The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:
"Leucine-rich Repeat Variant
".
FunFam 15: Catenin beta-1
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 77 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
RNA polymerase II transcription factor binding GO:0001085
Interacting selectively and non-covalently with an RNA polymerase II transcription factor, any protein required to initiate or regulate transcription by RNA polymerase II.
|
115 |
B1MV73 (/ISS)
B1MV73 (/ISS)
B1MV73 (/ISS)
B1MV73 (/ISS)
B1MV73 (/ISS)
B1MV73 (/ISS)
B1MV73 (/ISS)
B1MV73 (/ISS)
B1MV73 (/ISS)
B1MV73 (/ISS)
(105 more) |
|
Transcription coactivator activity GO:0003713
A protein or a member of a complex that interacts specifically and non-covalently with a DNA-bound DNA-binding transcription factor to activate the transcription of specific genes. Coactivators often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second ATP-dependent class modifies the conformation of chromatin. Another type of coregulator activity is the bridging of a DNA-binding transcription factor to the basal transcription machinery. The Mediator complex, which bridges transcription factors and RNA polymerase, is also a transcription coactivator.
|
115 |
B1MV73 (/ISS)
B1MV73 (/ISS)
B1MV73 (/ISS)
B1MV73 (/ISS)
B1MV73 (/ISS)
B1MV73 (/ISS)
B1MV73 (/ISS)
B1MV73 (/ISS)
B1MV73 (/ISS)
B1MV73 (/ISS)
(105 more) |
|
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
93 |
B6V8E6 (/IPI)
B6V8E6 (/IPI)
B6V8E6 (/IPI)
B6V8E6 (/IPI)
B6V8E6 (/IPI)
B6V8E6 (/IPI)
B6V8E6 (/IPI)
B6V8E6 (/IPI)
B6V8E6 (/IPI)
B6V8E6 (/IPI)
(83 more) |
|
Transcription coactivator activity GO:0003713
A protein or a member of a complex that interacts specifically and non-covalently with a DNA-bound DNA-binding transcription factor to activate the transcription of specific genes. Coactivators often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second ATP-dependent class modifies the conformation of chromatin. Another type of coregulator activity is the bridging of a DNA-binding transcription factor to the basal transcription machinery. The Mediator complex, which bridges transcription factors and RNA polymerase, is also a transcription coactivator.
|
39 |
P14923 (/IDA)
P14923 (/IDA)
P14923 (/IDA)
P14923 (/IDA)
P14923 (/IDA)
P14923 (/IDA)
P18824 (/IDA)
P18824 (/IDA)
P18824 (/IDA)
P35222 (/IDA)
(29 more) |
|
Alpha-catenin binding GO:0045294
Interacting selectively and non-covalently with the alpha subunit of the catenin complex.
|
37 |
P14923 (/IPI)
P14923 (/IPI)
P14923 (/IPI)
P14923 (/IPI)
P14923 (/IPI)
P14923 (/IPI)
P35222 (/IPI)
P35222 (/IPI)
P35222 (/IPI)
P35222 (/IPI)
(27 more) |
|
Cadherin binding GO:0045296
Interacting selectively and non-covalently with cadherin, a type I membrane protein involved in cell adhesion.
|
37 |
P14923 (/IPI)
P14923 (/IPI)
P14923 (/IPI)
P14923 (/IPI)
P14923 (/IPI)
P14923 (/IPI)
P35222 (/IPI)
P35222 (/IPI)
P35222 (/IPI)
P35222 (/IPI)
(27 more) |
|
Protein phosphatase binding GO:0019903
Interacting selectively and non-covalently with any protein phosphatase.
|
36 |
P14923 (/IPI)
P14923 (/IPI)
P14923 (/IPI)
P14923 (/IPI)
P14923 (/IPI)
P14923 (/IPI)
P35222 (/IPI)
P35222 (/IPI)
P35222 (/IPI)
P35222 (/IPI)
(26 more) |
|
Cadherin binding GO:0045296
Interacting selectively and non-covalently with cadherin, a type I membrane protein involved in cell adhesion.
|
31 |
P14923 (/HDA)
P14923 (/HDA)
P14923 (/HDA)
P14923 (/HDA)
P14923 (/HDA)
P14923 (/HDA)
P35222 (/HDA)
P35222 (/HDA)
P35222 (/HDA)
P35222 (/HDA)
(21 more) |
|
RNA polymerase II transcription factor binding GO:0001085
Interacting selectively and non-covalently with an RNA polymerase II transcription factor, any protein required to initiate or regulate transcription by RNA polymerase II.
|
30 |
P35222 (/IDA)
P35222 (/IDA)
P35222 (/IDA)
P35222 (/IDA)
P35222 (/IDA)
P35222 (/IDA)
P35222 (/IDA)
P35222 (/IDA)
P35222 (/IDA)
P35222 (/IDA)
(20 more) |
|
Transcription coactivator activity GO:0003713
A protein or a member of a complex that interacts specifically and non-covalently with a DNA-bound DNA-binding transcription factor to activate the transcription of specific genes. Coactivators often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second ATP-dependent class modifies the conformation of chromatin. Another type of coregulator activity is the bridging of a DNA-binding transcription factor to the basal transcription machinery. The Mediator complex, which bridges transcription factors and RNA polymerase, is also a transcription coactivator.
|
30 |
P35222 (/IMP)
P35222 (/IMP)
P35222 (/IMP)
P35222 (/IMP)
P35222 (/IMP)
P35222 (/IMP)
P35222 (/IMP)
P35222 (/IMP)
P35222 (/IMP)
P35222 (/IMP)
(20 more) |
|
Transcription factor binding GO:0008134
Interacting selectively and non-covalently with a transcription factor, a protein required to initiate or regulate transcription.
|
30 |
P35222 (/IPI)
P35222 (/IPI)
P35222 (/IPI)
P35222 (/IPI)
P35222 (/IPI)
P35222 (/IPI)
P35222 (/IPI)
P35222 (/IPI)
P35222 (/IPI)
P35222 (/IPI)
(20 more) |
|
Enzyme binding GO:0019899
Interacting selectively and non-covalently with any enzyme.
|
30 |
P35222 (/IPI)
P35222 (/IPI)
P35222 (/IPI)
P35222 (/IPI)
P35222 (/IPI)
P35222 (/IPI)
P35222 (/IPI)
P35222 (/IPI)
P35222 (/IPI)
P35222 (/IPI)
(20 more) |
|
Nuclear hormone receptor binding GO:0035257
Interacting selectively and non-covalently with a nuclear hormone receptor, a ligand-dependent receptor found in the nucleus of the cell.
|
30 |
P35222 (/IPI)
P35222 (/IPI)
P35222 (/IPI)
P35222 (/IPI)
P35222 (/IPI)
P35222 (/IPI)
P35222 (/IPI)
P35222 (/IPI)
P35222 (/IPI)
P35222 (/IPI)
(20 more) |
|
Kinase binding GO:0019900
Interacting selectively and non-covalently with a kinase, any enzyme that catalyzes the transfer of a phosphate group.
|
28 |
P18824 (/IPI)
P18824 (/IPI)
P18824 (/IPI)
P35222 (/IPI)
P35222 (/IPI)
P35222 (/IPI)
P35222 (/IPI)
P35222 (/IPI)
P35222 (/IPI)
P35222 (/IPI)
(18 more) |
|
Protein C-terminus binding GO:0008022
Interacting selectively and non-covalently with a protein C-terminus, the end of any peptide chain at which the 1-carboxyl function of a constituent amino acid is not attached in peptide linkage to another amino-acid residue.
|
27 |
O42486 (/IPI)
O42486 (/IPI)
P35222 (/IPI)
P35222 (/IPI)
P35222 (/IPI)
P35222 (/IPI)
P35222 (/IPI)
P35222 (/IPI)
P35222 (/IPI)
P35222 (/IPI)
(17 more) |
|
RNA polymerase II transcription factor binding GO:0001085
Interacting selectively and non-covalently with an RNA polymerase II transcription factor, any protein required to initiate or regulate transcription by RNA polymerase II.
|
25 |
P35222 (/IPI)
P35222 (/IPI)
P35222 (/IPI)
P35222 (/IPI)
P35222 (/IPI)
P35222 (/IPI)
P35222 (/IPI)
P35222 (/IPI)
P35222 (/IPI)
P35222 (/IPI)
(15 more) |
|
RNA polymerase II activating transcription factor binding GO:0001102
Interacting selectively and non-covalently with an RNA polymerase II transcription activating factor, a protein involved in positive regulation of transcription.
|
25 |
P35222 (/IPI)
P35222 (/IPI)
P35222 (/IPI)
P35222 (/IPI)
P35222 (/IPI)
P35222 (/IPI)
P35222 (/IPI)
P35222 (/IPI)
P35222 (/IPI)
P35222 (/IPI)
(15 more) |
|
Chromatin binding GO:0003682
Interacting selectively and non-covalently with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase.
|
25 |
P35222 (/ISS)
P35222 (/ISS)
P35222 (/ISS)
P35222 (/ISS)
P35222 (/ISS)
P35222 (/ISS)
P35222 (/ISS)
P35222 (/ISS)
P35222 (/ISS)
P35222 (/ISS)
(15 more) |
|
Transcription factor binding GO:0008134
Interacting selectively and non-covalently with a transcription factor, a protein required to initiate or regulate transcription.
|
25 |
P35222 (/TAS)
P35222 (/TAS)
P35222 (/TAS)
P35222 (/TAS)
P35222 (/TAS)
P35222 (/TAS)
P35222 (/TAS)
P35222 (/TAS)
P35222 (/TAS)
P35222 (/TAS)
(15 more) |
|
Estrogen receptor binding GO:0030331
Interacting selectively and non-covalently with an estrogen receptor.
|
25 |
P35222 (/IPI)
P35222 (/IPI)
P35222 (/IPI)
P35222 (/IPI)
P35222 (/IPI)
P35222 (/IPI)
P35222 (/IPI)
P35222 (/IPI)
P35222 (/IPI)
P35222 (/IPI)
(15 more) |
|
Nuclear hormone receptor binding GO:0035257
Interacting selectively and non-covalently with a nuclear hormone receptor, a ligand-dependent receptor found in the nucleus of the cell.
|
25 |
P35222 (/TAS)
P35222 (/TAS)
P35222 (/TAS)
P35222 (/TAS)
P35222 (/TAS)
P35222 (/TAS)
P35222 (/TAS)
P35222 (/TAS)
P35222 (/TAS)
P35222 (/TAS)
(15 more) |
|
Ion channel binding GO:0044325
Interacting selectively and non-covalently with one or more specific sites on an ion channel, a protein complex that spans a membrane and forms a water-filled channel across the phospholipid bilayer allowing selective ion transport down its electrochemical gradient.
|
25 |
P35222 (/IPI)
P35222 (/IPI)
P35222 (/IPI)
P35222 (/IPI)
P35222 (/IPI)
P35222 (/IPI)
P35222 (/IPI)
P35222 (/IPI)
P35222 (/IPI)
P35222 (/IPI)
(15 more) |
|
SMAD binding GO:0046332
Interacting selectively and non-covalently with a SMAD signaling protein.
|
25 |
P35222 (/IPI)
P35222 (/IPI)
P35222 (/IPI)
P35222 (/IPI)
P35222 (/IPI)
P35222 (/IPI)
P35222 (/IPI)
P35222 (/IPI)
P35222 (/IPI)
P35222 (/IPI)
(15 more) |
|
Androgen receptor binding GO:0050681
Interacting selectively and non-covalently with an androgen receptor.
|
25 |
P35222 (/NAS)
P35222 (/NAS)
P35222 (/NAS)
P35222 (/NAS)
P35222 (/NAS)
P35222 (/NAS)
P35222 (/NAS)
P35222 (/NAS)
P35222 (/NAS)
P35222 (/NAS)
(15 more) |
|
I-SMAD binding GO:0070411
Interacting selectively and non-covalently with an inhibitory SMAD signaling protein.
|
25 |
P35222 (/IPI)
P35222 (/IPI)
P35222 (/IPI)
P35222 (/IPI)
P35222 (/IPI)
P35222 (/IPI)
P35222 (/IPI)
P35222 (/IPI)
P35222 (/IPI)
P35222 (/IPI)
(15 more) |
|
Transcription coactivator activity GO:0003713
A protein or a member of a complex that interacts specifically and non-covalently with a DNA-bound DNA-binding transcription factor to activate the transcription of specific genes. Coactivators often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second ATP-dependent class modifies the conformation of chromatin. Another type of coregulator activity is the bridging of a DNA-binding transcription factor to the basal transcription machinery. The Mediator complex, which bridges transcription factors and RNA polymerase, is also a transcription coactivator.
|
6 | Q02248 (/ISO) Q02248 (/ISO) Q02248 (/ISO) Q02248 (/ISO) Q02248 (/ISO) Q02257 (/ISO) |
|
Structural molecule activity GO:0005198
The action of a molecule that contributes to the structural integrity of a complex or its assembly within or outside a cell.
|
6 | P14923 (/NAS) P14923 (/NAS) P14923 (/NAS) P14923 (/NAS) P14923 (/NAS) P14923 (/NAS) |
|
Structural constituent of cell wall GO:0005199
The action of a molecule that contributes to the structural integrity of a cell wall.
|
6 | P14923 (/IC) P14923 (/IC) P14923 (/IC) P14923 (/IC) P14923 (/IC) P14923 (/IC) |
|
Protein kinase binding GO:0019901
Interacting selectively and non-covalently with a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate.
|
6 | Q02248 (/IPI) Q02248 (/IPI) Q02248 (/IPI) Q02248 (/IPI) Q02248 (/IPI) Q6P0K8 (/IPI) |
|
Protein phosphatase binding GO:0019903
Interacting selectively and non-covalently with any protein phosphatase.
|
6 | Q02248 (/ISO) Q02248 (/ISO) Q02248 (/ISO) Q02248 (/ISO) Q02248 (/ISO) Q02257 (/ISO) |
|
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
|
6 | P14923 (/ISS) P14923 (/ISS) P14923 (/ISS) P14923 (/ISS) P14923 (/ISS) P14923 (/ISS) |
|
Alpha-catenin binding GO:0045294
Interacting selectively and non-covalently with the alpha subunit of the catenin complex.
|
6 | Q02248 (/ISO) Q02248 (/ISO) Q02248 (/ISO) Q02248 (/ISO) Q02248 (/ISO) Q02257 (/ISO) |
|
Cadherin binding GO:0045296
Interacting selectively and non-covalently with cadherin, a type I membrane protein involved in cell adhesion.
|
6 | Q02248 (/ISO) Q02248 (/ISO) Q02248 (/ISO) Q02248 (/ISO) Q02248 (/ISO) Q02257 (/ISO) |
|
Cell adhesion molecule binding GO:0050839
Interacting selectively and non-covalently with a cell adhesion molecule.
|
6 | P14923 (/IPI) P14923 (/IPI) P14923 (/IPI) P14923 (/IPI) P14923 (/IPI) P14923 (/IPI) |
|
Cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication GO:0086083
Interacting selectively and non-covalently with any protein or protein complex that results in the connection of a bundle of His cell with a Purkinje myocyte and contributes to the communication between the two cells.
|
6 | P14923 (/IC) P14923 (/IC) P14923 (/IC) P14923 (/IC) P14923 (/IC) P14923 (/IC) |
|
RNA polymerase II transcription factor binding GO:0001085
Interacting selectively and non-covalently with an RNA polymerase II transcription factor, any protein required to initiate or regulate transcription by RNA polymerase II.
|
5 | Q02248 (/ISO) Q02248 (/ISO) Q02248 (/ISO) Q02248 (/ISO) Q02248 (/ISO) |
|
RNA polymerase II activating transcription factor binding GO:0001102
Interacting selectively and non-covalently with an RNA polymerase II transcription activating factor, a protein involved in positive regulation of transcription.
|
5 | Q02248 (/ISO) Q02248 (/ISO) Q02248 (/ISO) Q02248 (/ISO) Q02248 (/ISO) |
|
Chromatin binding GO:0003682
Interacting selectively and non-covalently with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase.
|
5 | Q02248 (/IDA) Q02248 (/IDA) Q02248 (/IDA) Q02248 (/IDA) Q02248 (/IDA) |
|
Chromatin binding GO:0003682
Interacting selectively and non-covalently with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase.
|
5 | Q02248 (/IGI) Q02248 (/IGI) Q02248 (/IGI) Q02248 (/IGI) Q02248 (/IGI) |
|
DNA-binding transcription factor activity GO:0003700
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
|
5 | Q02248 (/IDA) Q02248 (/IDA) Q02248 (/IDA) Q02248 (/IDA) Q02248 (/IDA) |
|
Protein C-terminus binding GO:0008022
Interacting selectively and non-covalently with a protein C-terminus, the end of any peptide chain at which the 1-carboxyl function of a constituent amino acid is not attached in peptide linkage to another amino-acid residue.
|
5 | Q02248 (/ISO) Q02248 (/ISO) Q02248 (/ISO) Q02248 (/ISO) Q02248 (/ISO) |
|
Transcription factor binding GO:0008134
Interacting selectively and non-covalently with a transcription factor, a protein required to initiate or regulate transcription.
|
5 | Q02248 (/ISO) Q02248 (/ISO) Q02248 (/ISO) Q02248 (/ISO) Q02248 (/ISO) |
|
Enzyme binding GO:0019899
Interacting selectively and non-covalently with any enzyme.
|
5 | Q02248 (/ISO) Q02248 (/ISO) Q02248 (/ISO) Q02248 (/ISO) Q02248 (/ISO) |
|
Kinase binding GO:0019900
Interacting selectively and non-covalently with a kinase, any enzyme that catalyzes the transfer of a phosphate group.
|
5 | Q02248 (/ISO) Q02248 (/ISO) Q02248 (/ISO) Q02248 (/ISO) Q02248 (/ISO) |
|
Estrogen receptor binding GO:0030331
Interacting selectively and non-covalently with an estrogen receptor.
|
5 | Q02248 (/ISO) Q02248 (/ISO) Q02248 (/ISO) Q02248 (/ISO) Q02248 (/ISO) |
|
Ionotropic glutamate receptor binding GO:0035255
Interacting selectively and non-covalently with an ionotropic glutamate receptor. Ionotropic glutamate receptors bind glutamate and exert an effect through the regulation of ion channels.
|
5 | Q02248 (/ISO) Q02248 (/ISO) Q02248 (/ISO) Q02248 (/ISO) Q02248 (/ISO) |
|
Nuclear hormone receptor binding GO:0035257
Interacting selectively and non-covalently with a nuclear hormone receptor, a ligand-dependent receptor found in the nucleus of the cell.
|
5 | Q02248 (/ISO) Q02248 (/ISO) Q02248 (/ISO) Q02248 (/ISO) Q02248 (/ISO) |
|
Ion channel binding GO:0044325
Interacting selectively and non-covalently with one or more specific sites on an ion channel, a protein complex that spans a membrane and forms a water-filled channel across the phospholipid bilayer allowing selective ion transport down its electrochemical gradient.
|
5 | Q02248 (/ISO) Q02248 (/ISO) Q02248 (/ISO) Q02248 (/ISO) Q02248 (/ISO) |
|
Protein-containing complex binding GO:0044877
Interacting selectively and non-covalently with a macromolecular complex.
|
5 | Q02248 (/ISO) Q02248 (/ISO) Q02248 (/ISO) Q02248 (/ISO) Q02248 (/ISO) |
|
Alpha-catenin binding GO:0045294
Interacting selectively and non-covalently with the alpha subunit of the catenin complex.
|
5 | Q02248 (/IDA) Q02248 (/IDA) Q02248 (/IDA) Q02248 (/IDA) Q02248 (/IDA) |
|
SMAD binding GO:0046332
Interacting selectively and non-covalently with a SMAD signaling protein.
|
5 | Q02248 (/ISO) Q02248 (/ISO) Q02248 (/ISO) Q02248 (/ISO) Q02248 (/ISO) |
|
Protein heterodimerization activity GO:0046982
Interacting selectively and non-covalently with a nonidentical protein to form a heterodimer.
|
5 | Q02248 (/IDA) Q02248 (/IDA) Q02248 (/IDA) Q02248 (/IDA) Q02248 (/IDA) |
|
Nitric-oxide synthase binding GO:0050998
Interacting selectively and non-covalently with the enzyme nitric-oxide synthase.
|
5 | Q02248 (/ISO) Q02248 (/ISO) Q02248 (/ISO) Q02248 (/ISO) Q02248 (/ISO) |
|
I-SMAD binding GO:0070411
Interacting selectively and non-covalently with an inhibitory SMAD signaling protein.
|
5 | Q02248 (/ISO) Q02248 (/ISO) Q02248 (/ISO) Q02248 (/ISO) Q02248 (/ISO) |
|
Repressing transcription factor binding GO:0070491
Interacting selectively and non-covalently with a transcription repressor, any protein whose activity is required to prevent or downregulate transcription.
|
5 | Q02248 (/IPI) Q02248 (/IPI) Q02248 (/IPI) Q02248 (/IPI) Q02248 (/IPI) |
|
Disordered domain specific binding GO:0097718
Interacting selectively and non-covalently with a disordered domain of a protein.
|
5 | Q02248 (/IPI) Q02248 (/IPI) Q02248 (/IPI) Q02248 (/IPI) Q02248 (/IPI) |
|
Histone methyltransferase binding GO:1990226
Interacting selectively and non-covalently with a histone methyltransferase enzyme.
|
5 | Q02248 (/NAS) Q02248 (/NAS) Q02248 (/NAS) Q02248 (/NAS) Q02248 (/NAS) |
|
Transcription coactivator activity GO:0003713
A protein or a member of a complex that interacts specifically and non-covalently with a DNA-bound DNA-binding transcription factor to activate the transcription of specific genes. Coactivators often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second ATP-dependent class modifies the conformation of chromatin. Another type of coregulator activity is the bridging of a DNA-binding transcription factor to the basal transcription machinery. The Mediator complex, which bridges transcription factors and RNA polymerase, is also a transcription coactivator.
|
3 | P18824 (/IPI) P18824 (/IPI) P18824 (/IPI) |
|
Transcription factor binding GO:0008134
Interacting selectively and non-covalently with a transcription factor, a protein required to initiate or regulate transcription.
|
3 | P18824 (/IDA) P18824 (/IDA) P18824 (/IDA) |
|
Cadherin binding GO:0045296
Interacting selectively and non-covalently with cadherin, a type I membrane protein involved in cell adhesion.
|
3 | A1A5I6 (/IDA) F1QGH7 (/IDA) Q9WU82 (/IDA) |
|
Transcription coregulator activity GO:0003712
A protein or a member of a complex that interacts specifically and non-covalently with a DNA-bound DNA-binding transcription factor to either activate or repress the transcription of specific genes. Coregulators often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second ATP-dependent class modifies the conformation of chromatin. A third class modulates interactions of DNA-binding transcription factor with other transcription coregulators.
|
2 | O42486 (/IDA) O42486 (/IDA) |
|
Transcription factor binding GO:0008134
Interacting selectively and non-covalently with a transcription factor, a protein required to initiate or regulate transcription.
|
2 | Q17GS9 (/ISS) Q29I35 (/ISS) |
|
Nuclear receptor transcription coactivator activity GO:0030374
The function of a transcription cofactor that activates transcription in conjuction with a ligand-dependent nuclear receptor from a RNA polymerase II promoter; does not bind DNA itself.
|
2 | O42486 (/IDA) O42486 (/IDA) |
|
Sequence-specific DNA binding GO:0043565
Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.
|
2 | O42486 (/IDA) O42486 (/IDA) |
|
Transcription regulatory region DNA binding GO:0044212
Interacting selectively and non-covalently with a DNA region that regulates the transcription of a region of DNA, which may be a gene, cistron, or operon. Binding may occur as a sequence specific interaction or as an interaction observed only once a factor has been recruited to the DNA by other factors.
|
2 | O42486 (/IDA) O42486 (/IDA) |
|
Cadherin binding GO:0045296
Interacting selectively and non-covalently with cadherin, a type I membrane protein involved in cell adhesion.
|
2 | Q17GS9 (/ISS) Q29I35 (/ISS) |
|
Cadherin binding GO:0045296
Interacting selectively and non-covalently with cadherin, a type I membrane protein involved in cell adhesion.
|
2 | O42486 (/NAS) O42486 (/NAS) |
|
Protein N-terminus binding GO:0047485
Interacting selectively and non-covalently with a protein N-terminus, the end of any peptide chain at which the 2-amino (or 2-imino) function of a constituent amino acid is not attached in peptide linkage to another amino-acid residue.
|
2 | O42486 (/IPI) O42486 (/IPI) |
|
Extracellular matrix binding GO:0050840
Interacting selectively and non-covalently with a component of the extracellular matrix.
