The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
SC:1Syntaxin 12Syntaxin VAM3SC:2Syntaxin 3Syntaxin 4diablo homolog, mitochondrial isoform X1syntaxin-16 isoform X2Qa-SNARE, Sso1/Syntaxin1-type, SYP12A-groupSyntaxin-22 likesyntaxin-5 isoform X1Syntaxin 7ER-golgi SNARE complex subunitSyntaxin family proteinSyntaxin-43Syntaxin 132t-SNARE domain containing 1Syntaxin 11Syntaxin-32 likeSyntaxin 19SNARE domain proteint-SNAREt-SNARE domain-containing protein 1SNARE complex subunit (Tlg2)Syntaxin-5t-SNARE syntaxinSyntaxin, Qa-SNARE familySyntaxin-12Syntaxin-132Putative syntaxin-3Syntaxin, Qa-SNARE familySyntaxin, Qa-SNARE familyTLG2p Syntaxin-like t-SNARESyntaxin-32DIABLO isoform 9Unplaced genomic scaffold supercont1.13, whole genome shotgun sequenceSyntaxin 5Syntaxin-like proteinSNARE domain proteinPutative QA-SNARE proteinUnplaced genomic scaffold supercont1.17, whole genome shotgun sequenceCBN-SYX-2 proteinPep12pSyntaxin 11b, tandem duplicate 2Syntaxin, Qa-SNARE familyGM25395CRE-SYN-13 proteinCRE-SYN-16 proteinRelated to PEP12 syntaxin (t-SNARE), vacuolarSyntaxin 7-likeEhSyntaxin 1BEhSyntaxin 1A, putativeSyntaxin PM family proteinSyntaxin 5 family proteinUncharacterized proteinUncharacterized proteinQA-SNARE protein putativeSyntaxin-16Syntaxin 1-2Syntaxin 19Qa-SNARE proteinSyntaxin 2aSyntaxin 16/TLG2-like protein, putativeSyntaxin-16SyntaxinTarget SNARE, putativeSyntaxin 1At-SNARE family proteinPutative syntaxin-5Uncharacterized proteinUncharacterized proteinUncharacterized proteinPutative second mitochondria-derived activator of caspaseSyntaxin-16Syntaxin-5Tlg2pUncharacterized proteinQA-SNARE protein putativeYALI0E33165pSyntaxin-7AQa-SNARE, SYP2/Pep12p/Syntaxin 7-typeUncharacterized proteinSNAP receptorUncharacterized proteint-SNAREt-SNAREPutative snare protein pep12/vam3/syntaxin 7/syntaxin 17Syntaxin-12Syntaxin-12AFL232WpSyntaxin, putativeSTX1A proteinAaceriACR092CpPutative snare protein syntaxin 1Syntaxin-1AAGAP008756-PASyntaxin-22Syntaxin 1A (brain)Syntaxin 4-2Uncharacterized proteinPredicted proteinSyntaxin 4Protein CBR-SYX-5Uncharacterized proteinPredicted proteinDiablo, IAP-binding mitochondrial protein aDiablo, IAP-binding mitochondrial protein bQa-SNARE, Sso1/Syntaxin1-type, SYP13 groupSyntaxinUncharacterized proteinQa-SNARE protein, Sed5/Syntaxin5-familyQa-SNARE protein, Tlg2/Syntaxin16-familyUncharacterized proteint-SNARE affecting a late Golgi compartment protein 2Uncharacterized proteinSyntaxin 2aPredicted proteinSyntaxinSyntaxin-4-like ProteinUncharacterized proteinSyntaxin pep12Syntaxin-132Predicted proteinProbable syntaxin-7BSyntaxin 2aSyntaxin-22Uncharacterized proteinUncharacterized proteinUncharacterized proteinUncharacterized proteinSyntaxin 1A (brain)Uncharacterized proteinUncharacterized protein
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FunFam 2: syntaxin-16 isoform X2

