDA)
(10 more)
Intraciliary transport involved in cilium assembly GO:0035735
The bidirectional movement of large protein complexes along microtubules within a cilium that contributes to cilium assembly.
20 Q92973 (/TAS) Q92973 (/TAS) Q92973 (/TAS) Q92973 (/TAS) Q92973 (/TAS) Q92973 (/TAS) Q92973 (/TAS) Q92973 (/TAS) Q92973 (/TAS) Q92973 (/TAS)
(10 more)
Regulation of mRNA stability GO:0043488
Any process that modulates the propensity of mRNA molecules to degradation. Includes processes that both stabilize and destabilize mRNAs.
20 Q92973 (/TAS) Q92973 (/TAS) Q92973 (/TAS) Q92973 (/TAS) Q92973 (/TAS) Q92973 (/TAS) Q92973 (/TAS) Q92973 (/TAS) Q92973 (/TAS) Q92973 (/TAS)
(10 more)
Protein import into nucleus GO:0006606
The directed movement of a protein from the cytoplasm to the nucleus.
4 O76331 (/ISS) Q86PD5 (/ISS) Q8SX88 (/ISS) Q9VRV8 (/ISS)
Larval lymph gland hemopoiesis GO:0035167
The production of blood cells from the larval lymph gland. The lymph gland consists of three to six bilaterally paired lobes that are attached to the cardioblasts during larval stages, and it degenerates during pupal stages.
4 O76331 (/IMP) Q86PD5 (/IMP) Q8SX88 (/IMP) Q9VRV8 (/IMP)
Regulation of protein import into nucleus GO:0042306
Any process that modulates the frequency, rate or extent of movement of proteins from the cytoplasm to the nucleus.
4 O76331 (/IMP) Q86PD5 (/IMP) Q8SX88 (/IMP) Q9VRV8 (/IMP)
Protein import into nucleus GO:0006606
The directed movement of a protein from the cytoplasm to the nucleus.
2 Q8BFY9 (/ISO) Q8BFY9 (/ISO)
Smoothened signaling pathway GO:0007224
A series of molecular signals generated as a consequence of activation of the transmembrane protein Smoothened.
1 F1RDR1 (/IMP)
Somite development GO:0061053
The progression of a somite from its initial formation to the mature structure. Somites are mesodermal clusters that are arranged segmentally along the anterior posterior axis of an embryo.
1 F1RDR1 (/IMP)

There are 6 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
30 O14787 (/TAS) O14787 (/TAS) O14787 (/TAS) O14787 (/TAS) O14787 (/TAS) O14787 (/TAS) O14787 (/TAS) O14787 (/TAS) O14787 (/TAS) O14787 (/TAS)
(20 more)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
30 O14787 (/TAS) O14787 (/TAS) O14787 (/TAS) O14787 (/TAS) O14787 (/TAS) O14787 (/TAS) O14787 (/TAS) O14787 (/TAS) O14787 (/TAS) O14787 (/TAS)
(20 more)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
20 Q92973 (/TAS) Q92973 (/TAS) Q92973 (/TAS) Q92973 (/TAS) Q92973 (/TAS) Q92973 (/TAS) Q92973 (/TAS) Q92973 (/TAS) Q92973 (/TAS) Q92973 (/TAS)
(10 more)
Cilium GO:0005929
A specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface and of some cytoplasmic parts. Each cilium is largely bounded by an extrusion of the cytoplasmic (plasma) membrane, and contains a regular longitudinal array of microtubules, anchored to a basal body.
20 Q92973 (/TAS) Q92973 (/TAS) Q92973 (/TAS) Q92973 (/TAS) Q92973 (/TAS) Q92973 (/TAS) Q92973 (/TAS) Q92973 (/TAS) Q92973 (/TAS) Q92973 (/TAS)
(10 more)
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
20 Q92973 (/HDA) Q92973 (/HDA) Q92973 (/HDA) Q92973 (/HDA) Q92973 (/HDA) Q92973 (/HDA) Q92973 (/HDA) Q92973 (/HDA) Q92973 (/HDA) Q92973 (/HDA)
(10 more)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
4 O76331 (/ISS) Q86PD5 (/ISS) Q8SX88 (/ISS) Q9VRV8 (/ISS)
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