|
2 | O42486 (/IDA) O42486 (/IDA) |
|
Structural molecule activity GO:0005198
The action of a molecule that contributes to the structural integrity of a complex or its assembly within or outside a cell.
|
1 | Q6P0K8 (/IDA) |
|
Structural molecule activity GO:0005198
The action of a molecule that contributes to the structural integrity of a complex or its assembly within or outside a cell.
|
1 | Q02257 (/ISO) |
|
Protein kinase binding GO:0019901
Interacting selectively and non-covalently with a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate.
|
1 | Q02257 (/ISO) |
|
Ionotropic glutamate receptor binding GO:0035255
Interacting selectively and non-covalently with an ionotropic glutamate receptor. Ionotropic glutamate receptors bind glutamate and exert an effect through the regulation of ion channels.
|
1 | Q9WU82 (/IPI) |
|
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
|
1 | Q8SPJ1 (/IPI) |
|
Protein-containing complex binding GO:0044877
Interacting selectively and non-covalently with a macromolecular complex.
|
1 | Q9WU82 (/IPI) |
|
Cell adhesion molecule binding GO:0050839
Interacting selectively and non-covalently with a cell adhesion molecule.
|
1 | Q02257 (/ISO) |
|
Nitric-oxide synthase binding GO:0050998
Interacting selectively and non-covalently with the enzyme nitric-oxide synthase.
|
1 | Q9WU82 (/IPI) |
There are 411 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
|
145 |
B1MV73 (/ISS)
B1MV73 (/ISS)
B1MV73 (/ISS)
B1MV73 (/ISS)
B1MV73 (/ISS)
B1MV73 (/ISS)
B1MV73 (/ISS)
B1MV73 (/ISS)
B1MV73 (/ISS)
B1MV73 (/ISS)
(135 more) |
|
Cell adhesion GO:0007155
The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules.
|
120 |
B1MV73 (/ISS)
B1MV73 (/ISS)
B1MV73 (/ISS)
B1MV73 (/ISS)
B1MV73 (/ISS)
B1MV73 (/ISS)
B1MV73 (/ISS)
B1MV73 (/ISS)
B1MV73 (/ISS)
B1MV73 (/ISS)
(110 more) |
|
Negative regulation of cell population proliferation GO:0008285
Any process that stops, prevents or reduces the rate or extent of cell proliferation.
|
120 |
B1MV73 (/ISS)
B1MV73 (/ISS)
B1MV73 (/ISS)
B1MV73 (/ISS)
B1MV73 (/ISS)
B1MV73 (/ISS)
B1MV73 (/ISS)
B1MV73 (/ISS)
B1MV73 (/ISS)
B1MV73 (/ISS)
(110 more) |
|
Positive regulation of heparan sulfate proteoglycan biosynthetic process GO:0010909
Any process that increases the rate, frequency or extent of heparan sulfate proteoglycan biosynthesis. Heparan sulfate proteoglycan biosynthetic processes are the chemical reactions and pathways resulting in the formation of the heparan sulfate proteoglycan, a glycosaminoglycan with repeat unit consisting of alternating alpha-(1->4)-linked hexuronic acid and glucosamine residues.
|
120 |
B1MV73 (/ISS)
B1MV73 (/ISS)
B1MV73 (/ISS)
B1MV73 (/ISS)
B1MV73 (/ISS)
B1MV73 (/ISS)
B1MV73 (/ISS)
B1MV73 (/ISS)
B1MV73 (/ISS)
B1MV73 (/ISS)
(110 more) |
|
Regulation of centriole-centriole cohesion GO:0030997
Any process that modulates the extent to which the two centrioles within a centrosome remain tightly paired; may be mediated by the assembly and disassembly of a proteinaceous linker.
|
120 |
B1MV73 (/ISS)
B1MV73 (/ISS)
B1MV73 (/ISS)
B1MV73 (/ISS)
B1MV73 (/ISS)
B1MV73 (/ISS)
B1MV73 (/ISS)
B1MV73 (/ISS)
B1MV73 (/ISS)
B1MV73 (/ISS)
(110 more) |
|
Response to estradiol GO:0032355
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of stimulus by estradiol, a C18 steroid hormone hydroxylated at C3 and C17 that acts as a potent estrogen.
|
120 |
B1MV73 (/ISS)
B1MV73 (/ISS)
B1MV73 (/ISS)
B1MV73 (/ISS)
B1MV73 (/ISS)
B1MV73 (/ISS)
B1MV73 (/ISS)
B1MV73 (/ISS)
B1MV73 (/ISS)
B1MV73 (/ISS)
(110 more) |
|
Adherens junction assembly GO:0034333
The aggregation, arrangement and bonding together of a set of components to form an adherens junction. An adherens junction is a cell junction at which the cytoplasmic face of the plasma membrane is attached to actin filaments.
|
120 |
B1MV73 (/ISS)
B1MV73 (/ISS)
B1MV73 (/ISS)
B1MV73 (/ISS)
B1MV73 (/ISS)
B1MV73 (/ISS)
B1MV73 (/ISS)
B1MV73 (/ISS)
B1MV73 (/ISS)
B1MV73 (/ISS)
(110 more) |
|
Protein localization to cell surface GO:0034394
A process in which a protein is transported to, or maintained in, a location within the external part of the cell wall and/or plasma membrane.
|
120 |
B1MV73 (/ISS)
B1MV73 (/ISS)
B1MV73 (/ISS)
B1MV73 (/ISS)
B1MV73 (/ISS)
B1MV73 (/ISS)
B1MV73 (/ISS)
B1MV73 (/ISS)
B1MV73 (/ISS)
B1MV73 (/ISS)
(110 more) |
|
Positive regulation of apoptotic process GO:0043065
Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process.
|
120 |
B1MV73 (/ISS)
B1MV73 (/ISS)
B1MV73 (/ISS)
B1MV73 (/ISS)
B1MV73 (/ISS)
B1MV73 (/ISS)
B1MV73 (/ISS)
B1MV73 (/ISS)
B1MV73 (/ISS)
B1MV73 (/ISS)
(110 more) |
|
Canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition GO:0044334
The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes involved in the positive regulation of epithelial cell to mesenchymal cell transition.
|
120 |
B1MV73 (/ISS)
B1MV73 (/ISS)
B1MV73 (/ISS)
B1MV73 (/ISS)
B1MV73 (/ISS)
B1MV73 (/ISS)
B1MV73 (/ISS)
B1MV73 (/ISS)
B1MV73 (/ISS)
B1MV73 (/ISS)
(110 more) |
|
Regulation of smooth muscle cell proliferation GO:0048660
Any process that modulates the frequency, rate or extent of smooth muscle cell proliferation.
|
120 |
B1MV73 (/ISS)
B1MV73 (/ISS)
B1MV73 (/ISS)
B1MV73 (/ISS)
B1MV73 (/ISS)
B1MV73 (/ISS)
B1MV73 (/ISS)
B1MV73 (/ISS)
B1MV73 (/ISS)
B1MV73 (/ISS)
(110 more) |
|
Endothelial tube morphogenesis GO:0061154
The process in which the anatomical structures of a tube are generated and organized from an endothelium. Endothelium refers to the layer of cells lining blood vessels, lymphatics, the heart, and serous cavities, and is derived from bone marrow or mesoderm. Corneal endothelium is a special case, derived from neural crest cells.
|
120 |
B1MV73 (/ISS)
B1MV73 (/ISS)
B1MV73 (/ISS)
B1MV73 (/ISS)
B1MV73 (/ISS)
B1MV73 (/ISS)
B1MV73 (/ISS)
B1MV73 (/ISS)
B1MV73 (/ISS)
B1MV73 (/ISS)
(110 more) |
|
Cellular response to growth factor stimulus GO:0071363
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a growth factor stimulus.
|
120 |
B1MV73 (/ISS)
B1MV73 (/ISS)
B1MV73 (/ISS)
B1MV73 (/ISS)
B1MV73 (/ISS)
B1MV73 (/ISS)
B1MV73 (/ISS)
B1MV73 (/ISS)
B1MV73 (/ISS)
B1MV73 (/ISS)
(110 more) |
|
Cellular response to indole-3-methanol GO:0071681
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an indole-3-methanol stimulus.
|
120 |
B1MV73 (/ISS)
B1MV73 (/ISS)
B1MV73 (/ISS)
B1MV73 (/ISS)
B1MV73 (/ISS)
B1MV73 (/ISS)
B1MV73 (/ISS)
B1MV73 (/ISS)
B1MV73 (/ISS)
B1MV73 (/ISS)
(110 more) |
|
Regulation of calcium ion import GO:0090279
Any process that modulates the rate, frequency, or extent of the directed movement of calcium ions into a cell or organelle.
|
120 |
B1MV73 (/ISS)
B1MV73 (/ISS)
B1MV73 (/ISS)
B1MV73 (/ISS)
B1MV73 (/ISS)
B1MV73 (/ISS)
B1MV73 (/ISS)
B1MV73 (/ISS)
B1MV73 (/ISS)
B1MV73 (/ISS)
(110 more) |
|
Regulation of protein localization to cell surface GO:2000008
Any process that modulates the frequency, rate or extent of protein localization to the cell surface.
|
120 |
B1MV73 (/ISS)
B1MV73 (/ISS)
B1MV73 (/ISS)
B1MV73 (/ISS)
B1MV73 (/ISS)
B1MV73 (/ISS)
B1MV73 (/ISS)
B1MV73 (/ISS)
B1MV73 (/ISS)
B1MV73 (/ISS)
(110 more) |
|
Canonical Wnt signaling pathway GO:0060070
The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes. In this pathway, the activated receptor signals via downstream effectors that result in the inhibition of beta-catenin phosphorylation, thereby preventing degradation of beta-catenin. Stabilized beta-catenin can then accumulate and travel to the nucleus to trigger changes in transcription of target genes.
|
117 |
B1MV73 (/ISS)
B1MV73 (/ISS)
B1MV73 (/ISS)
B1MV73 (/ISS)
B1MV73 (/ISS)
B1MV73 (/ISS)
B1MV73 (/ISS)
B1MV73 (/ISS)
B1MV73 (/ISS)
B1MV73 (/ISS)
(107 more) |
|
Negative regulation of transcription, DNA-templated GO:0045892
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
|
115 |
B1MV73 (/ISS)
B1MV73 (/ISS)
B1MV73 (/ISS)
B1MV73 (/ISS)
B1MV73 (/ISS)
B1MV73 (/ISS)
B1MV73 (/ISS)
B1MV73 (/ISS)
B1MV73 (/ISS)
B1MV73 (/ISS)
(105 more) |
|
Positive regulation of transcription, DNA-templated GO:0045893
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
|
115 |
B1MV73 (/ISS)
B1MV73 (/ISS)
B1MV73 (/ISS)
B1MV73 (/ISS)
B1MV73 (/ISS)
B1MV73 (/ISS)
B1MV73 (/ISS)
B1MV73 (/ISS)
B1MV73 (/ISS)
B1MV73 (/ISS)
(105 more) |
|
Regulation of centromeric sister chromatid cohesion GO:0070602
Any process that modulates the frequency, rate or extent of sister chromatid cohesion in the centromeric region of a chromosome.
|
115 |
B1MV73 (/ISS)
B1MV73 (/ISS)
B1MV73 (/ISS)
B1MV73 (/ISS)
B1MV73 (/ISS)
B1MV73 (/ISS)
B1MV73 (/ISS)
B1MV73 (/ISS)
B1MV73 (/ISS)
B1MV73 (/ISS)
(105 more) |
|
Cell-cell adhesion GO:0098609
The attachment of one cell to another cell via adhesion molecules.
|
115 |
B1MV73 (/ISS)
B1MV73 (/ISS)
B1MV73 (/ISS)
B1MV73 (/ISS)
B1MV73 (/ISS)
B1MV73 (/ISS)
B1MV73 (/ISS)
B1MV73 (/ISS)
B1MV73 (/ISS)
B1MV73 (/ISS)
(105 more) |
|
Positive regulation of neuroblast proliferation GO:0002052
Any process that activates or increases the rate of neuroblast proliferation.
|
70 |
B6V8E6 (/ISS)
B6V8E6 (/ISS)
B6V8E6 (/ISS)
B6V8E6 (/ISS)
B6V8E6 (/ISS)
B6V8E6 (/ISS)
B6V8E6 (/ISS)
B6V8E6 (/ISS)
B6V8E6 (/ISS)
B6V8E6 (/ISS)
(60 more) |
|
Negative regulation of mitotic cell cycle, embryonic GO:0045976
Any process that stops, prevents or reduces the rate or extent of progression through the embryonic mitotic cell cycle.
|
70 |
B6V8E6 (/ISS)
B6V8E6 (/ISS)
B6V8E6 (/ISS)
B6V8E6 (/ISS)
B6V8E6 (/ISS)
B6V8E6 (/ISS)
B6V8E6 (/ISS)
B6V8E6 (/ISS)
B6V8E6 (/ISS)
B6V8E6 (/ISS)
(60 more) |
|
Sympathetic ganglion development GO:0061549
The process whose specific outcome is the progression of a sympathetic ganglion over time, from its formation to the mature structure.
|
70 |
B6V8E6 (/ISS)
B6V8E6 (/ISS)
B6V8E6 (/ISS)
B6V8E6 (/ISS)
B6V8E6 (/ISS)
B6V8E6 (/ISS)
B6V8E6 (/ISS)
B6V8E6 (/ISS)
B6V8E6 (/ISS)
B6V8E6 (/ISS)
(60 more) |
|
Neuron projection extension GO:1990138
Long distance growth of a single neuron projection involved in cellular development. A neuron projection is a prolongation or process extending from a nerve cell, e.g. an axon or dendrite.
|
50 |
B6V8E6 (/ISS)
B6V8E6 (/ISS)
B6V8E6 (/ISS)
B6V8E6 (/ISS)
B6V8E6 (/ISS)
B6V8E6 (/ISS)
B6V8E6 (/ISS)
B6V8E6 (/ISS)
B6V8E6 (/ISS)
B6V8E6 (/ISS)
(40 more) |
|
Cell-cell adhesion GO:0098609
The attachment of one cell to another cell via adhesion molecules.
|
40 |
P14923 (/IMP)
P14923 (/IMP)
P14923 (/IMP)
P14923 (/IMP)
P14923 (/IMP)
P14923 (/IMP)
P18824 (/IMP)
P18824 (/IMP)
P18824 (/IMP)
P35222 (/IMP)
(30 more) |
|
Canonical Wnt signaling pathway GO:0060070
The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes. In this pathway, the activated receptor signals via downstream effectors that result in the inhibition of beta-catenin phosphorylation, thereby preventing degradation of beta-catenin. Stabilized beta-catenin can then accumulate and travel to the nucleus to trigger changes in transcription of target genes.
|
36 |
O42486 (/IDA)
O42486 (/IDA)
P18824 (/IDA)
P18824 (/IDA)
P18824 (/IDA)
P35222 (/IDA)
P35222 (/IDA)
P35222 (/IDA)
P35222 (/IDA)
P35222 (/IDA)
(26 more) |
|
Positive regulation of transcription, DNA-templated GO:0045893
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
|
34 |
P18824 (/IMP)
P18824 (/IMP)
P18824 (/IMP)
P26233 (/IMP)
P35222 (/IMP)
P35222 (/IMP)
P35222 (/IMP)
P35222 (/IMP)
P35222 (/IMP)
P35222 (/IMP)
(24 more) |
|
Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
|
33 |
P18824 (/IDA)
P18824 (/IDA)
P18824 (/IDA)
P35222 (/IDA)
P35222 (/IDA)
P35222 (/IDA)
P35222 (/IDA)
P35222 (/IDA)
P35222 (/IDA)
P35222 (/IDA)
(23 more) |
|
Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
|
33 |
P18824 (/IMP)
P18824 (/IMP)
P18824 (/IMP)
P35222 (/IMP)
P35222 (/IMP)
P35222 (/IMP)
P35222 (/IMP)
P35222 (/IMP)
P35222 (/IMP)
P35222 (/IMP)
(23 more) |
|
Canonical Wnt signaling pathway GO:0060070
The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes. In this pathway, the activated receptor signals via downstream effectors that result in the inhibition of beta-catenin phosphorylation, thereby preventing degradation of beta-catenin. Stabilized beta-catenin can then accumulate and travel to the nucleus to trigger changes in transcription of target genes.
|
33 |
P18824 (/IMP)
P18824 (/IMP)
P18824 (/IMP)
P35222 (/IMP)
P35222 (/IMP)
P35222 (/IMP)
P35222 (/IMP)
P35222 (/IMP)
P35222 (/IMP)
P35222 (/IMP)
(23 more) |
|
Negative regulation of transcription, DNA-templated GO:0045892
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
|
31 |
P26233 (/IMP)
P35222 (/IMP)
P35222 (/IMP)
P35222 (/IMP)
P35222 (/IMP)
P35222 (/IMP)
P35222 (/IMP)
P35222 (/IMP)
P35222 (/IMP)
P35222 (/IMP)
(21 more) |
|
Cellular response to indole-3-methanol GO:0071681
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an indole-3-methanol stimulus.
|
31 |
P14923 (/IDA)
P14923 (/IDA)
P14923 (/IDA)
P14923 (/IDA)
P14923 (/IDA)
P14923 (/IDA)
P35222 (/IDA)
P35222 (/IDA)
P35222 (/IDA)
P35222 (/IDA)
(21 more) |
|
Stem cell population maintenance GO:0019827
The process by which an organism or tissue maintains a population of stem cells of a single type. This can be achieved by a number of mechanisms: stem cell asymmetric division maintains stem cell numbers; stem cell symmetric division increases them; maintenance of a stem cell niche maintains the conditions for commitment to the stem cell fate for some types of stem cell; stem cells may arise de novo from other cell types.
|
30 |
P35222 (/TAS)
P35222 (/TAS)
P35222 (/TAS)
P35222 (/TAS)
P35222 (/TAS)
P35222 (/TAS)
P35222 (/TAS)
P35222 (/TAS)
P35222 (/TAS)
P35222 (/TAS)
(20 more) |
|
Positive regulation of transcription, DNA-templated GO:0045893
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
|
30 |
P35222 (/IDA)
P35222 (/IDA)
P35222 (/IDA)
P35222 (/IDA)
P35222 (/IDA)
P35222 (/IDA)
P35222 (/IDA)
P35222 (/IDA)
P35222 (/IDA)
P35222 (/IDA)
(20 more) |
|
Regulation of centromeric sister chromatid cohesion GO:0070602
Any process that modulates the frequency, rate or extent of sister chromatid cohesion in the centromeric region of a chromosome.
|
30 |
P35222 (/IMP)
P35222 (/IMP)
P35222 (/IMP)
P35222 (/IMP)
P35222 (/IMP)
P35222 (/IMP)
P35222 (/IMP)
P35222 (/IMP)
P35222 (/IMP)
P35222 (/IMP)
(20 more) |
|
Positive regulation of core promoter binding GO:1904798
Any process that activates or increases the frequency, rate or extent of core promoter binding.
|
30 |
P35222 (/IDA)
P35222 (/IDA)
P35222 (/IDA)
P35222 (/IDA)
P35222 (/IDA)
P35222 (/IDA)
P35222 (/IDA)
P35222 (/IDA)
P35222 (/IDA)
P35222 (/IDA)
(20 more) |
|
Canonical Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation GO:1904954
Any canonical Wnt signaling pathway that is involved in midbrain dopaminergic neuron differentiation.
|
30 |
P35222 (/IC)
P35222 (/IC)
P35222 (/IC)
P35222 (/IC)
P35222 (/IC)
P35222 (/IC)
P35222 (/IC)
P35222 (/IC)
P35222 (/IC)
P35222 (/IC)
(20 more) |
|
Cell adhesion GO:0007155
The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules.
|
28 |
P18824 (/IMP)
P18824 (/IMP)
P18824 (/IMP)
P35222 (/IMP)
P35222 (/IMP)
P35222 (/IMP)
P35222 (/IMP)
P35222 (/IMP)
P35222 (/IMP)
P35222 (/IMP)
(18 more) |
|
Negative regulation of protein sumoylation GO:0033234
Any process that stops, prevents, or reduces the frequency, rate or extent of the addition of SUMO groups to a protein.
|
28 |
Q02248 (/ISS)
Q02248 (/ISS)
Q02248 (/ISS)
Q02248 (/ISS)
Q02248 (/ISS)
Q0VCX4 (/ISS)
Q0VCX4 (/ISS)
Q0VCX4 (/ISS)
Q0VCX4 (/ISS)
Q0VCX4 (/ISS)
(18 more) |
|
Negative regulation of cell population proliferation GO:0008285
Any process that stops, prevents or reduces the rate or extent of cell proliferation.
|
27 |
O42486 (/IDA)
O42486 (/IDA)
P35222 (/IDA)
P35222 (/IDA)
P35222 (/IDA)
P35222 (/IDA)
P35222 (/IDA)
P35222 (/IDA)
P35222 (/IDA)
P35222 (/IDA)
(17 more) |
|
Protein polyubiquitination GO:0000209
Addition of multiple ubiquitin groups to a protein, forming a ubiquitin chain.
|
25 |
P35222 (/IDA)
P35222 (/IDA)
P35222 (/IDA)
P35222 (/IDA)
P35222 (/IDA)
P35222 (/IDA)
P35222 (/IDA)
P35222 (/IDA)
P35222 (/IDA)
P35222 (/IDA)
(15 more) |
|
Branching involved in blood vessel morphogenesis GO:0001569
The process of coordinated growth and sprouting of blood vessels giving rise to the organized vascular system.
|
25 |
P35222 (/IC)
P35222 (/IC)
P35222 (/IC)
P35222 (/IC)
P35222 (/IC)
P35222 (/IC)
P35222 (/IC)
P35222 (/IC)
P35222 (/IC)
P35222 (/IC)
(15 more) |
|
Epithelial to mesenchymal transition GO:0001837
A transition where an epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell.
|
25 |
P35222 (/TAS)
P35222 (/TAS)
P35222 (/TAS)
P35222 (/TAS)
P35222 (/TAS)
P35222 (/TAS)
P35222 (/TAS)
P35222 (/TAS)
P35222 (/TAS)
P35222 (/TAS)
(15 more) |
|
Wnt signaling pathway, calcium modulating pathway GO:0007223
The series of molecular signals initiated by binding of a Wnt protein to a receptor on the surface of the target cell where activated receptors leads to an increase in intracellular calcium and activation of protein kinase C (PKC).
|
25 |
P35222 (/TAS)
P35222 (/TAS)
P35222 (/TAS)
P35222 (/TAS)
P35222 (/TAS)
P35222 (/TAS)
P35222 (/TAS)
P35222 (/TAS)
P35222 (/TAS)
P35222 (/TAS)
(15 more) |
|
Positive regulation of epithelial to mesenchymal transition GO:0010718
Any process that increases the rate, frequency, or extent of epithelial to mesenchymal transition. Epithelial to mesenchymal transition is where an epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell.
|
25 |
P35222 (/IGI)
P35222 (/IGI)
P35222 (/IGI)
P35222 (/IGI)
P35222 (/IGI)
P35222 (/IGI)
P35222 (/IGI)
P35222 (/IGI)
P35222 (/IGI)
P35222 (/IGI)
(15 more) |
|
Positive regulation of heparan sulfate proteoglycan biosynthetic process GO:0010909
Any process that increases the rate, frequency or extent of heparan sulfate proteoglycan biosynthesis. Heparan sulfate proteoglycan biosynthetic processes are the chemical reactions and pathways resulting in the formation of the heparan sulfate proteoglycan, a glycosaminoglycan with repeat unit consisting of alternating alpha-(1->4)-linked hexuronic acid and glucosamine residues.
|
25 |
P35222 (/IMP)
P35222 (/IMP)
P35222 (/IMP)
P35222 (/IMP)
P35222 (/IMP)
P35222 (/IMP)
P35222 (/IMP)
P35222 (/IMP)
P35222 (/IMP)
P35222 (/IMP)
(15 more) |
|
Wnt signaling pathway GO:0016055
The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell and ending with a change in cell state.
|
25 |
P35222 (/TAS)
P35222 (/TAS)
P35222 (/TAS)
P35222 (/TAS)
P35222 (/TAS)
P35222 (/TAS)
P35222 (/TAS)
P35222 (/TAS)
P35222 (/TAS)
P35222 (/TAS)
(15 more) |
|
Negative regulation of angiogenesis GO:0016525
Any process that stops, prevents, or reduces the frequency, rate or extent of angiogenesis.
|
25 |
P35222 (/ISS)
P35222 (/ISS)
P35222 (/ISS)
P35222 (/ISS)
P35222 (/ISS)
P35222 (/ISS)
P35222 (/ISS)
P35222 (/ISS)
P35222 (/ISS)
P35222 (/ISS)
(15 more) |
|
Androgen receptor signaling pathway GO:0030521
Any series of molecular signals generated as a consequence of an androgen binding to its receptor.
