The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 7: Cytoplasmic dynein 1 heavy chain 1-like

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 14 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO TermAnnotationsEvidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
6 P34036 (/IPI) P38650 (/IPI) Q14204 (/IPI) Q14204 (/IPI) Q14204 (/IPI) Q9JHU4 (/IPI)
Dynein light intermediate chain binding GO:0051959
Interacting selectively and non-covalently with a light intermediate chain of the dynein complex.
4 Q14204 (/IPI) Q14204 (/IPI) Q14204 (/IPI) Q9JHU4 (/IPI)
RNA binding GO:0003723
Interacting selectively and non-covalently with an RNA molecule or a portion thereof.
3 Q14204 (/HDA) Q14204 (/HDA) Q14204 (/HDA)
ATP binding GO:0005524
Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
1 P34036 (/IDA)
Microtubule binding GO:0008017
Interacting selectively and non-covalently with microtubules, filaments composed of tubulin monomers.
1 P34036 (/IDA)
ATP-dependent microtubule motor activity, minus-end-directed GO:0008569
Catalysis of movement along a microtubule toward the minus end, coupled to the hydrolysis of ATP.
1 P34036 (/IDA)
Tubulin binding GO:0015631
Interacting selectively and non-covalently with monomeric or multimeric forms of tubulin, including microtubules.
1 P34036 (/IDA)
Tubulin binding GO:0015631
Interacting selectively and non-covalently with monomeric or multimeric forms of tubulin, including microtubules.
1 P34036 (/IPI)
ATPase activity GO:0016887
Catalysis of the reaction: ATP + H2O = ADP + phosphate + 2 H+. May or may not be coupled to another reaction.
1 P34036 (/IDA)
ATPase activity, coupled GO:0042623
Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction directly drives some other reaction, for example ion transport across a membrane.
1 P34036 (/IDA)
Showing 1 to 10 of 14 entries

There are 39 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO TermAnnotationsEvidence
Positive regulation of cold-induced thermogenesis GO:0120162
Any process that activates or increases the frequency, rate or extent of cold-induced thermogenesis.
6 F1LRT9 (/ISS) M0R9X8 (/ISS) P38650 (/ISS) Q14204 (/ISS) Q14204 (/ISS) Q14204 (/ISS)
G2/M transition of mitotic cell cycle GO:0000086
The mitotic cell cycle transition by which a cell in G2 commits to M phase. The process begins when the kinase activity of M cyclin/CDK complex reaches a threshold high enough for the cell cycle to proceed. This is accomplished by activating a positive feedback loop that results in the accumulation of unphosphorylated and active M cyclin/CDK complex.
3 Q14204 (/TAS) Q14204 (/TAS) Q14204 (/TAS)
Endoplasmic reticulum to Golgi vesicle-mediated transport GO:0006888
The directed movement of substances from the endoplasmic reticulum (ER) to the Golgi, mediated by COP II vesicles. Small COP II coated vesicles form from the ER and then fuse directly with the cis-Golgi. Larger structures are transported along microtubules to the cis-Golgi.
3 Q14204 (/TAS) Q14204 (/TAS) Q14204 (/TAS)
Mitotic spindle organization GO:0007052
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle during a mitotic cell cycle.
3 Q14204 (/NAS) Q14204 (/NAS) Q14204 (/NAS)
Regulation of G2/M transition of mitotic cell cycle GO:0010389
Any signalling pathway that modulates the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G2 phase to M phase of the mitotic cell cycle.
3 Q14204 (/TAS) Q14204 (/TAS) Q14204 (/TAS)
Antigen processing and presentation of exogenous peptide antigen via MHC class II GO:0019886
The process in which an antigen-presenting cell expresses a peptide antigen of exogenous origin on its cell surface in association with an MHC class II protein complex. The peptide antigen is typically, but not always, processed from a whole protein.
3 Q14204 (/TAS) Q14204 (/TAS) Q14204 (/TAS)
Positive regulation of intracellular transport GO:0032388
Any process that activates or increases the frequency, rate or extent of the directed movement of substances within cells.
3 Q14204 (/IMP) Q14204 (/IMP) Q14204 (/IMP)
Cytoplasmic mRNA processing body assembly GO:0033962
The aggregation, arrangement and bonding together of proteins and RNA molecules to form a cytoplasmic mRNA processing body.
3 Q14204 (/ISS) Q14204 (/ISS) Q14204 (/ISS)
Stress granule assembly GO:0034063
The aggregation, arrangement and bonding together of proteins and RNA molecules to form a stress granule.
3 Q14204 (/ISS) Q14204 (/ISS) Q14204 (/ISS)
Neutrophil degranulation GO:0043312
The regulated exocytosis of secretory granules containing preformed mediators such as proteases, lipases, and inflammatory mediators by a neutrophil.
3 Q14204 (/TAS) Q14204 (/TAS) Q14204 (/TAS)
Showing 1 to 10 of 39 entries

There are 29 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO TermAnnotationsEvidence
Centrosome GO:0005813
A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle.
4 P34036 (/IDA) Q14204 (/IDA) Q14204 (/IDA) Q14204 (/IDA)
Cytoplasmic dynein complex GO:0005868
Any dynein complex with a homodimeric dynein heavy chain core that catalyzes movement along a microtubule. Cytoplasmic dynein complexes participate in many cytoplasmic transport activities in eukaryotes, such as mRNA localization, intermediate filament transport, nuclear envelope breakdown, apoptosis, transport of centrosomal proteins, mitotic spindle assembly, virus transport, kinetochore functions, and movement of signaling and spindle checkpoint proteins. Some complexes participate in intraflagellar transport. Subunits associated with the dynein heavy chain mediate association between dynein heavy chain and cargoes, and may include light chains and light intermediate chains.
4 P34036 (/IDA) Q14204 (/IDA) Q14204 (/IDA) Q14204 (/IDA)
Extracellular region GO:0005576
The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
3 Q14204 (/TAS) Q14204 (/TAS) Q14204 (/TAS)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
3 P34036 (/IDA) P38650 (/IDA) Q9JHU4 (/IDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
3 Q14204 (/TAS) Q14204 (/TAS) Q14204 (/TAS)
Cytoplasmic dynein complex GO:0005868
Any dynein complex with a homodimeric dynein heavy chain core that catalyzes movement along a microtubule. Cytoplasmic dynein complexes participate in many cytoplasmic transport activities in eukaryotes, such as mRNA localization, intermediate filament transport, nuclear envelope breakdown, apoptosis, transport of centrosomal proteins, mitotic spindle assembly, virus transport, kinetochore functions, and movement of signaling and spindle checkpoint proteins. Some complexes participate in intraflagellar transport. Subunits associated with the dynein heavy chain mediate association between dynein heavy chain and cargoes, and may include light chains and light intermediate chains.
3 Q14204 (/NAS) Q14204 (/NAS) Q14204 (/NAS)
Microtubule GO:0005874
Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle.
3 Q14204 (/IDA) Q14204 (/IDA) Q14204 (/IDA)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
3 Q14204 (/HDA) Q14204 (/HDA) Q14204 (/HDA)
Azurophil granule lumen GO:0035578
The volume enclosed by the membrane of an azurophil granule, a primary lysosomal granule found in neutrophil granulocytes that contains a wide range of hydrolytic enzymes and is released into the extracellular fluid.
3 Q14204 (/TAS) Q14204 (/TAS) Q14204 (/TAS)
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
3 Q14204 (/HDA) Q14204 (/HDA) Q14204 (/HDA)
Showing 1 to 10 of 29 entries
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