Structural domains comprising this superfamily share he structure of the C-terminal domain of the translesion synthesis (TLS) DNA polymerase Rev1, enzyme which allows DNA synthesis to proceed even in the presence of DNA damage. Rev1 belongs to the Y-family of TLS polymerases. Rev1 possess a limited catalytic activity but it has a second and more important function which involved the recruitment and coordination of other Y-family TLS polymerases and the regulatory subunit Rev7 of the B-family polymerase pol . This interaction is mediated by its C-terminal domain which therefore serves as a scaffold that allows access of the Y-family polymerases to their cognate DNA lesions and the subsequent exchange to pol , which then extends the distorted DNA primer terminus opposite the lesion PMID:22691049 PMID:22859296.