The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:

"
Neurotransmitter-gated ion-channel transmembrane domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 16: Putative acetylcholine receptor subunit alpha

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 11 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO TermAnnotationsEvidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
2 P04756 (/IPI) P04756 (/IPI)
Acetylcholine-gated cation-selective channel activity GO:0022848
Selectively enables the transmembrane transfer of a cation by a channel that opens upon binding acetylcholine.
2 P04756 (/ISO) P04756 (/ISO)
Transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential GO:1904315
Any transmitter-gated ion channel activity that is involved in regulation of postsynaptic membrane potential.
2 P04756 (/ISO) P04756 (/ISO)
Ion channel activity GO:0005216
Enables the facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. May be either selective (it enables passage of a specific ion only) or non-selective (it enables passage of two or more ions of same charge but different size).
1 P02708 (/TAS)
Cation channel activity GO:0005261
Enables the energy-independent passage of cations across a lipid bilayer down a concentration gradient.
1 Q98880 (/IDA)
Acetylcholine receptor activity GO:0015464
Combining with acetylcholine and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
1 P02708 (/TAS)
Acetylcholine-gated cation-selective channel activity GO:0022848
Selectively enables the transmembrane transfer of a cation by a channel that opens upon binding acetylcholine.
1 P25108 (/IDA)
Acetylcholine-gated cation-selective channel activity GO:0022848
Selectively enables the transmembrane transfer of a cation by a channel that opens upon binding acetylcholine.
1 P02708 (/IMP)
Acetylcholine-gated cation-selective channel activity GO:0022848
Selectively enables the transmembrane transfer of a cation by a channel that opens upon binding acetylcholine.
1 P02708 (/TAS)
Transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential GO:1904315
Any transmitter-gated ion channel activity that is involved in regulation of postsynaptic membrane potential.
1 P02708 (/IDA)
Showing 1 to 10 of 11 entries

There are 34 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO TermAnnotationsEvidence
Skeletal muscle contraction GO:0003009
A process in which force is generated within skeletal muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. In the skeletal muscle, the muscle contraction takes advantage of an ordered sarcomeric structure and in most cases it is under voluntary control.
2 P04756 (/ISO) P04756 (/ISO)
Cation transport GO:0006812
The directed movement of cations, atoms or small molecules with a net positive charge, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
2 P04756 (/ISO) P04756 (/ISO)
Neuromuscular synaptic transmission GO:0007274
The process of synaptic transmission from a neuron to a muscle, across a synapse.
2 P04756 (/ISO) P04756 (/ISO)
Neuromuscular junction development GO:0007528
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a neuromuscular junction.
2 P04756 (/ISO) P04756 (/ISO)
Neuronal action potential GO:0019228
An action potential that occurs in a neuron.
2 P04756 (/ISO) P04756 (/ISO)
Regulation of membrane potential GO:0042391
Any process that modulates the establishment or extent of a membrane potential, the electric potential existing across any membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane.
2 P04756 (/IGI) P04756 (/IGI)
Regulation of membrane potential GO:0042391
Any process that modulates the establishment or extent of a membrane potential, the electric potential existing across any membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane.
2 P04756 (/ISO) P04756 (/ISO)
Muscle cell cellular homeostasis GO:0046716
The cellular homeostatic process that preserves a muscle cell in a stable functional or structural state.
2 P04756 (/ISO) P04756 (/ISO)
Skeletal muscle tissue growth GO:0048630
The increase in size or mass of a skeletal muscle. This may be due to a change in the fiber number or size.
2 P04756 (/ISO) P04756 (/ISO)
Musculoskeletal movement GO:0050881
The movement of an organism or part of an organism using mechanoreceptors, the nervous system, striated muscle and/or the skeletal system.
2 P04756 (/ISO) P04756 (/ISO)
Showing 1 to 10 of 34 entries

There are 19 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO TermAnnotationsEvidence
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
5 A0A1B0GV17 (/IDA) P02708 (/IDA) P04756 (/IDA) P04756 (/IDA) Q53SH4 (/IDA)
Cell surface GO:0009986
The external part of the cell wall and/or plasma membrane.
3 P02708 (/IDA) P04756 (/IDA) P04756 (/IDA)
Neuromuscular junction GO:0031594
The junction between the axon of a motor neuron and a muscle fiber. In response to the arrival of action potentials, the presynaptic button releases molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane of the muscle fiber, leading to a change in post-synaptic potential.
3 P02708 (/IDA) P04756 (/IDA) P04756 (/IDA)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
2 P04756 (/ISO) P04756 (/ISO)
Acetylcholine-gated channel complex GO:0005892
A homo- or hetero-pentameric protein complex that forms a transmembrane channel through which ions may pass in response to acetylcholine binding.
2 P25108 (/IDA) Q98880 (/IDA)
Acetylcholine-gated channel complex GO:0005892
A homo- or hetero-pentameric protein complex that forms a transmembrane channel through which ions may pass in response to acetylcholine binding.
2 P04756 (/IPI) P04756 (/IPI)
Acetylcholine-gated channel complex GO:0005892
A homo- or hetero-pentameric protein complex that forms a transmembrane channel through which ions may pass in response to acetylcholine binding.
2 P04756 (/ISO) P04756 (/ISO)
Acetylcholine-gated channel complex GO:0005892
A homo- or hetero-pentameric protein complex that forms a transmembrane channel through which ions may pass in response to acetylcholine binding.
2 P02708 (/TAS) P25108 (/TAS)
Cell surface GO:0009986
The external part of the cell wall and/or plasma membrane.
2 P04756 (/ISO) P04756 (/ISO)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
2 P04756 (/IDA) P04756 (/IDA)
Showing 1 to 10 of 19 entries
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