|
25 |
P35222 (/NAS)
P35222 (/NAS)
P35222 (/NAS)
P35222 (/NAS)
P35222 (/NAS)
P35222 (/NAS)
P35222 (/NAS)
P35222 (/NAS)
P35222 (/NAS)
P35222 (/NAS)
(15 more) |
|
Regulation of centriole-centriole cohesion GO:0030997
Any process that modulates the extent to which the two centrioles within a centrosome remain tightly paired; may be mediated by the assembly and disassembly of a proteinaceous linker.
|
25 |
P35222 (/IDA)
P35222 (/IDA)
P35222 (/IDA)
P35222 (/IDA)
P35222 (/IDA)
P35222 (/IDA)
P35222 (/IDA)
P35222 (/IDA)
P35222 (/IDA)
P35222 (/IDA)
(15 more) |
|
Response to estradiol GO:0032355
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of stimulus by estradiol, a C18 steroid hormone hydroxylated at C3 and C17 that acts as a potent estrogen.
|
25 |
P35222 (/IDA)
P35222 (/IDA)
P35222 (/IDA)
P35222 (/IDA)
P35222 (/IDA)
P35222 (/IDA)
P35222 (/IDA)
P35222 (/IDA)
P35222 (/IDA)
P35222 (/IDA)
(15 more) |
|
Positive regulation of type I interferon production GO:0032481
Any process that activates or increases the frequency, rate, or extent of type I interferon production. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families.
|
25 |
P35222 (/TAS)
P35222 (/TAS)
P35222 (/TAS)
P35222 (/TAS)
P35222 (/TAS)
P35222 (/TAS)
P35222 (/TAS)
P35222 (/TAS)
P35222 (/TAS)
P35222 (/TAS)
(15 more) |
|
Negative regulation of protein sumoylation GO:0033234
Any process that stops, prevents, or reduces the frequency, rate or extent of the addition of SUMO groups to a protein.
|
25 |
P35222 (/IDA)
P35222 (/IDA)
P35222 (/IDA)
P35222 (/IDA)
P35222 (/IDA)
P35222 (/IDA)
P35222 (/IDA)
P35222 (/IDA)
P35222 (/IDA)
P35222 (/IDA)
(15 more) |
|
Adherens junction assembly GO:0034333
The aggregation, arrangement and bonding together of a set of components to form an adherens junction. An adherens junction is a cell junction at which the cytoplasmic face of the plasma membrane is attached to actin filaments.
|
25 |
P35222 (/IMP)
P35222 (/IMP)
P35222 (/IMP)
P35222 (/IMP)
P35222 (/IMP)
P35222 (/IMP)
P35222 (/IMP)
P35222 (/IMP)
P35222 (/IMP)
P35222 (/IMP)
(15 more) |
|
Protein localization to cell surface GO:0034394
A process in which a protein is transported to, or maintained in, a location within the external part of the cell wall and/or plasma membrane.
|
25 |
P35222 (/IMP)
P35222 (/IMP)
P35222 (/IMP)
P35222 (/IMP)
P35222 (/IMP)
P35222 (/IMP)
P35222 (/IMP)
P35222 (/IMP)
P35222 (/IMP)
P35222 (/IMP)
(15 more) |
|
Hair cell differentiation GO:0035315
The process in which a relatively unspecialized cell acquires specialized features of a hair cell.
|
25 |
P35222 (/TAS)
P35222 (/TAS)
P35222 (/TAS)
P35222 (/TAS)
P35222 (/TAS)
P35222 (/TAS)
P35222 (/TAS)
P35222 (/TAS)
P35222 (/TAS)
P35222 (/TAS)
(15 more) |
|
Entry of bacterium into host cell GO:0035635
The process in which a bacterium enters a host cell. The host is defined as the larger of the organisms involved in a symbiotic interaction.
|
25 |
P35222 (/TAS)
P35222 (/TAS)
P35222 (/TAS)
P35222 (/TAS)
P35222 (/TAS)
P35222 (/TAS)
P35222 (/TAS)
P35222 (/TAS)
P35222 (/TAS)
P35222 (/TAS)
(15 more) |
|
Embryonic skeletal limb joint morphogenesis GO:0036023
The process, occurring in the embryo, in which the anatomical structures of a skeletal limb joint are generated and organized. A skeletal limb joint is the connecting structure between the bones of a limb.
|
25 |
P35222 (/ISS)
P35222 (/ISS)
P35222 (/ISS)
P35222 (/ISS)
P35222 (/ISS)
P35222 (/ISS)
P35222 (/ISS)
P35222 (/ISS)
P35222 (/ISS)
P35222 (/ISS)
(15 more) |
|
Response to drug GO:0042493
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a drug stimulus. A drug is a substance used in the diagnosis, treatment or prevention of a disease.
|
25 |
P35222 (/IEP)
P35222 (/IEP)
P35222 (/IEP)
P35222 (/IEP)
P35222 (/IEP)
P35222 (/IEP)
P35222 (/IEP)
P35222 (/IEP)
P35222 (/IEP)
P35222 (/IEP)
(15 more) |
|
Positive regulation of apoptotic process GO:0043065
Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process.
|
25 |
P35222 (/IDA)
P35222 (/IDA)
P35222 (/IDA)
P35222 (/IDA)
P35222 (/IDA)
P35222 (/IDA)
P35222 (/IDA)
P35222 (/IDA)
P35222 (/IDA)
P35222 (/IDA)
(15 more) |
|
Negative regulation of apoptotic process GO:0043066
Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process.
|
25 |
P35222 (/IMP)
P35222 (/IMP)
P35222 (/IMP)
P35222 (/IMP)
P35222 (/IMP)
P35222 (/IMP)
P35222 (/IMP)
P35222 (/IMP)
P35222 (/IMP)
P35222 (/IMP)
(15 more) |
|
Proteasome-mediated ubiquitin-dependent protein catabolic process GO:0043161
The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome.
|
25 |
P35222 (/IDA)
P35222 (/IDA)
P35222 (/IDA)
P35222 (/IDA)
P35222 (/IDA)
P35222 (/IDA)
P35222 (/IDA)
P35222 (/IDA)
P35222 (/IDA)
P35222 (/IDA)
(15 more) |
|
Positive regulation of neuron apoptotic process GO:0043525
Any process that activates or increases the frequency, rate or extent of cell death of neurons by apoptotic process.
|
25 |
P35222 (/IDA)
P35222 (/IDA)
P35222 (/IDA)
P35222 (/IDA)
P35222 (/IDA)
P35222 (/IDA)
P35222 (/IDA)
P35222 (/IDA)
P35222 (/IDA)
P35222 (/IDA)
(15 more) |
|
Canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition GO:0044334
The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes involved in the positive regulation of epithelial cell to mesenchymal cell transition.
|
25 |
P35222 (/IMP)
P35222 (/IMP)
P35222 (/IMP)
P35222 (/IMP)
P35222 (/IMP)
P35222 (/IMP)
P35222 (/IMP)
P35222 (/IMP)
P35222 (/IMP)
P35222 (/IMP)
(15 more) |
|
Canonical Wnt signaling pathway involved in negative regulation of apoptotic process GO:0044336
The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes involved in the negative regulation of apoptotic process.
|
25 |
P35222 (/TAS)
P35222 (/TAS)
P35222 (/TAS)
P35222 (/TAS)
P35222 (/TAS)
P35222 (/TAS)
P35222 (/TAS)
P35222 (/TAS)
P35222 (/TAS)
P35222 (/TAS)
(15 more) |
|
Regulation of angiogenesis GO:0045765
Any process that modulates the frequency, rate or extent of angiogenesis.
|
25 |
P35222 (/TAS)
P35222 (/TAS)
P35222 (/TAS)
P35222 (/TAS)
P35222 (/TAS)
P35222 (/TAS)
P35222 (/TAS)
P35222 (/TAS)
P35222 (/TAS)
P35222 (/TAS)
(15 more) |
|
Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
|
25 |
P35222 (/TAS)
P35222 (/TAS)
P35222 (/TAS)
P35222 (/TAS)
P35222 (/TAS)
P35222 (/TAS)
P35222 (/TAS)
P35222 (/TAS)
P35222 (/TAS)
P35222 (/TAS)
(15 more) |
|
Regulation of fibroblast proliferation GO:0048145
Any process that modulates the frequency, rate or extent of multiplication or reproduction of fibroblast cells.
|
25 |
P35222 (/TAS)
P35222 (/TAS)
P35222 (/TAS)
P35222 (/TAS)
P35222 (/TAS)
P35222 (/TAS)
P35222 (/TAS)
P35222 (/TAS)
P35222 (/TAS)
P35222 (/TAS)
(15 more) |
|
Regulation of smooth muscle cell proliferation GO:0048660
Any process that modulates the frequency, rate or extent of smooth muscle cell proliferation.
|
25 |
P35222 (/IMP)
P35222 (/IMP)
P35222 (/IMP)
P35222 (/IMP)
P35222 (/IMP)
P35222 (/IMP)
P35222 (/IMP)
P35222 (/IMP)
P35222 (/IMP)
P35222 (/IMP)
(15 more) |
|
Regulation of neurogenesis GO:0050767
Any process that modulates the frequency, rate or extent of neurogenesis, the generation of cells in the nervous system.
|
25 |
P35222 (/TAS)
P35222 (/TAS)
P35222 (/TAS)
P35222 (/TAS)
P35222 (/TAS)
P35222 (/TAS)
P35222 (/TAS)
P35222 (/TAS)
P35222 (/TAS)
P35222 (/TAS)
(15 more) |
|
Positive regulation of DNA-binding transcription factor activity GO:0051091
Any process that activates or increases the frequency, rate or extent of activity of a transcription factor, any factor involved in the initiation or regulation of transcription.
|
25 |
P35222 (/IMP)
P35222 (/IMP)
P35222 (/IMP)
P35222 (/IMP)
P35222 (/IMP)
P35222 (/IMP)
P35222 (/IMP)
P35222 (/IMP)
P35222 (/IMP)
P35222 (/IMP)
(15 more) |
|
Positive regulation of muscle cell differentiation GO:0051149
Any process that activates or increases the frequency, rate or extent of muscle cell differentiation.
|
25 |
P35222 (/TAS)
P35222 (/TAS)
P35222 (/TAS)
P35222 (/TAS)
P35222 (/TAS)
P35222 (/TAS)
P35222 (/TAS)
P35222 (/TAS)
P35222 (/TAS)
P35222 (/TAS)
(15 more) |
|
Positive regulation of histone H3-K4 methylation GO:0051571
Any process that activates or increases the frequency, rate or extent of the covalent addition of a methyl group to the lysine at position 4 of histone H3.
|
25 |
P35222 (/IC)
P35222 (/IC)
P35222 (/IC)
P35222 (/IC)
P35222 (/IC)
P35222 (/IC)
P35222 (/IC)
P35222 (/IC)
P35222 (/IC)
P35222 (/IC)
(15 more) |
|
Regulation of canonical Wnt signaling pathway GO:0060828
Any process that modulates the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes.
|
25 |
P35222 (/TAS)
P35222 (/TAS)
P35222 (/TAS)
P35222 (/TAS)
P35222 (/TAS)
P35222 (/TAS)
P35222 (/TAS)
P35222 (/TAS)
P35222 (/TAS)
P35222 (/TAS)
(15 more) |
|
Endothelial tube morphogenesis GO:0061154
The process in which the anatomical structures of a tube are generated and organized from an endothelium. Endothelium refers to the layer of cells lining blood vessels, lymphatics, the heart, and serous cavities, and is derived from bone marrow or mesoderm. Corneal endothelium is a special case, derived from neural crest cells.
|
25 |
P35222 (/IMP)
P35222 (/IMP)
P35222 (/IMP)
P35222 (/IMP)
P35222 (/IMP)
P35222 (/IMP)
P35222 (/IMP)
P35222 (/IMP)
P35222 (/IMP)
P35222 (/IMP)
(15 more) |
|
Canonical Wnt signaling pathway involved in positive regulation of cardiac outflow tract cell proliferation GO:0061324
The canonical Wnt signaling pathway that contributes to the modulation of the expansion of a population of cardiac outflow tract cells.
|
25 |
P35222 (/ISS)
P35222 (/ISS)
P35222 (/ISS)
P35222 (/ISS)
P35222 (/ISS)
P35222 (/ISS)
P35222 (/ISS)
P35222 (/ISS)
P35222 (/ISS)
P35222 (/ISS)
(15 more) |
|
Cellular response to growth factor stimulus GO:0071363
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a growth factor stimulus.
|
25 |
P35222 (/IMP)
P35222 (/IMP)
P35222 (/IMP)
P35222 (/IMP)
P35222 (/IMP)
P35222 (/IMP)
P35222 (/IMP)
P35222 (/IMP)
P35222 (/IMP)
P35222 (/IMP)
(15 more) |
|
Regulation of nephron tubule epithelial cell differentiation GO:0072182
Any process that modulates the frequency, rate or extent of nephron tubule epithelial cell differentiation.
|
25 |
P35222 (/ISS)
P35222 (/ISS)
P35222 (/ISS)
P35222 (/ISS)
P35222 (/ISS)
P35222 (/ISS)
P35222 (/ISS)
P35222 (/ISS)
P35222 (/ISS)
P35222 (/ISS)
(15 more) |
|
Regulation of calcium ion import GO:0090279
Any process that modulates the rate, frequency, or extent of the directed movement of calcium ions into a cell or organelle.
|
25 |
P35222 (/IDA)
P35222 (/IDA)
P35222 (/IDA)
P35222 (/IDA)
P35222 (/IDA)
P35222 (/IDA)
P35222 (/IDA)
P35222 (/IDA)
P35222 (/IDA)
P35222 (/IDA)
(15 more) |
|
Beta-catenin-TCF complex assembly GO:1904837
The aggregation, arrangement and bonding together of a set of components to form a beta-catenin-TCF complex.
|
25 |
P35222 (/TAS)
P35222 (/TAS)
P35222 (/TAS)
P35222 (/TAS)
P35222 (/TAS)
P35222 (/TAS)
P35222 (/TAS)
P35222 (/TAS)
P35222 (/TAS)
P35222 (/TAS)
(15 more) |
|
Beta-catenin destruction complex disassembly GO:1904886
The disaggregation of a beta-catenin destruction complex into its constituent components.
|
25 |
P35222 (/TAS)
P35222 (/TAS)
P35222 (/TAS)
P35222 (/TAS)
P35222 (/TAS)
P35222 (/TAS)
P35222 (/TAS)
P35222 (/TAS)
P35222 (/TAS)
P35222 (/TAS)
(15 more) |
|
Midbrain dopaminergic neuron differentiation GO:1904948
The process in which a relatively unspecialized cell acquires the specialized features of a midbrain dopaminergic neuron.
|
25 |
P35222 (/ISS)
P35222 (/ISS)
P35222 (/ISS)
P35222 (/ISS)
P35222 (/ISS)
P35222 (/ISS)
P35222 (/ISS)
P35222 (/ISS)
P35222 (/ISS)
P35222 (/ISS)
(15 more) |
|
Neuron projection extension GO:1990138
Long distance growth of a single neuron projection involved in cellular development. A neuron projection is a prolongation or process extending from a nerve cell, e.g. an axon or dendrite.
|
25 |
P35222 (/IMP)
P35222 (/IMP)
P35222 (/IMP)
P35222 (/IMP)
P35222 (/IMP)
P35222 (/IMP)
P35222 (/IMP)
P35222 (/IMP)
P35222 (/IMP)
P35222 (/IMP)
(15 more) |
|
Regulation of protein localization to cell surface GO:2000008
Any process that modulates the frequency, rate or extent of protein localization to the cell surface.
|
25 |
P35222 (/IDA)
P35222 (/IDA)
P35222 (/IDA)
P35222 (/IDA)
P35222 (/IDA)
P35222 (/IDA)
P35222 (/IDA)
P35222 (/IDA)
P35222 (/IDA)
P35222 (/IDA)
(15 more) |
|
Positive regulation of DNA-templated transcription, initiation GO:2000144
Any process that activates or increases the frequency, rate or extent of DNA-templated transcription initiation.
|
25 |
P35222 (/IC)
P35222 (/IC)
P35222 (/IC)
P35222 (/IC)
P35222 (/IC)
P35222 (/IC)
P35222 (/IC)
P35222 (/IC)
P35222 (/IC)
P35222 (/IC)
(15 more) |
|
Bicellular tight junction assembly GO:0070830
The aggregation, arrangement and bonding together of a set of components to form a tight junction, an occluding cell-cell junction that is composed of a branching network of sealing strands that completely encircles the apical end of each cell in an epithelial sheet.
|
22 |
B6V8E6 (/IDA)
B6V8E6 (/IDA)
B6V8E6 (/IDA)
B6V8E6 (/IDA)
B6V8E6 (/IDA)
B6V8E6 (/IDA)
B6V8E6 (/IDA)
B6V8E6 (/IDA)
B6V8E6 (/IDA)
B6V8E6 (/IDA)
(12 more) |
|
Heart development GO:0007507
The process whose specific outcome is the progression of the heart over time, from its formation to the mature structure. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood.
|
11 |
A0A2R8QDB8 (/IMP)
F1QTT3 (/IMP)
P18824 (/IMP)
P18824 (/IMP)
P18824 (/IMP)
Q02248 (/IMP)
Q02248 (/IMP)
Q02248 (/IMP)
Q02248 (/IMP)
Q02248 (/IMP)
(1 more) |
|
Regulation of cell population proliferation GO:0042127
Any process that modulates the frequency, rate or extent of cell proliferation.
|
11 |
P14923 (/IDA)
P14923 (/IDA)
P14923 (/IDA)
P14923 (/IDA)
P14923 (/IDA)
P14923 (/IDA)
Q02248 (/IDA)
Q02248 (/IDA)
Q02248 (/IDA)
Q02248 (/IDA)
(1 more) |
|
Positive regulation of DNA-binding transcription factor activity GO:0051091
Any process that activates or increases the frequency, rate or extent of activity of a transcription factor, any factor involved in the initiation or regulation of transcription.
|
11 |
P14923 (/IDA)
P14923 (/IDA)
P14923 (/IDA)
P14923 (/IDA)
P14923 (/IDA)
P14923 (/IDA)
Q02248 (/IDA)
Q02248 (/IDA)
Q02248 (/IDA)
Q02248 (/IDA)
(1 more) |
|
Limb development GO:0060173
The process whose specific outcome is the progression of a limb over time, from its formation to the mature structure. A limb is an appendage of an animal used for locomotion or grasping. Examples include legs, arms or some types of fin.
|
11 |
A0A1D5NYE8 (/IMP)
A0A1D5NYE8 (/IMP)
A0A1D5NYE8 (/IMP)
A0A1D5NYE8 (/IMP)
A0A1D5NYE8 (/IMP)
A0A1D5NYE8 (/IMP)
Q02248 (/IMP)
Q02248 (/IMP)
Q02248 (/IMP)
Q02248 (/IMP)
(1 more) |
|
Canonical Wnt signaling pathway GO:0060070
The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes. In this pathway, the activated receptor signals via downstream effectors that result in the inhibition of beta-catenin phosphorylation, thereby preventing degradation of beta-catenin. Stabilized beta-catenin can then accumulate and travel to the nucleus to trigger changes in transcription of target genes.
|
10 | E7FC99 (/IGI) P18824 (/IGI) P18824 (/IGI) P18824 (/IGI) Q02248 (/IGI) Q02248 (/IGI) Q02248 (/IGI) Q02248 (/IGI) Q02248 (/IGI) Q8JID2 (/IGI) |
|
Protein localization to plasma membrane GO:0072659
A process in which a protein is transported to, or maintained in, a specific location in the plasma membrane.
|
9 | P14923 (/IMP) P14923 (/IMP) P14923 (/IMP) P14923 (/IMP) P14923 (/IMP) P14923 (/IMP) P18824 (/IMP) P18824 (/IMP) P18824 (/IMP) |
|
Cell fate determination GO:0001709
A process involved in cell fate commitment. Once determination has taken place, a cell becomes committed to differentiate down a particular pathway regardless of its environment.
|
8 | P18824 (/IMP) P18824 (/IMP) P18824 (/IMP) Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) |
|
Positive regulation of fibroblast growth factor production GO:0090271
Any process that increases the rate, frequency or extent of the appearance of a fibroblast growth factor due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.
|
8 | A0A1D5NYE8 (/IMP) A0A1D5NYE8 (/IMP) A0A1D5NYE8 (/IMP) A0A1D5NYE8 (/IMP) A0A1D5NYE8 (/IMP) A0A1D5NYE8 (/IMP) O42486 (/IMP) O42486 (/IMP) |
|
Cell-cell adhesion GO:0098609
The attachment of one cell to another cell via adhesion molecules.
|
8 | P14923 (/IDA) P14923 (/IDA) P14923 (/IDA) P14923 (/IDA) P14923 (/IDA) P14923 (/IDA) Q6P0K8 (/IDA) Q9WU82 (/IDA) |
|
Desmosome assembly GO:0002159
A cellular process that results in the aggregation, arrangement and bonding together of a set of components to form a desmosome. A desmosome is a patch-like intercellular junction found in vertebrate tissues, consisting of parallel zones of two cell membranes, separated by an space of 25-35 nm, and having dense fibrillar plaques in the subjacent cytoplasm.
|
7 | P14923 (/IMP) P14923 (/IMP) P14923 (/IMP) P14923 (/IMP) P14923 (/IMP) P14923 (/IMP) Q02257 (/IMP) |
|
Dorsal/ventral pattern formation GO:0009953
The regionalization process in which the areas along the dorsal/ventral axis are established that will lead to differences in cell differentiation. The dorsal/ventral axis is defined by a line that runs orthogonal to both the anterior/posterior and left/right axes. The dorsal end is defined by the upper or back side of an organism. The ventral end is defined by the lower or front side of an organism.
|
7 | E7FC99 (/IMP) Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) Q8JID2 (/IMP) |
|
Embryonic hindlimb morphogenesis GO:0035116
The process, occurring in the embryo, by which the anatomical structures of the hindlimbs are generated and organized. The hindlimbs are the posterior limbs of an animal.
|
7 | O42486 (/IMP) O42486 (/IMP) Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) |
|
Positive regulation of cell-matrix adhesion GO:0001954
Any process that activates or increases the rate or extent of cell adhesion to an extracellular matrix.
|
6 | P14923 (/IGI) P14923 (/IGI) P14923 (/IGI) P14923 (/IGI) P14923 (/IGI) P14923 (/IGI) |
|
Desmosome assembly GO:0002159
A cellular process that results in the aggregation, arrangement and bonding together of a set of components to form a desmosome. A desmosome is a patch-like intercellular junction found in vertebrate tissues, consisting of parallel zones of two cell membranes, separated by an space of 25-35 nm, and having dense fibrillar plaques in the subjacent cytoplasm.
|
6 | P14923 (/IDA) P14923 (/IDA) P14923 (/IDA) P14923 (/IDA) P14923 (/IDA) P14923 (/IDA) |
|
Cytoskeletal anchoring at plasma membrane GO:0007016
A cytoskeleton organization process that directly or indirectly links cytoskeletal filaments to the plasma membrane.
|
6 | P14923 (/NAS) P14923 (/NAS) P14923 (/NAS) P14923 (/NAS) P14923 (/NAS) P14923 (/NAS) |
|
Negative regulation of gene expression GO:0010629
Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
|
6 | Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) Q9WU82 (/IMP) |
|
Cell migration GO:0016477
The controlled self-propelled movement of a cell from one site to a destination guided by molecular cues. Cell migration is a central process in the development and maintenance of multicellular organisms.
|
6 | P14923 (/IMP) P14923 (/IMP) P14923 (/IMP) P14923 (/IMP) P14923 (/IMP) P14923 (/IMP) |
|
Neuron differentiation GO:0030182
The process in which a relatively unspecialized cell acquires specialized features of a neuron.
|
6 | Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) Q7ZX35 (/IMP) |
|
Keratinization GO:0031424
The process in which the cytoplasm of the outermost cells of the vertebrate epidermis is replaced by keratin. Keratinization occurs in the stratum corneum, feathers, hair, claws, nails, hooves, and horns.
|
6 | P14923 (/TAS) P14923 (/TAS) P14923 (/TAS) P14923 (/TAS) P14923 (/TAS) P14923 (/TAS) |
|
Adherens junction organization GO:0034332
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an adherens junction. An adherens junction is a cell junction at which the cytoplasmic face of the plasma membrane is attached to actin filaments.
