The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:

"
Son of sevenless (SoS) protein Chain: S domain 1
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 17: Rap guanine nucleotide exchange factor 1

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 7 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
8 A1L338 (/IPI) F1M8L9 (/IPI) F6ZDE5 (/IPI) Q13905 (/IPI) Q3UGX8 (/IPI) Q3UHC1 (/IPI) Q8C5V7 (/IPI) Q91ZZ2 (/IPI)
SH3/SH2 adaptor activity GO:0005070
Interacting selectively and non-covalently and simultaneously with one or more signal transduction molecules, usually acting as a scaffold to bring these molecules into close proximity either using their own SH2/SH3 domains (e.g. Grb2) or those of their target molecules (e.g. SAM68).
6 A1L338 (/TAS) F6ZDE5 (/TAS) Q3UGX8 (/TAS) Q3UHC1 (/TAS) Q8C5V7 (/TAS) Q91ZZ2 (/TAS)
Guanyl-nucleotide exchange factor activity GO:0005085
Stimulates the exchange of guanyl nucleotides associated with a GTPase. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase.
6 A1L338 (/IDA) F6ZDE5 (/IDA) Q3UGX8 (/IDA) Q3UHC1 (/IDA) Q8C5V7 (/IDA) Q91ZZ2 (/IDA)
Rap guanyl-nucleotide exchange factor activity GO:0017034
Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Rap family. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase.
6 A1L338 (/ISO) F6ZDE5 (/ISO) Q3UGX8 (/ISO) Q3UHC1 (/ISO) Q8C5V7 (/ISO) Q91ZZ2 (/ISO)
Guanyl-nucleotide exchange factor activity GO:0005085
Stimulates the exchange of guanyl nucleotides associated with a GTPase. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase.
2 Q13905 (/TAS) Q9QYV3 (/TAS)
Rap guanyl-nucleotide exchange factor activity GO:0017034
Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Rap family. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase.
1 Q13905 (/IDA)
Rap guanyl-nucleotide exchange factor activity GO:0017034
Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Rap family. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase.
1 Q13905 (/IMP)

There are 37 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Blood vessel development GO:0001568
The process whose specific outcome is the progression of a blood vessel over time, from its formation to the mature structure. The blood vessel is the vasculature carrying blood.
6 A1L338 (/IMP) F6ZDE5 (/IMP) Q3UGX8 (/IMP) Q3UHC1 (/IMP) Q8C5V7 (/IMP) Q91ZZ2 (/IMP)
Positive regulation of neuron projection development GO:0010976
Any process that increases the rate, frequency or extent of neuron projection development. Neuron projection development is the process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites).
6 A1L338 (/ISO) F6ZDE5 (/ISO) Q3UGX8 (/ISO) Q3UHC1 (/ISO) Q8C5V7 (/ISO) Q91ZZ2 (/ISO)
Rap protein signal transduction GO:0032486
A series of molecular signals within the cell that are mediated by a member of the Rap family of proteins switching to a GTP-bound active state.
6 A1L338 (/ISO) F6ZDE5 (/ISO) Q3UGX8 (/ISO) Q3UHC1 (/ISO) Q8C5V7 (/ISO) Q91ZZ2 (/ISO)
Nerve growth factor signaling pathway GO:0038180
A series of molecular signals initiated by the binding of nerve growth factor (NGF) to a receptor on the surface of the target cell, and ending with regulation of a downstream cellular process, e.g. transcription.
6 A1L338 (/ISO) F6ZDE5 (/ISO) Q3UGX8 (/ISO) Q3UHC1 (/ISO) Q8C5V7 (/ISO) Q91ZZ2 (/ISO)
Positive regulation of GTPase activity GO:0043547
Any process that activates or increases the activity of a GTPase.
6 A1L338 (/ISO) F6ZDE5 (/ISO) Q3UGX8 (/ISO) Q3UHC1 (/ISO) Q8C5V7 (/ISO) Q91ZZ2 (/ISO)
Regulation of JNK cascade GO:0046328
Any process that modulates the frequency, rate or extent of signal transduction mediated by the JNK cascade.
6 A1L338 (/ISO) F6ZDE5 (/ISO) Q3UGX8 (/ISO) Q3UHC1 (/ISO) Q8C5V7 (/ISO) Q91ZZ2 (/ISO)
Negative regulation of Ras protein signal transduction GO:0046580
Any process that stops, prevents, or reduces the frequency, rate or extent of Ras protein signal transduction.
6 A1L338 (/IMP) F6ZDE5 (/IMP) Q3UGX8 (/IMP) Q3UHC1 (/IMP) Q8C5V7 (/IMP) Q91ZZ2 (/IMP)
Platelet-derived growth factor receptor signaling pathway GO:0048008
The series of molecular signals generated as a consequence of a platelet-derived growth factor receptor binding to one of its physiological ligands.
