View in Gene3D

CATH Superfamily 1.20.58.60

The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
« Back to all FunFams

FunFam 20: Spectrin alpha chain, non-erythrocytic 1

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 16 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO TermAnnotationsEvidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
 15 P02549 (/IPI) P02549 (/IPI) P02549 (/IPI) P02549 (/IPI) P02549 (/IPI) P02549 (/IPI) P02549 (/IPI) P02549 (/IPI) P02549 (/IPI) P02549 (/IPI)
(5 more)
Structural constituent of cytoskeleton GO:0005200
The action of a molecule that contributes to the structural integrity of a cytoskeletal structure.
 13 P02549 (/TAS) P02549 (/TAS) P02549 (/TAS) P02549 (/TAS) P02549 (/TAS) P02549 (/TAS) P02549 (/TAS) P02549 (/TAS) P02549 (/TAS) P02549 (/TAS)
(3 more)
Protein heterodimerization activity GO:0046982
Interacting selectively and non-covalently with a nonidentical protein to form a heterodimer.
 12 P08032 (/IPI) P08032 (/IPI) P08032 (/IPI) P08032 (/IPI) P08032 (/IPI) P08032 (/IPI) P08032 (/IPI) P08032 (/IPI) P08032 (/IPI) P08032 (/IPI)
(2 more)
Actin filament binding GO:0051015
Interacting selectively and non-covalently with an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits.
 12 P02549 (/TAS) P02549 (/TAS) P02549 (/TAS) P02549 (/TAS) P02549 (/TAS) P02549 (/TAS) P02549 (/TAS) P02549 (/TAS) P02549 (/TAS) P02549 (/TAS)
(2 more)
Actin binding GO:0003779
Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments.
 2 P13395 (/IDA) P13395 (/IDA)
Actin binding GO:0003779
Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments.
 2 P13395 (/ISS) P13395 (/ISS)
Microtubule binding GO:0008017
Interacting selectively and non-covalently with microtubules, filaments composed of tubulin monomers.
 2 P13395 (/IDA) P13395 (/IDA)
Spectrin binding GO:0030507
Interacting selectively and non-covalently with spectrin, a protein that is the major constituent of the erythrocyte cytoskeletal network. It associates with band 4.1 (see band protein) and actin to form the cytoskeletal superstructure of the erythrocyte plasma membrane. It is composed of nonhomologous chains, alpha and beta, which aggregate side-to-side in an antiparallel fashion to form dimers, tetramers, and higher polymers.
 2 P16086 (/IDA) P16546 (/IDA)
Actin binding GO:0003779
Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments.
 1 Q13813 (/TAS)
Syntaxin binding GO:0019905
Interacting selectively and non-covalently with a syntaxin, a SNAP receptor involved in the docking of synaptic vesicles at the presynaptic zone of a synapse.
 1 P16086 (/IPI)
Showing 1 to 10 of 16 entries