|
6 | P14923 (/TAS) P14923 (/TAS) P14923 (/TAS) P14923 (/TAS) P14923 (/TAS) P14923 (/TAS) |
|
Positive regulation of protein import into nucleus GO:0042307
Any process that activates or increases the frequency, rate or extent of movement of proteins from the cytoplasm into the nucleus.
|
6 | P14923 (/IDA) P14923 (/IDA) P14923 (/IDA) P14923 (/IDA) P14923 (/IDA) P14923 (/IDA) |
|
Neutrophil degranulation GO:0043312
The regulated exocytosis of secretory granules containing preformed mediators such as proteases, lipases, and inflammatory mediators by a neutrophil.
|
6 | P14923 (/TAS) P14923 (/TAS) P14923 (/TAS) P14923 (/TAS) P14923 (/TAS) P14923 (/TAS) |
|
Negative regulation of blood vessel endothelial cell migration GO:0043537
Any process that stops, prevents, or reduces the frequency, rate or extent of the migration of the endothelial cells of blood vessels.
|
6 | P14923 (/IGI) P14923 (/IGI) P14923 (/IGI) P14923 (/IGI) P14923 (/IGI) P14923 (/IGI) |
|
Skin development GO:0043588
The process whose specific outcome is the progression of the skin over time, from its formation to the mature structure. The skin is the external membranous integument of an animal. In vertebrates the skin generally consists of two layers, an outer nonsensitive and nonvascular epidermis (cuticle or skarfskin) composed of cells which are constantly growing and multiplying in the deeper, and being thrown off in the superficial layers, as well as an inner vascular dermis (cutis, corium or true skin) composed mostly of connective tissue.
|
6 | Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) Q02257 (/IMP) |
|
Positive regulation of fibroblast growth factor receptor signaling pathway GO:0045743
Any process that activates or increases the frequency, rate or extent of fibroblast growth factor receptor signaling pathway activity.
|
6 | Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) Q7ZX35 (/IMP) |
|
Positive regulation of angiogenesis GO:0045766
Any process that activates or increases angiogenesis.
|
6 | P14923 (/IGI) P14923 (/IGI) P14923 (/IGI) P14923 (/IGI) P14923 (/IGI) P14923 (/IGI) |
|
Detection of mechanical stimulus GO:0050982
The series of events by which a mechanical stimulus is received and converted into a molecular signal.
|
6 | P14923 (/IDA) P14923 (/IDA) P14923 (/IDA) P14923 (/IDA) P14923 (/IDA) P14923 (/IDA) |
|
Positive regulation of DNA-binding transcription factor activity GO:0051091
Any process that activates or increases the frequency, rate or extent of activity of a transcription factor, any factor involved in the initiation or regulation of transcription.
|
6 | Q02248 (/ISO) Q02248 (/ISO) Q02248 (/ISO) Q02248 (/ISO) Q02248 (/ISO) Q02257 (/ISO) |
|
Protein heterooligomerization GO:0051291
The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of component monomers that are not all identical. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer.
|
6 | Q02248 (/ISO) Q02248 (/ISO) Q02248 (/ISO) Q02248 (/ISO) Q02248 (/ISO) Q02257 (/ISO) |
|
Cornification GO:0070268
A type of programmed cell death that occurs in the epidermis, morphologically and biochemically distinct from apoptosis. It leads to the formation of corneocytes, i.e. dead keratinocytes containing an amalgam of specific proteins (e.g., keratin, loricrin, SPR and involucrin) and lipids (e.g., fatty acids and ceramides), which are necessary for the function of the cornified skin layer (mechanical resistance, elasticity, water repellence and structural stability).
|
6 | P14923 (/TAS) P14923 (/TAS) P14923 (/TAS) P14923 (/TAS) P14923 (/TAS) P14923 (/TAS) |
|
Endothelial cell-cell adhesion GO:0071603
The attachment of an endothelial cell to another endothelial cell via adhesion molecules.
|
6 | P14923 (/ISS) P14923 (/ISS) P14923 (/ISS) P14923 (/ISS) P14923 (/ISS) P14923 (/ISS) |
|
Cellular response to indole-3-methanol GO:0071681
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an indole-3-methanol stimulus.
|
6 | Q02248 (/ISO) Q02248 (/ISO) Q02248 (/ISO) Q02248 (/ISO) Q02248 (/ISO) Q02257 (/ISO) |
|
Bundle of His cell-Purkinje myocyte adhesion involved in cell communication GO:0086073
The attachment of a bundle of His cell to a Purkinje myocyte via adhesion molecules that results in the cells being juxtaposed so that they can communicate.
|
6 | P14923 (/IMP) P14923 (/IMP) P14923 (/IMP) P14923 (/IMP) P14923 (/IMP) P14923 (/IMP) |
|
Regulation of heart rate by cardiac conduction GO:0086091
A cardiac conduction process that modulates the frequency or rate of heart contraction.
|
6 | P14923 (/IMP) P14923 (/IMP) P14923 (/IMP) P14923 (/IMP) P14923 (/IMP) P14923 (/IMP) |
|
Positive regulation of canonical Wnt signaling pathway GO:0090263
Any process that increases the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes.
|
6 | P14923 (/IC) P14923 (/IC) P14923 (/IC) P14923 (/IC) P14923 (/IC) P14923 (/IC) |
|
Cell-cell adhesion GO:0098609
The attachment of one cell to another cell via adhesion molecules.
|
6 | Q02248 (/ISO) Q02248 (/ISO) Q02248 (/ISO) Q02248 (/ISO) Q02248 (/ISO) Q02257 (/ISO) |
|
Regulation of ventricular cardiac muscle cell action potential GO:0098911
Any process that modulates the frequency, rate or extent of action potential creation, propagation or termination in a ventricular cardiac muscle cell contributing to the regulation of its contraction. This typically occurs via modulation of the activity or expression of voltage-gated ion channels.
|
6 | P14923 (/IMP) P14923 (/IMP) P14923 (/IMP) P14923 (/IMP) P14923 (/IMP) P14923 (/IMP) |
|
Negative regulation of transcription by RNA polymerase II GO:0000122
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
|
5 | Q02248 (/IDA) Q02248 (/IDA) Q02248 (/IDA) Q02248 (/IDA) Q02248 (/IDA) |
|
Protein polyubiquitination GO:0000209
Addition of multiple ubiquitin groups to a protein, forming a ubiquitin chain.
|
5 | Q02248 (/ISO) Q02248 (/ISO) Q02248 (/ISO) Q02248 (/ISO) Q02248 (/ISO) |
|
Embryonic axis specification GO:0000578
The establishment, maintenance and elaboration of a pattern along a line or a point in an embryo.
|
5 | Q02248 (/IDA) Q02248 (/IDA) Q02248 (/IDA) Q02248 (/IDA) Q02248 (/IDA) |
|
Cell morphogenesis involved in differentiation GO:0000904
The change in form (cell shape and size) that occurs when relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history.
|
5 | Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) |
|
Skeletal system development GO:0001501
The process whose specific outcome is the progression of the skeleton over time, from its formation to the mature structure. The skeleton is the bony framework of the body in vertebrates (endoskeleton) or the hard outer envelope of insects (exoskeleton or dermoskeleton).
|
5 | Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) |
|
Branching involved in blood vessel morphogenesis GO:0001569
The process of coordinated growth and sprouting of blood vessels giving rise to the organized vascular system.
|
5 | Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) |
|
Vasculogenesis GO:0001570
The differentiation of endothelial cells from progenitor cells during blood vessel development, and the de novo formation of blood vessels and tubes.
|
5 | Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) |
|
Branching involved in ureteric bud morphogenesis GO:0001658
The process in which the branching structure of the ureteric bud is generated and organized. The ureteric bud is an epithelial tube that grows out from the metanephric duct. The bud elongates and branches to give rise to the ureter and kidney collecting tubules.
|
5 | Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) |
|
In utero embryonic development GO:0001701
The process whose specific outcome is the progression of the embryo in the uterus over time, from formation of the zygote in the oviduct, to birth. An example of this process is found in Mus musculus.
|
5 | Q02248 (/IGI) Q02248 (/IGI) Q02248 (/IGI) Q02248 (/IGI) Q02248 (/IGI) |
|
In utero embryonic development GO:0001701
The process whose specific outcome is the progression of the embryo in the uterus over time, from formation of the zygote in the oviduct, to birth. An example of this process is found in Mus musculus.
|
5 | Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) |
|
Gastrulation with mouth forming second GO:0001702
A gastrulation process in which the initial invagination becomes the anus and the mouth forms second.
|
5 | Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) |
|
Endoderm formation GO:0001706
The formation of the endoderm during gastrulation.
|
5 | Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) |
|
Cell fate specification GO:0001708
The process involved in the specification of cell identity. Once specification has taken place, a cell will be committed to differentiate down a specific pathway if left in its normal environment.
|
5 | Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) |
|
Endodermal cell fate commitment GO:0001711
The cell differentiation process that results in commitment of a cell to become part of the endoderm.
|
5 | Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) |
|
Neuron migration GO:0001764
The characteristic movement of an immature neuron from germinal zones to specific positions where they will reside as they mature.
|
5 | Q02248 (/IGI) Q02248 (/IGI) Q02248 (/IGI) Q02248 (/IGI) Q02248 (/IGI) |
|
Kidney development GO:0001822
The process whose specific outcome is the progression of the kidney over time, from its formation to the mature structure. The kidney is an organ that filters the blood and/or excretes the end products of body metabolism in the form of urine.
|
5 | Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) |
|
Neural plate development GO:0001840
The process whose specific outcome is the progression of the neural plate over time, from its formation to the mature structure. The neural plate is a flat, thickened layer of ectodermal cells. The underlying dorsal mesoderm signals the ectodermal cells above it to elongate into columnar neural plate cells. The neural plate subsequently develops into the neural tube, which gives rise to the central nervous system.
|
5 | Q02248 (/IDA) Q02248 (/IDA) Q02248 (/IDA) Q02248 (/IDA) Q02248 (/IDA) |
|
Tissue homeostasis GO:0001894
A homeostatic process involved in the maintenance of an internal steady state within a defined tissue of an organism, including control of cellular proliferation and death and control of metabolic function.
|
5 | Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) |
|
Vasculature development GO:0001944
The process whose specific outcome is the progression of the vasculature over time, from its formation to the mature structure. The vasculature is an interconnected tubular multi-tissue structure that contains fluid that is actively transported around the organism.
|
5 | Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) |
|
Positive regulation of neuroblast proliferation GO:0002052
Any process that activates or increases the rate of neuroblast proliferation.
|
5 | Q02248 (/IGI) Q02248 (/IGI) Q02248 (/IGI) Q02248 (/IGI) Q02248 (/IGI) |
|
Positive regulation of neuroblast proliferation GO:0002052
Any process that activates or increases the rate of neuroblast proliferation.
|
5 | Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) |
|
Positive regulation of mesenchymal cell proliferation GO:0002053
The process of activating or increasing the rate or extent of mesenchymal cell proliferation. Mesenchymal cells are loosely organized embryonic cells.
|
5 | Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) |
|
Lens morphogenesis in camera-type eye GO:0002089
The process in which the anatomical structures of the lens are generated and organized. The lens is a transparent structure in the eye through which light is focused onto the retina. An example of this process is found in Mus musculus.
|
5 | Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) |
|
Ventricular compact myocardium morphogenesis GO:0003223
The process in which the anatomical structures of the compact cardiac ventricle muscle are generated and organized.
|
5 | Q02248 (/TAS) Q02248 (/TAS) Q02248 (/TAS) Q02248 (/TAS) Q02248 (/TAS) |
|
Regulation of secondary heart field cardioblast proliferation GO:0003266
Any process that modulates the frequency, rate or extent of cardioblast proliferation in the second heart field. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating. The secondary heart field is the region of the heart that will form the majority of the mesodermal component of the right ventricle, the arterial pole (outflow tract) and the venous pole (inflow tract).
|
5 | Q02248 (/IDA) Q02248 (/IDA) Q02248 (/IDA) Q02248 (/IDA) Q02248 (/IDA) |
|
Metanephros morphogenesis GO:0003338
The process in which the anatomical structures of the metanephros are generated and organized.
|
5 | Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) |
|
Negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis GO:0003340
Any process that decreases the rate, frequency or extent of the transition where a mesenchymal cell establishes apical/basolateral polarity,forms intercellular adhesive junctions, synthesizes basement membrane components and becomes an epithelial cell that will contribute to the shaping of the metanephros.
|
5 | Q02248 (/IDA) Q02248 (/IDA) Q02248 (/IDA) Q02248 (/IDA) Q02248 (/IDA) |
|
Regulation of transcription, DNA-templated GO:0006355
Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
|
5 | Q02248 (/IDA) Q02248 (/IDA) Q02248 (/IDA) Q02248 (/IDA) Q02248 (/IDA) |
|
Regulation of transcription by RNA polymerase II GO:0006357
Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II.
|
5 | Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) |
|
Cell adhesion GO:0007155
The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules.
|
5 | Q02248 (/ISO) Q02248 (/ISO) Q02248 (/ISO) Q02248 (/ISO) Q02248 (/ISO) |
|
Cell-matrix adhesion GO:0007160
The binding of a cell to the extracellular matrix via adhesion molecules.
|
5 | Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) |
|
Chemical synaptic transmission GO:0007268
The vesicular release of classical neurotransmitter molecules from a presynapse, across a chemical synapse, the subsequent activation of neurotransmitter receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse.
|
5 | Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) |
|
Ectoderm development GO:0007398
The process whose specific outcome is the progression of the ectoderm over time, from its formation to the mature structure. In animal embryos, the ectoderm is the outer germ layer of the embryo, formed during gastrulation.
|
5 | Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) |
|
Glial cell fate determination GO:0007403
The cell fate determination process in which a cell becomes capable of differentiating autonomously into a glial cell regardless of its environment; upon determination, the cell fate cannot be reversed.
|
5 | Q02248 (/IDA) Q02248 (/IDA) Q02248 (/IDA) Q02248 (/IDA) Q02248 (/IDA) |
|
Cell population proliferation GO:0008283
The multiplication or reproduction of cells, resulting in the expansion of a cell population.
|
5 | Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) |
|
Positive regulation of cell population proliferation GO:0008284
Any process that activates or increases the rate or extent of cell proliferation.
|
5 | Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) |
|
Negative regulation of cell population proliferation GO:0008285
Any process that stops, prevents or reduces the rate or extent of cell proliferation.
|
5 | Q02248 (/ISO) Q02248 (/ISO) Q02248 (/ISO) Q02248 (/ISO) Q02248 (/ISO) |
|
Anterior/posterior axis specification GO:0009948
The establishment, maintenance and elaboration of the anterior/posterior axis. The anterior-posterior axis is defined by a line that runs from the head or mouth of an organism to the tail or opposite end of the organism.
|
5 | Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) |
|
Dorsal/ventral axis specification GO:0009950
The establishment, maintenance and elaboration of the dorsal/ventral axis. The dorsal/ventral axis is defined by a line that runs orthogonal to both the anterior/posterior and left/right axes. The dorsal end is defined by the upper or back side of an organism. The ventral end is defined by the lower or front side of an organism.
|
5 | Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) |
|
Proximal/distal pattern formation GO:0009954
The regionalization process in which specific areas of cell differentiation are determined along a proximal/distal axis. The proximal/distal axis is defined by a line that runs from main body (proximal end) of an organism outward (distal end).
|
5 | Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) |
|
Cellular process GO:0009987
Any process that is carried out at the cellular level, but not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.
|
5 | Q02248 (/IDA) Q02248 (/IDA) Q02248 (/IDA) Q02248 (/IDA) Q02248 (/IDA) |
|
Regulation of gene expression GO:0010468
Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
|
5 | Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) |
|
Positive regulation of gene expression GO:0010628
Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
|
5 | Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) |
|
Negative regulation of gene expression GO:0010629
Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
|
5 | Q02248 (/ISO) Q02248 (/ISO) Q02248 (/ISO) Q02248 (/ISO) Q02248 (/ISO) |
|
Positive regulation of epithelial to mesenchymal transition GO:0010718
Any process that increases the rate, frequency, or extent of epithelial to mesenchymal transition. Epithelial to mesenchymal transition is where an epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell.
|
5 | Q02248 (/ISO) Q02248 (/ISO) Q02248 (/ISO) Q02248 (/ISO) Q02248 (/ISO) |
|
Positive regulation of epithelial to mesenchymal transition GO:0010718
Any process that increases the rate, frequency, or extent of epithelial to mesenchymal transition. Epithelial to mesenchymal transition is where an epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell.
|
5 | Q02248 (/TAS) Q02248 (/TAS) Q02248 (/TAS) Q02248 (/TAS) Q02248 (/TAS) |
|
Positive regulation of heparan sulfate proteoglycan biosynthetic process GO:0010909
Any process that increases the rate, frequency or extent of heparan sulfate proteoglycan biosynthesis. Heparan sulfate proteoglycan biosynthetic processes are the chemical reactions and pathways resulting in the formation of the heparan sulfate proteoglycan, a glycosaminoglycan with repeat unit consisting of alternating alpha-(1->4)-linked hexuronic acid and glucosamine residues.
|
5 | Q02248 (/ISO) Q02248 (/ISO) Q02248 (/ISO) Q02248 (/ISO) Q02248 (/ISO) |
|
Schwann cell proliferation GO:0014010
The multiplication or reproduction of Schwann cells, resulting in the expansion of their population. Schwann cells are a type of glial cell in the peripheral nervous system.
|
5 | Q02248 (/ISO) Q02248 (/ISO) Q02248 (/ISO) Q02248 (/ISO) Q02248 (/ISO) |
|
Morphogenesis of embryonic epithelium GO:0016331
The process in which the anatomical structures of embryonic epithelia are generated and organized.
|
5 | Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) |
|
Negative regulation of angiogenesis GO:0016525
Any process that stops, prevents, or reduces the frequency, rate or extent of angiogenesis.
|
5 | Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) |
|
Layer formation in cerebral cortex GO:0021819
The detachment of cells from radial glial fibers at the appropriate time when they cease to migrate and form distinct layer in the cerebral cortex.
|
5 | Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) |
|
Central nervous system vasculogenesis GO:0022009
The differentiation of endothelial cells from progenitor cells during blood vessel development, and the de novo formation of blood vessels and tubes in the central nervous system. The capillary endothelial cells in the brain are specialized to form the blood-brain barrier.
|
5 | Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) |
|
Hair cycle process GO:0022405
A multicellular organismal process involved in the cyclical phases of growth (anagen), regression (catagen), quiescence (telogen), and shedding (exogen) in the life of a hair; one of the collection or mass of filaments growing from the skin of an animal, and forming a covering for a part of the head or for any part or the whole of the body.
|
5 | Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) |
|
Hemopoiesis GO:0030097
The process whose specific outcome is the progression of the myeloid and lymphoid derived organ/tissue systems of the blood and other parts of the body over time, from formation to the mature structure. The site of hemopoiesis is variable during development, but occurs primarily in bone marrow or kidney in many adult vertebrates.
|
5 | Q02248 (/IDA) Q02248 (/IDA) Q02248 (/IDA) Q02248 (/IDA) Q02248 (/IDA) |
|
Cell differentiation GO:0030154
The process in which relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state.
|
5 | Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) |
|
T cell differentiation GO:0030217
The process in which a precursor cell type acquires characteristics of a more mature T-cell. A T cell is a type of lymphocyte whose definin characteristic is the expression of a T cell receptor complex.
|
5 | Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) |
|
Osteoclast differentiation GO:0030316
The process in which a relatively unspecialized monocyte acquires the specialized features of an osteoclast. An osteoclast is a specialized phagocytic cell associated with the absorption and removal of the mineralized matrix of bone tissue.
|
5 | Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) |
|
Lung development GO:0030324
The process whose specific outcome is the progression of the lung over time, from its formation to the mature structure. In all air-breathing vertebrates the lungs are developed from the ventral wall of the oesophagus as a pouch which divides into two sacs. In amphibians and many reptiles the lungs retain very nearly this primitive sac-like character, but in the higher forms the connection with the esophagus becomes elongated into the windpipe and the inner walls of the sacs become more and more divided, until, in the mammals, the air spaces become minutely divided into tubes ending in small air cells, in the walls of which the blood circulates in a fine network of capillaries. In mammals the lungs are more or less divided into lobes, and each lung occupies a separate cavity in the thorax.
|
5 | Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) |
|
Male genitalia development GO:0030539
The process whose specific outcome is the progression of the male genitalia over time, from its formation to the mature structure.
|
5 | Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) |
|
Regulation of epithelial cell differentiation GO:0030856
Any process that modulates the frequency, rate or extent of epithelial cell differentiation.
|
5 | Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) |
|
Positive regulation of epithelial cell differentiation GO:0030858
Any process that activates or increases the frequency, rate or extent of epithelial cell differentiation.
|
5 | Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) |
|
Forebrain development GO:0030900
The process whose specific outcome is the progression of the forebrain over time, from its formation to the mature structure. The forebrain is the anterior of the three primary divisions of the developing chordate brain or the corresponding part of the adult brain (in vertebrates, includes especially the cerebral hemispheres, the thalamus, and the hypothalamus and especially in higher vertebrates is the main control center for sensory and associative information processing, visceral functions, and voluntary motor functions).
|
5 | Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) |
|
Midbrain development GO:0030901
The process whose specific outcome is the progression of the midbrain over time, from its formation to the mature structure. The midbrain is the middle division of the three primary divisions of the developing chordate brain or the corresponding part of the adult brain (in vertebrates, includes a ventral part containing the cerebral peduncles and a dorsal tectum containing the corpora quadrigemina and that surrounds the aqueduct of Sylvius connecting the third and fourth ventricles).
|
5 | Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) |
|
Hindbrain development GO:0030902
The process whose specific outcome is the progression of the hindbrain over time, from its formation to the mature structure. The hindbrain is the posterior of the three primary divisions of the developing chordate brain, or the corresponding part of the adult brain (in vertebrates, includes the cerebellum, pons, and medulla oblongata and controls the autonomic functions and equilibrium).
|
5 | Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) |
|
Regulation of centriole-centriole cohesion GO:0030997
Any process that modulates the extent to which the two centrioles within a centrosome remain tightly paired; may be mediated by the assembly and disassembly of a proteinaceous linker.
|
5 | Q02248 (/ISO) Q02248 (/ISO) Q02248 (/ISO) Q02248 (/ISO) Q02248 (/ISO) |
|
Pancreas development GO:0031016
The process whose specific outcome is the progression of the pancreas over time, from its formation to the mature structure. The pancreas is an endoderm derived structure that produces precursors of digestive enzymes and blood glucose regulating enzymes.
|
5 | Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) |
|
Hair follicle morphogenesis GO:0031069
The process in which the anatomical structures of the hair follicle are generated and organized.
|
5 | Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) |
|
Regulation of myelination GO:0031641
Any process that modulates the frequency, rate or extent of the formation of a myelin sheath around nerve axons.
|
5 | Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) |
|
Positive regulation of telomere maintenance via telomerase GO:0032212
Any process that activates or increases the frequency, rate or extent of the addition of telomeric repeats by telomerase.
|
5 | Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) |
|
Negative regulation of chondrocyte differentiation GO:0032331
Any process that stops, prevents, or reduces the frequency, rate or extent of chondrocyte differentiation.
|
5 | Q02248 (/IGI) Q02248 (/IGI) Q02248 (/IGI) Q02248 (/IGI) Q02248 (/IGI) |
|
Response to estradiol GO:0032355
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of stimulus by estradiol, a C18 steroid hormone hydroxylated at C3 and C17 that acts as a potent estrogen.
|
5 | Q02248 (/ISO) Q02248 (/ISO) Q02248 (/ISO) Q02248 (/ISO) Q02248 (/ISO) |
|
T cell differentiation in thymus GO:0033077
The process in which a precursor cell type acquires the specialized features of a T cell via a differentiation pathway dependent upon transit through the thymus.
|
5 | Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) |
|
Negative regulation of protein sumoylation GO:0033234
Any process that stops, prevents, or reduces the frequency, rate or extent of the addition of SUMO groups to a protein.
|
5 | Q02248 (/ISO) Q02248 (/ISO) Q02248 (/ISO) Q02248 (/ISO) Q02248 (/ISO) |
|
Response to cytokine GO:0034097
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cytokine stimulus.
|
5 | Q02248 (/ISO) Q02248 (/ISO) Q02248 (/ISO) Q02248 (/ISO) Q02248 (/ISO) |
|
Adherens junction organization GO:0034332
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an adherens junction. An adherens junction is a cell junction at which the cytoplasmic face of the plasma membrane is attached to actin filaments.
|
5 | Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) |
|
Adherens junction assembly GO:0034333
The aggregation, arrangement and bonding together of a set of components to form an adherens junction. An adherens junction is a cell junction at which the cytoplasmic face of the plasma membrane is attached to actin filaments.
