The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:
"Neurotransmitter-gated ion-channel transmembrane domain
".
FunFam 5: Putative gamma-aminobutyric acid receptor subunit ...
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 23 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Protein domain specific binding GO:0019904
Interacting selectively and non-covalently with a specific domain of a protein.
|
4 | B2RXA8 (/ISO) P56475 (/ISO) P56476 (/ISO) Q3URA6 (/ISO) |
Protein domain specific binding GO:0019904
Interacting selectively and non-covalently with a specific domain of a protein.
|
3 | P47742 (/IPI) P50572 (/IPI) P50573 (/IPI) |
GABA-A receptor activity GO:0004890
Combining with the amino acid gamma-aminobutyric acid (GABA, 4-aminobutyrate) to initiate a change in cell activity. GABA-A receptors function as chloride channels.
|
2 | P24046 (/TAS) P28476 (/TAS) |
Transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential GO:1904315
Any transmitter-gated ion channel activity that is involved in regulation of postsynaptic membrane potential.
|
2 | P47742 (/IDA) P56475 (/IDA) |
GABA-A receptor activity GO:0004890
Combining with the amino acid gamma-aminobutyric acid (GABA, 4-aminobutyrate) to initiate a change in cell activity. GABA-A receptors function as chloride channels.
|
1 | P47742 (/IDA) |
GABA-A receptor activity GO:0004890
Combining with the amino acid gamma-aminobutyric acid (GABA, 4-aminobutyrate) to initiate a change in cell activity. GABA-A receptors function as chloride channels.
|
1 | P56476 (/IMP) |
GABA-A receptor activity GO:0004890
Combining with the amino acid gamma-aminobutyric acid (GABA, 4-aminobutyrate) to initiate a change in cell activity. GABA-A receptors function as chloride channels.
|
1 | P56476 (/ISO) |
GABA-A receptor activity GO:0004890
Combining with the amino acid gamma-aminobutyric acid (GABA, 4-aminobutyrate) to initiate a change in cell activity. GABA-A receptors function as chloride channels.
|
1 | A8MPY1 (/NAS) |
Inhibitory extracellular ligand-gated ion channel activity GO:0005237
Enables the transmembrane transfer of an ion by a channel that opens when a specific extracellular inhibitory ligand has been bound by the channel complex or one of its constituent parts. Inhibitory ligands, such as GABA or glycine, open chloride-selective channels.
|
1 | P47742 (/TAS) |
Chloride channel activity GO:0005254
Enables the facilitated diffusion of a chloride (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism.
|
1 | P47742 (/TAS) |
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
1 | P50572 (/IPI) |
GABA receptor activity GO:0016917
Combining with gamma-aminobutyric acid (GABA), and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. (GABA, 4-aminobutyrate) is an amino acid which acts as a neurotransmitter in some organisms.
|
1 | P50572 (/IDA) |
GABA receptor activity GO:0016917
Combining with gamma-aminobutyric acid (GABA), and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. (GABA, 4-aminobutyrate) is an amino acid which acts as a neurotransmitter in some organisms.
|
1 | P56475 (/ISO) |
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
|
1 | P50572 (/IDA) |
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
|
1 | P56475 (/ISO) |
Protein heterodimerization activity GO:0046982
Interacting selectively and non-covalently with a nonidentical protein to form a heterodimer.
|
1 | P50572 (/IDA) |
Protein heterodimerization activity GO:0046982
Interacting selectively and non-covalently with a nonidentical protein to form a heterodimer.
|
1 | P56475 (/ISO) |
Ligand-gated ion channel activity involved in regulation of presynaptic membrane potential GO:0099507
Any ligand-gated ion channel activity, occurring in the presynaptic membrane, that is involved in regulation of presynaptic membrane potential.
|
1 | P56475 (/EXP) |
Ligand-gated ion channel activity involved in regulation of presynaptic membrane potential GO:0099507
Any ligand-gated ion channel activity, occurring in the presynaptic membrane, that is involved in regulation of presynaptic membrane potential.
|
1 | P56475 (/IDA) |
Ligand-gated ion channel activity involved in regulation of presynaptic membrane potential GO:0099507
Any ligand-gated ion channel activity, occurring in the presynaptic membrane, that is involved in regulation of presynaptic membrane potential.