6 A1L338 (/IMP) F6ZDE5 (/IMP) Q3UGX8 (/IMP) Q3UHC1 (/IMP) Q8C5V7 (/IMP) Q91ZZ2 (/IMP)
Negative regulation of protein kinase B signaling GO:0051898
Any process that stops, prevents, or reduces the frequency, rate or extent of protein kinase B signaling, a series of reactions mediated by the intracellular serine/threonine kinase protein kinase B.
6 A1L338 (/IGI) F6ZDE5 (/IGI) Q3UGX8 (/IGI) Q3UHC1 (/IGI) Q8C5V7 (/IGI) Q91ZZ2 (/IGI)
Establishment of endothelial barrier GO:0061028
The establishment of a barrier between endothelial cell layers, such as those in the brain, lung or intestine, to exert specific and selective control over the passage of water and solutes, thus allowing formation and maintenance of compartments that differ in fluid and solute composition.
6 A1L338 (/ISO) F6ZDE5 (/ISO) Q3UGX8 (/ISO) Q3UHC1 (/ISO) Q8C5V7 (/ISO) Q91ZZ2 (/ISO)
Negative regulation of ERK1 and ERK2 cascade GO:0070373
Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade.
6 A1L338 (/IGI) F6ZDE5 (/IGI) Q3UGX8 (/IGI) Q3UHC1 (/IGI) Q8C5V7 (/IGI) Q91ZZ2 (/IGI)
Positive regulation of ERK1 and ERK2 cascade GO:0070374
Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade.
6 A1L338 (/ISO) F6ZDE5 (/ISO) Q3UGX8 (/ISO) Q3UHC1 (/ISO) Q8C5V7 (/ISO) Q91ZZ2 (/ISO)
Cellular response to cAMP GO:0071320
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate) stimulus.
6 A1L338 (/ISO) F6ZDE5 (/ISO) Q3UGX8 (/ISO) Q3UHC1 (/ISO) Q8C5V7 (/ISO) Q91ZZ2 (/ISO)
Negative regulation of canonical Wnt signaling pathway GO:0090090
Any process that decreases the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes.
6 A1L338 (/IGI) F6ZDE5 (/IGI) Q3UGX8 (/IGI) Q3UHC1 (/IGI) Q8C5V7 (/IGI) Q91ZZ2 (/IGI)
Activation of GTPase activity GO:0090630
Any process that initiates the activity of an inactive GTPase through the replacement of GDP by GTP.
6 A1L338 (/IGI) F6ZDE5 (/IGI) Q3UGX8 (/IGI) Q3UHC1 (/IGI) Q8C5V7 (/IGI) Q91ZZ2 (/IGI)
Cell-cell adhesion GO:0098609
The attachment of one cell to another cell via adhesion molecules.
6 A1L338 (/IMP) F6ZDE5 (/IMP) Q3UGX8 (/IMP) Q3UHC1 (/IMP) Q8C5V7 (/IMP) Q91ZZ2 (/IMP)
Regulation of cell junction assembly GO:1901888
Any process that modulates the frequency, rate or extent of cell junction assembly.
6 A1L338 (/ISO) F6ZDE5 (/ISO) Q3UGX8 (/ISO) Q3UHC1 (/ISO) Q8C5V7 (/ISO) Q91ZZ2 (/ISO)
Positive regulation of Fc-gamma receptor signaling pathway involved in phagocytosis GO:1905451
Any process that activates or increases the frequency, rate or extent of Fc-gamma receptor signaling pathway involved in phagocytosis.
6 A1L338 (/ISO) F6ZDE5 (/ISO) Q3UGX8 (/ISO) Q3UHC1 (/ISO) Q8C5V7 (/ISO) Q91ZZ2 (/ISO)
Cellular response to nerve growth factor stimulus GO:1990090
A process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nerve growth factor stimulus.
6 A1L338 (/ISO) F6ZDE5 (/ISO) Q3UGX8 (/ISO) Q3UHC1 (/ISO) Q8C5V7 (/ISO) Q91ZZ2 (/ISO)
Negative regulation of neural precursor cell proliferation GO:2000178
Any process that stops, prevents, or reduces the frequency, rate or extent of neural precursor cell proliferation.
6 A1L338 (/IMP) F6ZDE5 (/IMP) Q3UGX8 (/IMP) Q3UHC1 (/IMP) Q8C5V7 (/IMP) Q91ZZ2 (/IMP)
Positive regulation of neuron projection development GO:0010976
Any process that increases the rate, frequency or extent of neuron projection development. Neuron projection development is the process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites).
2 F1M8L9 (/IMP) Q13905 (/IMP)
Activation of MAPKK activity GO:0000186
The initiation of the activity of the inactive enzyme MAP kinase kinase (MAPKK).
1 Q13905 (/TAS)
Signal transduction GO:0007165
The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.