|
5 | Q02248 (/ISO) Q02248 (/ISO) Q02248 (/ISO) Q02248 (/ISO) Q02248 (/ISO) |
|
Protein localization to cell surface GO:0034394
A process in which a protein is transported to, or maintained in, a location within the external part of the cell wall and/or plasma membrane.
|
5 | Q02248 (/ISO) Q02248 (/ISO) Q02248 (/ISO) Q02248 (/ISO) Q02248 (/ISO) |
|
Cellular protein localization GO:0034613
Any process in which a protein is transported to, and/or maintained in, a specific location at the level of a cell. Localization at the cellular level encompasses movement within the cell, from within the cell to the cell surface, or from one location to another at the surface of a cell.
|
5 | Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) |
|
Embryonic heart tube development GO:0035050
The process whose specific outcome is the progression of the embryonic heart tube over time, from its formation to the mature structure. The heart tube forms as the heart rudiment from the heart field.
|
5 | Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) |
|
Genitalia morphogenesis GO:0035112
The process in which the anatomical structures of genitalia are generated and organized. The genitalia are the organs of reproduction or generation, external and internal.
|
5 | Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) |
|
Embryonic forelimb morphogenesis GO:0035115
The process, occurring in the embryo, by which the anatomical structures of the forelimb are generated and organized. The forelimbs are the front limbs of an animal, e.g. the arms of a human.
|
5 | Q02248 (/IDA) Q02248 (/IDA) Q02248 (/IDA) Q02248 (/IDA) Q02248 (/IDA) |
|
Embryonic skeletal limb joint morphogenesis GO:0036023
The process, occurring in the embryo, in which the anatomical structures of a skeletal limb joint are generated and organized. A skeletal limb joint is the connecting structure between the bones of a limb.
|
5 | Q02248 (/IGI) Q02248 (/IGI) Q02248 (/IGI) Q02248 (/IGI) Q02248 (/IGI) |
|
Regulation of cell population proliferation GO:0042127
Any process that modulates the frequency, rate or extent of cell proliferation.
|
5 | Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) |
|
Regulation of T cell proliferation GO:0042129
Any process that modulates the frequency, rate or extent of T cell proliferation.
|
5 | Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) |
|
Odontogenesis of dentin-containing tooth GO:0042475
The process whose specific outcome is the progression of a dentin-containing tooth over time, from its formation to the mature structure. A dentin-containing tooth is a hard, bony organ borne on the jaw or other bone of a vertebrate, and is composed mainly of dentin, a dense calcified substance, covered by a layer of enamel.
|
5 | Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) |
|
Embryonic digit morphogenesis GO:0042733
The process, occurring in the embryo, by which the anatomical structures of the digit are generated and organized. A digit is one of the terminal divisions of an appendage, such as a finger or toe.
|
5 | Q02248 (/IGI) Q02248 (/IGI) Q02248 (/IGI) Q02248 (/IGI) Q02248 (/IGI) |
|
Embryonic digit morphogenesis GO:0042733
The process, occurring in the embryo, by which the anatomical structures of the digit are generated and organized. A digit is one of the terminal divisions of an appendage, such as a finger or toe.
|
5 | Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) |
|
Regulation of apoptotic process GO:0042981
Any process that modulates the occurrence or rate of cell death by apoptotic process.
|
5 | Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) |
|
Positive regulation of apoptotic process GO:0043065
Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process.
|
5 | Q02248 (/ISO) Q02248 (/ISO) Q02248 (/ISO) Q02248 (/ISO) Q02248 (/ISO) |
|
Negative regulation of apoptotic process GO:0043066
Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process.
|
5 | Q02248 (/ISO) Q02248 (/ISO) Q02248 (/ISO) Q02248 (/ISO) Q02248 (/ISO) |
|
Positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123
Any process that activates or increases the frequency, rate or extent of I-kappaB kinase/NF-kappaB signaling.
|
5 | Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) |
|
Proteasome-mediated ubiquitin-dependent protein catabolic process GO:0043161
The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome.
|
5 | Q02248 (/ISO) Q02248 (/ISO) Q02248 (/ISO) Q02248 (/ISO) Q02248 (/ISO) |
|
Positive regulation of MAPK cascade GO:0043410
Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the MAPK cascade.
|
5 | Q02248 (/IGI) Q02248 (/IGI) Q02248 (/IGI) Q02248 (/IGI) Q02248 (/IGI) |
|
Positive regulation of neuron apoptotic process GO:0043525
Any process that activates or increases the frequency, rate or extent of cell death of neurons by apoptotic process.
|
5 | Q02248 (/ISO) Q02248 (/ISO) Q02248 (/ISO) Q02248 (/ISO) Q02248 (/ISO) |
|
Response to estrogen GO:0043627
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of stimulus by an estrogen, C18 steroid hormones that can stimulate the development of female sexual characteristics.
|
5 | Q02248 (/ISO) Q02248 (/ISO) Q02248 (/ISO) Q02248 (/ISO) Q02248 (/ISO) |
|
Positive regulation of molecular function GO:0044093
Any process that activates or increases the rate or extent of a molecular function, an elemental biological activity occurring at the molecular level, such as catalysis or binding.
|
5 | Q02248 (/IDA) Q02248 (/IDA) Q02248 (/IDA) Q02248 (/IDA) Q02248 (/IDA) |
|
Canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition GO:0044334
The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes involved in the positive regulation of epithelial cell to mesenchymal cell transition.
|
5 | Q02248 (/ISO) Q02248 (/ISO) Q02248 (/ISO) Q02248 (/ISO) Q02248 (/ISO) |
|
Bone resorption GO:0045453
The process in which specialized cells known as osteoclasts degrade the organic and inorganic portions of bone, and endocytose and transport the degradation products.
|
5 | Q02248 (/IGI) Q02248 (/IGI) Q02248 (/IGI) Q02248 (/IGI) Q02248 (/IGI) |
|
Bone resorption GO:0045453
The process in which specialized cells known as osteoclasts degrade the organic and inorganic portions of bone, and endocytose and transport the degradation products.
|
5 | Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) |
|
Regulation of cell differentiation GO:0045595
Any process that modulates the frequency, rate or extent of cell differentiation, the process in which relatively unspecialized cells acquire specialized structural and functional features.
|
5 | Q02248 (/IDA) Q02248 (/IDA) Q02248 (/IDA) Q02248 (/IDA) Q02248 (/IDA) |
|
Negative regulation of cell differentiation GO:0045596
Any process that stops, prevents, or reduces the frequency, rate or extent of cell differentiation.
|
5 | Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) |
|
Positive regulation of endothelial cell differentiation GO:0045603
Any process that activates or increases the frequency, rate or extent of endothelial cell differentiation.
|
5 | Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) |
|
Regulation of osteoblast differentiation GO:0045667
Any process that modulates the frequency, rate or extent of osteoblast differentiation.
|
5 | Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) |
|
Positive regulation of osteoblast differentiation GO:0045669
Any process that activates or increases the frequency, rate or extent of osteoblast differentiation.
|
5 | Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) |
|
Regulation of osteoclast differentiation GO:0045670
Any process that modulates the frequency, rate or extent of osteoclast differentiation.
|
5 | Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) |
|
Negative regulation of osteoclast differentiation GO:0045671
Any process that stops, prevents, or reduces the frequency, rate or extent of osteoclast differentiation.
|
5 | Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) |
|
Negative regulation of transcription, DNA-templated GO:0045892
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
|
5 | Q02248 (/IDA) Q02248 (/IDA) Q02248 (/IDA) Q02248 (/IDA) Q02248 (/IDA) |
|
Negative regulation of transcription, DNA-templated GO:0045892
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
|
5 | Q02248 (/ISO) Q02248 (/ISO) Q02248 (/ISO) Q02248 (/ISO) Q02248 (/ISO) |
|
Positive regulation of transcription, DNA-templated GO:0045893
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
|
5 | Q02248 (/ISO) Q02248 (/ISO) Q02248 (/ISO) Q02248 (/ISO) Q02248 (/ISO) |
|
Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
|
5 | Q02248 (/IGI) Q02248 (/IGI) Q02248 (/IGI) Q02248 (/IGI) Q02248 (/IGI) |
|
Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
|
5 | Q02248 (/ISO) Q02248 (/ISO) Q02248 (/ISO) Q02248 (/ISO) Q02248 (/ISO) |
|
Negative regulation of mitotic cell cycle, embryonic GO:0045976
Any process that stops, prevents or reduces the rate or extent of progression through the embryonic mitotic cell cycle.
|
5 | Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) |
|
Chromatin-mediated maintenance of transcription GO:0048096
Maintenance of transcription by remodelling of chromatin into an 'open configuration'. Once established, this regulation is mitotically stable and is maintained over many cell divisions. It is also heritable.
|
5 | Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) |
|
Cell maturation GO:0048469
A developmental process, independent of morphogenetic (shape) change, that is required for a cell to attain its fully functional state.
|
5 | Q02248 (/IDA) Q02248 (/IDA) Q02248 (/IDA) Q02248 (/IDA) Q02248 (/IDA) |
|
Cell maturation GO:0048469
A developmental process, independent of morphogenetic (shape) change, that is required for a cell to attain its fully functional state.
|
5 | Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) |
|
Synaptic vesicle transport GO:0048489
The directed movement of synaptic vesicles.
|
5 | Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) |
|
Animal organ development GO:0048513
Development of a tissue or tissues that work together to perform a specific function or functions. Development pertains to the process whose specific outcome is the progression of a structure over time, from its formation to the mature structure. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions.
|
5 | Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) |
|
Thymus development GO:0048538
The process whose specific outcome is the progression of the thymus over time, from its formation to the mature structure. The thymus is a symmetric bi-lobed organ involved primarily in the differentiation of immature to mature T cells, with unique vascular, nervous, epithelial, and lymphoid cell components.
|
5 | Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) |
|
Oocyte development GO:0048599
The process whose specific outcome is the progression of an oocyte over time, from initial commitment of the cell to its specific fate, to the fully functional differentiated cell.
|
5 | Q02248 (/IGI) Q02248 (/IGI) Q02248 (/IGI) Q02248 (/IGI) Q02248 (/IGI) |
|
Embryonic foregut morphogenesis GO:0048617
The process in which the anatomical structures of the foregut are generated and organized, during the embryonic phase.
|
5 | Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) |
|
Positive regulation of skeletal muscle tissue development GO:0048643
Any process that activates, maintains or increases the rate of skeletal muscle tissue development.
|
5 | Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) |
|
Regulation of smooth muscle cell proliferation GO:0048660
Any process that modulates the frequency, rate or extent of smooth muscle cell proliferation.
|
5 | Q02248 (/ISO) Q02248 (/ISO) Q02248 (/ISO) Q02248 (/ISO) Q02248 (/ISO) |
|
Negative regulation of oligodendrocyte differentiation GO:0048715
Any process that stops, prevents, or reduces the frequency, rate or extent of oligodendrocyte differentiation.
|
5 | Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) |
|
Negative regulation of neurogenesis GO:0050768
Any process that stops, prevents, or reduces the frequency, rate or extent of neurogenesis, the generation of cells within the nervous system.
|
5 | Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) |
|
Synapse organization GO:0050808
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a synapse, the junction between a neuron and a target (neuron, muscle, or secretory cell).
|
5 | Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) |
|
Smooth muscle cell differentiation GO:0051145
The process in which a relatively unspecialized cell acquires specialized features of a smooth muscle cell; smooth muscle lacks transverse striations in its constituent fibers and are almost always involuntary.
|
5 | Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) |
|
Regulation of histone H3-K4 methylation GO:0051569
Any process that modulates the frequency, rate or extent of the covalent addition of a methyl group to the lysine at position 4 of histone H3.
|
5 | Q02248 (/NAS) Q02248 (/NAS) Q02248 (/NAS) Q02248 (/NAS) Q02248 (/NAS) |
|
Regulation of histone H3-K4 methylation GO:0051569
Any process that modulates the frequency, rate or extent of the covalent addition of a methyl group to the lysine at position 4 of histone H3.
|
5 | Q02248 (/TAS) Q02248 (/TAS) Q02248 (/TAS) Q02248 (/TAS) Q02248 (/TAS) |
|
Regulation of timing of anagen GO:0051884
Any process that modulates the frequency, rate or extent of timing of anagen, the growth phase of the hair cycle.
|
5 | Q02248 (/IDA) Q02248 (/IDA) Q02248 (/IDA) Q02248 (/IDA) Q02248 (/IDA) |
|
Positive regulation of telomerase activity GO:0051973
Any process that activates or increases the frequency, rate or extent of telomerase activity, the catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).
|
5 | Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) |
|
Cardiac muscle cell proliferation GO:0060038
The expansion of a cardiac muscle cell population by cell division.
|
5 | Q02248 (/TAS) Q02248 (/TAS) Q02248 (/TAS) Q02248 (/TAS) Q02248 (/TAS) |
|
Oviduct development GO:0060066
The reproductive developmental process whose specific outcome is the progression of an oviduct over time, from its formation to the mature structure. An oviduct is a tube through which an ova passes from the ovary to the uterus, or from the ovary to the outside of the organism.
|
5 | Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) |
|
Canonical Wnt signaling pathway GO:0060070
The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes. In this pathway, the activated receptor signals via downstream effectors that result in the inhibition of beta-catenin phosphorylation, thereby preventing degradation of beta-catenin. Stabilized beta-catenin can then accumulate and travel to the nucleus to trigger changes in transcription of target genes.
|
5 | Q02248 (/ISO) Q02248 (/ISO) Q02248 (/ISO) Q02248 (/ISO) Q02248 (/ISO) |
|
Delamination GO:0060232
The process of negative regulation of cell adhesion that results in a cell or sheet of cells splitting off from an existing epithelial sheet.
|
5 | O42486 (/IMP) O42486 (/IMP) P18824 (/IMP) P18824 (/IMP) P18824 (/IMP) |
|
Trachea morphogenesis GO:0060439
The process in which a trachea is generated and organized. The trachea is the portion of the airway that attaches to the bronchi as it branches.
|
5 | Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) |
|
Trachea formation GO:0060440
The process pertaining to the initial formation of a trachea from unspecified parts. The process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the trachea is recognizable. The trachea is the portion of the airway that attaches to the bronchi as it branches.
|
5 | Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) |
|
Epithelial tube branching involved in lung morphogenesis GO:0060441
The process in which a highly ordered sequence of patterning events generates the branched epithelial tubes of the lung, consisting of reiterated combinations of bud outgrowth, elongation, and dichotomous subdivision of terminal units.
|
5 | Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) |
|
Lung cell differentiation GO:0060479
The process in which relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features of a mature cell found in the lung. Differentiation includes the processes involved in commitment of a cell to a specific fate.
|
5 | Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) |
|
Lung-associated mesenchyme development GO:0060484
The biological process whose specific outcome is the progression of a lung-associated mesenchyme from an initial condition to its mature state. This process begins with the formation of lung-associated mesenchyme and ends with the mature structure. Lung-associated mesenchyme is the tissue made up of loosely connected mesenchymal cells in the lung.
|
5 | Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) |
|
Mesenchyme development GO:0060485
The process whose specific outcome is the progression of a mesenchymal tissue over time, from its formation to the mature structure. A mesenchymal tissue is made up of loosely packed stellate cells.
|
5 | Q02248 (/TAS) Q02248 (/TAS) Q02248 (/TAS) Q02248 (/TAS) Q02248 (/TAS) |
|
Lung induction GO:0060492
The close range interaction of two or more cells or tissues that causes the cells of the foregut to change their fates and specify the development of the lung.
|
5 | Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) |
|
Epithelial cell differentiation involved in prostate gland development GO:0060742
The process in which a relatively unspecialized cell acquires specialized features of an epithelial cell of the prostate gland.
|
5 | Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) |
|
Positive regulation of epithelial cell proliferation involved in prostate gland development GO:0060769
Any process that increases the rate, frequency or extent of epithelial cell proliferation that contributes to the progression of the prostate gland over time.
|
5 | Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) |
|
Hair follicle placode formation GO:0060789
The developmental process in which a hair placode forms. An hair follicle placode is a thickening of the ectoderm that will give rise to the hair follicle bud.
|
5 | Q02248 (/IGI) Q02248 (/IGI) Q02248 (/IGI) Q02248 (/IGI) Q02248 (/IGI) |
|
Hair follicle placode formation GO:0060789
The developmental process in which a hair placode forms. An hair follicle placode is a thickening of the ectoderm that will give rise to the hair follicle bud.
|
5 | Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) |
|
Mesenchymal cell proliferation involved in lung development GO:0060916
The multiplication or reproduction of cells, resulting in the expansion of a mesenchymal cell population that contributes to the progression of the lung over time. A mesenchymal cell is a cell that normally gives rise to other cells that are organized as three-dimensional masses, rather than sheets.
|
5 | Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) |
|
Cardiac vascular smooth muscle cell differentiation GO:0060947
The process in which a relatively unspecialized cell acquires specialized features of a cardiac vascular smooth muscle cell. A cardiac vascular smooth muscle cell covers the heart vasculature and lacks transverse striations in its constituent fibers.
|
5 | Q02248 (/TAS) Q02248 (/TAS) Q02248 (/TAS) Q02248 (/TAS) Q02248 (/TAS) |
|
Coronary artery morphogenesis GO:0060982
The process in which the anatomical structures of coronary arteries are generated and organized. Coronary arteries are blood vessels that transport blood to the heart muscle.
|
5 | Q02248 (/TAS) Q02248 (/TAS) Q02248 (/TAS) Q02248 (/TAS) Q02248 (/TAS) |
|
Epicardium-derived cardiac vascular smooth muscle cell differentiation GO:0060983
The process in which a relatively unspecialized cell derived from the epicardium acquires specialized features of a cardiac vascular smooth muscle cell. A cardiac vascular smooth muscle cell covers the heart vasculature and lacks transverse striations in its constituent fibers.
|
5 | Q02248 (/TAS) Q02248 (/TAS) Q02248 (/TAS) Q02248 (/TAS) Q02248 (/TAS) |
|
Positive regulation of branching involved in lung morphogenesis GO:0061047
Any process that increases the rate, frequency, or extent of the process in which a highly ordered sequence of patterning events generates the branched structures of the lung, consisting of reiterated combinations of bud outgrowth, elongation, and dichotomous subdivision of terminal units.
|
5 | Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) |
|
Endothelial tube morphogenesis GO:0061154
The process in which the anatomical structures of a tube are generated and organized from an endothelium. Endothelium refers to the layer of cells lining blood vessels, lymphatics, the heart, and serous cavities, and is derived from bone marrow or mesoderm. Corneal endothelium is a special case, derived from neural crest cells.
|
5 | Q02248 (/ISO) Q02248 (/ISO) Q02248 (/ISO) Q02248 (/ISO) Q02248 (/ISO) |
|
Fungiform papilla formation GO:0061198
The developmental process pertaining to the initial formation of a spongiform papilla from unspecified parts. The fungiform papilla is a mushroom-shaped papilla of the tongue.
|
5 | Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) |
|
Canonical Wnt signaling pathway involved in positive regulation of cardiac outflow tract cell proliferation GO:0061324
The canonical Wnt signaling pathway that contributes to the modulation of the expansion of a population of cardiac outflow tract cells.
|
5 | Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) |
|
Sympathetic ganglion development GO:0061549
The process whose specific outcome is the progression of a sympathetic ganglion over time, from its formation to the mature structure.
|
5 | Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) |
|
Cranial ganglion development GO:0061550
The process whose specific outcome is the progression of a cranial ganglion over time, from its formation to the mature structure.
|
5 | Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) |
|
Regulation of centromeric sister chromatid cohesion GO:0070602
Any process that modulates the frequency, rate or extent of sister chromatid cohesion in the centromeric region of a chromosome.
|
5 | Q02248 (/ISO) Q02248 (/ISO) Q02248 (/ISO) Q02248 (/ISO) Q02248 (/ISO) |
|
Cellular response to mechanical stimulus GO:0071260
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mechanical stimulus.
|
5 | Q02248 (/ISO) Q02248 (/ISO) Q02248 (/ISO) Q02248 (/ISO) Q02248 (/ISO) |
|
Cellular response to growth factor stimulus GO:0071363
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a growth factor stimulus.
|
5 | Q02248 (/ISO) Q02248 (/ISO) Q02248 (/ISO) Q02248 (/ISO) Q02248 (/ISO) |
|
Renal vesicle formation GO:0072033
The developmental process pertaining to the initial formation of the renal vesicle from condensed mesenchymal cells. The renal vesicle is the primordial structure of the nephron epithelium, and is formed by the condensation of mesenchymal cells.
|
5 | Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) |
|
Renal inner medulla development GO:0072053
The process whose specific outcome is the progression of the renal inner medulla over time, from its formation to the mature structure. The renal inner medulla is unique to mammalian kidneys and is the innermost region of the mammalian kidney.
|
5 | Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) |
|
Renal outer medulla development GO:0072054
The process whose specific outcome is the progression of the renal outer medulla over time, from its formation to the mature structure. The renal outer medulla is the region of the kidney that lies between the renal cortex and the renal inner medulla.
|
5 | Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) |
|
Nephron tubule formation GO:0072079
The developmental process pertaining to the initial formation of a nephron tubule from unspecified parts. A nephron tubule is an epithelial tube that is part of the nephron, the functional part of the kidney.
|
5 | Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) |
|
Mesenchyme morphogenesis GO:0072132
The process in which the anatomical structures of a mesenchymal tissue are generated and organized. A mesenchymal tissue is made up of loosely packed stellate cells.
|
5 | Q02248 (/TAS) Q02248 (/TAS) Q02248 (/TAS) Q02248 (/TAS) Q02248 (/TAS) |
|
Regulation of nephron tubule epithelial cell differentiation GO:0072182
Any process that modulates the frequency, rate or extent of nephron tubule epithelial cell differentiation.
|
5 | Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) |
|
Regulation of calcium ion import GO:0090279
Any process that modulates the rate, frequency, or extent of the directed movement of calcium ions into a cell or organelle.
|
5 | Q02248 (/ISO) Q02248 (/ISO) Q02248 (/ISO) Q02248 (/ISO) Q02248 (/ISO) |
|
Synaptic vesicle clustering GO:0097091
The process that results in grouping synaptic vesicles in presynaptic structures.
|
5 | Q02248 (/IDA) Q02248 (/IDA) Q02248 (/IDA) Q02248 (/IDA) Q02248 (/IDA) |
|
Synaptic vesicle clustering GO:0097091
The process that results in grouping synaptic vesicles in presynaptic structures.
|
5 | Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) |
|
Negative regulation of neuron death GO:1901215
Any process that stops, prevents or reduces the frequency, rate or extent of neuron death.
|
5 | Q02248 (/IGI) Q02248 (/IGI) Q02248 (/IGI) Q02248 (/IGI) Q02248 (/IGI) |
|
Negative regulation of oxidative stress-induced neuron death GO:1903204
Any process that stops, prevents or reduces the frequency, rate or extent of oxidative stress-induced neuron death.
|
5 | Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) |
|
Regulation of histone demethylase activity (H3-K4 specific) GO:1904173
Any process that modulates the frequency, rate or extent of histone demethylase activity (H3-K4 specific).
|
5 | Q02248 (/TAS) Q02248 (/TAS) Q02248 (/TAS) Q02248 (/TAS) Q02248 (/TAS) |
|
Regulation of chromatin-mediated maintenance of transcription GO:1904499
Any process that modulates the frequency, rate or extent of chromatin-mediated maintenance of transcription.
|
5 | Q02248 (/NAS) Q02248 (/NAS) Q02248 (/NAS) Q02248 (/NAS) Q02248 (/NAS) |
|
Positive regulation of chromatin-mediated maintenance of transcription GO:1904501
Any process that activates or increases the frequency, rate or extent of chromatin-mediated maintenance of transcription.
|
5 | Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) |
|
Regulation of euchromatin binding GO:1904793
Any process that modulates the frequency, rate or extent of euchromatin binding.
|
5 | Q02248 (/IDA) Q02248 (/IDA) Q02248 (/IDA) Q02248 (/IDA) Q02248 (/IDA) |
|
Regulation of core promoter binding GO:1904796
Any process that modulates the frequency, rate or extent of core promoter binding.
|
5 | Q02248 (/IDA) Q02248 (/IDA) Q02248 (/IDA) Q02248 (/IDA) Q02248 (/IDA) |
|
Positive regulation of core promoter binding GO:1904798
Any process that activates or increases the frequency, rate or extent of core promoter binding.
|
5 | Q02248 (/ISO) Q02248 (/ISO) Q02248 (/ISO) Q02248 (/ISO) Q02248 (/ISO) |
|
Cranial skeletal system development GO:1904888
The process whose specific outcome is the progression of a cranial skeletal system over time, from its formation to the mature structure. The cranial skeletal system is the skeletal subdivision of the head, and includes the skull (cranium plus mandible), pharyngeal and/or hyoid apparatus.
|
5 | Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) |
|
Midbrain dopaminergic neuron differentiation GO:1904948
The process in which a relatively unspecialized cell acquires the specialized features of a midbrain dopaminergic neuron.