|
1 | P56475 (/IMP) |
Transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential GO:1904315
Any transmitter-gated ion channel activity that is involved in regulation of postsynaptic membrane potential.
|
1 | P47742 (/EXP) |
Transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential GO:1904315
Any transmitter-gated ion channel activity that is involved in regulation of postsynaptic membrane potential.
|
1 | P56475 (/IMP) |
Transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential GO:1904315
Any transmitter-gated ion channel activity that is involved in regulation of postsynaptic membrane potential.
|
1 | P56476 (/ISO) |
There are 9 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Chemical synaptic transmission GO:0007268
The vesicular release of classical neurotransmitter molecules from a presynapse, across a chemical synapse, the subsequent activation of neurotransmitter receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse.
|
2 | P24046 (/TAS) P28476 (/TAS) |
Chloride transport GO:0006821
The directed movement of chloride into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
|
1 | P56476 (/TAS) |
Signal transduction GO:0007165
The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.
|
1 | P28476 (/TAS) |
Gamma-aminobutyric acid signaling pathway GO:0007214
The series of molecular signals generated by the binding of gamma-aminobutyric acid (GABA, 4-aminobutyrate), an amino acid which acts as a neurotransmitter in some organisms, to a cell surface receptor.
|
1 | P56476 (/IMP) |
Gamma-aminobutyric acid signaling pathway GO:0007214
The series of molecular signals generated by the binding of gamma-aminobutyric acid (GABA, 4-aminobutyrate), an amino acid which acts as a neurotransmitter in some organisms, to a cell surface receptor.
|
1 | A8MPY1 (/NAS) |
Gamma-aminobutyric acid signaling pathway GO:0007214
The series of molecular signals generated by the binding of gamma-aminobutyric acid (GABA, 4-aminobutyrate), an amino acid which acts as a neurotransmitter in some organisms, to a cell surface receptor.
|
1 | P24046 (/TAS) |
Chemical synaptic transmission GO:0007268
The vesicular release of classical neurotransmitter molecules from a presynapse, across a chemical synapse, the subsequent activation of neurotransmitter receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse.
|
1 | A8MPY1 (/NAS) |
Visual perception GO:0007601
The series of events required for an organism to receive a visual stimulus, convert it to a molecular signal, and recognize and characterize the signal. Visual stimuli are detected in the form of photons and are processed to form an image.
|
1 | P56476 (/IMP) |
Visual perception GO:0007601
The series of events required for an organism to receive a visual stimulus, convert it to a molecular signal, and recognize and characterize the signal. Visual stimuli are detected in the form of photons and are processed to form an image.
|
1 | P50572 (/NAS) |
There are 10 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
3 | A8MPY1 (/TAS) P24046 (/TAS) P28476 (/TAS) |
Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
|
2 | P24046 (/TAS) P28476 (/TAS) |
GABA-ergic synapse GO:0098982
A synapse that uses GABA as a neurotransmitter. These synapses are typically inhibitory.
|
2 | P47742 (/IDA) P56475 (/IDA) |
Axon GO:0030424
The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter.
|
1 | P56476 (/TAS) |
Glutamatergic synapse GO:0098978
A synapse that uses glutamate as a neurotransmitter.
|
1 | P56475 (/EXP) |
Glutamatergic synapse GO:0098978
A synapse that uses glutamate as a neurotransmitter.
|
1 | P56475 (/IDA) |
Glutamatergic synapse GO:0098978
A synapse that uses glutamate as a neurotransmitter.
|
1 | P56475 (/IMP) |
GABA-ergic synapse GO:0098982
A synapse that uses GABA as a neurotransmitter. These synapses are typically inhibitory.
|
1 | P47742 (/EXP) |
GABA-ergic synapse GO:0098982
A synapse that uses GABA as a neurotransmitter. These synapses are typically inhibitory.
|
1 | P56475 (/IMP) |
GABA-ergic synapse GO:0098982
A synapse that uses GABA as a neurotransmitter. These synapses are typically inhibitory.
|
1 | P56476 (/ISO) |