The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:
"Son of sevenless (SoS) protein Chain: S domain 1
".
FunFam 10: ras guanyl-releasing protein 3 isoform X2
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 10 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Ras guanyl-nucleotide exchange factor activity GO:0005088
Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Ras superfamily. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase.
|
3 | Q2PHE9 (/IDA) Q69ZX7 (/IDA) Q6NZH9 (/IDA) |
|
GTPase activator activity GO:0005096
Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP.
|
3 | Q2PHE9 (/ISO) Q69ZX7 (/ISO) Q6NZH9 (/ISO) |
|
Ras GTPase binding GO:0017016
Interacting selectively and non-covalently with any member of the Ras superfamily of monomeric GTPases.
|
3 | Q2PHE9 (/IDA) Q69ZX7 (/IDA) Q6NZH9 (/IDA) |
|
Ras GTPase binding GO:0017016
Interacting selectively and non-covalently with any member of the Ras superfamily of monomeric GTPases.
|
3 | Q2PHE9 (/IPI) Q69ZX7 (/IPI) Q6NZH9 (/IPI) |
|
Kinase binding GO:0019900
Interacting selectively and non-covalently with a kinase, any enzyme that catalyzes the transfer of a phosphate group.
|
3 | Q2PHE9 (/IPI) Q69ZX7 (/IPI) Q6NZH9 (/IPI) |
|
Guanyl-nucleotide exchange factor activity GO:0005085
Stimulates the exchange of guanyl nucleotides associated with a GTPase. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase.
|
1 | Q8IV61 (/TAS) |
|
GTPase activator activity GO:0005096
Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP.
|
1 | Q8IV61 (/IDA) |
|
Calcium ion binding GO:0005509
Interacting selectively and non-covalently with calcium ions (Ca2+).
|
1 | Q8IV61 (/NAS) |
|
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
1 | Q8IV61 (/IPI) |
|
Diacylglycerol binding GO:0019992
Interacting selectively and non-covalently with diacylglycerol, a diester of glycerol and two fatty acids.
|
1 | Q8IV61 (/NAS) |
There are 5 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Ras protein signal transduction GO:0007265
A series of molecular signals within the cell that are mediated by a member of the Ras superfamily of proteins switching to a GTP-bound active state.
|
3 | Q2PHE9 (/IDA) Q69ZX7 (/IDA) Q6NZH9 (/IDA) |
|
Regulation of GTPase activity GO:0043087
Any process that modulates the rate of GTP hydrolysis by a GTPase.
|
3 | Q2PHE9 (/IDA) Q69ZX7 (/IDA) Q6NZH9 (/IDA) |
|
MAPK cascade GO:0000165
An intracellular protein kinase cascade containing at least a MAPK, a MAPKK and a MAP3K. The cascade can also contain an additional tiers: the upstream MAP4K. The kinases in each tier phosphorylate and activate the kinase in the downstream tier to transmit a signal within a cell.
|
1 | Q8IV61 (/NAS) |
|
MAPK cascade GO:0000165
An intracellular protein kinase cascade containing at least a MAPK, a MAPKK and a MAP3K. The cascade can also contain an additional tiers: the upstream MAP4K. The kinases in each tier phosphorylate and activate the kinase in the downstream tier to transmit a signal within a cell.
|
1 | Q8IV61 (/TAS) |
|
Small GTPase mediated signal transduction GO:0007264
Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals.
|
1 | Q8IV61 (/TAS) |
There are 6 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
3 | Q2PHE9 (/IDA) Q69ZX7 (/IDA) Q6NZH9 (/IDA) |
|
Guanyl-nucleotide exchange factor complex GO:0032045
A protein complex that stimulates the exchange of guanyl nucleotides associated with a GTPase.
|
3 | Q2PHE9 (/IDA) Q69ZX7 (/IDA) Q6NZH9 (/IDA) |
|
Perinuclear region of cytoplasm GO:0048471
Cytoplasm situated near, or occurring around, the nucleus.
|
3 | Q2PHE9 (/IDA) Q69ZX7 (/IDA) Q6NZH9 (/IDA) |
|
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
2 | Q2PHE9 (/TAS) Q8IV61 (/TAS) |
|
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
1 | Q2PHE9 (/TAS) |
|
Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
|
1 | Q8IV61 (/NAS) |