1 Q13905 (/NAS)
Transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169
A series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of the target cell where the receptor possesses tyrosine kinase activity, and ending with regulation of a downstream cellular process, e.g. transcription.
1 Q13905 (/TAS)
Cytokine-mediated signaling pathway GO:0019221
A series of molecular signals initiated by the binding of a cytokine to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.
1 Q13905 (/TAS)
Rap protein signal transduction GO:0032486
A series of molecular signals within the cell that are mediated by a member of the Rap family of proteins switching to a GTP-bound active state.
1 Q13905 (/IMP)
Nerve growth factor signaling pathway GO:0038180
A series of molecular signals initiated by the binding of nerve growth factor (NGF) to a receptor on the surface of the target cell, and ending with regulation of a downstream cellular process, e.g. transcription.
1 Q13905 (/IDA)
Positive regulation of GTPase activity GO:0043547
Any process that activates or increases the activity of a GTPase.
1 Q13905 (/IDA)
Positive regulation of GTPase activity GO:0043547
Any process that activates or increases the activity of a GTPase.
1 Q13905 (/IMP)
Regulation of JNK cascade GO:0046328
Any process that modulates the frequency, rate or extent of signal transduction mediated by the JNK cascade.
1 F1M8L9 (/IMP)
Positive regulation of Ras protein signal transduction GO:0046579
Any process that activates or increases the frequency, rate or extent of Ras protein signal transduction.
1 Q13905 (/TAS)
Establishment of endothelial barrier GO:0061028
The establishment of a barrier between endothelial cell layers, such as those in the brain, lung or intestine, to exert specific and selective control over the passage of water and solutes, thus allowing formation and maintenance of compartments that differ in fluid and solute composition.
1 Q13905 (/IMP)
Positive regulation of ERK1 and ERK2 cascade GO:0070374
Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade.
1 F1M8L9 (/IMP)
Cellular response to cAMP GO:0071320
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate) stimulus.
1 Q13905 (/IDA)
Regulation of cell junction assembly GO:1901888
Any process that modulates the frequency, rate or extent of cell junction assembly.
1 Q13905 (/IMP)
Positive regulation of Fc-gamma receptor signaling pathway involved in phagocytosis GO:1905451
Any process that activates or increases the frequency, rate or extent of Fc-gamma receptor signaling pathway involved in phagocytosis.
1 F1M8L9 (/IMP)
Cellular response to nerve growth factor stimulus GO:1990090
A process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nerve growth factor stimulus.
1 Q13905 (/IDA)

There are 11 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
6 A1L338 (/ISO) F6ZDE5 (/ISO) Q3UGX8 (/ISO) Q3UHC1 (/ISO) Q8C5V7 (/ISO) Q91ZZ2 (/ISO)
Early endosome GO:0005769
A membrane-bounded organelle that receives incoming material from primary endocytic vesicles that have been generated by clathrin-dependent and clathrin-independent endocytosis; vesicles fuse with the early endosome to deliver cargo for sorting into recycling or degradation pathways.
6 A1L338 (/ISO) F6ZDE5 (/ISO) Q3UGX8 (/ISO) Q3UHC1 (/ISO) Q8C5V7 (/ISO) Q91ZZ2 (/ISO)
Phagocytic vesicle membrane GO:0030670
The lipid bilayer surrounding a phagocytic vesicle.
6 A1L338 (/ISO) F6ZDE5 (/ISO) Q3UGX8 (/ISO) Q3UHC1 (/ISO) Q8C5V7 (/ISO) Q91ZZ2 (/ISO)
Protein-containing complex GO:0032991
A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.
6 A1L338 (/ISO) F6ZDE5 (/ISO) Q3UGX8 (/ISO) Q3UHC1 (/ISO) Q8C5V7 (/ISO) Q91ZZ2 (/ISO)
Perinuclear region of cytoplasm GO:0048471
Cytoplasm situated near, or occurring around, the nucleus.
6 A1L338 (/ISO) F6ZDE5 (/ISO) Q3UGX8 (/ISO) Q3UHC1 (/ISO) Q8C5V7 (/ISO) Q91ZZ2 (/ISO)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
3 Q13905 (/TAS) Q3UHC1 (/TAS) Q9QYV3 (/TAS)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 Q13905 (/IDA)
Early endosome GO:0005769
A membrane-bounded organelle that receives incoming material from primary endocytic vesicles that have been generated by clathrin-dependent and clathrin-independent endocytosis; vesicles fuse with the early endosome to deliver cargo for sorting into recycling or degradation pathways.
1 Q13905 (/IDA)
Phagocytic vesicle membrane GO:0030670
The lipid bilayer surrounding a phagocytic vesicle.
1 F1M8L9 (/IDA)
Protein-containing complex GO:0032991
A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.
1 F1M8L9 (/IDA)
Perinuclear region of cytoplasm GO:0048471
Cytoplasm situated near, or occurring around, the nucleus.
1 F1M8L9 (/IDA)
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