|
5 | Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) |
|
Neuron projection extension GO:1990138
Long distance growth of a single neuron projection involved in cellular development. A neuron projection is a prolongation or process extending from a nerve cell, e.g. an axon or dendrite.
|
5 | Q02248 (/ISO) Q02248 (/ISO) Q02248 (/ISO) Q02248 (/ISO) Q02248 (/ISO) |
|
Cellular response to insulin-like growth factor stimulus GO:1990314
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insulin-like growth factor stimulus.
|
5 | Q02248 (/ISO) Q02248 (/ISO) Q02248 (/ISO) Q02248 (/ISO) Q02248 (/ISO) |
|
Embryonic brain development GO:1990403
The process occurring during the embryonic phase whose specific outcome is the progression of the brain over time, from its formation to the mature structure.
|
5 | Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) |
|
Dorsal root ganglion development GO:1990791
The process whose specific outcome is the progression of a dorsal root ganglion over time, from its formation to the mature structure.
|
5 | Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) |
|
Regulation of protein localization to cell surface GO:2000008
Any process that modulates the frequency, rate or extent of protein localization to the cell surface.
|
5 | Q02248 (/ISO) Q02248 (/ISO) Q02248 (/ISO) Q02248 (/ISO) Q02248 (/ISO) |
|
Positive regulation of determination of dorsal identity GO:2000017
Any process that activates or increases the frequency, rate or extent of determination of dorsal identity.
|
5 | Q02248 (/IDA) Q02248 (/IDA) Q02248 (/IDA) Q02248 (/IDA) Q02248 (/IDA) |
|
Positive regulation of DNA-templated transcription, initiation GO:2000144
Any process that activates or increases the frequency, rate or extent of DNA-templated transcription initiation.
|
5 | Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) |
|
Positive regulation of neural precursor cell proliferation GO:2000179
Any process that activates or increases the frequency, rate or extent of neural precursor cell proliferation.
|
5 | Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) |
|
Negative regulation of apoptotic signaling pathway GO:2001234
Any process that stops, prevents or reduces the frequency, rate or extent of apoptotic signaling pathway.
|
5 | Q02248 (/IGI) Q02248 (/IGI) Q02248 (/IGI) Q02248 (/IGI) Q02248 (/IGI) |
|
Negative regulation of apoptotic signaling pathway GO:2001234
Any process that stops, prevents or reduces the frequency, rate or extent of apoptotic signaling pathway.
|
5 | Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) |
|
Cell adhesion GO:0007155
The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules.
|
4 | A0A2R8QDB8 (/IC) F1QGH7 (/IC) F1QTT3 (/IC) Q9PVF7 (/IC) |
|
Negative regulation of transcription by RNA polymerase II GO:0000122
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
|
3 | P18824 (/IMP) P18824 (/IMP) P18824 (/IMP) |
|
Cell morphogenesis GO:0000902
The developmental process in which the size or shape of a cell is generated and organized.
|
3 | P18824 (/IMP) P18824 (/IMP) P18824 (/IMP) |
|
Compound eye morphogenesis GO:0001745
The morphogenetic process in which the anatomical structures of the compound eye are generated and organized. The adult compound eye is a precise assembly of 700-800 ommatidia. Each ommatidium is composed of 20 cells, identified by cell type and position. An example of compound eye morphogenesis is found in Drosophila melanogaster.
|
3 | P18824 (/IMP) P18824 (/IMP) P18824 (/IMP) |
|
Atrioventricular valve morphogenesis GO:0003181
The process in which the structure of the atrioventricular valve is generated and organized.
|
3 | A0A2R8QDB8 (/IMP) F1QTT3 (/IMP) Q9PVF7 (/IMP) |
|
Negative regulation of Wnt signaling pathway involved in heart development GO:0003308
Any process that decreases the rate, frequency, or extent of the series of molecular signals initiated by binding of Wnt protein to a frizzled family receptor on the surface of the target cell, resulting a change in cell state that contributes to the progression of the heart over time.
|
3 | A0A2R8QDB8 (/IGI) F1QTT3 (/IGI) Q9PVF7 (/IGI) |
|
Segment polarity determination GO:0007367
Division of the 14 parasegments of the embryo into anterior and posterior compartments; exemplified by the actions of the segment polarity gene products.
|
3 | P18824 (/IMP) P18824 (/IMP) P18824 (/IMP) |
|
Ventral furrow formation GO:0007370
Formation of a ventral indentation (furrow) from the blastoderm epithelium, which is internalized to form a tube in the interior of the embryo, marking the start of gastrulation.
|
3 | P18824 (/IMP) P18824 (/IMP) P18824 (/IMP) |
|
Dorsal closure GO:0007391
The process during Drosophila embryogenesis whereby the ectodermal cells of the lateral epithelium stretch in a coordinated fashion to internalize the amnioserosa cells and close the embryo dorsally.
|
3 | P18824 (/IGI) P18824 (/IGI) P18824 (/IGI) |
|
Dorsal closure GO:0007391
The process during Drosophila embryogenesis whereby the ectodermal cells of the lateral epithelium stretch in a coordinated fashion to internalize the amnioserosa cells and close the embryo dorsally.
|
3 | P18824 (/IMP) P18824 (/IMP) P18824 (/IMP) |
|
Nervous system development GO:0007399
The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state.
|
3 | P18824 (/IMP) P18824 (/IMP) P18824 (/IMP) |
|
Wing disc morphogenesis GO:0007472
The process in which the anatomical structures derived from the wing disc are generated and organized. This includes the transformation of a wing imaginal disc from a monolayered epithelium in the larvae of holometabolous insects into recognizable adult structures including the wing hinge, wing blade and pleura.
|
3 | P18824 (/IMP) P18824 (/IMP) P18824 (/IMP) |
|
Long-term memory GO:0007616
The memory process that deals with the storage, retrieval and modification of information a long time (typically weeks, months or years) after receiving that information. This type of memory is typically dependent on gene transcription regulated by second messenger activation.
|
3 | P18824 (/IMP) P18824 (/IMP) P18824 (/IMP) |
|
Imaginal disc-derived wing margin morphogenesis GO:0008587
The process in which the anatomical structures of the imaginal disc-derived wing margin are generated and organized. The wing margin is a strip of cells in the third instar disc at the boundary between the presumptive dorsal and ventral surfaces of the wing blade.
|
3 | P18824 (/IMP) P18824 (/IMP) P18824 (/IMP) |
|
Dorsal/ventral pattern formation GO:0009953
The regionalization process in which the areas along the dorsal/ventral axis are established that will lead to differences in cell differentiation. The dorsal/ventral axis is defined by a line that runs orthogonal to both the anterior/posterior and left/right axes. The dorsal end is defined by the upper or back side of an organism. The ventral end is defined by the lower or front side of an organism.
|
3 | F1QGH7 (/IGI) O42486 (/IGI) O42486 (/IGI) |
|
Neuroblast development GO:0014019
The process aimed at the progression of a neuroblast over time, from initial commitment of the cell to a specific state, to the mature neuroblast. It does not include processes where the neuroblast turns into a glial cell or a neuron.
|
3 | P18824 (/IMP) P18824 (/IMP) P18824 (/IMP) |
|
Negative regulation of Wnt signaling pathway GO:0030178
Any process that stops, prevents, or reduces the frequency, rate or extent of the Wnt signaling pathway.
|
3 | A0A2R8QDB8 (/IMP) F1QTT3 (/IMP) Q9PVF7 (/IMP) |
|
Cuticle pattern formation GO:0035017
The regionalization process that gives rise to the patterns of cell differentiation in the cuticle.
|
3 | P18824 (/IMP) P18824 (/IMP) P18824 (/IMP) |
|
Somatic stem cell population maintenance GO:0035019
Any process by which an organism retains a population of somatic stem cells, undifferentiated cells in the embryo or adult which can undergo unlimited division and give rise to cell types of the body other than those of the germ-line.
|
3 | P18824 (/IMP) P18824 (/IMP) P18824 (/IMP) |
|
Branch fusion, open tracheal system GO:0035147
Fusing of specific tracheal branches in an open tracheal system to branches from neighboring hemisegments to form a continuous tracheal network. Branch fusion is mediated by individual cells at the tip of each branch, which contact a similar cell and undergo a coordinated series of morphogenetic events that create a bicellular fusion joint.
|
3 | P18824 (/IMP) P18824 (/IMP) P18824 (/IMP) |
|
Epithelial cell type specification, open tracheal system GO:0035153
Allocation of epithelial cells within each migrating branch in an open tracheal system to distinct tracheal cell fates. During the migration phase each branch forms a well-defined number of cell types (including fusion cells, terminal cells and branch cells) at precise positions.
|
3 | P18824 (/IMP) P18824 (/IMP) P18824 (/IMP) |
|
Chitin-based larval cuticle pattern formation GO:0035293
The process that gives rise to the patterns of cell differentiation in the chitin-based larval cuticle. An example of this is found in Drosophila melanogaster.
|
3 | P18824 (/IMP) P18824 (/IMP) P18824 (/IMP) |
|
Zonula adherens assembly GO:0045186
Assembly of the zonula adherens, a cell-cell adherens junction which forms a continuous belt near the apex of epithelial cells.
|
3 | P18824 (/IMP) P18824 (/IMP) P18824 (/IMP) |
|
Photoreceptor cell differentiation GO:0046530
The specialization of organization of a photoreceptor, a cell that responds to incident electromagnetic radiation, particularly visible light. An example of this process is found in Drosophila melanogaster.
|
3 | P18824 (/IMP) P18824 (/IMP) P18824 (/IMP) |
|
Compound eye retinal cell programmed cell death GO:0046667
Programmed cell death that occurs in the retina to remove excess cells between ommatidia, thus resulting in a hexagonal lattice, precise with respect to cell number and position surrounding each ommatidium.
|
3 | P18824 (/IMP) P18824 (/IMP) P18824 (/IMP) |
|
Oogenesis GO:0048477
The complete process of formation and maturation of an ovum or female gamete from a primordial female germ cell. Examples of this process are found in Mus musculus and Drosophila melanogaster.
|
3 | P18824 (/IMP) P18824 (/IMP) P18824 (/IMP) |
|
Imaginal disc-derived wing expansion GO:0048526
The process of expanding or inflating the folded imaginal disc-derived pupal wing, and the adhering of the dorsal and ventral surfaces, to form the mature adult wing.
|
3 | P18824 (/IMP) P18824 (/IMP) P18824 (/IMP) |
|
Branching morphogenesis of an epithelial tube GO:0048754
The process in which the anatomical structures of branches in an epithelial tube are generated and organized. A tube is a long hollow cylinder.
|
3 | P18824 (/IMP) P18824 (/IMP) P18824 (/IMP) |
|
Convergent extension GO:0060026
The morphogenetic process in which an epithelium narrows along one axis and lengthens in a perpendicular axis.
|
3 | E7FC99 (/IGI) F1QGH7 (/IGI) Q8JID2 (/IGI) |
|
Heart formation GO:0060914
The developmental process pertaining to the initial formation of the heart from unspecified parts. This process begins with the specific processes that contribute to the appearance of the heart field and the arrival of cardiac neural crest to the heart region. The process ends when the structural rudiment is recognizable.
|
3 | P18824 (/IMP) P18824 (/IMP) P18824 (/IMP) |
|
Protein localization to adherens junction GO:0071896
Any process in which a protein is transported to, and/or maintained at the adherens junction.
|
3 | P18824 (/IMP) P18824 (/IMP) P18824 (/IMP) |
|
Cell elongation involved in imaginal disc-derived wing morphogenesis GO:0090254
The process in which a cell elongates and contributes to imaginal disc-derived wing morphogenesis.
|
3 | P18824 (/IMP) P18824 (/IMP) P18824 (/IMP) |
|
Dorsal/ventral axis specification GO:0009950
The establishment, maintenance and elaboration of the dorsal/ventral axis. The dorsal/ventral axis is defined by a line that runs orthogonal to both the anterior/posterior and left/right axes. The dorsal end is defined by the upper or back side of an organism. The ventral end is defined by the lower or front side of an organism.
|
2 | E7FC99 (/IGI) Q8JID2 (/IGI) |
|
Positive regulation of gene expression GO:0010628
Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
|
2 | O42486 (/IDA) O42486 (/IDA) |
|
Neuroblast fate commitment GO:0014017
The process in which the developmental fate of a cell becomes restricted such that it will differentiate into a neuroblast.
|
2 | Q17GS9 (/ISS) Q29I35 (/ISS) |
|
Negative regulation of cell migration GO:0030336
Any process that stops, prevents, or reduces the frequency, rate or extent of cell migration.
|
2 | O42486 (/IDA) O42486 (/IDA) |
|
Negative regulation of cell adhesion mediated by integrin GO:0033629
Any process that stops, prevents, or reduces the frequency, rate, or extent of cell adhesion mediated by integrin.
|
2 | O42486 (/IDA) O42486 (/IDA) |
|
Limb morphogenesis GO:0035108
The process in which the anatomical structures of a limb are generated and organized. A limb is a paired appendage of a tetrapod used for locomotion or grasping.
|
2 | O42486 (/IGI) O42486 (/IGI) |
|
Limb morphogenesis GO:0035108
The process in which the anatomical structures of a limb are generated and organized. A limb is a paired appendage of a tetrapod used for locomotion or grasping.
|
2 | O42486 (/NAS) O42486 (/NAS) |
|
Embryonic forelimb morphogenesis GO:0035115
The process, occurring in the embryo, by which the anatomical structures of the forelimb are generated and organized. The forelimbs are the front limbs of an animal, e.g. the arms of a human.
|
2 | O42486 (/IMP) O42486 (/IMP) |
|
Determination of dorsal identity GO:0048263
Determination of the identity of part of an organism or organ where those parts are of the type that occur in the dorsal region. Identity is considered to be the aggregate of characteristics by which a structure is recognized.
|
2 | E7FC99 (/IMP) Q8JID2 (/IMP) |
|
Protein heterooligomerization GO:0051291
The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of component monomers that are not all identical. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer.
|
2 | Q6P0K8 (/IPI) Q9WU82 (/IPI) |
|
Canonical Wnt signaling pathway GO:0060070
The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes. In this pathway, the activated receptor signals via downstream effectors that result in the inhibition of beta-catenin phosphorylation, thereby preventing degradation of beta-catenin. Stabilized beta-catenin can then accumulate and travel to the nucleus to trigger changes in transcription of target genes.
|
2 | O42486 (/NAS) O42486 (/NAS) |
|
Cardiac epithelial to mesenchymal transition GO:0060317
A transition where a cardiac epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell.
|
2 | O42486 (/IMP) O42486 (/IMP) |
|
Embryonic axis specification GO:0000578
The establishment, maintenance and elaboration of a pattern along a line or a point in an embryo.
|
1 | F1QGH7 (/IMP) |
|
Cartilage condensation GO:0001502
The condensation of mesenchymal cells that have been committed to differentiate into chondrocytes.
|
1 | P26233 (/IMP) |
|
Liver development GO:0001889
The process whose specific outcome is the progression of the liver over time, from its formation to the mature structure. The liver is an exocrine gland which secretes bile and functions in metabolism of protein and carbohydrate and fat, synthesizes substances involved in the clotting of the blood, synthesizes vitamin A, detoxifies poisonous substances, stores glycogen, and breaks down worn-out erythrocytes.
|
1 | Q9WU82 (/IEP) |
|
Liver development GO:0001889
The process whose specific outcome is the progression of the liver over time, from its formation to the mature structure. The liver is an exocrine gland which secretes bile and functions in metabolism of protein and carbohydrate and fat, synthesizes substances involved in the clotting of the blood, synthesizes vitamin A, detoxifies poisonous substances, stores glycogen, and breaks down worn-out erythrocytes.
|
1 | F1QGH7 (/IGI) |
|
Positive regulation of cell-matrix adhesion GO:0001954
Any process that activates or increases the rate or extent of cell adhesion to an extracellular matrix.
|
1 | Q02257 (/ISO) |
|
Chondrocyte differentiation GO:0002062
The process in which a chondroblast acquires specialized structural and/or functional features of a chondrocyte. A chondrocyte is a polymorphic cell that forms cartilage.
|
1 | P26233 (/IMP) |
|
Desmosome assembly GO:0002159
A cellular process that results in the aggregation, arrangement and bonding together of a set of components to form a desmosome. A desmosome is a patch-like intercellular junction found in vertebrate tissues, consisting of parallel zones of two cell membranes, separated by an space of 25-35 nm, and having dense fibrillar plaques in the subjacent cytoplasm.
|
1 | Q02257 (/ISO) |
|
Glomerular filtration GO:0003094
The process in which plasma is filtered through the glomerular membrane which consists of capillary endothelial cells, the basement membrane, and epithelial cells. The glomerular filtrate is the same as plasma except it has no significant amount of protein.
|
1 | F1QGH7 (/IMP) |
|
Cell adhesion GO:0007155
The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules.
|
1 | Q02257 (/IDA) |
|
Cell adhesion GO:0007155
The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules.
|
1 | Q9WU82 (/NAS) |
|
Ectoderm development GO:0007398
The process whose specific outcome is the progression of the ectoderm over time, from its formation to the mature structure. In animal embryos, the ectoderm is the outer germ layer of the embryo, formed during gastrulation.
|
1 | F1QGH7 (/IGI) |
|
Midgut development GO:0007494
The process whose specific outcome is the progression of the midgut over time, from its formation to the mature structure. The midgut is the middle part of the alimentary canal from the stomach, or entrance of the bile duct, to, or including, the large intestine.
|
1 | Q9WU82 (/IEP) |
|
Response to hormone GO:0009725
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hormone stimulus.
|
1 | Q9WU82 (/IEP) |
|
Anterior/posterior axis specification GO:0009948
The establishment, maintenance and elaboration of the anterior/posterior axis. The anterior-posterior axis is defined by a line that runs from the head or mouth of an organism to the tail or opposite end of the organism.
|
1 | Q63ZT4 (/IGI) |
|
Schwann cell proliferation GO:0014010
The multiplication or reproduction of Schwann cells, resulting in the expansion of their population. Schwann cells are a type of glial cell in the peripheral nervous system.
|
1 | Q9WU82 (/IMP) |
|
Response to organic cyclic compound GO:0014070
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic cyclic compound stimulus.
|
1 | Q9WU82 (/IEP) |
|
Response to activity GO:0014823
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an activity stimulus.
|
1 | Q9WU82 (/IEP) |
|
Cell migration GO:0016477
The controlled self-propelled movement of a cell from one site to a destination guided by molecular cues. Cell migration is a central process in the development and maintenance of multicellular organisms.
|
1 | Q02257 (/ISO) |
|
Negative regulation of cell migration GO:0030336
Any process that stops, prevents, or reduces the frequency, rate or extent of cell migration.
|
1 | P26233 (/IMP) |
|
Embryonic camera-type eye development GO:0031076
The process occurring during the embryonic phase whose specific outcome is the progression of the eye over time, from its formation to the mature structure.
|
1 | P26233 (/IMP) |
|
Positive regulation of protein ubiquitination GO:0031398
Any process that activates or increases the frequency, rate or extent of the addition of ubiquitin groups to a protein.
|
1 | P26233 (/IMP) |
|
Negative regulation of chondrocyte differentiation GO:0032331
Any process that stops, prevents, or reduces the frequency, rate or extent of chondrocyte differentiation.
|
1 | P26233 (/IMP) |
|
Response to estradiol GO:0032355
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of stimulus by estradiol, a C18 steroid hormone hydroxylated at C3 and C17 that acts as a potent estrogen.
|
1 | Q9WU82 (/IEP) |
|
Response to cytokine GO:0034097
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cytokine stimulus.
|
1 | Q9WU82 (/IDA) |
|
Wound healing GO:0042060
The series of events that restore integrity to a damaged tissue, following an injury.
|
1 | P26233 (/IMP) |
|
Regulation of cell population proliferation GO:0042127
Any process that modulates the frequency, rate or extent of cell proliferation.
|
1 | Q02257 (/ISO) |
|
Positive regulation of protein import into nucleus GO:0042307
Any process that activates or increases the frequency, rate or extent of movement of proteins from the cytoplasm into the nucleus.
|
1 | Q02257 (/ISO) |
|
Odontogenesis of dentin-containing tooth GO:0042475
The process whose specific outcome is the progression of a dentin-containing tooth over time, from its formation to the mature structure. A dentin-containing tooth is a hard, bony organ borne on the jaw or other bone of a vertebrate, and is composed mainly of dentin, a dense calcified substance, covered by a layer of enamel.
|
1 | Q9WU82 (/IEP) |
|
Negative regulation of DNA-binding transcription factor activity GO:0043433
Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of a transcription factor, any factor involved in the initiation or regulation of transcription.
|
1 | P26233 (/IMP) |
|
Negative regulation of blood vessel endothelial cell migration GO:0043537
Any process that stops, prevents, or reduces the frequency, rate or extent of the migration of the endothelial cells of blood vessels.
|
1 | Q02257 (/ISO) |
|
Response to estrogen GO:0043627
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of stimulus by an estrogen, C18 steroid hormones that can stimulate the development of female sexual characteristics.
|
1 | Q9WU82 (/IDA) |
|
Cellular response to fibroblast growth factor stimulus GO:0044344
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an fibroblast growth factor stimulus.
|
1 | Q9WU82 (/IEP) |
|
Myoblast differentiation GO:0045445
The process in which a relatively unspecialized cell acquires specialized features of a myoblast. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into striated muscle fibers.
|
1 | Q9WU82 (/IEP) |
|
Positive regulation of angiogenesis GO:0045766
Any process that activates or increases angiogenesis.
|
1 | Q02257 (/ISO) |
|
Positive regulation of transcription, DNA-templated GO:0045893
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
|
1 | P26233 (/NAS) |
|
Response to cadmium ion GO:0046686
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cadmium (Cd) ion stimulus.
|
1 | Q9WU82 (/IEP) |
|
Bone remodeling GO:0046849
The continuous turnover of bone matrix and mineral that involves first, an increase in resorption (osteoclastic activity) and later, reactive bone formation (osteoblastic activity). The process of bone remodeling takes place in the adult skeleton at discrete foci. The process ensures the mechanical integrity of the skeleton throughout life and plays an important role in calcium homeostasis. An imbalance in the regulation of bone resorption and bone formation results in many of the metabolic bone diseases, such as osteoporosis.
|
1 | Q9WU82 (/IEP) |
|
Determination of dorsal/ventral asymmetry GO:0048262
Determination of asymmetry from the dorsal to the ventral side; as, the dorsoventral axis.
|
1 | F1QGH7 (/IDA) |
|
Determination of dorsal/ventral asymmetry GO:0048262
Determination of asymmetry from the dorsal to the ventral side; as, the dorsoventral axis.
|
1 | F1QGH7 (/IMP) |
|
Neuron fate commitment GO:0048663
The process in which the developmental fate of a cell becomes restricted such that it will develop into a neuron.
|
1 | Q7ZX35 (/IMP) |
|
Cardiac muscle tissue development GO:0048738
The process whose specific outcome is the progression of cardiac muscle over time, from its formation to the mature structure.
|
1 | P26233 (/IMP) |
|
Detection of mechanical stimulus GO:0050982
The series of events by which a mechanical stimulus is received and converted into a molecular signal.
|
1 | Q02257 (/ISO) |
|
Embryonic retina morphogenesis in camera-type eye GO:0060059
The process in which the anatomical structure of the retina is generated and organized in a camera-type eye during the embryonic life stage.
|
1 | Q7ZX35 (/IMP) |
|
Camera-type eye photoreceptor cell differentiation GO:0060219
The process in which a relatively unspecialized cell acquires the specialized features of a photoreceptor cell in a camera-type eye.
|
1 | Q7ZX35 (/IMP) |
|
Negative regulation of cartilage development GO:0061037
Any process that decreases the rate, frequency, or extent of cartilage development, the process whose specific outcome is the progression of the cartilage over time, from its formation to the mature structure. Cartilage is a connective tissue dominated by extracellular matrix containing collagen type II and large amounts of proteoglycan, particularly chondroitin sulfate.
|
1 | P26233 (/IMP) |
|
Cellular response to mechanical stimulus GO:0071260
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mechanical stimulus.
|
1 | Q9WU82 (/IDA) |
|
Cellular response to lithium ion GO:0071285
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lithium (Li+) ion stimulus.
|
1 | Q9WU82 (/IEP) |
|
Endothelial cell-cell adhesion GO:0071603
The attachment of an endothelial cell to another endothelial cell via adhesion molecules.
|
1 | Q8SPJ1 (/IDA) |
|
Protein localization to plasma membrane GO:0072659
A process in which a protein is transported to, or maintained in, a specific location in the plasma membrane.