There are 34 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO TermAnnotationsEvidence
MAPK cascade GO:0000165
An intracellular protein kinase cascade containing at least a MAPK, a MAPKK and a MAP3K. The cascade can also contain an additional tiers: the upstream MAP4K. The kinases in each tier phosphorylate and activate the kinase in the downstream tier to transmit a signal within a cell.
 13 P02549 (/TAS) P02549 (/TAS) P02549 (/TAS) P02549 (/TAS) P02549 (/TAS) P02549 (/TAS) P02549 (/TAS) P02549 (/TAS) P02549 (/TAS) P02549 (/TAS)
(3 more)
Endoplasmic reticulum to Golgi vesicle-mediated transport GO:0006888
The directed movement of substances from the endoplasmic reticulum (ER) to the Golgi, mediated by COP II vesicles. Small COP II coated vesicles form from the ER and then fuse directly with the cis-Golgi. Larger structures are transported along microtubules to the cis-Golgi.
 13 P02549 (/TAS) P02549 (/TAS) P02549 (/TAS) P02549 (/TAS) P02549 (/TAS) P02549 (/TAS) P02549 (/TAS) P02549 (/TAS) P02549 (/TAS) P02549 (/TAS)
(3 more)
Axon guidance GO:0007411
The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues.
 13 P02549 (/TAS) P02549 (/TAS) P02549 (/TAS) P02549 (/TAS) P02549 (/TAS) P02549 (/TAS) P02549 (/TAS) P02549 (/TAS) P02549 (/TAS) P02549 (/TAS)
(3 more)
Lymphocyte homeostasis GO:0002260
The process of regulating the proliferation and elimination of lymphocytes such that the total number of lymphocytes within a whole or part of an organism is stable over time in the absence of an outside stimulus.
 12 P08032 (/IMP) P08032 (/IMP) P08032 (/IMP) P08032 (/IMP) P08032 (/IMP) P08032 (/IMP) P08032 (/IMP) P08032 (/IMP) P08032 (/IMP) P08032 (/IMP)
(2 more)
Porphyrin-containing compound biosynthetic process GO:0006779
The chemical reactions and pathways resulting in the formation of any member of a large group of derivatives or analogs of porphyrin. Porphyrin consists of a ring of four pyrrole nuclei linked each to the next at their alpha positions through a methine group.
 12 P08032 (/IMP) P08032 (/IMP) P08032 (/IMP) P08032 (/IMP) P08032 (/IMP) P08032 (/IMP) P08032 (/IMP) P08032 (/IMP) P08032 (/IMP) P08032 (/IMP)
(2 more)
Plasma membrane organization GO:0007009
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the plasma membrane.
 12 P08032 (/IMP) P08032 (/IMP) P08032 (/IMP) P08032 (/IMP) P08032 (/IMP) P08032 (/IMP) P08032 (/IMP) P08032 (/IMP) P08032 (/IMP) P08032 (/IMP)
(2 more)
Actin filament organization GO:0007015
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments. Includes processes that control the spatial distribution of actin filaments, such as organizing filaments into meshworks, bundles, or other structures, as by cross-linking.
 12 P02549 (/TAS) P02549 (/TAS) P02549 (/TAS) P02549 (/TAS) P02549 (/TAS) P02549 (/TAS) P02549 (/TAS) P02549 (/TAS) P02549 (/TAS) P02549 (/TAS)
(2 more)
Regulation of cell shape GO:0008360
Any process that modulates the surface configuration of a cell.
 12 P08032 (/IMP) P08032 (/IMP) P08032 (/IMP) P08032 (/IMP) P08032 (/IMP) P08032 (/IMP) P08032 (/IMP) P08032 (/IMP) P08032 (/IMP) P08032 (/IMP)
(2 more)
Actin cytoskeleton organization GO:0030036
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins.
 12 P08032 (/IMP) P08032 (/IMP) P08032 (/IMP) P08032 (/IMP) P08032 (/IMP) P08032 (/IMP) P08032 (/IMP) P08032 (/IMP) P08032 (/IMP) P08032 (/IMP)
(2 more)
Hemopoiesis GO:0030097
The process whose specific outcome is the progression of the myeloid and lymphoid derived organ/tissue systems of the blood and other parts of the body over time, from formation to the mature structure. The site of hemopoiesis is variable during development, but occurs primarily in bone marrow or kidney in many adult vertebrates.
 12 P08032 (/IMP) P08032 (/IMP) P08032 (/IMP) P08032 (/IMP) P08032 (/IMP) P08032 (/IMP) P08032 (/IMP) P08032 (/IMP) P08032 (/IMP) P08032 (/IMP)
(2 more)
Showing 1 to 10 of 34 entries