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 5 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO TermAnnotationsEvidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
2 O14662 (/IPI) Q8BVI5 (/IPI)
SNAP receptor activity GO:0005484
Acting as a marker to identify a membrane and interacting selectively with one or more SNAREs on another membrane to mediate membrane fusion.
1 O14662 (/IDA)
SNAP receptor activity GO:0005484
Acting as a marker to identify a membrane and interacting selectively with one or more SNAREs on another membrane to mediate membrane fusion.
1 Q8BVI5 (/ISO)
Syntaxin binding GO:0019905
Interacting selectively and non-covalently with a syntaxin, a SNAP receptor involved in the docking of synaptic vesicles at the presynaptic zone of a synapse.
1 O14662 (/IPI)
Syntaxin binding GO:0019905
Interacting selectively and non-covalently with a syntaxin, a SNAP receptor involved in the docking of synaptic vesicles at the presynaptic zone of a synapse.
1 Q8BVI5 (/ISO)
Showing 1 to 5 of 5 entries

There are 7 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO TermAnnotationsEvidence
Pronephric duct morphogenesis GO:0039023
The process in which the anatomical structures of the pronephric duct are generated and organized. The pronephric duct collects the filtrate from the pronephric tubules and opens to the exterior of the kidney.
2 A0A2R8Q071 (/IMP) X1WEE0 (/IMP)
Retrograde transport, endosome to Golgi GO:0042147
The directed movement of membrane-bounded vesicles from endosomes back to the trans-Golgi network where they are recycled for further rounds of transport.
1 O14662 (/IDA)
Retrograde transport, endosome to Golgi GO:0042147
The directed movement of membrane-bounded vesicles from endosomes back to the trans-Golgi network where they are recycled for further rounds of transport.
1 O14662 (/IMP)
Retrograde transport, endosome to Golgi GO:0042147
The directed movement of membrane-bounded vesicles from endosomes back to the trans-Golgi network where they are recycled for further rounds of transport.
1 Q8BVI5 (/ISO)
Retrograde transport, endosome to Golgi GO:0042147
The directed movement of membrane-bounded vesicles from endosomes back to the trans-Golgi network where they are recycled for further rounds of transport.
1 Q8BVI5 (/ISS)
Golgi ribbon formation GO:0090161
The formation of a continuous ribbon of interconnected Golgi stacks of flat cisternae.
1 O14662 (/IMP)
Golgi ribbon formation GO:0090161
The formation of a continuous ribbon of interconnected Golgi stacks of flat cisternae.
1 Q8BVI5 (/ISO)
Showing 1 to 7 of 7 entries

There are 23 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO TermAnnotationsEvidence
Golgi apparatus GO:0005794
A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions.
2 O14662 (/IDA) Q8BVI5 (/IDA)
Intracellular membrane-bounded organelle GO:0043231
Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.
2 F8W9Z6 (/IDA) O14662 (/IDA)
Golgi membrane GO:0000139
The lipid bilayer surrounding any of the compartments of the Golgi apparatus.
1 O14662 (/TAS)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 O14662 (/IDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 Q8BVI5 (/ISO)
Golgi apparatus GO:0005794
A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions.
1 Q8BVI5 (/ISO)
Trans-Golgi network GO:0005802
The network of interconnected tubular and cisternal structures located within the Golgi apparatus on the side distal to the endoplasmic reticulum, from which secretory vesicles emerge. The trans-Golgi network is important in the later stages of protein secretion where it is thought to play a key role in the sorting and targeting of secreted proteins to the correct destination.
1 O14662 (/IDA)
Trans-Golgi network GO:0005802
The network of interconnected tubular and cisternal structures located within the Golgi apparatus on the side distal to the endoplasmic reticulum, from which secretory vesicles emerge. The trans-Golgi network is important in the later stages of protein secretion where it is thought to play a key role in the sorting and targeting of secreted proteins to the correct destination.
1 Q8BVI5 (/ISO)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 Q8BVI5 (/ISO)
Focal adhesion GO:0005925
Small region on the surface of a cell that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments.
1 O14662 (/HDA)
Showing 1 to 10 of 23 entries
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