|
1 | Q02257 (/ISO) |
|
Bundle of His cell-Purkinje myocyte adhesion involved in cell communication GO:0086073
The attachment of a bundle of His cell to a Purkinje myocyte via adhesion molecules that results in the cells being juxtaposed so that they can communicate.
|
1 | Q02257 (/ISO) |
|
Regulation of heart rate by cardiac conduction GO:0086091
A cardiac conduction process that modulates the frequency or rate of heart contraction.
|
1 | Q02257 (/ISO) |
|
Cell-cell adhesion GO:0098609
The attachment of one cell to another cell via adhesion molecules.
|
1 | Q9WU82 (/TAS) |
|
Regulation of ventricular cardiac muscle cell action potential GO:0098911
Any process that modulates the frequency, rate or extent of action potential creation, propagation or termination in a ventricular cardiac muscle cell contributing to the regulation of its contraction. This typically occurs via modulation of the activity or expression of voltage-gated ion channels.
|
1 | Q02257 (/ISO) |
|
Cellular response to insulin-like growth factor stimulus GO:1990314
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insulin-like growth factor stimulus.
|
1 | Q9WU82 (/IEP) |
|
Cellular response to insulin-like growth factor stimulus GO:1990314
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insulin-like growth factor stimulus.
|
1 | Q9WU82 (/IMP) |
|
Positive regulation of Wnt signaling pathway involved in dorsal/ventral axis specification GO:2000055
Any process that activates or increases the frequency, rate or extent of Wnt signaling pathway involved in dorsal/ventral axis specification.
|
1 | F1QGH7 (/IDA) |
There are 131 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
120 |
B1MV73 (/ISS)
B1MV73 (/ISS)
B1MV73 (/ISS)
B1MV73 (/ISS)
B1MV73 (/ISS)
B1MV73 (/ISS)
B1MV73 (/ISS)
B1MV73 (/ISS)
B1MV73 (/ISS)
B1MV73 (/ISS)
(110 more) |
|
Cell cortex GO:0005938
The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins.
|
120 |
B1MV73 (/ISS)
B1MV73 (/ISS)
B1MV73 (/ISS)
B1MV73 (/ISS)
B1MV73 (/ISS)
B1MV73 (/ISS)
B1MV73 (/ISS)
B1MV73 (/ISS)
B1MV73 (/ISS)
B1MV73 (/ISS)
(110 more) |
|
Catenin complex GO:0016342
Complex of peripheral cytoplasmic proteins (alpha-, beta- and gamma-catenin) that interact with the cytoplasmic region of uvomorulin/E-cadherin to connect it to the actin cytoskeleton.
|
120 |
B1MV73 (/ISS)
B1MV73 (/ISS)
B1MV73 (/ISS)
B1MV73 (/ISS)
B1MV73 (/ISS)
B1MV73 (/ISS)
B1MV73 (/ISS)
B1MV73 (/ISS)
B1MV73 (/ISS)
B1MV73 (/ISS)
(110 more) |
|
Cell junction GO:0030054
A cellular component that forms a specialized region of connection between two or more cells or between a cell and the extracellular matrix. At a cell junction, anchoring proteins extend through the plasma membrane to link cytoskeletal proteins in one cell to cytoskeletal proteins in neighboring cells or to proteins in the extracellular matrix.
|
120 |
B1MV73 (/ISS)
B1MV73 (/ISS)
B1MV73 (/ISS)
B1MV73 (/ISS)
B1MV73 (/ISS)
B1MV73 (/ISS)
B1MV73 (/ISS)
B1MV73 (/ISS)
B1MV73 (/ISS)
B1MV73 (/ISS)
(110 more) |
|
Beta-catenin destruction complex GO:0030877
A cytoplasmic protein complex containing glycogen synthase kinase-3-beta (GSK-3-beta), the adenomatous polyposis coli protein (APC), and the scaffolding protein axin, among others; phosphorylates beta-catenin, targets it for degradation by the proteasome.
|
120 |
B1MV73 (/ISS)
B1MV73 (/ISS)
B1MV73 (/ISS)
B1MV73 (/ISS)
B1MV73 (/ISS)
B1MV73 (/ISS)
B1MV73 (/ISS)
B1MV73 (/ISS)
B1MV73 (/ISS)
B1MV73 (/ISS)
(110 more) |
|
Protein-DNA complex GO:0032993
A macromolecular complex containing both protein and DNA molecules.
|
120 |
B1MV73 (/ISS)
B1MV73 (/ISS)
B1MV73 (/ISS)
B1MV73 (/ISS)
B1MV73 (/ISS)
B1MV73 (/ISS)
B1MV73 (/ISS)
B1MV73 (/ISS)
B1MV73 (/ISS)
B1MV73 (/ISS)
(110 more) |
|
Perinuclear region of cytoplasm GO:0048471
Cytoplasm situated near, or occurring around, the nucleus.
|
120 |
B1MV73 (/ISS)
B1MV73 (/ISS)
B1MV73 (/ISS)
B1MV73 (/ISS)
B1MV73 (/ISS)
B1MV73 (/ISS)
B1MV73 (/ISS)
B1MV73 (/ISS)
B1MV73 (/ISS)
B1MV73 (/ISS)
(110 more) |
|
Beta-catenin-TCF7L2 complex GO:0070369
A protein complex that contains beta-catenin and TCF7L2 (TCF4), binds to the TCF DNA motif within a promoter element, and is involved in the regulation of WNT target gene transcription.
|
120 |
B1MV73 (/ISS)
B1MV73 (/ISS)
B1MV73 (/ISS)
B1MV73 (/ISS)
B1MV73 (/ISS)
B1MV73 (/ISS)
B1MV73 (/ISS)
B1MV73 (/ISS)
B1MV73 (/ISS)
B1MV73 (/ISS)
(110 more) |
|
Cell periphery GO:0071944
The part of a cell encompassing the cell cortex, the plasma membrane, and any external encapsulating structures.
|
120 |
B1MV73 (/ISS)
B1MV73 (/ISS)
B1MV73 (/ISS)
B1MV73 (/ISS)
B1MV73 (/ISS)
B1MV73 (/ISS)
B1MV73 (/ISS)
B1MV73 (/ISS)
B1MV73 (/ISS)
B1MV73 (/ISS)
(110 more) |
|
Cell-cell junction GO:0005911
A cell junction that forms a connection between two or more cells in a multicellular organism; excludes direct cytoplasmic junctions such as ring canals.
|
116 |
B1MV73 (/ISS)
B1MV73 (/ISS)
B1MV73 (/ISS)
B1MV73 (/ISS)
B1MV73 (/ISS)
B1MV73 (/ISS)
B1MV73 (/ISS)
B1MV73 (/ISS)
B1MV73 (/ISS)
B1MV73 (/ISS)
(106 more) |
|
Transcription factor complex GO:0005667
A protein complex that is capable of associating with DNA by direct binding, or via other DNA-binding proteins or complexes, and regulating transcription.
|
115 |
B1MV73 (/ISS)
B1MV73 (/ISS)
B1MV73 (/ISS)
B1MV73 (/ISS)
B1MV73 (/ISS)
B1MV73 (/ISS)
B1MV73 (/ISS)
B1MV73 (/ISS)
B1MV73 (/ISS)
B1MV73 (/ISS)
(105 more) |
|
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
115 |
B1MV73 (/ISS)
B1MV73 (/ISS)
B1MV73 (/ISS)
B1MV73 (/ISS)
B1MV73 (/ISS)
B1MV73 (/ISS)
B1MV73 (/ISS)
B1MV73 (/ISS)
B1MV73 (/ISS)
B1MV73 (/ISS)
(105 more) |
|
Centrosome GO:0005813
A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle.
|
115 |
B1MV73 (/ISS)
B1MV73 (/ISS)
B1MV73 (/ISS)
B1MV73 (/ISS)
B1MV73 (/ISS)
B1MV73 (/ISS)
B1MV73 (/ISS)
B1MV73 (/ISS)
B1MV73 (/ISS)
B1MV73 (/ISS)
(105 more) |
|
Cell-cell adherens junction GO:0005913
An adherens junction which connects a cell to another cell.
|
115 |
B1MV73 (/ISS)
B1MV73 (/ISS)
B1MV73 (/ISS)
B1MV73 (/ISS)
B1MV73 (/ISS)
B1MV73 (/ISS)
B1MV73 (/ISS)
B1MV73 (/ISS)
B1MV73 (/ISS)
B1MV73 (/ISS)
(105 more) |
|
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
114 |
B1MV73 (/ISS)
B1MV73 (/ISS)
B1MV73 (/ISS)
B1MV73 (/ISS)
B1MV73 (/ISS)
B1MV73 (/ISS)
B1MV73 (/ISS)
B1MV73 (/ISS)
B1MV73 (/ISS)
B1MV73 (/ISS)
(104 more) |
|
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
98 |
A0A024R2Q3 (/IDA)
A0A024R2Q3 (/IDA)
A0A024R2Q3 (/IDA)
A0A024R2Q3 (/IDA)
A0A024R2Q3 (/IDA)
A0A024R2Q3 (/IDA)
A0A024R2Q3 (/IDA)
A0A024R2Q3 (/IDA)
A0A024R2Q3 (/IDA)
A0A024R2Q3 (/IDA)
(88 more) |
|
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
93 |
B1MV73 (/ISS)
B1MV73 (/ISS)
B1MV73 (/ISS)
B1MV73 (/ISS)
B1MV73 (/ISS)
B1MV73 (/ISS)
B1MV73 (/ISS)
B1MV73 (/ISS)
B1MV73 (/ISS)
B1MV73 (/ISS)
(83 more) |
|
Synapse GO:0045202
The junction between a nerve fiber of one neuron and another neuron, muscle fiber or glial cell. As the nerve fiber approaches the synapse it enlarges into a specialized structure, the presynaptic nerve ending, which contains mitochondria and synaptic vesicles. At the tip of the nerve ending is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic nerve ending secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane.
|
69 |
B6V8E6 (/ISS)
B6V8E6 (/ISS)
B6V8E6 (/ISS)
B6V8E6 (/ISS)
B6V8E6 (/ISS)
B6V8E6 (/ISS)
B6V8E6 (/ISS)
B6V8E6 (/ISS)
B6V8E6 (/ISS)
B6V8E6 (/ISS)
(59 more) |
|
Cell-cell junction GO:0005911
A cell junction that forms a connection between two or more cells in a multicellular organism; excludes direct cytoplasmic junctions such as ring canals.
|
60 |
B6V8E6 (/IDA)
B6V8E6 (/IDA)
B6V8E6 (/IDA)
B6V8E6 (/IDA)
B6V8E6 (/IDA)
B6V8E6 (/IDA)
B6V8E6 (/IDA)
B6V8E6 (/IDA)
B6V8E6 (/IDA)
B6V8E6 (/IDA)
(50 more) |
|
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
49 |
A0A2R8QDB8 (/IDA)
E7FC99 (/IDA)
F1QGH7 (/IDA)
F1QTT3 (/IDA)
O42486 (/IDA)
O42486 (/IDA)
P18824 (/IDA)
P18824 (/IDA)
P18824 (/IDA)
P26233 (/IDA)
(39 more) |
|
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
|
47 |
P35222 (/ISS)
P35222 (/ISS)
P35222 (/ISS)
P35222 (/ISS)
P35222 (/ISS)
P35222 (/ISS)
P35222 (/ISS)
P35222 (/ISS)
P35222 (/ISS)
P35222 (/ISS)
(37 more) |
|
Catenin complex GO:0016342
Complex of peripheral cytoplasmic proteins (alpha-, beta- and gamma-catenin) that interact with the cytoplasmic region of uvomorulin/E-cadherin to connect it to the actin cytoskeleton.
|
44 |
A0A2R8QDB8 (/IDA)
F1QGH7 (/IDA)
F1QTT3 (/IDA)
P14923 (/IDA)
P14923 (/IDA)
P14923 (/IDA)
P14923 (/IDA)
P14923 (/IDA)
P14923 (/IDA)
P18824 (/IDA)
(34 more) |
|
Cell-cell adherens junction GO:0005913
An adherens junction which connects a cell to another cell.
|
43 |
A0A2R8QDB8 (/IDA)
F1QGH7 (/IDA)
F1QTT3 (/IDA)
P14923 (/IDA)
P14923 (/IDA)
P14923 (/IDA)
P14923 (/IDA)
P14923 (/IDA)
P14923 (/IDA)
P35222 (/IDA)
(33 more) |
|
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
41 |
A0A1D5NYE8 (/IDA)
A0A1D5NYE8 (/IDA)
A0A1D5NYE8 (/IDA)
A0A1D5NYE8 (/IDA)
A0A1D5NYE8 (/IDA)
A0A1D5NYE8 (/IDA)
O42486 (/IDA)
O42486 (/IDA)
P35222 (/IDA)
P35222 (/IDA)
(31 more) |
|
Adherens junction GO:0005912
A cell junction at which anchoring proteins (cadherins or integrins) extend through the plasma membrane and are attached to actin filaments.
|
36 |
F1QGH7 (/IDA)
O42486 (/IDA)
O42486 (/IDA)
P18824 (/IDA)
P18824 (/IDA)
P18824 (/IDA)
P35222 (/IDA)
P35222 (/IDA)
P35222 (/IDA)
P35222 (/IDA)
(26 more) |
|
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
34 |
O42486 (/IDA)
O42486 (/IDA)
P35222 (/IDA)
P35222 (/IDA)
P35222 (/IDA)
P35222 (/IDA)
P35222 (/IDA)
P35222 (/IDA)
P35222 (/IDA)
P35222 (/IDA)
(24 more) |
|
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
33 |
P18824 (/TAS)
P18824 (/TAS)
P18824 (/TAS)
P35222 (/TAS)
P35222 (/TAS)
P35222 (/TAS)
P35222 (/TAS)
P35222 (/TAS)
P35222 (/TAS)
P35222 (/TAS)
(23 more) |
|
Beta-catenin-TCF complex GO:1990907
A protein complex that contains beta-catenin and a member of the T-cell factor (TCF)/lymphoid enhancer binding factor (LEF) family of transcription factors.
|
33 |
P18824 (/IDA)
P18824 (/IDA)
P18824 (/IDA)
P35222 (/IDA)
P35222 (/IDA)
P35222 (/IDA)
P35222 (/IDA)
P35222 (/IDA)
P35222 (/IDA)
P35222 (/IDA)
(23 more) |
|
Focal adhesion GO:0005925
Small region on the surface of a cell that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments.
|
31 |
P14923 (/HDA)
P14923 (/HDA)
P14923 (/HDA)
P14923 (/HDA)
P14923 (/HDA)
P14923 (/HDA)
P35222 (/HDA)
P35222 (/HDA)
P35222 (/HDA)
P35222 (/HDA)
(21 more) |
|
Lateral plasma membrane GO:0016328
The portion of the plasma membrane at the lateral side of the cell. In epithelial cells, lateral plasma membranes are on the sides of cells which lie at the interface of adjacent cells.
|
31 |
P35222 (/IDA)
P35222 (/IDA)
P35222 (/IDA)
P35222 (/IDA)
P35222 (/IDA)
P35222 (/IDA)
P35222 (/IDA)
P35222 (/IDA)
P35222 (/IDA)
P35222 (/IDA)
(21 more) |
|
Protein-DNA complex GO:0032993
A macromolecular complex containing both protein and DNA molecules.
|
31 |
P14923 (/IDA)
P14923 (/IDA)
P14923 (/IDA)
P14923 (/IDA)
P14923 (/IDA)
P14923 (/IDA)
P35222 (/IDA)
P35222 (/IDA)
P35222 (/IDA)
P35222 (/IDA)
(21 more) |
|
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
|
31 |
P14923 (/HDA)
P14923 (/HDA)
P14923 (/HDA)
P14923 (/HDA)
P14923 (/HDA)
P14923 (/HDA)
P35222 (/HDA)
P35222 (/HDA)
P35222 (/HDA)
P35222 (/HDA)
(21 more) |
|
Transcription factor complex GO:0005667
A protein complex that is capable of associating with DNA by direct binding, or via other DNA-binding proteins or complexes, and regulating transcription.
|
30 |
P35222 (/IDA)
P35222 (/IDA)
P35222 (/IDA)
P35222 (/IDA)
P35222 (/IDA)
P35222 (/IDA)
P35222 (/IDA)
P35222 (/IDA)
P35222 (/IDA)
P35222 (/IDA)
(20 more) |
|
Nuclear euchromatin GO:0005719
The dispersed less dense form of chromatin in the interphase nucleus. It exists in at least two forms, a some being in the form of transcriptionally active chromatin which is the least condensed, while the rest is inactive euchromatin which is more condensed than active chromatin but less condensed than heterochromatin.
|
30 |
P35222 (/IDA)
P35222 (/IDA)
P35222 (/IDA)
P35222 (/IDA)
P35222 (/IDA)
P35222 (/IDA)
P35222 (/IDA)
P35222 (/IDA)
P35222 (/IDA)
P35222 (/IDA)
(20 more) |
|
Centrosome GO:0005813
A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle.
|
30 |
P35222 (/IDA)
P35222 (/IDA)
P35222 (/IDA)
P35222 (/IDA)
P35222 (/IDA)
P35222 (/IDA)
P35222 (/IDA)
P35222 (/IDA)
P35222 (/IDA)
P35222 (/IDA)
(20 more) |
|
Basolateral plasma membrane GO:0016323
The region of the plasma membrane that includes the basal end and sides of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis.
|
30 |
P35222 (/IDA)
P35222 (/IDA)
P35222 (/IDA)
P35222 (/IDA)
P35222 (/IDA)
P35222 (/IDA)
P35222 (/IDA)
P35222 (/IDA)
P35222 (/IDA)
P35222 (/IDA)
(20 more) |
|
Beta-catenin destruction complex GO:0030877
A cytoplasmic protein complex containing glycogen synthase kinase-3-beta (GSK-3-beta), the adenomatous polyposis coli protein (APC), and the scaffolding protein axin, among others; phosphorylates beta-catenin, targets it for degradation by the proteasome.
|
30 |
P35222 (/IDA)
P35222 (/IDA)
P35222 (/IDA)
P35222 (/IDA)
P35222 (/IDA)
P35222 (/IDA)
P35222 (/IDA)
P35222 (/IDA)
P35222 (/IDA)
P35222 (/IDA)
(20 more) |
|
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
|
28 |
P18824 (/TAS)
P18824 (/TAS)
P18824 (/TAS)
P35222 (/TAS)
P35222 (/TAS)
P35222 (/TAS)
P35222 (/TAS)
P35222 (/TAS)
P35222 (/TAS)
P35222 (/TAS)
(18 more) |
|
Beta-catenin-TCF complex GO:1990907
A protein complex that contains beta-catenin and a member of the T-cell factor (TCF)/lymphoid enhancer binding factor (LEF) family of transcription factors.
|
28 |
P18824 (/IPI)
P18824 (/IPI)
P18824 (/IPI)
P35222 (/IPI)
P35222 (/IPI)
P35222 (/IPI)
P35222 (/IPI)
P35222 (/IPI)
P35222 (/IPI)
P35222 (/IPI)
(18 more) |
|
Cell cortex GO:0005938
The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins.
|
26 |
F1QGH7 (/IDA)
P35222 (/IDA)
P35222 (/IDA)
P35222 (/IDA)
P35222 (/IDA)
P35222 (/IDA)
P35222 (/IDA)
P35222 (/IDA)
P35222 (/IDA)
P35222 (/IDA)
(16 more) |
|
Protein-containing complex GO:0032991
A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.
|
26 |
P35222 (/IDA)
P35222 (/IDA)
P35222 (/IDA)
P35222 (/IDA)
P35222 (/IDA)
P35222 (/IDA)
P35222 (/IDA)
P35222 (/IDA)
P35222 (/IDA)
P35222 (/IDA)
(16 more) |
|
Perinuclear region of cytoplasm GO:0048471
Cytoplasm situated near, or occurring around, the nucleus.
|
26 |
P35222 (/IDA)
P35222 (/IDA)
P35222 (/IDA)
P35222 (/IDA)
P35222 (/IDA)
P35222 (/IDA)
P35222 (/IDA)
P35222 (/IDA)
P35222 (/IDA)
P35222 (/IDA)
(16 more) |
|
Cell junction GO:0030054
A cellular component that forms a specialized region of connection between two or more cells or between a cell and the extracellular matrix. At a cell junction, anchoring proteins extend through the plasma membrane to link cytoskeletal proteins in one cell to cytoskeletal proteins in neighboring cells or to proteins in the extracellular matrix.
|
25 |
P35222 (/IDA)
P35222 (/IDA)
P35222 (/IDA)
P35222 (/IDA)
P35222 (/IDA)
P35222 (/IDA)
P35222 (/IDA)
P35222 (/IDA)
P35222 (/IDA)
P35222 (/IDA)
(15 more) |
|
Cell junction GO:0030054
A cellular component that forms a specialized region of connection between two or more cells or between a cell and the extracellular matrix. At a cell junction, anchoring proteins extend through the plasma membrane to link cytoskeletal proteins in one cell to cytoskeletal proteins in neighboring cells or to proteins in the extracellular matrix.
|
25 |
P35222 (/TAS)
P35222 (/TAS)
P35222 (/TAS)
P35222 (/TAS)
P35222 (/TAS)
P35222 (/TAS)
P35222 (/TAS)
P35222 (/TAS)
P35222 (/TAS)
P35222 (/TAS)
(15 more) |
|
Beta-catenin-TCF7L2 complex GO:0070369
A protein complex that contains beta-catenin and TCF7L2 (TCF4), binds to the TCF DNA motif within a promoter element, and is involved in the regulation of WNT target gene transcription.
|
25 |
P35222 (/IDA)
P35222 (/IDA)
P35222 (/IDA)
P35222 (/IDA)
P35222 (/IDA)
P35222 (/IDA)
P35222 (/IDA)
P35222 (/IDA)
P35222 (/IDA)
P35222 (/IDA)
(15 more) |
|
Cell periphery GO:0071944
The part of a cell encompassing the cell cortex, the plasma membrane, and any external encapsulating structures.
|
25 |
P35222 (/IDA)
P35222 (/IDA)
P35222 (/IDA)
P35222 (/IDA)
P35222 (/IDA)
P35222 (/IDA)
P35222 (/IDA)
P35222 (/IDA)
P35222 (/IDA)
P35222 (/IDA)
(15 more) |
|
Wnt signalosome GO:1990909
A multiprotein protein complex containing membrane-localized Wnt receptors and cytosolic protein complexes, which is capable of transmitting the Wnt signal. Contains at least a Wnt protein, LRP5 or LRP6, a member of the Frizzled (Fz) family, Axin and and a Dishevelled (DVL) protein.
|
25 |
P35222 (/NAS)
P35222 (/NAS)
P35222 (/NAS)
P35222 (/NAS)
P35222 (/NAS)
P35222 (/NAS)
P35222 (/NAS)
P35222 (/NAS)
P35222 (/NAS)
P35222 (/NAS)
(15 more) |
|
Exocytic vesicle GO:0070382
A transport vesicle that mediates transport from an intracellular compartment to the plasma membrane, and fuses with the plasma membrane to release various cargo molecules, such as proteins or hormones, by exocytosis.
|
22 |
B6V8E6 (/IDA)
B6V8E6 (/IDA)
B6V8E6 (/IDA)
B6V8E6 (/IDA)
B6V8E6 (/IDA)
B6V8E6 (/IDA)
B6V8E6 (/IDA)
B6V8E6 (/IDA)
B6V8E6 (/IDA)
B6V8E6 (/IDA)
(12 more) |
|
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
|
16 |
A0A1D5NYE8 (/IDA)
A0A1D5NYE8 (/IDA)
A0A1D5NYE8 (/IDA)
A0A1D5NYE8 (/IDA)
A0A1D5NYE8 (/IDA)
A0A1D5NYE8 (/IDA)
F1QGH7 (/IDA)
O42486 (/IDA)
O42486 (/IDA)
P26233 (/IDA)
(6 more) |
|
Intercalated disc GO:0014704
A complex cell-cell junction at which myofibrils terminate in cardiomyocytes; mediates mechanical and electrochemical integration between individual cardiomyocytes. The intercalated disc contains regions of tight mechanical attachment (fasciae adherentes and desmosomes) and electrical coupling (gap junctions) between adjacent cells.
|
13 |
F1QGH7 (/IDA)
P14923 (/IDA)
P14923 (/IDA)
P14923 (/IDA)
P14923 (/IDA)
P14923 (/IDA)
P14923 (/IDA)
Q02248 (/IDA)
Q02248 (/IDA)
Q02248 (/IDA)
(3 more) |
|
Desmosome GO:0030057
A cell-cell junction in which: on the cytoplasmic surface of each interacting plasma membrane is a dense plaque composed of a mixture of intracellular anchor proteins; a bundle of keratin intermediate filaments is attached to the surface of each plaque; transmembrane adhesion proteins of the cadherin family bind to the plaques and interact through their extracellular domains to hold the adjacent membranes together by a Ca2+-dependent mechanism.