There are 42 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO TermAnnotationsEvidence
Spectrin GO:0008091
Membrane associated dimeric protein (240 and 220 kDa) of erythrocytes. Forms a complex with ankyrin, actin and probably other components of the membrane cytoskeleton, so that there is a mesh of proteins underlying the plasma membrane, potentially restricting the lateral mobility of integral proteins.
 26 P02549 (/TAS) P02549 (/TAS) P02549 (/TAS) P02549 (/TAS) P02549 (/TAS) P02549 (/TAS) P02549 (/TAS) P02549 (/TAS) P02549 (/TAS) P02549 (/TAS)
(16 more)
Cytoplasmic side of plasma membrane GO:0009898
The leaflet the plasma membrane that faces the cytoplasm and any proteins embedded or anchored in it or attached to its surface.
 24 D4A678 (/IDA) D4A678 (/IDA) D4A678 (/IDA) D4A678 (/IDA) D4A678 (/IDA) D4A678 (/IDA) D4A678 (/IDA) D4A678 (/IDA) D4A678 (/IDA) D4A678 (/IDA)
(14 more)
Axon GO:0030424
The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter.
 24 D4A678 (/IDA) D4A678 (/IDA) D4A678 (/IDA) D4A678 (/IDA) D4A678 (/IDA) D4A678 (/IDA) D4A678 (/IDA) D4A678 (/IDA) D4A678 (/IDA) D4A678 (/IDA)
(14 more)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
 14 P02549 (/TAS) P02549 (/TAS) P02549 (/TAS) P02549 (/TAS) P02549 (/TAS) P02549 (/TAS) P02549 (/TAS) P02549 (/TAS) P02549 (/TAS) P02549 (/TAS)
(4 more)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
 13 P08032 (/IDA) P08032 (/IDA) P08032 (/IDA) P08032 (/IDA) P08032 (/IDA) P08032 (/IDA) P08032 (/IDA) P08032 (/IDA) P08032 (/IDA) P08032 (/IDA)
(3 more)
Cortical cytoskeleton GO:0030863
The portion of the cytoskeleton that lies just beneath the plasma membrane.
 13 P08032 (/IDA) P08032 (/IDA) P08032 (/IDA) P08032 (/IDA) P08032 (/IDA) P08032 (/IDA) P08032 (/IDA) P08032 (/IDA) P08032 (/IDA) P08032 (/IDA)
(3 more)
Cuticular plate GO:0032437
A dense network of actin filaments found beneath the apical cell surface of hair cells, and into which stereocilia are inserted.
 13 P08032 (/IDA) P08032 (/IDA) P08032 (/IDA) P08032 (/IDA) P08032 (/IDA) P08032 (/IDA) P08032 (/IDA) P08032 (/IDA) P08032 (/IDA) P08032 (/IDA)
(3 more)
Spectrin GO:0008091
Membrane associated dimeric protein (240 and 220 kDa) of erythrocytes. Forms a complex with ankyrin, actin and probably other components of the membrane cytoskeleton, so that there is a mesh of proteins underlying the plasma membrane, potentially restricting the lateral mobility of integral proteins.
 12 P08032 (/IMP) P08032 (/IMP) P08032 (/IMP) P08032 (/IMP) P08032 (/IMP) P08032 (/IMP) P08032 (/IMP) P08032 (/IMP) P08032 (/IMP) P08032 (/IMP)
(2 more)
Cytoplasmic side of plasma membrane GO:0009898
The leaflet the plasma membrane that faces the cytoplasm and any proteins embedded or anchored in it or attached to its surface.
 12 P08032 (/ISO) P08032 (/ISO) P08032 (/ISO) P08032 (/ISO) P08032 (/ISO) P08032 (/ISO) P08032 (/ISO) P08032 (/ISO) P08032 (/ISO) P08032 (/ISO)
(2 more)
Spectrin-associated cytoskeleton GO:0014731
The part of the cytoskeleton composed of spectrin, protein 4.1 and ankyrin. Spectrin-associated cytoskeleton is associated with the plasma membrane.
 12 P02549 (/IDA) P02549 (/IDA) P02549 (/IDA) P02549 (/IDA) P02549 (/IDA) P02549 (/IDA) P02549 (/IDA) P02549 (/IDA) P02549 (/IDA) P02549 (/IDA)
(2 more)
Showing 1 to 10 of 42 entries
CATH-Gene3D is a Global Biodata Core Resource Learn more...