|
12 |
A0A2R8QDB8 (/IDA)
F1QTT3 (/IDA)
P14923 (/IDA)
P14923 (/IDA)
P14923 (/IDA)
P14923 (/IDA)
P14923 (/IDA)
P14923 (/IDA)
Q02257 (/IDA)
Q6P0K8 (/IDA)
(2 more) |
|
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
11 |
P14923 (/IMP)
P14923 (/IMP)
P14923 (/IMP)
P14923 (/IMP)
P14923 (/IMP)
P14923 (/IMP)
Q02248 (/IMP)
Q02248 (/IMP)
Q02248 (/IMP)
Q02248 (/IMP)
(1 more) |
|
Cornified envelope GO:0001533
A type of plasma membrane that has been modified through addition of distinct intracellular and extracellular components, including ceramide, found in cornifying epithelial cells (corneocytes).
|
6 | P14923 (/TAS) P14923 (/TAS) P14923 (/TAS) P14923 (/TAS) P14923 (/TAS) P14923 (/TAS) |
|
Extracellular region GO:0005576
The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
|
6 | P14923 (/TAS) P14923 (/TAS) P14923 (/TAS) P14923 (/TAS) P14923 (/TAS) P14923 (/TAS) |
|
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
6 | Q02248 (/ISO) Q02248 (/ISO) Q02248 (/ISO) Q02248 (/ISO) Q02248 (/ISO) Q02257 (/ISO) |
|
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
6 | P14923 (/IMP) P14923 (/IMP) P14923 (/IMP) P14923 (/IMP) P14923 (/IMP) P14923 (/IMP) |
|
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
6 | Q02248 (/ISO) Q02248 (/ISO) Q02248 (/ISO) Q02248 (/ISO) Q02248 (/ISO) Q02257 (/ISO) |
|
Cytoskeleton GO:0005856
Any of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles.
|
6 | P14923 (/ISS) P14923 (/ISS) P14923 (/ISS) P14923 (/ISS) P14923 (/ISS) P14923 (/ISS) |
|
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
6 | Q02248 (/ISO) Q02248 (/ISO) Q02248 (/ISO) Q02248 (/ISO) Q02248 (/ISO) Q02257 (/ISO) |
|
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
6 | P14923 (/TAS) P14923 (/TAS) P14923 (/TAS) P14923 (/TAS) P14923 (/TAS) P14923 (/TAS) |
|
Cell-cell junction GO:0005911
A cell junction that forms a connection between two or more cells in a multicellular organism; excludes direct cytoplasmic junctions such as ring canals.
|
6 | Q02248 (/ISO) Q02248 (/ISO) Q02248 (/ISO) Q02248 (/ISO) Q02248 (/ISO) Q02257 (/ISO) |
|
Cell-cell adherens junction GO:0005913
An adherens junction which connects a cell to another cell.
|
6 | Q02248 (/ISO) Q02248 (/ISO) Q02248 (/ISO) Q02248 (/ISO) Q02248 (/ISO) Q02257 (/ISO) |
|
Zonula adherens GO:0005915
A cell-cell adherens junction which forms a continuous belt near the apex of epithelial cells.
|
6 | P14923 (/ISS) P14923 (/ISS) P14923 (/ISS) P14923 (/ISS) P14923 (/ISS) P14923 (/ISS) |
|
Fascia adherens GO:0005916
A cell-cell adherens junction that contains the transmembrane protein N-cadherin, which interacts with identical molecules from neighboring cells to form a tight mechanical intercellular link; forms a large portion of the intercalated disc, the structure at which myofibrils terminate in cardiomyocytes.
|
6 | Q02248 (/IDA) Q02248 (/IDA) Q02248 (/IDA) Q02248 (/IDA) Q02248 (/IDA) Q6P0K8 (/IDA) |
|
Cytoplasmic side of plasma membrane GO:0009898
The leaflet the plasma membrane that faces the cytoplasm and any proteins embedded or anchored in it or attached to its surface.
|
6 | P14923 (/ISS) P14923 (/ISS) P14923 (/ISS) P14923 (/ISS) P14923 (/ISS) P14923 (/ISS) |
|
Intercalated disc GO:0014704
A complex cell-cell junction at which myofibrils terminate in cardiomyocytes; mediates mechanical and electrochemical integration between individual cardiomyocytes. The intercalated disc contains regions of tight mechanical attachment (fasciae adherentes and desmosomes) and electrical coupling (gap junctions) between adjacent cells.
|
6 | Q02248 (/ISO) Q02248 (/ISO) Q02248 (/ISO) Q02248 (/ISO) Q02248 (/ISO) Q02257 (/ISO) |
|
Lateral plasma membrane GO:0016328
The portion of the plasma membrane at the lateral side of the cell. In epithelial cells, lateral plasma membranes are on the sides of cells which lie at the interface of adjacent cells.
|
6 | Q02248 (/ISO) Q02248 (/ISO) Q02248 (/ISO) Q02248 (/ISO) Q02248 (/ISO) Q02257 (/ISO) |
|
Catenin complex GO:0016342
Complex of peripheral cytoplasmic proteins (alpha-, beta- and gamma-catenin) that interact with the cytoplasmic region of uvomorulin/E-cadherin to connect it to the actin cytoskeleton.
|
6 | Q02248 (/ISO) Q02248 (/ISO) Q02248 (/ISO) Q02248 (/ISO) Q02248 (/ISO) Q02257 (/ISO) |
|
Z disc GO:0030018
Platelike region of a muscle sarcomere to which the plus ends of actin filaments are attached.
|
6 | Q02248 (/IDA) Q02248 (/IDA) Q02248 (/IDA) Q02248 (/IDA) Q02248 (/IDA) Q02257 (/IDA) |
|
Protein-DNA complex GO:0032993
A macromolecular complex containing both protein and DNA molecules.
|
6 | Q02248 (/ISO) Q02248 (/ISO) Q02248 (/ISO) Q02248 (/ISO) Q02248 (/ISO) Q02257 (/ISO) |
|
Specific granule lumen GO:0035580
The volume enclosed by the membrane of a specific granule, a granule with a membranous, tubular internal structure, found primarily in mature neutrophil cells. Most are released into the extracellular fluid. Specific granules contain lactoferrin, lysozyme, vitamin B12 binding protein and elastase.
|
6 | P14923 (/TAS) P14923 (/TAS) P14923 (/TAS) P14923 (/TAS) P14923 (/TAS) P14923 (/TAS) |
|
Synapse GO:0045202
The junction between a nerve fiber of one neuron and another neuron, muscle fiber or glial cell. As the nerve fiber approaches the synapse it enlarges into a specialized structure, the presynaptic nerve ending, which contains mitochondria and synaptic vesicles. At the tip of the nerve ending is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic nerve ending secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane.
|
6 | Q02248 (/IDA) Q02248 (/IDA) Q02248 (/IDA) Q02248 (/IDA) Q02248 (/IDA) Q9WU82 (/IDA) |
|
Gamma-catenin-TCF7L2 complex GO:0071665
A protein complex that contains gamma-catenin and TCF7L2 (TCF4), binds to the TCF DNA motif within a promoter element, and is involved in the regulation of WNT target gene transcription.
|
6 | P14923 (/IDA) P14923 (/IDA) P14923 (/IDA) P14923 (/IDA) P14923 (/IDA) P14923 (/IDA) |
|
Ficolin-1-rich granule lumen GO:1904813
Any membrane-enclosed lumen that is part of a ficolin-1-rich granule.
|
6 | P14923 (/TAS) P14923 (/TAS) P14923 (/TAS) P14923 (/TAS) P14923 (/TAS) P14923 (/TAS) |
|
Transcription factor complex GO:0005667
A protein complex that is capable of associating with DNA by direct binding, or via other DNA-binding proteins or complexes, and regulating transcription.
|
5 | Q02248 (/ISO) Q02248 (/ISO) Q02248 (/ISO) Q02248 (/ISO) Q02248 (/ISO) |
|
Nuclear euchromatin GO:0005719
The dispersed less dense form of chromatin in the interphase nucleus. It exists in at least two forms, a some being in the form of transcriptionally active chromatin which is the least condensed, while the rest is inactive euchromatin which is more condensed than active chromatin but less condensed than heterochromatin.
|
5 | Q02248 (/ISO) Q02248 (/ISO) Q02248 (/ISO) Q02248 (/ISO) Q02248 (/ISO) |
|
Centrosome GO:0005813
A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle.
|
5 | Q02248 (/ISO) Q02248 (/ISO) Q02248 (/ISO) Q02248 (/ISO) Q02248 (/ISO) |
|
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
5 | Q02248 (/ISO) Q02248 (/ISO) Q02248 (/ISO) Q02248 (/ISO) Q02248 (/ISO) |
|
Adherens junction GO:0005912
A cell junction at which anchoring proteins (cadherins or integrins) extend through the plasma membrane and are attached to actin filaments.
|
5 | Q02248 (/ISO) Q02248 (/ISO) Q02248 (/ISO) Q02248 (/ISO) Q02248 (/ISO) |
|
Zonula adherens GO:0005915
A cell-cell adherens junction which forms a continuous belt near the apex of epithelial cells.
|
5 | F1QGH7 (/IDA) P18824 (/IDA) P18824 (/IDA) P18824 (/IDA) Q8SPJ1 (/IDA) |
|
Bicellular tight junction GO:0005923
An occluding cell-cell junction that is composed of a branching network of sealing strands that completely encircles the apical end of each cell in an epithelial sheet; the outer leaflets of the two interacting plasma membranes are seen to be tightly apposed where sealing strands are present. Each sealing strand is composed of a long row of transmembrane adhesion proteins embedded in each of the two interacting plasma membranes.
|
5 | Q02248 (/IDA) Q02248 (/IDA) Q02248 (/IDA) Q02248 (/IDA) Q02248 (/IDA) |
|
Cell cortex GO:0005938
The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins.
|
5 | Q02248 (/ISO) Q02248 (/ISO) Q02248 (/ISO) Q02248 (/ISO) Q02248 (/ISO) |
|
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
|
5 | Q02248 (/ISO) Q02248 (/ISO) Q02248 (/ISO) Q02248 (/ISO) Q02248 (/ISO) |
|
Basolateral plasma membrane GO:0016323
The region of the plasma membrane that includes the basal end and sides of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis.
|
5 | Q02248 (/ISO) Q02248 (/ISO) Q02248 (/ISO) Q02248 (/ISO) Q02248 (/ISO) |
|
Catenin complex GO:0016342
Complex of peripheral cytoplasmic proteins (alpha-, beta- and gamma-catenin) that interact with the cytoplasmic region of uvomorulin/E-cadherin to connect it to the actin cytoskeleton.
|
5 | Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) |
|
Flotillin complex GO:0016600
A protein complex that contains flotillin-1 and flotillin-2, and may contain associated proteins. Flotillins associate into membrane microdomains resembling caveolae.
|
5 | Q02248 (/IDA) Q02248 (/IDA) Q02248 (/IDA) Q02248 (/IDA) Q02248 (/IDA) |
|
Lamellipodium GO:0030027
A thin sheetlike process extended by the leading edge of a migrating cell or extending cell process; contains a dense meshwork of actin filaments.
|
5 | Q02248 (/IDA) Q02248 (/IDA) Q02248 (/IDA) Q02248 (/IDA) Q02248 (/IDA) |
|
Cell junction GO:0030054
A cellular component that forms a specialized region of connection between two or more cells or between a cell and the extracellular matrix. At a cell junction, anchoring proteins extend through the plasma membrane to link cytoskeletal proteins in one cell to cytoskeletal proteins in neighboring cells or to proteins in the extracellular matrix.
|
5 | Q02248 (/ISO) Q02248 (/ISO) Q02248 (/ISO) Q02248 (/ISO) Q02248 (/ISO) |
|
Beta-catenin destruction complex GO:0030877
A cytoplasmic protein complex containing glycogen synthase kinase-3-beta (GSK-3-beta), the adenomatous polyposis coli protein (APC), and the scaffolding protein axin, among others; phosphorylates beta-catenin, targets it for degradation by the proteasome.
|
5 | Q02248 (/ISO) Q02248 (/ISO) Q02248 (/ISO) Q02248 (/ISO) Q02248 (/ISO) |
|
Cell projection membrane GO:0031253
The portion of the plasma membrane surrounding a plasma membrane bounded cell surface projection.
|
5 | Q02248 (/IDA) Q02248 (/IDA) Q02248 (/IDA) Q02248 (/IDA) Q02248 (/IDA) |
|
Microvillus membrane GO:0031528
The portion of the plasma membrane surrounding a microvillus.
|
5 | Q02248 (/IDA) Q02248 (/IDA) Q02248 (/IDA) Q02248 (/IDA) Q02248 (/IDA) |
|
Nuclear membrane GO:0031965
Either of the lipid bilayers that surround the nucleus and form the nuclear envelope; excludes the intermembrane space.
|
5 | Q02248 (/ISO) Q02248 (/ISO) Q02248 (/ISO) Q02248 (/ISO) Q02248 (/ISO) |
|
Protein-containing complex GO:0032991
A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.
|
5 | Q02248 (/ISO) Q02248 (/ISO) Q02248 (/ISO) Q02248 (/ISO) Q02248 (/ISO) |
|
Scrib-APC-beta-catenin complex GO:0034750
A protein complex that contains the Scribble protein (a cell polarity determinant), the tumor suppressor protein adenomatous polyposis coli (APC), and beta-catenin; may be involved in the control of cell proliferation.
|
5 | Q02248 (/IDA) Q02248 (/IDA) Q02248 (/IDA) Q02248 (/IDA) Q02248 (/IDA) |
|
Presynaptic membrane GO:0042734
A specialized area of membrane of the axon terminal that faces the plasma membrane of the neuron or muscle fiber with which the axon terminal establishes a synaptic junction; many synaptic junctions exhibit structural presynaptic characteristics, such as conical, electron-dense internal protrusions, that distinguish it from the remainder of the axon plasma membrane.
|
5 | Q02248 (/IDA) Q02248 (/IDA) Q02248 (/IDA) Q02248 (/IDA) Q02248 (/IDA) |
|
Dendritic shaft GO:0043198
Cylindric portion of the dendrite, directly stemming from the perikaryon, and carrying the dendritic spines.
|
5 | Q02248 (/ISO) Q02248 (/ISO) Q02248 (/ISO) Q02248 (/ISO) Q02248 (/ISO) |
|
Apical junction complex GO:0043296
A functional unit located near the cell apex at the points of contact between epithelial cells, which in vertebrates is composed of the tight junction, the zonula adherens, and desmosomes and in some invertebrates, such as Drosophila, is composed of the subapical complex (SAC), the zonula adherens and the septate junction. Functions in the regulation of cell polarity, tissue integrity and intercellular adhesion and permeability.
|
5 | Q02248 (/IDA) Q02248 (/IDA) Q02248 (/IDA) Q02248 (/IDA) Q02248 (/IDA) |
|
Nuclear transcription factor complex GO:0044798
A protein complex, located in the nucleus, that is capable of associating with DNA by direct binding, or via other DNA-binding proteins or complexes, and regulating transcription.
|
5 | Q02248 (/IDA) Q02248 (/IDA) Q02248 (/IDA) Q02248 (/IDA) Q02248 (/IDA) |
|
Apical part of cell GO:0045177
The region of a polarized cell that forms a tip or is distal to a base. For example, in a polarized epithelial cell, the apical region has an exposed surface and lies opposite to the basal lamina that separates the epithelium from other tissue.
|
5 | Q02248 (/IDA) Q02248 (/IDA) Q02248 (/IDA) Q02248 (/IDA) Q02248 (/IDA) |
|
Synapse GO:0045202
The junction between a nerve fiber of one neuron and another neuron, muscle fiber or glial cell. As the nerve fiber approaches the synapse it enlarges into a specialized structure, the presynaptic nerve ending, which contains mitochondria and synaptic vesicles. At the tip of the nerve ending is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic nerve ending secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane.
|
5 | Q02248 (/ISO) Q02248 (/ISO) Q02248 (/ISO) Q02248 (/ISO) Q02248 (/ISO) |
|
Postsynaptic membrane GO:0045211
A specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft). Neurotransmitters cross the synaptic cleft and transmit the signal to the postsynaptic membrane.
|
5 | Q02248 (/IDA) Q02248 (/IDA) Q02248 (/IDA) Q02248 (/IDA) Q02248 (/IDA) |
|
Perinuclear region of cytoplasm GO:0048471
Cytoplasm situated near, or occurring around, the nucleus.
|
5 | Q02248 (/ISO) Q02248 (/ISO) Q02248 (/ISO) Q02248 (/ISO) Q02248 (/ISO) |
|
Beta-catenin-TCF7L2 complex GO:0070369
A protein complex that contains beta-catenin and TCF7L2 (TCF4), binds to the TCF DNA motif within a promoter element, and is involved in the regulation of WNT target gene transcription.
|
5 | Q02248 (/ISO) Q02248 (/ISO) Q02248 (/ISO) Q02248 (/ISO) Q02248 (/ISO) |
|
Cell periphery GO:0071944
The part of a cell encompassing the cell cortex, the plasma membrane, and any external encapsulating structures.
|
5 | Q02248 (/ISO) Q02248 (/ISO) Q02248 (/ISO) Q02248 (/ISO) Q02248 (/ISO) |
|
Schaffer collateral - CA1 synapse GO:0098685
A synapse between the Schaffer collateral axon of a CA3 pyramidal cell and a CA1 pyramidal cell.
|
5 | Q02248 (/IDA) Q02248 (/IDA) Q02248 (/IDA) Q02248 (/IDA) Q02248 (/IDA) |
|
Schaffer collateral - CA1 synapse GO:0098685
A synapse between the Schaffer collateral axon of a CA3 pyramidal cell and a CA1 pyramidal cell.
|
5 | Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) Q02248 (/IMP) |
|
Presynaptic active zone cytoplasmic component GO:0098831
A specialized region below the presynaptic membrane, characterized by electron-dense material, a specialized cytoskeletal matrix and accumulated (associated) synaptic vesicles.
|
5 | Q02248 (/IDA) Q02248 (/IDA) Q02248 (/IDA) Q02248 (/IDA) Q02248 (/IDA) |
|
Postsynaptic density, intracellular component GO:0099092
A network of proteins adjacent to the postsynaptic membrane forming an electron dense disc. Its major components include neurotransmitter receptors and the proteins that spatially and functionally organize neurotransmitter receptors in the adjacent membrane, such as anchoring and scaffolding molecules, signaling enzymes and cytoskeletal components.
|
5 | Q02248 (/IDA) Q02248 (/IDA) Q02248 (/IDA) Q02248 (/IDA) Q02248 (/IDA) |
|
Beta-catenin-TCF complex GO:1990907
A protein complex that contains beta-catenin and a member of the T-cell factor (TCF)/lymphoid enhancer binding factor (LEF) family of transcription factors.
|
5 | Q02248 (/IC) Q02248 (/IC) Q02248 (/IC) Q02248 (/IC) Q02248 (/IC) |
|
Beta-catenin-TCF complex GO:1990907
A protein complex that contains beta-catenin and a member of the T-cell factor (TCF)/lymphoid enhancer binding factor (LEF) family of transcription factors.
|
5 | Q02248 (/ISO) Q02248 (/ISO) Q02248 (/ISO) Q02248 (/ISO) Q02248 (/ISO) |
|
Wnt signalosome GO:1990909
A multiprotein protein complex containing membrane-localized Wnt receptors and cytosolic protein complexes, which is capable of transmitting the Wnt signal. Contains at least a Wnt protein, LRP5 or LRP6, a member of the Frizzled (Fz) family, Axin and and a Dishevelled (DVL) protein.
|
5 | Q02248 (/IDA) Q02248 (/IDA) Q02248 (/IDA) Q02248 (/IDA) Q02248 (/IDA) |
|
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
3 | P18824 (/HDA) P18824 (/HDA) P18824 (/HDA) |
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Apical plasma membrane GO:0016324
The region of the plasma membrane located at the apical end of the cell.
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3 | P18824 (/IDA) P18824 (/IDA) P18824 (/IDA) |
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Endocytic vesicle GO:0030139
A membrane-bounded intracellular vesicle formed by invagination of the plasma membrane around an extracellular substance. Endocytic vesicles fuse with early endosomes to deliver the cargo for further sorting.
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3 | P18824 (/IDA) P18824 (/IDA) P18824 (/IDA) |
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Axon GO:0030424
The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter.
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3 | P18824 (/IDA) P18824 (/IDA) P18824 (/IDA) |
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Adherens junction GO:0005912
A cell junction at which anchoring proteins (cadherins or integrins) extend through the plasma membrane and are attached to actin filaments.
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2 | Q17GS9 (/ISS) Q29I35 (/ISS) |
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Cytoplasmic side of plasma membrane GO:0009898
The leaflet the plasma membrane that faces the cytoplasm and any proteins embedded or anchored in it or attached to its surface.
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2 | Q6P0K8 (/IDA) Q8SPJ1 (/IDA) |
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Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
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1 | Q9WU82 (/TAS) |
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Cytoskeleton GO:0005856
Any of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles.
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1 | Q8SPJ1 (/IDA) |
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Intermediate filament GO:0005882
A cytoskeletal structure that forms a distinct elongated structure, characteristically 10 nm in diameter, that occurs in the cytoplasm of eukaryotic cells. Intermediate filaments form a fibrous system, composed of chemically heterogeneous subunits and involved in mechanically integrating the various components of the cytoplasmic space. Intermediate filaments may be divided into five chemically distinct classes: Type I, acidic keratins; Type II, basic keratins; Type III, including desmin, vimentin and others; Type IV, neurofilaments and related filaments; and Type V, lamins.
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1 | Q02257 (/IDA) |
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Microvillus GO:0005902
Thin cylindrical membrane-covered projections on the surface of an animal cell containing a core bundle of actin filaments. Present in especially large numbers on the absorptive surface of intestinal cells.
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1 | F1QGH7 (/IDA) |
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Fascia adherens GO:0005916
A cell-cell adherens junction that contains the transmembrane protein N-cadherin, which interacts with identical molecules from neighboring cells to form a tight mechanical intercellular link; forms a large portion of the intercalated disc, the structure at which myofibrils terminate in cardiomyocytes.
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1 | Q02257 (/ISO) |
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Cytoplasmic side of plasma membrane GO:0009898
The leaflet the plasma membrane that faces the cytoplasm and any proteins embedded or anchored in it or attached to its surface.
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1 | Q02257 (/ISO) |
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Apicolateral plasma membrane GO:0016327
The apical end of the lateral plasma membrane of epithelial cells.
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1 | Q6P0K8 (/IDA) |
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Apicolateral plasma membrane GO:0016327
The apical end of the lateral plasma membrane of epithelial cells.
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1 | Q02257 (/ISO) |
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Desmosome GO:0030057
A cell-cell junction in which: on the cytoplasmic surface of each interacting plasma membrane is a dense plaque composed of a mixture of intracellular anchor proteins; a bundle of keratin intermediate filaments is attached to the surface of each plaque; transmembrane adhesion proteins of the cadherin family bind to the plaques and interact through their extracellular domains to hold the adjacent membranes together by a Ca2+-dependent mechanism.
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1 | Q02257 (/IMP) |
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Desmosome GO:0030057
A cell-cell junction in which: on the cytoplasmic surface of each interacting plasma membrane is a dense plaque composed of a mixture of intracellular anchor proteins; a bundle of keratin intermediate filaments is attached to the surface of each plaque; transmembrane adhesion proteins of the cadherin family bind to the plaques and interact through their extracellular domains to hold the adjacent membranes together by a Ca2+-dependent mechanism.
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1 | Q02257 (/ISO) |
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Nuclear membrane GO:0031965
Either of the lipid bilayers that surround the nucleus and form the nuclear envelope; excludes the intermembrane space.
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1 | Q9WU82 (/IDA) |
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Dendritic shaft GO:0043198
Cylindric portion of the dendrite, directly stemming from the perikaryon, and carrying the dendritic spines.
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1 | Q9WU82 (/IDA) |
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Basal part of cell GO:0045178
The region of a cell situated near the base. For example, in a polarized epithelial cell, the basal surface rests on the basal lamina that separates the epithelium from other tissue.
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1 | P26233 (/IDA) |
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Gamma-catenin-TCF7L2 complex GO:0071665
A protein complex that contains gamma-catenin and TCF7L2 (TCF4), binds to the TCF DNA motif within a promoter element, and is involved in the regulation of WNT target gene transcription.
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1 | Q02257 (/ISO) |
